ATE149833T1 - Verwendung von amino-2-trifluormethoxy-6- benzothiazol (riluzol) zur herstellung eines medikamentes zur behandlung von erkrankungen des motoneurons - Google Patents
Verwendung von amino-2-trifluormethoxy-6- benzothiazol (riluzol) zur herstellung eines medikamentes zur behandlung von erkrankungen des motoneuronsInfo
- Publication number
- ATE149833T1 ATE149833T1 AT92923852T AT92923852T ATE149833T1 AT E149833 T1 ATE149833 T1 AT E149833T1 AT 92923852 T AT92923852 T AT 92923852T AT 92923852 T AT92923852 T AT 92923852T AT E149833 T1 ATE149833 T1 AT E149833T1
- Authority
- AT
- Austria
- Prior art keywords
- benzothiazole
- trifluoromethoxy
- amino
- treatment
- riluzole
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Surgical Instruments (AREA)
- Percussion Or Vibration Massage (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9202696A FR2688138B1 (fr) | 1992-03-06 | 1992-03-06 | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE149833T1 true ATE149833T1 (de) | 1997-03-15 |
Family
ID=9427427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92923852T ATE149833T1 (de) | 1992-03-06 | 1992-10-22 | Verwendung von amino-2-trifluormethoxy-6- benzothiazol (riluzol) zur herstellung eines medikamentes zur behandlung von erkrankungen des motoneurons |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5527814A (de) |
| EP (2) | EP0558861A1 (de) |
| JP (1) | JP2713384B2 (de) |
| KR (1) | KR100190296B1 (de) |
| AT (1) | ATE149833T1 (de) |
| AU (1) | AU666150B2 (de) |
| CA (1) | CA2117466C (de) |
| CZ (1) | CZ281293B6 (de) |
| DE (1) | DE69218255T2 (de) |
| DK (1) | DK0627919T3 (de) |
| ES (1) | ES2098558T3 (de) |
| FR (1) | FR2688138B1 (de) |
| GR (1) | GR3022797T3 (de) |
| HU (1) | HU217130B (de) |
| IL (1) | IL103493A (de) |
| MX (1) | MX9206109A (de) |
| NO (1) | NO306534B1 (de) |
| RU (1) | RU2110260C1 (de) |
| SK (1) | SK279046B6 (de) |
| UA (1) | UA41879C2 (de) |
| WO (1) | WO1993017683A1 (de) |
| ZA (1) | ZA928213B (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2699077B1 (fr) * | 1992-12-16 | 1995-01-13 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes. |
| FR2702148B1 (fr) * | 1993-03-05 | 1995-04-07 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement du neuro-sida. |
| FR2714828B1 (fr) * | 1994-01-12 | 1996-02-02 | Rhone Poulenc Rorer Sa | Application du riluzole dans le traitement des maladies mitochondriales. |
| ES2159362T3 (es) * | 1995-10-26 | 2001-10-01 | Sanofi Synthelabo | Utilizacion de la 1-(2-naft-2-iletil)-4-(3-trifluorometilfenil)-1,2,3,6-tetrahidropiridina para la preparacion de medicamentos destinados para el tratamiento de la esclerosis lateral amiotrofica. |
| FR2753379B1 (fr) * | 1996-09-13 | 1998-10-30 | Rhone Poulenc Rorer Sa | Methode de traitement de la sclerose laterale amyotrophique |
| ATE279387T1 (de) | 1997-07-25 | 2004-10-15 | Nippon Kayaku Kk | Verbindungen zur förderung der neuronendifferenzierung |
| EP1043996A2 (de) * | 1998-01-09 | 2000-10-18 | Mor-Research Applications Ltd. | Behandlung von dyskinesien |
| US6417210B1 (en) | 1998-01-09 | 2002-07-09 | Mor-Research Applications Ltd. | Treatment of dyskinesias and Parkinson's disease with riluzole and levodopa |
| FR2785808B1 (fr) * | 1998-11-13 | 2002-12-06 | Aventis Laboratoire | Association riluzole et alpha-tocopherol |
| CA2375874A1 (en) * | 1999-06-04 | 2000-12-14 | Chris Polman | Use of riluzole for the treatment of multiple sclerosis |
| US6872739B1 (en) | 1999-06-04 | 2005-03-29 | Vereniging Voor Christelijk Wetenshappelikjk Onderwijs | Use of riluzole for the treatment of multiple sclerosis |
| JP2001021609A (ja) * | 1999-07-07 | 2001-01-26 | Mitsubishi Electric Corp | 半導体集積回路の検査方法 |
| DE19940524C2 (de) * | 1999-08-26 | 2003-06-18 | Karl-Heinz Lenzkes | Fahrzeugrad, insbesondere für Personenkraftfahrzeuge |
| FR2801217B1 (fr) * | 1999-11-24 | 2002-12-06 | Aventis Pharma Sa | Association de riluzole et de gabapentine et son utilisation comme medicament |
| US6350768B1 (en) | 1999-11-24 | 2002-02-26 | Aventis Pharma S.A. | Combination of riluzole and of gabapentin and its use as a medicament |
| US6573402B1 (en) | 2000-04-20 | 2003-06-03 | Neurotech Co., Ltd. | Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system |
| IL136687A0 (en) * | 2000-06-12 | 2001-06-14 | Mor Research Applic Ltd | Pharmaceutical composition for the treatment of multiple sclerosis |
| ES2248144T3 (es) | 2000-10-24 | 2006-03-16 | Mitsubishi Pharma Corporation | Medicamentos para tratar la esclerosis lateral amiotrofica (ela). |
| AU2002239329B2 (en) * | 2000-11-22 | 2006-08-10 | Allergan, Inc. | A high-throughput screen for identifying channel blockers that selectively distinguish transient from persistent sodium channels |
| US6479458B1 (en) | 2001-11-08 | 2002-11-12 | Allergan, Inc. | Targeting the reverse mode of the Na+/Ca2+ exchanger for the treatment of optic neuropathy associated with glaucoma and ischemic optic neuropathy |
| US7361478B2 (en) * | 2001-11-20 | 2008-04-22 | Allergan, Inc. | High-throughput screen for identifying selective persistent sodium channels channel blockers |
| KR20040066890A (ko) * | 2001-12-11 | 2004-07-27 | 유니버시티 오브 버지니아 페이턴트 파운데이션 | 근위축성 측삭 경화증 치료를 위한 프라미펙솔의 용도 |
| KR100545745B1 (ko) * | 2002-06-19 | 2006-01-24 | 주식회사 뉴로테크 | 테트라플루오로벤질 유도체 및 이를 함유하는 급성 및퇴행성 뇌신경계 질환의 예방 및 치료용 약학적 조성물 |
| SI1567152T1 (sl) * | 2002-11-15 | 2013-10-30 | Teva Pharmaceutical Industries Ltd. | Uporaba rasagilina z riluzolom za zdravljenje amiotrofične lateralne skleroze |
| KR20060121768A (ko) * | 2005-05-25 | 2006-11-29 | 주식회사 중외제약 | 테트라플루오로벤질 아닐린 유도체 및 이의 약학적으로허용가능한 염 화합물의 제조방법 |
| US20070298129A1 (en) * | 2005-08-24 | 2007-12-27 | Neurotech Pharmaceuticals Co., Ltd. | Compounds and compositions for treating neuronal death or neurological dysfunction |
| US20070049565A1 (en) * | 2005-08-24 | 2007-03-01 | Neurotech Pharmaceuticals Co., Ltd. | Combination of cell necrosis inhibitor and lithium for treating neuronal death or neurological dysfunction |
| EP1924326B1 (de) | 2005-08-25 | 2016-10-12 | Steven Michael Weiss | Reduzierung von myokard-schaden und inzidenz von arrhythmien durch verlust, verringerung oder unterbrechung des koronaren blutflusses |
| US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| CN102160865A (zh) | 2006-05-16 | 2011-08-24 | 诺普神经科学股份有限公司 | R(+)和s(-)普拉克索的组合物以及使用该组合物的方法 |
| WO2008010315A1 (en) | 2006-07-19 | 2008-01-24 | Nippon Medical School Foundation | Therapeutic agent for amyotrophic lateral sclerosis |
| US20100099700A1 (en) * | 2006-09-20 | 2010-04-22 | David Hung | Hydrogenated pyrido (4,3-b) indoles for treating amyotrophic lateral sclerosis (als) |
| US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| US8519148B2 (en) | 2007-03-14 | 2013-08-27 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
| KR100852962B1 (ko) * | 2007-11-12 | 2008-08-20 | 주식회사 뉴로테크 | 2-하이드록시-5-페닐알킬아미노벤조산 유도체 및 이의 염의제조방법 |
| WO2009121759A2 (en) * | 2008-04-03 | 2009-10-08 | F. Hoffmann-La Roche Ag | Use of pegylated igf-i variants for the treatment of neuromuscular disorders |
| JP2012500283A (ja) | 2008-08-19 | 2012-01-05 | ノップ ニューロサイエンシーズ、インク. | (r)−プラミペキソールを使用した組成物並びにその方法 |
| EP2228055A1 (de) | 2009-03-13 | 2010-09-15 | ITALFARMACO S.p.A. | Flüssige Riluzol-Emulsionen |
| EP2228054A1 (de) | 2009-03-13 | 2010-09-15 | ITALFARMACO S.p.A. | Wässrige Riluzol-Suspensionen |
| AU2010262970A1 (en) * | 2009-06-19 | 2012-01-12 | Knopp Neurosciences, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
| US20130115622A1 (en) | 2009-12-14 | 2013-05-09 | Kyoto University | Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis |
| US9856210B2 (en) | 2010-09-02 | 2018-01-02 | Kyoto University | Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US10357497B2 (en) * | 2012-06-23 | 2019-07-23 | Biohaven Pharmaceutical Holding Company Limited | Pro-drugs of riluzole and their method of use for the treatment of amyotrophic lateral sclerosis |
| WO2014025761A1 (en) | 2012-08-07 | 2014-02-13 | Children's Medical Center Corporation | Methods to treat neurodegenerative diseases |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| RS67279B1 (sr) | 2013-07-12 | 2025-10-31 | Areteia Therapeutics Inc | Lečenje povišenih nivoa eozinofila i/ili bazofila |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| ES2813674T3 (es) | 2013-08-13 | 2021-03-24 | Knopp Biosciences Llc | Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b |
| EP3033081B1 (de) | 2013-08-13 | 2021-05-12 | Knopp Biosciences LLC | Zusammensetzungen und verfahren zur behandlung von chronischer nesselsucht |
| US20150210679A1 (en) | 2014-01-28 | 2015-07-30 | Northwestern University | Small molecule inhibitors of superoxide dismutase expression |
| EP3246046A4 (de) | 2015-01-13 | 2018-12-05 | Kyoto University | Mittel zur prävention und/oder behandlung von amyotropher lateralsklerose |
| US11911369B2 (en) * | 2015-03-03 | 2024-02-27 | Biohaven Therapeutics Ltd. | Prodrugs of riluzole and their method of use |
| MA46716A (fr) | 2016-11-03 | 2019-09-11 | Juno Therapeutics Inc | Polythérapie de thérapie cellulaire et d'inhibiteur de la microglie |
| EP3631468A1 (de) | 2017-06-02 | 2020-04-08 | Juno Therapeutics, Inc. | Artikel zur herstellung und verfahren im zusammenhang mit der mit einer zelltherapie einherenden toxizität |
| IL327498A (en) | 2017-06-02 | 2026-05-01 | Juno Therapeutics Inc | Articles of manufacture and methods for treatment using adoptive cell therapy |
| CN111050545A (zh) | 2017-06-29 | 2020-04-21 | 朱诺治疗学股份有限公司 | 评估与免疫疗法相关的毒性的小鼠模型 |
| US10322114B2 (en) | 2017-07-31 | 2019-06-18 | Above And Beyond Nb, Llc | Formulation of a riluzole solution with beta-cyclodextrins |
| WO2019046832A1 (en) | 2017-09-01 | 2019-03-07 | Juno Therapeutics, Inc. | GENE EXPRESSION AND EVALUATION OF RISK OF DEVELOPMENT OF TOXICITY FOLLOWING CELL THERAPY |
| WO2019089848A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
| CA3118692A1 (en) | 2018-11-06 | 2020-05-14 | Alsatech, Inc. | Cell-based gene therapy for neurodegenerative diseases |
| KR20210110811A (ko) | 2018-11-30 | 2021-09-09 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 요법에서 b 세포 악성 종양의 투약 및 치료 방법 |
| EP4427810A3 (de) | 2018-11-30 | 2024-12-04 | Juno Therapeutics, Inc. | Behandlungsverfahren mit adoptiver zelltherapie |
| EP4070097A1 (de) | 2019-12-06 | 2022-10-12 | Juno Therapeutics, Inc. | Verfahren in zusammenhang mit toxizität und ansprechen bei einer zelltherapie zur behandlung von b-zell-malignitäten |
| JPWO2023238869A1 (de) | 2022-06-07 | 2023-12-14 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2492258A1 (fr) * | 1980-10-17 | 1982-04-23 | Pharmindustrie | Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole |
| US4826860A (en) * | 1987-03-16 | 1989-05-02 | Warner-Lambert Company | Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents |
| FR2619713B1 (fr) * | 1987-08-25 | 1990-08-31 | Rhone Poulenc Sante | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement des troubles du sommeil et de la depression |
| US4918090A (en) * | 1988-01-25 | 1990-04-17 | Warner-Lambert Company | Substituted 2-aminbenzothiazoles and derivatives useful as cerebrovascular agents |
| ES2052954T3 (es) * | 1988-12-15 | 1994-07-16 | Rhone Poulenc Sante | Derivados de imino-2-polifluoroalcoxi-6-benzotiazol, sus procedimientos de preparacion y los medicamentos que les contienen. |
| US5236940A (en) * | 1988-12-15 | 1993-08-17 | Rhone-Poulenc Sante | Pharmaceutical compositions, 2-benzothiazolamine derivatives, and their preparation |
| FR2649702B1 (fr) * | 1989-07-13 | 1991-11-22 | Rhone Poulenc Sante | Derives d'alkylimino-2 benzothiazoline, leurs procedes de preparation et les medicaments les contenant |
| FR2662160B1 (fr) * | 1990-05-18 | 1992-07-24 | Rhone Poulenc Sante | Derives d'alkylthio-3 propyl-3 benzothiazoline leur preparation et les medicaments les contenant. |
| FR2663029B1 (fr) * | 1990-06-07 | 1992-07-31 | Rhone Poulenc Sante | Derives de benzothiazole, leur preparation et les medicaments les contenant. |
-
1992
- 1992-03-06 FR FR9202696A patent/FR2688138B1/fr not_active Expired - Fee Related
- 1992-10-21 IL IL10349392A patent/IL103493A/en not_active IP Right Cessation
- 1992-10-22 EP EP92402878A patent/EP0558861A1/de active Pending
- 1992-10-22 WO PCT/FR1992/000992 patent/WO1993017683A1/fr not_active Ceased
- 1992-10-22 ES ES92923852T patent/ES2098558T3/es not_active Expired - Lifetime
- 1992-10-22 DK DK92923852.5T patent/DK0627919T3/da active
- 1992-10-22 AT AT92923852T patent/ATE149833T1/de active
- 1992-10-22 SK SK1047-94A patent/SK279046B6/sk not_active IP Right Cessation
- 1992-10-22 CA CA002117466A patent/CA2117466C/fr not_active Expired - Lifetime
- 1992-10-22 KR KR1019940703081A patent/KR100190296B1/ko not_active Expired - Lifetime
- 1992-10-22 JP JP5515371A patent/JP2713384B2/ja not_active Expired - Lifetime
- 1992-10-22 DE DE69218255T patent/DE69218255T2/de not_active Expired - Lifetime
- 1992-10-22 CZ CZ942120A patent/CZ281293B6/cs not_active IP Right Cessation
- 1992-10-22 HU HU9402558A patent/HU217130B/hu unknown
- 1992-10-22 UA UA94085678A patent/UA41879C2/uk unknown
- 1992-10-22 AU AU29482/92A patent/AU666150B2/en not_active Expired
- 1992-10-22 RU RU94041223A patent/RU2110260C1/ru active
- 1992-10-22 EP EP92923852A patent/EP0627919B1/de not_active Expired - Lifetime
- 1992-10-23 ZA ZA928213A patent/ZA928213B/xx unknown
- 1992-10-23 MX MX9206109A patent/MX9206109A/es unknown
-
1994
- 1994-09-02 NO NO19943256A patent/NO306534B1/no not_active IP Right Cessation
- 1994-10-21 US US08/327,343 patent/US5527814A/en not_active Expired - Lifetime
-
1997
- 1997-03-13 GR GR960403093T patent/GR3022797T3/el unknown
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