IL101751A0 - Stable pur a vectors and uses thereof - Google Patents

Stable pur a vectors and uses thereof

Info

Publication number: IL101751A0
Authority: IL; Israel
Prior art keywords: selection; vectors; complementation; maintenance; stable
Prior art date: 1991-05-03

Application number

IL101751A

Other languages

English (en)

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-03

Filing date

1992-04-30

Publication date

1992-12-30

1992-04-30 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1992-12-30 Publication of IL101751A0 publication Critical patent/IL101751A0/xx

Links

239000013598 vector Substances 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
102000005291 Adenylosuccinate synthase Human genes 0.000 abstract 1
108010056443 Adenylosuccinate synthase Proteins 0.000 abstract 1
241000894006 Bacteria Species 0.000 abstract 1
206010061764 Chromosomal deletion Diseases 0.000 abstract 1
241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 abstract 1
230000002238 attenuated effect Effects 0.000 abstract 1
230000001580 bacterial effect Effects 0.000 abstract 1
230000003115 biocidal effect Effects 0.000 abstract 1
230000002759 chromosomal effect Effects 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
238000012423 maintenance Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000035772 mutation Effects 0.000 abstract 1
230000027086 plasmid maintenance Effects 0.000 abstract 1
101150002764 purA gene Proteins 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
- A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/68—Stabilisation of the vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Mycology (AREA)
Tropical Medicine & Parasitology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

IL101751A 1991-05-03 1992-04-30 Stable pur a vectors and uses thereof IL101751A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US69570691A	1991-05-03	1991-05-03

Publications (1)

Publication Number	Publication Date
IL101751A0 true IL101751A0 (en)	1992-12-30

Family

ID=24794162

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL101751A IL101751A0 (en)	1991-05-03	1992-04-30	Stable pur a vectors and uses thereof

Country Status (16)

Country	Link
US (2)	US5919663A (fr)
EP (1)	EP0512260B1 (fr)
JP (1)	JP3320095B2 (fr)
KR (1)	KR100242798B1 (fr)
AT (1)	ATE202800T1 (fr)
AU (1)	AU654347B2 (fr)
CA (1)	CA2067862C (fr)
DE (1)	DE69231907T2 (fr)
DK (1)	DK0512260T3 (fr)
ES (1)	ES2160573T3 (fr)
FI (1)	FI111013B (fr)
GR (1)	GR3036487T3 (fr)
IL (1)	IL101751A0 (fr)
NO (1)	NO314043B1 (fr)
PT (1)	PT512260E (fr)
TW (1)	TW201794B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2738842B1 (fr) *	1995-09-15	1997-10-31	Rhone Poulenc Rorer Sa	Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique
US7279313B2 (en) *	1995-09-15	2007-10-09	Centelion	Circular DNA molecule having a conditional origin of replication, process for their preparation and their use in gene therapy
WO1998010074A2 (fr) *	1996-09-04	1998-03-12	Basf Aktiengesellschaft	Adenylosuccinate-synthetase
US6010705A (en) *	1997-04-11	2000-01-04	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Attenuated, invasive vaccines against fish pathogens
US6350454B1 (en) *	1997-04-11	2002-02-26	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Attenuated Pasteurella piscicida vaccine for fish
AU772356B2 (en) *	1998-12-04	2004-04-22	Aventis Pasteur Limited	Two-step immunization procedure against chlamydia infection
KR100427587B1 (ko) *	2001-01-12	2004-04-27	주식회사 바이오리더스	신규 ｄ-글루탐산 합성효소 유전자 ｄｎａ 및 이를 이용한 항생제 비의존성 벡터
FI116851B (fi) *	2001-05-03	2006-03-15	Fit Biotech Oyj Plc	Ilmentämisvektori, sen käyttöjä ja menetelmä sen valmistamiseksi sekä sitä sisältäviä tuotteita
US20040009937A1 (en) *	2002-01-31	2004-01-15	Wei Chen	Methods and composition for delivering nucleic acids and/or proteins to the respiratory system
WO2003063786A2 (fr) *	2002-01-31	2003-08-07	Symbigene, Inc.	Methodes et compositions permettant de distribuer des acides nucleiques et/ou des proteines au systeme respiratoire
CN1276076C (zh) *	2004-12-14	2006-09-20	华东理工大学	一种鳗弧菌野生毒株的无标记基因缺失减毒突变株及其应用
US20100317084A1 (en) *	2007-05-10	2010-12-16	The Arizona Board Of Regents For And On Behalf Of Arizona State University	Recombinant bacteria comprising vectors for expression of nucleic acid sequences encoding antigens
WO2009025888A2 (fr)	2007-05-10	2009-02-26	The Arizona Board Of Regents For And On Behalf Of Arizona State University	Expression régulée d'antigène et/ou atténuation régulée pour accroître l'immunogénicité et/ou la sécurité de vaccins
WO2009046449A1 (fr)	2007-10-05	2009-04-09	The Arizona Board Of Regents For And On Behalf Of Arizona State University	Bactéries recombinantes capables de susciter une réponse immunitaire contre des agents pathogènes entériques
WO2010045620A1 (fr) *	2008-10-17	2010-04-22	The Arizona Board Of Regents For And On Behalf Of Arizona State University	Bactérie recombinante pouvant éliciter une réponse immunitaire contre le streptococcus pneumoniae
US9163219B2 (en) *	2009-04-14	2015-10-20	Arizona Board Of Regents On Behalf Of Arizona State University	Single expression vector for generation of a virus with a segmented genome
GB2483595B (en)	2009-05-22	2017-03-29	The Arizona Board Of Regents For And On Behalf Of Arizona State Univ	Recombinant bacterium and methods of antigen and nucleic acid delivery
US9045742B2 (en) *	2009-05-29	2015-06-02	The Arizona Board Of Regents For And On Behalf Of Arizona State University	Recombinant Edwardsiella bacterium
US9062297B2 (en)	2010-01-13	2015-06-23	The Arizona Board Of Regents For And On Behalf Of Arizona State University	Yersinia pestis vaccine
EP2526185A4 (fr)	2010-01-22	2013-07-24	Univ Arizona	Bactérie renfermant un acide nucléique régulé par le rfah
US9598697B2 (en)	2010-05-28	2017-03-21	The Arizona Board Of Regents For And On Behalf Of Arizona State University	Recombinant bacterium to decrease tumor growth
WO2012082946A2 (fr) *	2010-12-14	2012-06-21	The Regents Of The University Of California	Création de plasmides de cole1 super-stables par duplication de la séquence sl 1-4 et mutations ponctuelles.
US9303264B2 (en)	2012-05-18	2016-04-05	The Arizona Board Of Regents For And On Behalf Of Arizona State University	Photosynthetic microorganisms expressing thermostable lipase
US9580718B2 (en)	2013-06-17	2017-02-28	Arizona Board Of Regents On Behalf Of Arizona State University	Attenuated live bacteria with increased acid resistance and methods of use thereof
KR102006976B1 (ko) *	2019-02-26	2019-08-06	씨제이제일제당 주식회사	신규 프로모터 및 이를 이용한 퓨린 뉴클레오티드 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0025118A1 (fr) *	1979-08-18	1981-03-18	Riedlinger, Rainer, Dr.-Ing.	Dispositif pour la reproduction acoustique de signaux qui sont représentables au moyen de canaux stéréophoniques de droite et de gauche
US4735801A (en) *	1982-09-07	1988-04-05	Board Of Trustees Of Leland Stanford Jr. University	Novel non-reverting salmonella live vaccines
US4550081A (en) *	1980-05-19	1985-10-29	The Board Of Trustees Of The Leland Stanford Jr. University	Non-reverting salmonella
US4837151A (en) *	1980-05-19	1989-06-06	The Board Of Trustees Of The Leland Stanford Junior University, Stanford University	Live vaccines comprising two mutations and foreign antigen
DK410783D0 (da) *	1982-09-16	1983-09-09	Benzon A Salfred	Fremgangsmade til stabilisering af plasmider
EP0251579A3 (fr) *	1986-06-24	1989-03-22	Enterovax Research Pty. Ltd.	Système de marquage non-antibiotique
CA1340903C (fr) *	1986-08-05	2000-02-22	Transgene S.A.	Procede de stabilisation d'un plasmide contenu dans une soche bacterienne et souche obtenue
JPS6427477A (en) *	1987-04-01	1989-01-30	Takeda Chemical Industries Ltd	Dna and use thereof
US5112749A (en) *	1987-10-02	1992-05-12	Praxis Biologics, Inc.	Vaccines for the malaria circumsporozoite protein
GB8730037D0 (en) *	1987-12-23	1988-02-03	Wellcome Found	Vaccines
IL93957A0 (en) *	1989-03-31	1990-12-23	Univ Washington	Bordetella outer membrane proteins,their use in vaccines and their expression
CA2097931C (fr) *	1990-12-18	2003-07-29	Samuel I. Miller, Iii	Vaccins contre la salmonelle

1992
- 1992-02-11 TW TW081100950A patent/TW201794B/zh active
- 1992-04-06 ES ES92105887T patent/ES2160573T3/es not_active Expired - Lifetime
- 1992-04-06 DK DK92105887T patent/DK0512260T3/da active
- 1992-04-06 DE DE69231907T patent/DE69231907T2/de not_active Expired - Fee Related
- 1992-04-06 AT AT92105887T patent/ATE202800T1/de not_active IP Right Cessation
- 1992-04-06 PT PT92105887T patent/PT512260E/pt unknown
- 1992-04-06 EP EP92105887A patent/EP0512260B1/fr not_active Expired - Lifetime
- 1992-04-28 JP JP13437592A patent/JP3320095B2/ja not_active Expired - Fee Related
- 1992-04-30 IL IL101751A patent/IL101751A0/xx not_active IP Right Cessation
- 1992-04-30 NO NO19921729A patent/NO314043B1/no unknown
- 1992-04-30 FI FI921940A patent/FI111013B/fi not_active IP Right Cessation
- 1992-05-01 AU AU15959/92A patent/AU654347B2/en not_active Ceased
- 1992-05-01 CA CA002067862A patent/CA2067862C/fr not_active Expired - Fee Related
- 1992-05-02 KR KR1019920007559A patent/KR100242798B1/ko not_active Expired - Fee Related
1995
- 1995-01-30 US US08/380,297 patent/US5919663A/en not_active Expired - Fee Related
- 1995-05-24 US US08/448,907 patent/US5961983A/en not_active Expired - Fee Related
2001
- 2001-08-31 GR GR20010401346T patent/GR3036487T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO921729D0 (no)	1992-04-30
CA2067862A1 (fr)	1992-11-04
PT512260E (pt)	2001-12-28
US5961983A (en)	1999-10-05
NO921729L (no)	1992-11-04
JP3320095B2 (ja)	2002-09-03
EP0512260B1 (fr)	2001-07-04
JPH05192161A (ja)	1993-08-03
CA2067862C (fr)	2003-12-30
ATE202800T1 (de)	2001-07-15
FI921940L (fi)	1992-11-04
GR3036487T3 (en)	2001-11-30
AU1595992A (en)	1992-11-05
NO314043B1 (no)	2003-01-20
EP0512260A2 (fr)	1992-11-11
TW201794B (fr)	1993-03-11
FI111013B (fi)	2003-05-15
FI921940A0 (fi)	1992-04-30
KR920021701A (ko)	1992-12-18
DK0512260T3 (da)	2001-09-17
EP0512260A3 (en)	1993-07-28
KR100242798B1 (ko)	2000-02-01
US5919663A (en)	1999-07-06
ES2160573T3 (es)	2001-11-16
DE69231907D1 (de)	2001-08-09
AU654347B2 (en)	1994-11-03
DE69231907T2 (de)	2001-10-18

Legal Events

Date	Code	Title
2004-06-20	FF	Patent granted
2004-09-27	KB	Patent renewed
2006-12-27	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL101751A0 (en)	1992-12-30	Stable pur a vectors and uses thereof
Galán et al.	1990	Cloning and characterization of the asd gene of Salmonella typhimurium: use in stable maintenance of recombinant plasmids in Salmonella vaccine strains
O'Callaghan et al.	1990	High efficiency transformation of Salmonella typhimurium and Salmonella typhi by electroporation
Taylor et al.	1988	Safe, live Vibrio cholerae vaccines?
Kaniga et al.	1991	A wide-host-range suicide vector for improving reverse genetics in gram-negative bacteria: inactivation of the blaA gene of Yersinia enterocolitica
DK2942391T3 (en)	2018-08-27	PROCEDURES FOR THE MANUFACTURE OF ANTIBIOTICS-RESISTANCE-FREE VACCINES
Kutyrev et al.	1992	Analysis of Yersinia pestis chromosomal determinants Pgm+ and Psts associated with virulence
EP0500699A4 (en)	1993-04-28	Cross-protective salmonella vaccines
IL136131A0 (en)	2001-05-20	Recombinant vaccines comprising immunogenic attenuated bacteria having rpos positive phenotype
Miller et al.	1993	The PhoP virulence regulon and live oral Salmonella vaccines
PL343246A1 (en)	2001-07-30	Bacteria attenuated by a non-reverting mutation in each of the aroc, ompf and ompc genes, useful as vaccines
KR20080082156A (ko)	2008-09-11	ｌｏｎ 유전자 및／또는 ｃｐｘＲ 유전자가 결실된살모넬라 변이균주 및 이를 함유하는 살모넬라 생백신
Chen et al.	1994	L-(+)-lactate dehydrogenase deficiency is lethal in Streptococcus mutans
Coulson et al.	1994	Effect of different plasmids on colonization of mouse tissues by the aromatic amino acid dependent Salmonella typhimurium SL 3261.
CN112118865B (zh)	2025-03-28	肺炎球菌表面蛋白a(pspa)的表达
Alačević	1963	Interspecific recombination in Streptomyces
Sandoval et al.	1985	Screening of plasmids in non-pathogenic corynebacteria
Leong et al.	1991	Molecular analysis of iron transport in plant growth-promoting Pseudomonas putida WCS358
Roggenkamp et al.	1995	Dissection of the Yersinia enterocolitica virulence plasmid pYVO8 into an operating unit and virulence gene modules
RU94037007A (ru)	1996-07-27	Вакцина против стрептококкоза и пастереллеза нутрий
McPheat et al.	1987	Phase I and phase IV strains of Bordetella pertussis carry a repeated DNA sequence not found in other Bordetella species
Kasuga et al.	1968	Drug resistance of staphylococci VIII. Genetic properties of resistance to tetracycline in Staphylococcus aureus E169
ES2279963T3 (es)	2007-09-01	Estabilizacion de plasmidos in vivo.
AU558008B2 (en)	1987-01-15	Ozone inactivated organisms as vaccines
Thiele	1970	Virulence of R-factor-bearing Salmonella typhimurium