IL103493A - Use of 2 - amino - 6 -) trifluoromethoxy (benzothiazole for the preparation of the drug for the treatment of neuro-motor diseases - Google Patents

Use of 2 - amino - 6 -) trifluoromethoxy (benzothiazole for the preparation of the drug for the treatment of neuro-motor diseases

Info

Publication number
IL103493A
IL103493A IL10349392A IL10349392A IL103493A IL 103493 A IL103493 A IL 103493A IL 10349392 A IL10349392 A IL 10349392A IL 10349392 A IL10349392 A IL 10349392A IL 103493 A IL103493 A IL 103493A
Authority
IL
Israel
Prior art keywords
amino
benzothiazole
treatment
trifluoromethoxy
preparing
Prior art date
Application number
IL10349392A
Other languages
English (en)
Hebrew (he)
Other versions
IL103493A0 (en
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9427427&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL103493(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of IL103493A0 publication Critical patent/IL103493A0/xx
Publication of IL103493A publication Critical patent/IL103493A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Percussion Or Vibration Massage (AREA)
IL10349392A 1992-03-06 1992-10-21 Use of 2 - amino - 6 -) trifluoromethoxy (benzothiazole for the preparation of the drug for the treatment of neuro-motor diseases IL103493A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9202696A FR2688138B1 (fr) 1992-03-06 1992-03-06 Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique.

Publications (2)

Publication Number Publication Date
IL103493A0 IL103493A0 (en) 1993-03-15
IL103493A true IL103493A (en) 1996-07-23

Family

ID=9427427

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10349392A IL103493A (en) 1992-03-06 1992-10-21 Use of 2 - amino - 6 -) trifluoromethoxy (benzothiazole for the preparation of the drug for the treatment of neuro-motor diseases

Country Status (22)

Country Link
US (1) US5527814A (de)
EP (2) EP0558861A1 (de)
JP (1) JP2713384B2 (de)
KR (1) KR100190296B1 (de)
AT (1) ATE149833T1 (de)
AU (1) AU666150B2 (de)
CA (1) CA2117466C (de)
CZ (1) CZ281293B6 (de)
DE (1) DE69218255T2 (de)
DK (1) DK0627919T3 (de)
ES (1) ES2098558T3 (de)
FR (1) FR2688138B1 (de)
GR (1) GR3022797T3 (de)
HU (1) HU217130B (de)
IL (1) IL103493A (de)
MX (1) MX9206109A (de)
NO (1) NO306534B1 (de)
RU (1) RU2110260C1 (de)
SK (1) SK279046B6 (de)
UA (1) UA41879C2 (de)
WO (1) WO1993017683A1 (de)
ZA (1) ZA928213B (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
FR2702148B1 (fr) * 1993-03-05 1995-04-07 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement du neuro-sida.
FR2714828B1 (fr) * 1994-01-12 1996-02-02 Rhone Poulenc Rorer Sa Application du riluzole dans le traitement des maladies mitochondriales.
ES2159362T3 (es) * 1995-10-26 2001-10-01 Sanofi Synthelabo Utilizacion de la 1-(2-naft-2-iletil)-4-(3-trifluorometilfenil)-1,2,3,6-tetrahidropiridina para la preparacion de medicamentos destinados para el tratamiento de la esclerosis lateral amiotrofica.
FR2753379B1 (fr) 1996-09-13 1998-10-30 Rhone Poulenc Rorer Sa Methode de traitement de la sclerose laterale amyotrophique
EP0999204B1 (de) 1997-07-25 2004-10-13 Nippon Kayaku Kabushiki Kaisha Verbindungen zur förderung der neuronendifferenzierung
CA2317811A1 (en) * 1998-01-09 1999-07-15 Mor-Research Applications Ltd. Treatment of dyskinesias
US6417210B1 (en) 1998-01-09 2002-07-09 Mor-Research Applications Ltd. Treatment of dyskinesias and Parkinson's disease with riluzole and levodopa
FR2785808B1 (fr) * 1998-11-13 2002-12-06 Aventis Laboratoire Association riluzole et alpha-tocopherol
US6872739B1 (en) 1999-06-04 2005-03-29 Vereniging Voor Christelijk Wetenshappelikjk Onderwijs Use of riluzole for the treatment of multiple sclerosis
JP2003522121A (ja) * 1999-06-04 2003-07-22 フェレニヒング フォール クリステレイク ウェテンスハッペリキク オンデルウェイス 多発性硬化症の処置のためのリルゾールの使用
JP2001021609A (ja) * 1999-07-07 2001-01-26 Mitsubishi Electric Corp 半導体集積回路の検査方法
DE19940524C2 (de) * 1999-08-26 2003-06-18 Karl-Heinz Lenzkes Fahrzeugrad, insbesondere für Personenkraftfahrzeuge
FR2801217B1 (fr) * 1999-11-24 2002-12-06 Aventis Pharma Sa Association de riluzole et de gabapentine et son utilisation comme medicament
US6350768B1 (en) 1999-11-24 2002-02-26 Aventis Pharma S.A. Combination of riluzole and of gabapentin and its use as a medicament
US6964982B2 (en) 2000-04-20 2005-11-15 Neurotech Co., Ltd. Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
IL136687A0 (en) * 2000-06-12 2001-06-14 Mor Research Applic Ltd Pharmaceutical composition for the treatment of multiple sclerosis
WO2002034264A1 (en) * 2000-10-24 2002-05-02 Mitsubishi Pharma Corporation Remedies for amyotrophic lateral sclerosis (als)
WO2002042842A2 (en) * 2000-11-22 2002-05-30 Allergan, Inc. A high-throughput screen for identifying channel blockers that selectively distinguish transient from persistent sodium channels
US6479458B1 (en) 2001-11-08 2002-11-12 Allergan, Inc. Targeting the reverse mode of the Na+/Ca2+ exchanger for the treatment of optic neuropathy associated with glaucoma and ischemic optic neuropathy
US7361478B2 (en) * 2001-11-20 2008-04-22 Allergan, Inc. High-throughput screen for identifying selective persistent sodium channels channel blockers
ES2432527T3 (es) * 2001-12-11 2013-12-04 University Of Virginia Patent Foundation Uso de pramipexol para tratar la esclerosis lateral amiotrófica
EP1551793B1 (de) * 2002-06-19 2016-01-20 AmKor Pharma, Inc. Tetrafluorbenzylderivate und diese enthaltende pharmazeutische zusammensetzung zur prävention und behandlung akuter und chronischer neurodegenerativer erkrankungen des zentralen nervensystems
SI1567152T1 (sl) * 2002-11-15 2013-10-30 Teva Pharmaceutical Industries Ltd. Uporaba rasagilina z riluzolom za zdravljenje amiotrofične lateralne skleroze
EP1883619B8 (de) * 2005-05-25 2013-05-01 JW Pharmaceutical Corporation Verfahren zur herstellung einer substituierten tetrafluorbenzylanilinverbindung und deren pharmazeutisch zugelassenen salzen
US20070298129A1 (en) * 2005-08-24 2007-12-27 Neurotech Pharmaceuticals Co., Ltd. Compounds and compositions for treating neuronal death or neurological dysfunction
US20070049565A1 (en) * 2005-08-24 2007-03-01 Neurotech Pharmaceuticals Co., Ltd. Combination of cell necrosis inhibitor and lithium for treating neuronal death or neurological dysfunction
EP1924326B1 (de) 2005-08-25 2016-10-12 Steven Michael Weiss Reduzierung von myokard-schaden und inzidenz von arrhythmien durch verlust, verringerung oder unterbrechung des koronaren blutflusses
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
ATE537826T1 (de) 2006-05-16 2012-01-15 Knopp Neurosciences Inc Zusammensetzungen aus r(+)- und s(-)-pramipexol sowie verfahren zu ihrer anwendung
JP5110536B2 (ja) 2006-07-19 2012-12-26 学校法人日本医科大学 筋萎縮性側索硬化症治療薬
JP2010504338A (ja) * 2006-09-20 2010-02-12 メディベイション ニューロロジー, インコーポレイテッド 筋萎縮性側索硬化症(ALS)の治療のための水素化ピリド[4,3−b]インドール
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
JP2010521496A (ja) 2007-03-14 2010-06-24 ノップ ニューロサイエンシーズ、インク. キラル精製置換ベンゾチアゾールジアミンの合成
KR100852962B1 (ko) * 2007-11-12 2008-08-20 주식회사 뉴로테크 2-하이드록시-5-페닐알킬아미노벤조산 유도체 및 이의 염의제조방법
JP5173018B2 (ja) * 2008-04-03 2013-03-27 エフ.ホフマン−ラ ロシュ アーゲー 神経筋障害の処置のためのpeg化igf−i変異体の使用
US20110190356A1 (en) 2008-08-19 2011-08-04 Knopp Neurosciences Inc. Compositions and Methods of Using (R)- Pramipexole
EP2228055A1 (de) 2009-03-13 2010-09-15 ITALFARMACO S.p.A. Flüssige Riluzol-Emulsionen
EP2228054A1 (de) 2009-03-13 2010-09-15 ITALFARMACO S.p.A. Wässrige Riluzol-Suspensionen
AU2010262970A1 (en) * 2009-06-19 2012-01-12 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
WO2011074690A1 (en) 2009-12-14 2011-06-23 Kyoto University Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis
WO2012029994A1 (en) 2010-09-02 2012-03-08 Kyoto University Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US10357497B2 (en) * 2012-06-23 2019-07-23 Biohaven Pharmaceutical Holding Company Limited Pro-drugs of riluzole and their method of use for the treatment of amyotrophic lateral sclerosis
CA3132310C (en) 2012-08-07 2024-01-09 Children's Medical Center Corporation Potassium channel openers for treating neurodegenerative diseases
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
PL3019167T3 (pl) 2013-07-12 2021-06-14 Knopp Biosciences Llc Leczenie podwyższonych poziomów eozynofili i/lub bazofili
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
DK3033081T3 (da) 2013-08-13 2021-05-31 Knopp Biosciences Llc Sammensætninger og fremgangsmåder til behandling af kronisk urticaria
EP3038467B1 (de) 2013-08-13 2020-07-29 Knopp Biosciences LLC Zusammensetzungen und verfahren zur behandlung von plasmazellenerkrankungen und prolymphozytischen b-zellen-erkrankungen
US20150210679A1 (en) * 2014-01-28 2015-07-30 Northwestern University Small molecule inhibitors of superoxide dismutase expression
CN107530430A (zh) 2015-01-13 2018-01-02 国立大学法人京都大学 用于预防和/或治疗肌萎缩性侧索硬化症的药剂
US11911369B2 (en) * 2015-03-03 2024-02-27 Biohaven Therapeutics Ltd. Prodrugs of riluzole and their method of use
WO2018093591A1 (en) 2016-11-03 2018-05-24 Juno Therapeutics, Inc. Combination therapy of a cell based therapy and a microglia inhibitor
MA48781A (fr) 2017-06-02 2020-04-08 Juno Therapeutics Inc Articles de fabrication et procédés liés à la toxicité associée à la thérapie cellulaire
AU2018275894B2 (en) 2017-06-02 2025-04-24 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
JP2020526194A (ja) 2017-06-29 2020-08-31 ジュノー セラピューティクス インコーポレイテッド 免疫療法薬と関連する毒性を評価するためのマウスモデル
US10322114B2 (en) * 2017-07-31 2019-06-18 Above And Beyond Nb, Llc Formulation of a riluzole solution with beta-cyclodextrins
WO2019046832A1 (en) 2017-09-01 2019-03-07 Juno Therapeutics, Inc. GENE EXPRESSION AND EVALUATION OF RISK OF DEVELOPMENT OF TOXICITY FOLLOWING CELL THERAPY
US11564946B2 (en) 2017-11-01 2023-01-31 Juno Therapeutics, Inc. Methods associated with tumor burden for assessing response to a cell therapy
CA3118692A1 (en) 2018-11-06 2020-05-14 Alsatech, Inc. Cell-based gene therapy for neurodegenerative diseases
PT3886875T (pt) 2018-11-30 2024-06-27 Juno Therapeutics Inc Métodos para tratamento utilizando terapia celular adotiva
CN113692285A (zh) 2018-11-30 2021-11-23 朱诺治疗学股份有限公司 在过继细胞疗法中给药和治疗b细胞恶性肿瘤的方法
MX2022006715A (es) 2019-12-06 2022-09-23 Juno Therapeutics Inc Metodos relacionados con toxicidad y respuesta asociada con terapia celular para tratar neoplasias malignas de celulas b.
JPWO2023238869A1 (de) 2022-06-07 2023-12-14

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2492258A1 (fr) * 1980-10-17 1982-04-23 Pharmindustrie Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
US4826860A (en) * 1987-03-16 1989-05-02 Warner-Lambert Company Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
FR2619713B1 (fr) * 1987-08-25 1990-08-31 Rhone Poulenc Sante Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement des troubles du sommeil et de la depression
US4918090A (en) * 1988-01-25 1990-04-17 Warner-Lambert Company Substituted 2-aminbenzothiazoles and derivatives useful as cerebrovascular agents
US5236940A (en) * 1988-12-15 1993-08-17 Rhone-Poulenc Sante Pharmaceutical compositions, 2-benzothiazolamine derivatives, and their preparation
DE68903484T2 (de) * 1988-12-15 1993-03-18 Rhone Poulenc Sante 2-imino-6-polyfluoralkoxy-benzothiazol-derivate, verfahren zu deren herstellung und arzneimittel, die sie enthalten.
FR2649702B1 (fr) * 1989-07-13 1991-11-22 Rhone Poulenc Sante Derives d'alkylimino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant
FR2662160B1 (fr) * 1990-05-18 1992-07-24 Rhone Poulenc Sante Derives d'alkylthio-3 propyl-3 benzothiazoline leur preparation et les medicaments les contenant.
FR2663029B1 (fr) * 1990-06-07 1992-07-31 Rhone Poulenc Sante Derives de benzothiazole, leur preparation et les medicaments les contenant.

Also Published As

Publication number Publication date
JPH07504655A (ja) 1995-05-25
NO943256L (no) 1994-09-02
JP2713384B2 (ja) 1998-02-16
SK104794A3 (en) 1995-05-10
EP0627919A1 (de) 1994-12-14
UA41879C2 (uk) 2001-10-15
CA2117466C (fr) 2000-01-25
AU666150B2 (en) 1996-02-01
HUT70946A (en) 1995-11-28
SK279046B6 (sk) 1998-06-03
NO943256D0 (no) 1994-09-02
DE69218255D1 (de) 1997-04-17
US5527814A (en) 1996-06-18
CZ281293B6 (cs) 1996-08-14
GR3022797T3 (en) 1997-06-30
KR950700060A (ko) 1995-01-16
AU2948292A (en) 1993-10-05
FR2688138B1 (fr) 1995-05-05
DK0627919T3 (da) 1997-05-12
HU9402558D0 (en) 1994-11-28
CZ212094A3 (en) 1994-12-15
IL103493A0 (en) 1993-03-15
FR2688138A1 (fr) 1993-09-10
ES2098558T3 (es) 1997-05-01
DE69218255T2 (de) 1997-09-11
EP0558861A1 (de) 1993-09-08
KR100190296B1 (ko) 1999-06-01
NO306534B1 (no) 1999-11-22
EP0627919B1 (de) 1997-03-12
ATE149833T1 (de) 1997-03-15
RU2110260C1 (ru) 1998-05-10
ZA928213B (en) 1993-04-30
CA2117466A1 (fr) 1993-09-16
RU94041223A (ru) 1996-10-20
WO1993017683A1 (fr) 1993-09-16
HU217130B (hu) 1999-11-29
MX9206109A (es) 1993-09-01

Similar Documents

Publication Publication Date Title
IL103493A (en) Use of 2 - amino - 6 -) trifluoromethoxy (benzothiazole for the preparation of the drug for the treatment of neuro-motor diseases
IL108284A (en) Pharmaceutical preparations containing rilosol for the treatment of Parkinson's disease and Parkinson's syndromes
PT687176E (pt) Aplicacao de riluzol no tratamento da neuro-sida
JP3593357B2 (ja) 抗菌剤
JPH0196132A (ja) 精神分裂症を治療するためのある種の化合物の使用
US6432992B1 (en) Use of riluzole or its salts for the prevention and treatment of adrenoleukodystrophy
US6642262B2 (en) Riluzole and alpha-tocopherol combination
JPWO2004017973A1 (ja) 統合失調症治療剤
AU609564B2 (en) Anti-psychotic imidazobenzodiazepine
JP2003507352A (ja) 急なベンゾジアゼピン離脱処置のためのシアメマジンの使用
IL137608A (en) Use of 2-amino-6-trifluoromethoxy-benzothiazole in the preparation of drugs for the prevention or treatment of dysfunction of the serum
CN1309564A (zh) 治疗方法
AU2001274195B2 (en) Use of riluzole or its salts for preventing and treating adrenoleukodystrophy
IL108283A (en) Use of rilozole for the preparation of a pharmaceutical preparation for increased rehabilitation after radiation

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired