IES20180077A2 - Medicine intermediates terephthalic acid synthesis method - Google Patents
Medicine intermediates terephthalic acid synthesis methodInfo
- Publication number
- IES20180077A2 IES20180077A2 IES20180077A IES20180077A IES20180077A2 IE S20180077 A2 IES20180077 A2 IE S20180077A2 IE S20180077 A IES20180077 A IE S20180077A IE S20180077 A IES20180077 A IE S20180077A IE S20180077 A2 IES20180077 A2 IE S20180077A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- terephthalic acid
- mol
- temperature
- synthesis method
- Prior art date
Links
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 title abstract 6
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- HCFAJYNVAYBARA-UHFFFAOYSA-N 4-heptanone Chemical compound CCCC(=O)CCC HCFAJYNVAYBARA-UHFFFAOYSA-N 0.000 abstract 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- AOPDRZXCEAKHHW-UHFFFAOYSA-N 1-pentoxypentane Chemical compound CCCCCOCCCCC AOPDRZXCEAKHHW-UHFFFAOYSA-N 0.000 abstract 1
- -1 4-ethyl-5-amino-benzyl Chemical group 0.000 abstract 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 abstract 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N benzyl alcohol Substances OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 229910052719 titanium Inorganic materials 0.000 abstract 1
- 239000010936 titanium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Medicine intermediates terephthalic acid synthesis method, comprises the following steps: 2 mol 4-ethyl-5-amino-benzyl alcohol and 4-5 mol 2,5-dimethy1-2,5-hexanediol were added to the reaction vessel, raised the temperature of the solution to 60-67 V, controlled the stirring speed at 170-190 rpm, kept for 130-170 min, then add 3-4 mol dicyldiphenyl titanium in 6 to 9 times, raised the temperature of the solution to 80-86°C, kept for 70-90 min, precipitated solid, filtered, the solid washed with potassium bromide solution, washed with dipentyl ether solution, 4-heptanone solution, reduced solution temperature to 3-6°C , recrystallized in diisopropyl ether solution, dehydrated with dehydration, got the finished product terephthalic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710213308.8A CN108238899A (en) | 2017-04-02 | 2017-04-02 | A kind of synthetic method of medicine intermediate terephthalic acid (TPA) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IES20180077A2 true IES20180077A2 (en) | 2019-04-03 |
| IES86989B2 IES86989B2 (en) | 2019-05-01 |
Family
ID=58744574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180077A IES86989B2 (en) | 2017-04-02 | 2018-03-27 | Medicine intermediates terephthalic acid synthesis method |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN108238899A (en) |
| AU (1) | AU2018100411A4 (en) |
| GB (1) | GB201705835D0 (en) |
| IE (1) | IES86989B2 (en) |
-
2017
- 2017-04-02 CN CN201710213308.8A patent/CN108238899A/en active Pending
- 2017-04-11 GB GBGB1705835.5A patent/GB201705835D0/en not_active Ceased
-
2018
- 2018-03-27 IE IES20180077A patent/IES86989B2/en unknown
- 2018-03-31 AU AU2018100411A patent/AU2018100411A4/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| GB201705835D0 (en) | 2017-05-24 |
| IES86989B2 (en) | 2019-05-01 |
| CN108238899A (en) | 2018-07-03 |
| AU2018100411A4 (en) | 2018-05-10 |
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