IL101945A - Methods for determining an analyte using induced luminescence, and kits therefor - Google Patents
Methods for determining an analyte using induced luminescence, and kits thereforInfo
- Publication number
- IL101945A IL101945A IL101945A IL10194592A IL101945A IL 101945 A IL101945 A IL 101945A IL 101945 A IL101945 A IL 101945A IL 10194592 A IL10194592 A IL 10194592A IL 101945 A IL101945 A IL 101945A
- Authority
- IL
- Israel
- Prior art keywords
- analyte
- photosensitizer
- pacc
- assay
- medium
- Prior art date
Links
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Classifications
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
- G01N33/587—Nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Nanotechnology (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Luminescent Compositions (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11630092A IL116300A (en) | 1991-05-22 | 1992-05-21 | Assay methods utilizing induced luminescence |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/704,569 US6251581B1 (en) | 1991-05-22 | 1991-05-22 | Assay method utilizing induced luminescence |
| US07/718,490 US5340716A (en) | 1991-06-20 | 1991-06-20 | Assay method utilizing photoactivated chemiluminescent label |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL101945A0 IL101945A0 (en) | 1992-12-30 |
| IL101945A true IL101945A (en) | 1998-02-08 |
Family
ID=27107346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL101945A IL101945A (en) | 1991-05-22 | 1992-05-21 | Methods for determining an analyte using induced luminescence, and kits therefor |
Country Status (10)
| Country | Link |
|---|---|
| EP (4) | EP1418430A3 (fr) |
| JP (1) | JP3892912B2 (fr) |
| AT (3) | ATE350665T1 (fr) |
| AU (1) | AU657134B2 (fr) |
| CA (1) | CA2069145C (fr) |
| DE (3) | DE69232161T2 (fr) |
| DK (1) | DK0984282T3 (fr) |
| ES (3) | ES2204050T3 (fr) |
| IL (1) | IL101945A (fr) |
| PT (1) | PT984282E (fr) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5578498A (en) | 1991-05-22 | 1996-11-26 | Behringwerke Ag | Metal chelate containing compositions for use in chemiluminescent assays |
| US6251581B1 (en) | 1991-05-22 | 2001-06-26 | Dade Behring Marburg Gmbh | Assay method utilizing induced luminescence |
| CA2141451C (fr) * | 1992-07-31 | 2003-10-07 | John S. Pease | Matrices chimioluminescentes pouvant etre photoactivees |
| WO1995006877A1 (fr) * | 1993-09-03 | 1995-03-09 | Behringwerke Ag | Immunotitrages a formation de canaux d'oxygene fluorescent |
| US5783453A (en) * | 1995-06-29 | 1998-07-21 | Chiron Diagnostics Corporation | Non-separation specific binding chemiluminescent assay |
| EP0793970A1 (fr) * | 1996-03-08 | 1997-09-10 | Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk | Inactivation photodynamique de virus |
| DE69736382T2 (de) * | 1996-05-01 | 2007-08-09 | Dade Behring Marburg Gmbh | Chemilumineszente zusammensetungen und ihre verwendung zum nachweis von wasserstoffperoxid |
| DE19756782A1 (de) | 1997-12-19 | 1999-06-24 | Dade Behring Marburg Gmbh | Nachweis und Bestimmung festphasenassoziierter Faktoren |
| DE19756773A1 (de) | 1997-12-19 | 1999-06-24 | Dade Behring Marburg Gmbh | Neues Verfahren und Diagnosemittel zur Hämostase-Diagnostik |
| US6365346B1 (en) | 1998-02-18 | 2002-04-02 | Dade Behring Inc. | Quantitative determination of nucleic acid amplification products |
| JP2002504689A (ja) | 1998-02-18 | 2002-02-12 | デイド・ベーリング・インコーポレイテッド | 複数の検体の検出において使用するための化学ルミネセンス組成物 |
| DE19811017A1 (de) | 1998-03-13 | 1999-09-16 | Dade Behring Marburg Gmbh | Neues Verfahren zur Bestimmung von Plasmaproteinen und Faktoren der Hämostase sowie ein neues, implantierbares Meßgerät |
| US6303325B1 (en) | 1998-05-29 | 2001-10-16 | Dade Behring Inc. | Method for detecting analytes |
| AUPP405098A0 (en) * | 1998-06-12 | 1998-07-02 | Access Pharmaceuticals Australia Pty Limited | Novel methods of preparation of vitamin b12 derivatives suitable for conjugation to pharmaceuticals |
| US6703248B1 (en) * | 1999-12-15 | 2004-03-09 | Dade Behring Marburg Gmbh | Particles for diagnostic and therapeutic use |
| ATE395364T1 (de) | 1999-12-22 | 2008-05-15 | Dade Behring Marburg Gmbh | Gegen procalcitonin gerichtete antikörper, ihre herstellung und verwendung |
| DE50014159D1 (de) | 1999-12-22 | 2007-04-26 | Dade Behring Marburg Gmbh | Lösungen von humanem Procalcitonin |
| KR20030011777A (ko) * | 2000-02-28 | 2003-02-11 | 다이이치 가가쿠 야쿠힝 가부시키가이샤 | 장수명 여기형 형광을 이용하는 측정방법 |
| US7179660B1 (en) | 2000-03-06 | 2007-02-20 | Dade Behring Marburg Gmbh | Carriers coated with polysaccharides, their preparation and use |
| US6346384B1 (en) * | 2000-03-27 | 2002-02-12 | Dade Behring Inc. | Real-time monitoring of PCR using LOCI |
| EP1305632B1 (fr) * | 2000-05-04 | 2011-07-27 | Siemens Healthcare Diagnostics Products GmbH | Methodes servant a la detection d'analytes multiples |
| DE10064827A1 (de) | 2000-12-22 | 2002-06-27 | Dade Behring Marburg Gmbh | Nachweisverfahren |
| JP2004535371A (ja) * | 2001-03-16 | 2004-11-25 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデーション | 蛍光コバラミンおよびその使用 |
| US7524974B2 (en) | 2002-07-08 | 2009-04-28 | Tetsuo Nagano | Fluorescent probe |
| US6764819B2 (en) * | 2002-07-16 | 2004-07-20 | Emp Biotech Gmbh | Method for chemiluminescent detection |
| US7696245B2 (en) | 2003-03-28 | 2010-04-13 | Sekisui Medical Co., Ltd. | Fluorescent probe for zinc |
| WO2005062048A1 (fr) | 2003-12-01 | 2005-07-07 | Dade Behring Marburg Gmbh | Procede de detection homogene |
| JP2005194244A (ja) | 2004-01-09 | 2005-07-21 | Shigenobu Yano | 亜鉛イオン蛍光センサー |
| DE102005026163A1 (de) | 2004-08-24 | 2006-03-02 | Dade Behring Marburg Gmbh | Gegen den Marburg I Polymorphismus der Faktor VII aktivierenden Protease (FSAP) gerichtete Antikörper, ihre Herstellung und Verwendung |
| DE102004042124B4 (de) * | 2004-08-30 | 2006-07-06 | Dade Behring Marburg Gmbh | Homogenes Verfahren zur Bestimmung eines Analyten in Gegenwart eines Überschusses von kreuzreagierenden Substanzen |
| JP2008513794A (ja) * | 2004-09-17 | 2008-05-01 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド | 三価金属媒介均一発光近接アッセイ |
| US20060166376A1 (en) | 2005-01-21 | 2006-07-27 | Craig Alan R | Compositions for use as a signal generation component and methods of using same |
| US7682839B2 (en) * | 2005-03-14 | 2010-03-23 | Lumigen, Inc. | Methods using novel chemiluminescent labels |
| IL168184A (en) * | 2005-04-21 | 2011-11-30 | Univ Ariel Res & Dev Co Ltd | Use of a ligand-photosensitizer conjugate in combination with a chemiluminescent agent in the manufacture of a medicament for photodynamic therapy |
| DE102005022047A1 (de) | 2005-05-09 | 2006-11-30 | Dade Behring Marburg Gmbh | Bindungspartner des Plazentalen Wachstumsfaktors insbesondere gegen den Plazentalen Wachstumsfaktor gerichtete Antikörper, ihre Herstellung und Verwendung |
| GB0520436D0 (en) | 2005-10-07 | 2005-11-16 | Photobiotics Ltd | Biological materials and uses thereof |
| US7732153B2 (en) * | 2006-05-09 | 2010-06-08 | Beckman Coulter, Inc. | Nonseparation assay methods |
| US20080213797A1 (en) * | 2007-03-01 | 2008-09-04 | Abbott Laboratories | Immunoassays exhibiting a reduction in prozone phenomena |
| DE102007017906A1 (de) | 2007-04-17 | 2008-10-23 | Dade Behring Marburg Gmbh | Verfahren zur Bestimmung der Reaktions-Lag-Phase in einer analytabhängigen Reaktion |
| US7790401B2 (en) * | 2007-08-06 | 2010-09-07 | Siemens Healthcare Diagnostics | Methods for detection of immunosuppressant drugs |
| US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
| DE102008049601A1 (de) | 2008-09-30 | 2010-04-01 | Siemens Healthcare Diagnostics Products Gmbh | Antikörper zur Bestimmung des Prothrombin-Fragments F2/F1+2 in einem homogenen Immunoassay |
| EP2177624A1 (fr) * | 2008-10-02 | 2010-04-21 | Siemens Healthcare Diagnostics Products GmbH | Analyses de coagulation sanguine |
| JP5419775B2 (ja) * | 2010-03-30 | 2014-02-19 | 日本電信電話株式会社 | 測定用基板、並びに、これを用いた生化学的結合形成および生化学的結合量の測定方法 |
| EP2395354A1 (fr) | 2010-06-10 | 2011-12-14 | Siemens Healthcare Diagnostics Products GmbH | Test d'activité homogène destiné à la détermination de réactions enzymatiques |
| EP2471945A1 (fr) | 2010-12-30 | 2012-07-04 | Siemens Healthcare Diagnostics Products GmbH | Procédé de détermination d'inhibiteurs de coagulation |
| RU2473885C2 (ru) * | 2011-02-02 | 2013-01-27 | Государственное образовательное учреждение высшего профессионального образования "Самарский государственный университет" | Количественный анализ тиомочевины и флуоресцеина натрия при их совместном присутствии в пластовых водах |
| DE102011007546A1 (de) * | 2011-04-15 | 2012-10-18 | Humboldt-Universität Zu Berlin | Messvorrichtung für eine Messung einer Singulettsauerstoff-Lumineszenz |
| WO2013044099A1 (fr) | 2011-09-23 | 2013-03-28 | Siemens Healthcare Diagnostics Inc. | Dosage de sensibilité cellulaire pour un cancer et procédés de production et d'utilisation associés |
| EP2708892B1 (fr) | 2012-09-18 | 2015-04-15 | Siemens Healthcare Diagnostics Products GmbH | Méthode pour la détermination d'analytes associés aux thrombocytes |
| DE102012220083B3 (de) * | 2012-11-05 | 2014-03-06 | Technische Universität Dresden | Verfahren und System zum direkten, strahlungslosen Energietransfer über flüssige Phasengrenzen |
| DK2972245T3 (da) | 2013-03-15 | 2020-09-07 | Siemens Healthcare Diagnostics Inc | Heterogene luminescerende oxygenkanaliserende immunoassays |
| EP2790019A1 (fr) | 2013-04-10 | 2014-10-15 | Siemens Healthcare Diagnostics Products GmbH | Détection d'effet crochet à haute dose |
| US10124072B2 (en) | 2013-09-18 | 2018-11-13 | Caliper Life Sciences, Inc. | In-vivo reactive species imaging |
| GB201319180D0 (en) * | 2013-10-30 | 2013-12-11 | Mast Group Ltd | Nucleic acid probe |
| ES2614352T3 (es) | 2014-03-11 | 2017-05-30 | Siemens Healthcare Diagnostics Products Gmbh | Método para la detección de moduladores de la interacción de GPIb-trombina |
| JP6596440B2 (ja) * | 2014-03-26 | 2019-10-23 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド | 3つの抗体を利用する発光酸素チャネリング免疫測定法並びにその製造方法及び使用 |
| EP2955517A1 (fr) | 2014-06-10 | 2015-12-16 | Siemens Healthcare Diagnostics Products GmbH | Procédé de stabilisation d'échantillons de liquide corporel par administration de détergent |
| WO2018106945A1 (fr) * | 2016-12-07 | 2018-06-14 | Progenity Inc. | Procédés, dispositifs et systèmes de détection du tractus gastro-intestinal |
| ES2826394T3 (es) | 2017-06-09 | 2021-05-18 | Siemens Healthcare Diagnostics Products Gmbh | Ensayo de activación para el diagnóstico de una trombocitopenia inducida por heparina |
| EP3438667B1 (fr) | 2017-08-02 | 2020-12-30 | Siemens Healthcare Diagnostics Products GmbH | Essai de liaison pour diagnostiquer la thrombocytopénie induite par l'héparine |
| WO2019043553A1 (fr) * | 2017-08-31 | 2019-03-07 | 3M Innovative Properties Company | Identification de motifs périodiques lisibles par machine |
| EP3514541A1 (fr) | 2018-01-17 | 2019-07-24 | Siemens Healthcare Diagnostics Products GmbH | Procédé de détermination quantitative d'un inhibiteur du tnf-alpha thérapeutique |
| CN108676555B (zh) * | 2018-05-28 | 2020-11-20 | 青岛农业大学 | 一种含铕离子液体红光材料及制备方法和应用 |
| CN116577319A (zh) * | 2018-07-18 | 2023-08-11 | 上海索昕生物科技有限公司 | 一种用于化学发光检测的微球组合物及其应用 |
| CN116593713A (zh) * | 2019-07-19 | 2023-08-15 | 科美博阳诊断技术(上海)有限公司 | 一种供体试剂在诊断主体心肌损伤中的用途 |
| CN113125705B (zh) * | 2019-12-31 | 2023-08-04 | 科美诊断技术(苏州)有限公司 | 一种肌红蛋白的均相检测试剂盒及其应用 |
| JP7116819B2 (ja) * | 2020-03-19 | 2022-08-10 | 財團法人工業技術研究院 | 1級アミド化合物の検出試薬、検出装置、および検出方法 |
| CN111795960B (zh) * | 2020-08-10 | 2022-08-09 | 齐齐哈尔大学 | 一种光谱法和比色法检测不同形式碘的分子平台及其制备方法和应用 |
| CN117241884A (zh) * | 2021-04-21 | 2023-12-15 | 美国西门子医学诊断股份有限公司 | 使用抗人免疫球蛋白抗体用于抗微生物血清学测定的组合物、试剂盒和方法 |
| WO2022235065A1 (fr) * | 2021-05-07 | 2022-11-10 | Seegene, Inc. | Procédé et système pour détermination de concentration de billes magnétiques en suspension |
| EP4239338A1 (fr) | 2022-03-03 | 2023-09-06 | Siemens Healthcare Diagnostics Products GmbH | Essai général destiné à la détermination de l'état du système de coagulation sanguine |
| EP4325224A1 (fr) | 2022-08-18 | 2024-02-21 | Siemens Healthcare Diagnostics Products GmbH | Essai d'activation plaquettaire destiné au diagnostic d'une thrombocytopénie induite à l'héparine |
| CN116429752B (zh) * | 2023-02-13 | 2024-07-19 | 科美博阳诊断技术(上海)有限公司 | Afp检测试剂盒及其使用方法 |
| EP4585926A1 (fr) | 2024-01-09 | 2025-07-16 | Siemens Healthcare Diagnostics Products GmbH | Procédé et kit pour réduire les interférences dans des dosages immunologiques |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3720622A (en) * | 1970-01-02 | 1973-03-13 | American Cyanamid Co | Generation of light from the decomposition of dioxetaneones in the presence of a fluorescer |
| AU517292B2 (en) * | 1978-06-20 | 1981-07-23 | Syva Co. | Fluorescence quenching system |
| CA1190838A (fr) * | 1981-07-17 | 1985-07-23 | Cavit Akin | Procede de diagnostic d'hybridation |
| CA1273552A (fr) * | 1985-12-23 | 1990-09-04 | Michael J. Heller | Sondes fluorescentes a decalage de stoke pour les determinations d'hybridation des polynucleotides |
| US5004565A (en) * | 1986-07-17 | 1991-04-02 | The Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
| US5616729A (en) * | 1986-07-17 | 1997-04-01 | Board Of Governors Of Wayne State University | Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers |
| US4959182A (en) * | 1986-07-17 | 1990-09-25 | Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
| US4891324A (en) * | 1987-01-07 | 1990-01-02 | Syntex (U.S.A.) Inc. | Particle with luminescer for assays |
| US4881191A (en) * | 1987-01-13 | 1989-11-14 | Hewlett-Packard Company | Multichannel decimation/interpolation filter |
| WO1989012232A1 (fr) * | 1988-06-08 | 1989-12-14 | London Diagnostics, Inc. | Analyses mettant en oeuvre la production de signaux detectables induite par activateur |
| CA2035029C (fr) * | 1989-09-06 | 2001-12-18 | Applied Biosystems, Llc | Synthese de 1,2-dioxoethanes hydrosolubles stables et chimiluminescents, et leurs intermediaires |
| WO1991005605A1 (fr) | 1989-10-10 | 1991-05-02 | Kosak Kenneth M | Marqueurs en cyclodextrine pour essais immunitaires et analyses biochimiques |
| DE69125992T2 (de) * | 1990-09-14 | 1997-08-21 | Tosoh Corp | Verfahren und Kit für Immunoassay |
-
1992
- 1992-05-21 DE DE69232161T patent/DE69232161T2/de not_active Expired - Lifetime
- 1992-05-21 AT AT99121547T patent/ATE350665T1/de not_active IP Right Cessation
- 1992-05-21 EP EP03028362A patent/EP1418430A3/fr not_active Ceased
- 1992-05-21 IL IL101945A patent/IL101945A/en not_active IP Right Cessation
- 1992-05-21 CA CA002069145A patent/CA2069145C/fr not_active Expired - Lifetime
- 1992-05-21 DE DE69233146T patent/DE69233146T2/de not_active Expired - Lifetime
- 1992-05-21 EP EP99121547A patent/EP0984281B1/fr not_active Expired - Lifetime
- 1992-05-21 EP EP99121551A patent/EP0984282B1/fr not_active Expired - Lifetime
- 1992-05-21 DE DE69233674T patent/DE69233674T2/de not_active Expired - Lifetime
- 1992-05-21 ES ES99121551T patent/ES2204050T3/es not_active Expired - Lifetime
- 1992-05-21 AU AU17068/92A patent/AU657134B2/en not_active Expired
- 1992-05-21 AT AT99121551T patent/ATE246360T1/de active
- 1992-05-21 ES ES92304630T patent/ES2168092T3/es not_active Expired - Lifetime
- 1992-05-21 AT AT92304630T patent/ATE208039T1/de not_active IP Right Cessation
- 1992-05-21 PT PT99121551T patent/PT984282E/pt unknown
- 1992-05-21 EP EP92304630A patent/EP0515194B1/fr not_active Expired - Lifetime
- 1992-05-21 DK DK99121551T patent/DK0984282T3/da active
- 1992-05-21 ES ES99121547T patent/ES2280110T3/es not_active Expired - Lifetime
- 1992-05-22 JP JP13103992A patent/JP3892912B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0984282B1 (fr) | 2003-07-30 |
| ATE246360T1 (de) | 2003-08-15 |
| EP1418430A3 (fr) | 2004-09-01 |
| AU657134B2 (en) | 1995-03-02 |
| JPH05180773A (ja) | 1993-07-23 |
| ES2204050T3 (es) | 2004-04-16 |
| EP0984281A3 (fr) | 2000-06-07 |
| EP1418430A2 (fr) | 2004-05-12 |
| PT984282E (pt) | 2003-12-31 |
| JP3892912B2 (ja) | 2007-03-14 |
| EP0984282A3 (fr) | 2000-06-07 |
| DE69233674T2 (de) | 2007-10-18 |
| DE69232161D1 (de) | 2001-12-06 |
| DK0984282T3 (da) | 2003-11-17 |
| ATE350665T1 (de) | 2007-01-15 |
| CA2069145C (fr) | 2007-07-31 |
| EP0984281B1 (fr) | 2007-01-03 |
| ES2168092T3 (es) | 2002-06-01 |
| DE69233146T2 (de) | 2004-04-29 |
| IL101945A0 (en) | 1992-12-30 |
| ES2280110T3 (es) | 2007-09-01 |
| CA2069145A1 (fr) | 1992-11-23 |
| DE69233674D1 (de) | 2007-02-15 |
| EP0515194A3 (en) | 1993-10-20 |
| ATE208039T1 (de) | 2001-11-15 |
| EP0984281A2 (fr) | 2000-03-08 |
| AU1706892A (en) | 1992-11-26 |
| DE69233146D1 (de) | 2003-09-04 |
| EP0515194B1 (fr) | 2001-10-31 |
| EP0515194A2 (fr) | 1992-11-25 |
| EP0984282A2 (fr) | 2000-03-08 |
| DE69232161T2 (de) | 2002-05-16 |
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