IL105003A - Indole carboxamide derivatives and esters of tricyclic indole carboxylic acids their preparation and pharmaceutical compositions containing them - Google Patents

Indole carboxamide derivatives and esters of tricyclic indole carboxylic acids their preparation and pharmaceutical compositions containing them

Info

Publication number: IL105003A
Authority: IL; Israel
Prior art keywords: indole; alkyl; methyl; hydrogen; treated
Prior art date: 1992-03-12

Application number

IL10500393A

Other languages

English (en)

Other versions

IL105003A0 (en

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-12

Filing date

1993-03-10

Publication date

1996-09-12

1992-03-12 Priority claimed from GB929205428A external-priority patent/GB9205428D0/en

1992-09-05 Priority claimed from GB929218846A external-priority patent/GB9218846D0/en

1992-12-29 Priority claimed from GB929227045A external-priority patent/GB9227045D0/en

1993-03-10 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1993-07-08 Publication of IL105003A0 publication Critical patent/IL105003A0/xx

1996-09-12 Publication of IL105003A publication Critical patent/IL105003A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/452—Piperidinium derivatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IL10500393A 1992-03-12 1993-03-10 Indole carboxamide derivatives and esters of tricyclic indole carboxylic acids their preparation and pharmaceutical compositions containing them IL105003A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB929205428A GB9205428D0 (en)	1992-03-12	1992-03-12	Pharmaceuticals
GB929218846A GB9218846D0 (en)	1992-09-05	1992-09-05	Pharmaceuticals
GB929227045A GB9227045D0 (en)	1992-12-29	1992-12-29	Pharmaceuticals

Publications (2)

Publication Number	Publication Date
IL105003A0 IL105003A0 (en)	1993-07-08
IL105003A true IL105003A (en)	1996-09-12

Family

ID=27266092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10500393A IL105003A (en)	1992-03-12	1993-03-10	Indole carboxamide derivatives and esters of tricyclic indole carboxylic acids their preparation and pharmaceutical compositions containing them

Country Status (29)

Country	Link
EP (2)	EP0630376B1 (fr)
JP (1)	JP2831467B2 (fr)
KR (1)	KR100282730B1 (fr)
CN (2)	CN1043893C (fr)
AP (1)	AP401A (fr)
AT (2)	ATE180785T1 (fr)
AU (1)	AU671102B2 (fr)
CA (1)	CA2131797C (fr)
CY (1)	CY2510B1 (fr)
CZ (1)	CZ286194B6 (fr)
DE (2)	DE69333504T2 (fr)
DK (2)	DK0884319T3 (fr)
ES (2)	ES2219813T3 (fr)
FI (1)	FI107158B (fr)
GR (1)	GR3030668T3 (fr)
HU (1)	HU219121B (fr)
IL (1)	IL105003A (fr)
MA (1)	MA22819A1 (fr)
MX (1)	MX9301348A (fr)
MY (1)	MY110110A (fr)
NO (1)	NO303638B1 (fr)
NZ (1)	NZ249565A (fr)
PT (1)	PT884319E (fr)
RU (1)	RU2104279C1 (fr)
SG (1)	SG50693A1 (fr)
SI (1)	SI9300114B (fr)
SK (1)	SK281423B6 (fr)
UA (1)	UA41311C2 (fr)
WO (1)	WO1993018036A1 (fr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5998409A (en) *	1992-03-12	1999-12-07	Smithkline Beecham Plc	Condensed indole derivatives as 5HT4 -receptor antagonists
GB9316195D0 (en) *	1993-08-05	1993-09-22	Smithkline Beecham Plc	Pharmaceuticals
US5852014A (en) *	1992-03-12	1998-12-22	Smithkline Beecham P.L.C.	Condensed indole derivatives as 5HT4 -receptor antagonists
MX9305947A (es) *	1992-09-29	1994-06-30	Smithkline Beecham Plc	Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
US5726187A (en) *	1992-10-16	1998-03-10	Smithkline Beecham Plc	N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists
NZ257545A (en) *	1992-11-05	1997-01-29	Smithkline Beecham Plc	Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions
FR2699921B1 (fr) *	1992-12-30	1995-02-10	Synthelabo	Dérivés d'acide 2-(thien-2-yl)imidazo[2,1-b]benzothiazole-3-acétique, leur préparation et leur application en thérapeutique.
GB9303340D0 (en) *	1993-02-19	1993-04-07	Smithkline Beecham Plc	Pharmaceuticals
GB9310582D0 (en) *	1993-05-22	1993-07-07	Smithkline Beecham Plc	Pharmaceuticals
GB9312348D0 (en) *	1993-06-16	1993-07-28	Smithkline Beecham Plc	Pharmaceuticals
KR100219922B1 (ko) *	1996-05-16	1999-09-01	이서봉	신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
US6013666A (en) *	1996-07-02	2000-01-11	Sang Sup Jew	Oxirane carboxylic acid derivative and its manufacturing method
JP3911297B2 (ja) *	1996-08-16	2007-05-09	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	Ｎ―［（１―ｎブチル―４―ピペリジル）メチル］―３，４―ジヒドロ―２Ｈ―［１，３］オキサジノ［３，２―ａ］インドール―１０―カルボキシアミドおよび塩ならびに製造における中間体
US6100397A (en) *	1996-08-16	2000-08-08	Smithkline Beecham Plc	Process for the preparation of N-[(1-n butyl-4-piperidyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
GB9618967D0 (en) *	1996-09-11	1996-10-23	Smithkline Beecham Plc	Pharmaceuticals
GB9725933D0 (en) *	1997-12-05	1998-02-04	Smithkline Beecham Plc	Pharmaceuticals
US6277870B1 (en) *	1998-05-04	2001-08-21	Astra Ab	Use
US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US20020091271A1 (en)	1998-07-16	2002-07-11	Smithkline Beecham Plc	Process for the preparation of an indole derivative
GB9819035D0 (en)	1998-09-01	1998-10-28	Cerebrus Res Ltd	Chemical compounds VII
AU758807B2 (en) *	1998-09-10	2003-03-27	F. Hoffmann-La Roche Ag	Dihydrobenzodioxine carboxamide and ketone derivatives as 5-HT4 receptor antagonists
GB9820294D0 (en) *	1998-09-17	1998-11-11	Smithkline Beecham Plc	Pharmaceuticals
US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
US6545004B1 (en)	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
IL154279A0 (en) *	2000-08-07	2003-09-17	Glaxosmithkline Lab Sas	Use of 5ht4 receptor antagonists in the manufacture of a medicament for the prophylaxis or treatment of atrial fibrillation
AU2005203196B9 (en) *	2000-08-07	2009-04-09	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782870C (en) *	2000-08-07	2007-03-15	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782863C (en) *	2000-08-07	2006-08-31	Glaxo Group Limited	The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
NZ535261A (en) *	2000-08-08	2004-12-24	Smithkline Beecham P	A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide
AU7655801A (en) *	2000-08-08	2002-02-18	Smithkline Beecham Plc	Pharmaceutical composition comprising condensed indole compound
JP2005523276A (ja) *	2002-02-14	2005-08-04	グラクソ　グループ　リミテッド	Ｎ−［（１−ｎ−ブチル−４−ピペリジニル）メチル］−３，４−ジヒドロ−２ｈ−［１，３］オキサジノ［３，２−ａ］インドール−１０−カルボキシアミド（ｓｂ２０７２６６）またはその塩および乾燥造粒操作を含む方法
WO2003070701A2 (fr)	2002-02-15	2003-08-28	Cytokinetics, Inc.	Syntheses de quinazolinones
CA2485148A1 (fr)	2002-05-09	2003-11-20	Cytokinetics, Inc.	Composes, compositions et procedes
US7214800B2 (en)	2002-05-09	2007-05-08	Cytokinetics, Inc.	Compounds, compositions, and methods
GB0211230D0 (en)	2002-05-16	2002-06-26	Medinnova Sf	Treatment of heart failure
EP1513820A4 (fr)	2002-05-23	2006-09-13	Cytokinetics Inc	Composes, compositions et procedes
WO2003106426A1 (fr)	2002-06-14	2003-12-24	Cytokinetics, Inc.	Composes, compositions et procedes
AU2003256805A1 (en)	2002-07-23	2004-02-09	Cytokinetics, Inc.	Compounds compositions and methods
WO2004034972A2 (fr)	2002-09-30	2004-04-29	Cytokinetics, Inc.	Composes, compositions, et procedes
ITMI20031468A1 (it)	2003-07-18	2005-01-19	Acraf	Farmaco ativo nel dolore neuropatico
ITMI20031467A1 (it) *	2003-07-18	2005-01-19	Acraf	Farmaco attivo nel dolore neuropatico
EP1692112A4 (fr)	2003-12-08	2008-09-24	Cytokinetics Inc	Composes, compositions, et methodes associees
JP4740152B2 (ja)	2003-12-23	2011-08-03	セロドスアクスイェセルスカブ	末梢性５−ｈｔ受容体の修飾因子
JP4612301B2 (ja) *	2003-12-26	2011-01-12	広栄化学工業株式会社	１−アルキル−４−アミノメチルピペリジンの製造法
EP1824820A2 (fr) *	2004-12-07	2007-08-29	Janssen Pharmaceutica N.V.	Dérivés tetracycliques substitués de tetrahydrofurane, de pyrrolidine et de tetrahydrothiophène
RU2320662C1 (ru) *	2006-08-24	2008-03-27	Андрей Александрович Иващенко	ЗАМЕЩЕННЫЕ ПИРРОЛО[4,3-b]ИНДОЛЫ, КОМБИНАТОРНАЯ И ФОКУСИРОВАННАЯ БИБЛИОТЕКИ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
AU2008268613A1 (en)	2007-06-22	2008-12-31	Arqule, Inc.	Quinazolinone compounds and methods of use thereof
GB0905641D0 (en) *	2009-04-01	2009-05-13	Serodus As	Compounds
WO2021116487A1 (fr)	2019-12-13	2021-06-17	Som Innovation Biotech, S.A.	Composés destinés à être utilisés dans le traitement d'une maladie de niemann-pick de type c
WO2025077825A1 (fr) *	2023-10-13	2025-04-17	Fauna Bio Incorporated	Méthodes et compositions pour le traitement de troubles cardio-pulmonaires

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2557342A1 (de) *	1975-12-19	1977-06-30	Hoechst Ag	Basisch substituierte indolderivate und verfahren zu ihrer herstellung
AU622330B2 (en) *	1989-06-23	1992-04-02	Takeda Chemical Industries Ltd.	Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
CA2030051C (fr) *	1989-11-17	2001-08-07	Haruhiko Kikuchi	Derives indole
US5189041A (en) *	1990-11-16	1993-02-23	Syntex (U.S.A.) Inc.	Tricyclic 5-ht3 receptor antagonists
GB9103862D0 (en) *	1991-02-25	1991-04-10	Glaxo Group Ltd	Chemical compounds
US5206382A (en) *	1991-06-27	1993-04-27	Fidia Georgetown Institute For The Neurosciences	Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders

1993
- 1993-03-10 RU RU94040864A patent/RU2104279C1/ru not_active IP Right Cessation
- 1993-03-10 IL IL10500393A patent/IL105003A/en not_active IP Right Cessation
- 1993-03-10 AT AT93905561T patent/ATE180785T1/de active
- 1993-03-10 NZ NZ249565A patent/NZ249565A/en not_active IP Right Cessation
- 1993-03-10 MA MA23113A patent/MA22819A1/fr unknown
- 1993-03-10 SI SI9300114A patent/SI9300114B/sl active Search and Examination
- 1993-03-10 DK DK98114130T patent/DK0884319T3/da active
- 1993-03-10 EP EP93905561A patent/EP0630376B1/fr not_active Expired - Lifetime
- 1993-03-10 CA CA2131797A patent/CA2131797C/fr not_active Expired - Fee Related
- 1993-03-10 SK SK1078-94A patent/SK281423B6/sk not_active IP Right Cessation
- 1993-03-10 ES ES98114130T patent/ES2219813T3/es not_active Expired - Lifetime
- 1993-03-10 DK DK93905561T patent/DK0630376T3/da active
- 1993-03-10 AP APAP/P/1993/000494A patent/AP401A/en active
- 1993-03-10 DE DE69333504T patent/DE69333504T2/de not_active Expired - Lifetime
- 1993-03-10 HU HU9402601A patent/HU219121B/hu unknown
- 1993-03-10 PT PT98114130T patent/PT884319E/pt unknown
- 1993-03-10 DE DE69325167T patent/DE69325167T2/de not_active Expired - Lifetime
- 1993-03-10 WO PCT/GB1993/000506 patent/WO1993018036A1/fr not_active Ceased
- 1993-03-10 AU AU36448/93A patent/AU671102B2/en not_active Expired
- 1993-03-10 KR KR1019940703167A patent/KR100282730B1/ko not_active Expired - Fee Related
- 1993-03-10 JP JP5515490A patent/JP2831467B2/ja not_active Expired - Lifetime
- 1993-03-10 SG SG1996008846A patent/SG50693A1/en unknown
- 1993-03-10 CZ CZ19942210A patent/CZ286194B6/cs not_active IP Right Cessation
- 1993-03-10 MY MYPI93000436A patent/MY110110A/en unknown
- 1993-03-10 ES ES93905561T patent/ES2132223T3/es not_active Expired - Lifetime
- 1993-03-10 UA UA94095780A patent/UA41311C2/uk unknown
- 1993-03-10 AT AT98114130T patent/ATE266033T1/de active
- 1993-03-10 EP EP98114130A patent/EP0884319B1/fr not_active Expired - Lifetime
- 1993-03-11 CN CN93102648A patent/CN1043893C/zh not_active Expired - Fee Related
- 1993-03-11 MX MX9301348A patent/MX9301348A/es not_active IP Right Cessation
- 1993-05-22 CN CN93107234A patent/CN1085083A/zh active Pending
1994
- 1994-09-09 NO NO943348A patent/NO303638B1/no not_active IP Right Cessation
- 1994-09-12 FI FI944204A patent/FI107158B/fi not_active IP Right Cessation
1999
- 1999-06-30 GR GR990401755T patent/GR3030668T3/el unknown
2005
- 2005-04-12 CY CY0500021A patent/CY2510B1/xx unknown

Also Published As

Publication number	Publication date
UA41311C2 (uk)	2001-09-17
HUT71121A (en)	1995-11-28
SI9300114B (sl)	2006-08-31
NO303638B1 (no)	1998-08-10
RU94040864A (ru)	1996-07-20
WO1993018036A1 (fr)	1993-09-16
NZ249565A (en)	1997-07-27
NO943348L (no)	1994-11-09
GR3030668T3 (en)	1999-10-29
AP401A (en)	1995-08-29
EP0630376A1 (fr)	1994-12-28
DE69333504D1 (de)	2004-06-09
ES2132223T3 (es)	1999-08-16
CZ286194B6 (cs)	2000-02-16
CN1085083A (zh)	1994-04-13
NO943348D0 (no)	1994-09-09
SG50693A1 (en)	1998-07-20
SI9300114A (sl)	1993-12-31
HU9402601D0 (en)	1994-12-28
EP0884319B1 (fr)	2004-05-06
DK0884319T3 (da)	2004-08-30
RU2104279C1 (ru)	1998-02-10
MY110110A (en)	1998-01-27
CY2510B1 (en)	2005-12-23
AP9300494A0 (en)	1993-04-30
JP2831467B2 (ja)	1998-12-02
DE69333504T2 (de)	2005-05-12
CA2131797A1 (fr)	1993-09-16
MA22819A1 (fr)	1993-10-01
MX9301348A (es)	1993-09-01
HK1012352A1 (en)	1999-07-30
CZ221094A3 (en)	1995-09-13
CN1043893C (zh)	1999-06-30
CN1078471A (zh)	1993-11-17
ATE266033T1 (de)	2004-05-15
FI107158B (fi)	2001-06-15
ATE180785T1 (de)	1999-06-15
IL105003A0 (en)	1993-07-08
ES2219813T3 (es)	2004-12-01
DE69325167T2 (de)	2000-01-20
FI944204L (fi)	1994-09-12
HU219121B (hu)	2001-02-28
AU3644893A (en)	1993-10-05
FI944204A0 (fi)	1994-09-12
DK0630376T3 (da)	1999-06-23
KR950700304A (ko)	1995-01-16
EP0884319A3 (fr)	1999-02-10
DE69325167D1 (de)	1999-07-08
EP0630376B1 (fr)	1999-06-02
SK281423B6 (sk)	2001-03-12
KR100282730B1 (ko)	2001-02-15
JPH07504433A (ja)	1995-05-18
AU671102B2 (en)	1996-08-15
PT884319E (pt)	2004-09-30
EP0884319A2 (fr)	1998-12-16
CA2131797C (fr)	2010-05-18
SK107894A3 (en)	1995-04-12

Legal Events

Date	Code	Title
1997-02-18	FF	Patent granted
1997-04-15	KB	Patent renewed
1999-10-28	KB	Patent renewed
2003-05-29	KB	Patent renewed
2007-06-17	KB	Patent renewed
2011-12-29	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
AP401A (en)	1995-08-29	Condensed indole derivatives as 5H4-receptor antagonists.
JP3294611B2 (ja)	2002-06-24	５−ｈｔ４レセプター・アンタゴニスト
BRPI1101193A2 (pt)	2014-02-25	Lâmina vibratória, vibrador, oscilador, e dispositivo eletrônico
NZ243993A (en)	1994-10-26	Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
KR100200438B1 (ko)	1999-06-15	3,9-디아자비시클로(3,3.1) 노난-7-일 유도체, 이들의 제조를 위한 방법 및 중간체 및 이들을 함유한 제약학적 조성물
US5852014A (en)	1998-12-22	Condensed indole derivatives as 5HT4 -receptor antagonists
US5998409A (en)	1999-12-07	Condensed indole derivatives as 5HT4 -receptor antagonists
EP0712406B1 (fr)	1998-10-28	Derives condenses d'indoles en tant qu'antagonistes du recepteur de 5-ht 4
AP373A (en)	1994-12-07	Compounds having 5TH4 receptor antagonist activity.
HK1012352B (en)	2000-06-23	Condensed indole derivatives as 5-ht4-receptor antagonists
PL172692B1 (pl)	1997-11-28	Skondensowane pochodne indolu PL
TW396158B (en)	2000-07-01	Compound having 5-HT4 receptor antagonist activity, process for preparation the same and its use
HK1023560A1 (en)	2000-09-15	N-(1-nbutyl-4-piperidyl)methyl-3,4-dihydro-2h-1,3 oxazino 3,2-a indole-10-carboxamide or a pharmaceutically acceptable salt thereof
HK1023560B (en)	2005-03-04	N-(1-nbutyl-4-piperidyl)methyl-3,4-dihydro-2h-1,3 oxazino 3,2-a indole-10-carboxamide or a pharmaceutically acceptable salt thereof
HK1012347B (en)	2000-05-12	Condensed indole derivatives as 5-ht 4-receptor antagonists
WO2000017207A1 (fr)	2000-03-30	3,4-dihydro-$i(n)-[[1-(3-hydroxybutyl)-4-piperidinyl]methyl]-2$i(h)-[1,3]oxazino[3,2-$i(a)]indole-10-carboxamide utilise comme antagoniste du recepteur 5-ht(4)