IE37998B1 - Indole derivatives - Google Patents

Indole derivatives

Info

Publication number: IE37998B1
Authority: IE; Ireland
Prior art keywords: alkyl; alkoxy; halogen; possibly; therapeutic compositions
Prior art date: 1971-11-03

Application number

IE1320/72A

Other languages

English (en)

Other versions

IE37998L (en

Original Assignee

Ici Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-11-03

Filing date

1972-09-28

Publication date

1977-12-07

1972-09-28 Application filed by Ici Ltd filed Critical Ici Ltd

1973-05-03 Publication of IE37998L publication Critical patent/IE37998L/xx

1977-12-07 Publication of IE37998B1 publication Critical patent/IE37998B1/xx

Links

229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000002475 indoles Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 3
-1 1,3-dicyclohexylureido Chemical group 0.000 abstract 2
230000003110 anti-inflammatory effect Effects 0.000 abstract 2
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 2
230000001225 therapeutic effect Effects 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
WHTVZRBIWZFKQO-AWEZNQCLSA-N (S)-chloroquine Chemical compound ClC1=CC=C2C(N[C@@H](C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-AWEZNQCLSA-N 0.000 abstract 1
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 1
229940116731 Uricosuric agent Drugs 0.000 abstract 1
229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 abstract 1
229910021502 aluminium hydroxide Inorganic materials 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
229940069428 antacid Drugs 0.000 abstract 1
239000003159 antacid agent Substances 0.000 abstract 1
230000001458 anti-acid effect Effects 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
230000001754 anti-pyretic effect Effects 0.000 abstract 1
125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
229960003677 chloroquine Drugs 0.000 abstract 1
WHTVZRBIWZFKQO-UHFFFAOYSA-N chloroquine Natural products ClC1=CC=C2C(NC(C)CCCN(CC)CC)=CC=NC2=C1 WHTVZRBIWZFKQO-UHFFFAOYSA-N 0.000 abstract 1
125000000259 cinnolinyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 abstract 1
229960004126 codeine Drugs 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 abstract 1
CYWFCPPBTWOZSF-UHFFFAOYSA-N ibufenac Chemical compound CC(C)CC1=CC=C(CC(O)=O)C=C1 CYWFCPPBTWOZSF-UHFFFAOYSA-N 0.000 abstract 1
229950009183 ibufenac Drugs 0.000 abstract 1
229960000905 indomethacin Drugs 0.000 abstract 1
125000005956 isoquinolyl group Chemical group 0.000 abstract 1
229960003464 mefenamic acid Drugs 0.000 abstract 1
HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
229960000649 oxyphenbutazone Drugs 0.000 abstract 1
HFHZKZSRXITVMK-UHFFFAOYSA-N oxyphenbutazone Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 HFHZKZSRXITVMK-UHFFFAOYSA-N 0.000 abstract 1
229960002895 phenylbutazone Drugs 0.000 abstract 1
VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 abstract 1
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 abstract 1
229960005205 prednisolone Drugs 0.000 abstract 1
DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 abstract 1
229960003081 probenecid Drugs 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
125000005493 quinolyl group Chemical group 0.000 abstract 1
125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
239000003383 uricosuric agent Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

IE1320/72A 1971-11-03 1972-09-28 Indole derivatives IE37998B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB1811672A GB1356834A (en)	1971-11-03	1971-11-03	Indole derivatives
GB1811672		1972-04-19
GB3076772		1972-06-30

Publications (2)

Publication Number	Publication Date
IE37998L IE37998L (en)	1973-05-03
IE37998B1 true IE37998B1 (en)	1977-12-07

Family

ID=27257588

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IE1320/72A IE37998B1 (en)	1971-11-03	1972-09-28	Indole derivatives

Country Status (17)

Country	Link
US (1)	US3884919A (2)
JP (1)	JPS4856667A (2)
AR (3)	AR198064A1 (2)
BE (1)	BE790679A (2)
CA (1)	CA983932A (2)
CH (1)	CH577499A5 (2)
DD (1)	DD105611A5 (2)
DE (1)	DE2253927A1 (2)
EG (1)	EG11358A (2)
ES (2)	ES408226A1 (2)
FR (1)	FR2158464B1 (2)
GB (1)	GB1356834A (2)
HU (1)	HU169711B (2)
IE (1)	IE37998B1 (2)
IL (1)	IL40521A (2)
NL (1)	NL7214807A (2)
SE (1)	SE384856B (2)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4022780A (en) *	1973-03-06	1977-05-10	Imperial Chemical Industries Limited	Process for the manufacture of indole derivatives
FR2421900A1 (fr) *	1977-03-17	1979-11-02	Sauba Lab	Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques
US4316847A (en) *	1979-07-30	1982-02-23	Hoffmann-La Roche Inc.	Pyrroles and pyrrolidines
US4459227A (en) *	1981-03-02	1984-07-10	Duke University	Para-hydroxyphenylhydrazines as in situ precursors of iminoquinones and quinones
BR9506936A (pt) *	1994-02-23	1997-09-09	Pfizer	Derivados de quinazolina substituídos com 4-heterociclila processos para sua preparaçao e seu uso como agentes anticancerosos
US6252084B1 (en) *	1994-03-15	2001-06-26	Eli Lilly And Company	1H-indole-3-acetamide sPLA2 inhibitors
EE200000488A (et) *	1998-02-25	2002-02-15	Genetics Institute, Inc.	Fosfolipaasensüümide inhibiitorid ja farmatseutilised kompositsioonid
US6500853B1 (en)	1998-02-28	2002-12-31	Genetics Institute, Llc	Inhibitors of phospholipase enzymes
SE0200411D0 (sv) *	2002-02-05	2002-02-05	Astrazeneca Ab	Novel use
SE0200356D0 (sv) *	2002-02-05	2002-02-05	Astrazeneca Ab	Novel use
TW200307542A (en)	2002-05-30	2003-12-16	Astrazeneca Ab	Novel compounds
SE0201635D0 (sv)	2002-05-30	2002-05-30	Astrazeneca Ab	Novel compounds
SE0202241D0 (sv)	2002-07-17	2002-07-17	Astrazeneca Ab	Novel Compounds
SE0301010D0 (sv) *	2003-04-07	2003-04-07	Astrazeneca Ab	Novel compounds
SE0301009D0 (sv) *	2003-04-07	2003-04-07	Astrazeneca Ab	Novel compounds
DE60303238T2 (de)	2003-04-25	2006-09-14	Actimis Pharmaceuticals, Inc., La Jolla	Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten
CA2524221A1 (en) *	2003-04-30	2004-11-18	The Institutes For Pharmaceutical Discovery, Llc	Substituted heteroaryls as inhibitors of protein tyrosine phosphatases
SE0301569D0 (sv)	2003-05-27	2003-05-27	Astrazeneca Ab	Novel compounds
SE0302232D0 (sv) *	2003-08-18	2003-08-18	Astrazeneca Ab	Novel Compounds
SA04250253B1 (ar)	2003-08-21	2009-11-10	استرازينيكا ايه بي	احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
GB0324763D0 (en)	2003-10-23	2003-11-26	Oxagen Ltd	Use of compounds in therapy
SE0303180D0 (sv)	2003-11-26	2003-11-26	Astrazeneca Ab	Novel compounds
CA2551778C (en)	2004-01-31	2013-10-22	Actimis Pharmaceuticals, Inc.	Imidazo[1,2-c]pyrimidinylacetic acid derivatives
GB0415320D0 (en)	2004-07-08	2004-08-11	Astrazeneca Ab	Novel compounds
GB0418830D0 (en)	2004-08-24	2004-09-22	Astrazeneca Ab	Novel compounds
JP5208510B2 (ja)	2004-11-23	2013-06-12	アストラゼネカ・アクチエボラーグ	呼吸器疾患の処置に有用なフェノキシ酢酸誘導体
GB0500604D0 (en)	2005-01-13	2005-02-16	Astrazeneca Ab	Novel process
TW200745003A (en)	2005-10-06	2007-12-16	Astrazeneca Ab	Novel compounds
US8148572B2 (en)	2005-10-06	2012-04-03	Astrazeneca Ab	Compounds
CN101454284A (zh)	2006-05-26	2009-06-10	阿斯利康(瑞典)有限公司	联芳基或芳基-杂芳基取代的吲哚类化合物
US7999119B2 (en)	2006-07-22	2011-08-16	Oxagen Limited	Compounds having CRTH2 antagonist activity
UA100983C2 (ru)	2007-07-05	2013-02-25	Астразенека Аб	Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты
ATE547407T1 (de)	2007-09-25	2012-03-15	Actimis Pharmaceuticals Inc	Alkylthiopyrimidine als crth2-antagonisten
WO2009042139A1 (en)	2007-09-25	2009-04-02	Actimis Pharmaceuticals, Inc.	2-s-benzyl substituted pyrimidines as crth2 antagonists
US7750027B2 (en)	2008-01-18	2010-07-06	Oxagen Limited	Compounds having CRTH2 antagonist activity
AU2009204700B2 (en)	2008-01-18	2013-07-04	Atopix Therapeutics Limited	Compounds having CRTH2 antagonist activity
EP2265581A1 (en)	2008-01-22	2010-12-29	Oxagen Limited	Compounds having crth2 antagonist activity
JP2011509991A (ja)	2008-01-22	2011-03-31	オキサジェンリミテッド	Ｃｒｔｈ２アンタゴニスト活性を有する化合物
GB201322273D0 (en)	2013-12-17	2014-01-29	Atopix Therapeutics Ltd	Process
GB201407807D0 (en)	2014-05-02	2014-06-18	Atopix Therapeutics Ltd	Polymorphic form
GB201407820D0 (en)	2014-05-02	2014-06-18	Atopix Therapeutics Ltd	Polymorphic form
JOP20210060A1 (ar) *	2018-10-05	2023-01-30	Vertex Pharma	معدلات لمضاد تريبسين ألفا-1

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL125443C (2) *	1963-06-06
US3679692A (en) *	1969-10-01	1972-07-25	Mead Johnson & Co	Iminomethylindolines

0
- BE BE790679D patent/BE790679A/xx unknown
1971
- 1971-11-03 GB GB1811672A patent/GB1356834A/en not_active Expired
1972
- 1972-09-28 IE IE1320/72A patent/IE37998B1/xx unknown
- 1972-09-29 CA CA152,944A patent/CA983932A/en not_active Expired
- 1972-10-06 IL IL40521A patent/IL40521A/xx unknown
- 1972-10-10 US US296202A patent/US3884919A/en not_active Expired - Lifetime
- 1972-10-27 AR AR244863A patent/AR198064A1/es active
- 1972-10-29 EG EG446/72A patent/EG11358A/xx active
- 1972-11-02 NL NL7214807A patent/NL7214807A/xx unknown
- 1972-11-02 JP JP47110172A patent/JPS4856667A/ja active Pending
- 1972-11-02 DD DD166646A patent/DD105611A5/xx unknown
- 1972-11-02 CH CH1597672A patent/CH577499A5/xx not_active IP Right Cessation
- 1972-11-02 SE SE7214215A patent/SE384856B/xx unknown
- 1972-11-02 FR FR7238836A patent/FR2158464B1/fr not_active Expired
- 1972-11-03 DE DE2253927A patent/DE2253927A1/de active Pending
- 1972-11-03 HU HUIE540A patent/HU169711B/hu unknown
- 1972-11-03 ES ES408226A patent/ES408226A1/es not_active Expired
1973
- 1973-07-31 AR AR249382A patent/AR203627A1/es active
- 1973-07-31 AR AR249381A patent/AR203626A1/es active
1975
- 1975-04-30 ES ES437331A patent/ES437311A1/es not_active Expired

Also Published As

Publication number	Publication date
ES437311A1 (es)	1977-04-01
AR198064A1 (es)	1974-05-31
IL40521A0 (en)	1972-12-29
SE384856B (sv)	1976-05-24
US3884919A (en)	1975-05-20
JPS4856667A (2)	1973-08-09
CA983932A (en)	1976-02-17
NL7214807A (2)	1973-05-07
IL40521A (en)	1975-06-25
GB1356834A (en)	1974-06-19
FR2158464A1 (2)	1973-06-15
EG11358A (en)	1977-02-28
AR203626A1 (es)	1975-09-30
HU169711B (2)	1977-02-28
DE2253927A1 (de)	1973-05-10
IE37998L (en)	1973-05-03
AR203627A1 (es)	1975-09-30
FR2158464B1 (2)	1976-07-02
ES408226A1 (es)	1976-02-01
DD105611A5 (2)	1974-05-05
CH577499A5 (2)	1976-07-15
BE790679A (fr)	1973-04-27

Publication	Publication Date	Title
IE37998L (en)	1973-05-03	Indole derivatives
SE7902954L (sv)	1979-04-03	Tiazolylettiksyraforeningar
SE7508789L (sv)	1976-02-10	Forfarande for framstellnign av nya 5,9-beta-disubstituerade 2-tetrahydrofurfuryl-6,7-bensomorfaner, deras syraadditionssalter och anvendning som lekemedel
NO157452C (no)	1988-03-23	Analogifremgangsmaate for fremstilling av et terapeutisk aktivt bispidinderivat.
GB1459065A (en)	1976-12-22	Therapeutic thiophene derivatives
SE7413548L (2)	1975-04-30
SE7604476L (sv)	1976-10-17	Forfarande for framstellning av 1-(3,3,3-triarylpropyl)-4-fenyl-4-piperidinmetanolforeningar
GB1290818A (2)	1972-09-27
SE7706976L (sv)	1977-12-23	Forfarande for framstellning av derivat av indolettiksyraestrar
GB1411583A (en)	1975-10-29	Aminophenyl-substituted alkyl-heterocyclic derivatives and processes for producing them
IE42763L (en)	1976-06-20	Tertiary amino alkylphenyl ether compounds, anesthetics
ES2001852A6 (es)	1988-07-01	Procedimiento para preparar un derivado de acido quinolocarboxilico
GB1530074A (en)	1978-10-25	Rho-acetamidophenol derivatives the preparation thereof and the use of such derivatives as therapeutic agents
GB1460348A (en)	1977-01-06	Quinazoline derivativesa
SU1189337A3 (ru)	1985-10-30	"cпocoб пoлучehия пpoизboдhыx пиpидилaлkилhиtpatob или иx coлeй c фapmaцebtичeckи пpиemлemыmи kиcлotamи"
IE36011L (en)	1971-11-25	Indole derivatives
GB1463505A (en)	1977-02-02	Pharmaceutical compositions
GB1239266A (2)	1971-07-14
GB1091109A (en)	1967-11-15	New derivative of phenylbutazone and its preparation
NO180534C (no)	1997-05-07	Nonatetraensyrederivat, farmasöytisk preparat inneholdende dette, og anvendelser av derivatet
AU562643B2 (en)	1987-06-18	N-arylpiperazine derivatives
GB1466051A (en)	1977-03-02	Compositions containing prostaglandins
GB1463955A (en)	1977-02-09	Compositions containing prostaglandins
GB1463953A (en)	1977-02-09	Compositions containing prostaglandins
GB1245155A (en)	1971-09-08	NOVEL 5-SUBSTITUTED-gamma-CARBOLINE DERIVATIVES AND THE SALTS THEREOF