IES20180088A2 - Drugs intermediates 2-ethylhexanoic acid synthesis method - Google Patents
Drugs intermediates 2-ethylhexanoic acid synthesis methodInfo
- Publication number
- IES20180088A2 IES20180088A2 IES20180088A IES20180088A IES20180088A2 IE S20180088 A2 IES20180088 A2 IE S20180088A2 IE S20180088 A IES20180088 A IE S20180088A IE S20180088 A IES20180088 A IE S20180088A IE S20180088 A2 IES20180088 A2 IE S20180088A2
- Authority
- IE
- Ireland
- Prior art keywords
- solution
- ethylhexanoic acid
- synthesis method
- acid synthesis
- extracted
- Prior art date
Links
- OBETXYAYXDNJHR-SSDOTTSWSA-M (2r)-2-ethylhexanoate Chemical compound CCCC[C@@H](CC)C([O-])=O OBETXYAYXDNJHR-SSDOTTSWSA-M 0.000 title abstract 3
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title abstract 2
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 abstract 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 abstract 2
- XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Chemical compound NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 abstract 2
- UEPUAIXWJWNKTC-UHFFFAOYSA-N 2-bromo-3-ethylhept-1-en-1-amine Chemical compound NC=C(C(CCCC)CC)Br UEPUAIXWJWNKTC-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 abstract 1
- 229960004419 dimethyl fumarate Drugs 0.000 abstract 1
- CDZOGLJOFWFVOZ-UHFFFAOYSA-N n-propylaniline Chemical compound CCCNC1=CC=CC=C1 CDZOGLJOFWFVOZ-UHFFFAOYSA-N 0.000 abstract 1
- CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 abstract 1
- 229910000343 potassium bisulfate Inorganic materials 0.000 abstract 1
- 235000010333 potassium nitrate Nutrition 0.000 abstract 1
- 239000004323 potassium nitrate Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Drugs intermediates 2-ethylhexanoic acid synthesis method, comprises the following steps: 3 mol 1-amino-2-bromo-3-ethylheptene, 4-5 mol dimethyl fumarate solution were added to the reaction vessel, controlled the stirring speed at 130-160 rpm, raised the temperature of the solution to 40-48°C, reacted for 2-3 h, washed with potassium nitrate solution for 4-6 times, adjusted the pH to 3-4 with potassium hydrogen sulfate solution, after the solution layered, extracted 5-7 times by 1,3-propanediamine solution, extracted 6-9 times by propylene glycol methyl ether solution, recrystallized from N-propylaniline solution, obtained 2-ethylhexanoic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710215504.9A CN108238892A (en) | 2017-04-05 | 2017-04-05 | A kind of synthetic method of pharmaceutical intermediate 2 ethyl hexanoic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IES20180088A2 true IES20180088A2 (en) | 2019-04-03 |
| IES86993B2 IES86993B2 (en) | 2019-05-01 |
Family
ID=59220567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IES20180088A IES86993B2 (en) | 2017-04-05 | 2018-04-03 | Drugs intermediates 2-ethylhexanoic acid synthesis method |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN108238892A (en) |
| AU (1) | AU2018100422A4 (en) |
| GB (1) | GB201708118D0 (en) |
| IE (1) | IES86993B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109134538B (en) * | 2018-09-25 | 2021-05-14 | 万华化学集团股份有限公司 | Iodophosphine oxide ligands, method for the production thereof, complexes, catalyst systems comprising the complexes and use thereof |
-
2017
- 2017-04-05 CN CN201710215504.9A patent/CN108238892A/en active Pending
- 2017-05-22 GB GBGB1708118.3A patent/GB201708118D0/en not_active Ceased
-
2018
- 2018-04-01 AU AU2018100422A patent/AU2018100422A4/en not_active Ceased
- 2018-04-03 IE IES20180088A patent/IES86993B2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IES86993B2 (en) | 2019-05-01 |
| GB201708118D0 (en) | 2017-07-05 |
| CN108238892A (en) | 2018-07-03 |
| AU2018100422A4 (en) | 2018-05-17 |
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