IES20180084A2 - Vitamin medicine pyridine-3-formic acid synthesis method - Google Patents
Vitamin medicine pyridine-3-formic acid synthesis methodInfo
- Publication number
- IES20180084A2 IES20180084A2 IES20180084A IES20180084A IES20180084A2 IE S20180084 A2 IES20180084 A2 IE S20180084A2 IE S20180084 A IES20180084 A IE S20180084A IE S20180084 A IES20180084 A IE S20180084A IE S20180084 A2 IES20180084 A2 IE S20180084A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- pyridine
- washed
- added
- synthesis method
- Prior art date
Links
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- 229940088594 vitamin Drugs 0.000 title abstract 2
- 229930003231 vitamin Natural products 0.000 title abstract 2
- 235000013343 vitamin Nutrition 0.000 title abstract 2
- 239000011782 vitamin Substances 0.000 title abstract 2
- 150000003722 vitamin derivatives Chemical class 0.000 title abstract 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 3
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 abstract 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 abstract 1
- OURIJMKHJHNWBG-UHFFFAOYSA-N 4-amino-3-ethyl-1H-pyridin-2-one Chemical compound NC1=C(C(NC=C1)=O)CC OURIJMKHJHNWBG-UHFFFAOYSA-N 0.000 abstract 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 235000006408 oxalic acid Nutrition 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- KKOFCVMVBJXDFP-UHFFFAOYSA-N triethylstibane Chemical compound CC[Sb](CC)CC KKOFCVMVBJXDFP-UHFFFAOYSA-N 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Vitamin medicine pyridine-3-formic acid synthesis method, comprises the following steps: 3 mol 2-hydroxy-3-ethyl-4-aminopyridine and 6-7 mol ethylene glycol monobutyl ether were added to the reaction vessel, controlled the stirring speed of 170-190 rpm, raised the temperature of the solution to 60-70 °C, then added 3-4 mol of triethyl antimony in 3-6 times, raised the temperature of the solution to 75-80 V, kept for 50-70 min, precipitated the solid, washed with potassium bromide solution in 6-9 times, merged the filtrate and the washing liquid, the oxalic acid solution was added to adjust the pH to 2-3, the solution temperature is reduced to 5-9 °C, the solid is precipitated, washed with N-dimethylacetamide solution, and washed with the dimethylamine solution, recrystallized in p-cresol solution.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710209149.4A CN108239024A (en) | 2017-04-02 | 2017-04-02 | A kind of synthetic method of vitamin medicaments Nicotinicum Acidum |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IES20180084A2 true IES20180084A2 (en) | 2019-04-03 |
| IES86978B2 IES86978B2 (en) | 2019-05-01 |
Family
ID=58744609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180084A IES86978B2 (en) | 2017-04-02 | 2018-03-27 | Vitamin medicine pyridine-3-formic acid synthesis method |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN108239024A (en) |
| AU (1) | AU2018100412A4 (en) |
| GB (1) | GB201705841D0 (en) |
| IE (1) | IES86978B2 (en) |
-
2017
- 2017-04-02 CN CN201710209149.4A patent/CN108239024A/en active Pending
- 2017-04-11 GB GBGB1705841.3A patent/GB201705841D0/en not_active Ceased
-
2018
- 2018-03-27 IE IES20180084A patent/IES86978B2/en unknown
- 2018-03-31 AU AU2018100412A patent/AU2018100412A4/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| GB201705841D0 (en) | 2017-05-24 |
| CN108239024A (en) | 2018-07-03 |
| AU2018100412A4 (en) | 2018-05-10 |
| IES86978B2 (en) | 2019-05-01 |
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