IL106493A - Particles for NMR imaging and their manufacture - Google Patents

Particles for NMR imaging and their manufacture

Info

Publication number
IL106493A
IL106493A IL10649393A IL10649393A IL106493A IL 106493 A IL106493 A IL 106493A IL 10649393 A IL10649393 A IL 10649393A IL 10649393 A IL10649393 A IL 10649393A IL 106493 A IL106493 A IL 106493A
Authority
IL
Israel
Prior art keywords
particles
core
glycerophospholipid
micellar
shell
Prior art date
Application number
IL10649393A
Other languages
English (en)
Other versions
IL106493A0 (en
Inventor
Herve Tournier
Roland Hyacinthe
Michel Schneider
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of IL106493A0 publication Critical patent/IL106493A0/xx
Publication of IL106493A publication Critical patent/IL106493A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • A61K49/1839—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a lipid, a fatty acid having 8 or more carbon atoms in the main chain, or a phospholipid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
    • Y10S977/838—Magnetic property of nanomaterial
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/905—Specially adapted for travel through blood circulatory system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
    • Y10S977/953—Detector using nanostructure
    • Y10S977/96—Of magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Hard Magnetic Materials (AREA)
  • Oxygen, Ozone, And Oxides In General (AREA)
  • Soft Magnetic Materials (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
IL10649393A 1992-08-13 1993-07-27 Particles for NMR imaging and their manufacture IL106493A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92810618 1992-08-13
EP93810380 1993-05-25

Publications (2)

Publication Number Publication Date
IL106493A0 IL106493A0 (en) 1993-11-15
IL106493A true IL106493A (en) 1997-02-18

Family

ID=26132520

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10649393A IL106493A (en) 1992-08-13 1993-07-27 Particles for NMR imaging and their manufacture

Country Status (20)

Country Link
US (3) US5464696A (fr)
EP (1) EP0607401B1 (fr)
JP (1) JP2968588B2 (fr)
KR (1) KR100307773B1 (fr)
CN (1) CN1076205C (fr)
AT (1) ATE144714T1 (fr)
AU (1) AU660108B2 (fr)
CA (1) CA2119654C (fr)
DE (1) DE69305730T2 (fr)
DK (1) DK0607401T3 (fr)
ES (1) ES2094558T3 (fr)
FI (1) FI941677A7 (fr)
GR (1) GR3022288T3 (fr)
HU (1) HU221805B1 (fr)
IL (1) IL106493A (fr)
IS (1) IS1648B (fr)
MX (1) MX9304924A (fr)
NO (1) NO307244B1 (fr)
NZ (1) NZ254791A (fr)
WO (1) WO1994004197A1 (fr)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465188B1 (en) 1990-06-11 2002-10-15 Gilead Sciences, Inc. Nucleic acid ligand complexes
DE4428851C2 (de) * 1994-08-04 2000-05-04 Diagnostikforschung Inst Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie
US5520904A (en) * 1995-01-27 1996-05-28 Mallinckrodt Medical, Inc. Calcium/oxyanion-containing particles with a polymerical alkoxy coating for use in medical diagnostic imaging
TW319763B (fr) 1995-02-01 1997-11-11 Epix Medical Inc
DE19508772C2 (de) * 1995-03-01 1998-01-29 Schering Ag Verfahren und Verbindungen zur Detektion von Analyten mittels Remanenzmessung und deren Verwendung
US8071737B2 (en) * 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
US5833948A (en) * 1995-06-15 1998-11-10 Bracco Research S.A. Blood-pool imaging composition comprising micelles containing a lipophilic chelating agent and a non-ionic surfactant
DE19529921C2 (de) * 1995-08-01 1997-09-25 Schering Ag Verwendung von MRT-Kontrastmitteln zur Ventilations-Bildgebung der Lunge
DE69628731T3 (de) * 1995-11-01 2012-09-20 Bracco Suisse S.A. Gezielte magnetisch markierte molekularmarkersysteme als nmr-bilderzeugungsmittel
GB9600427D0 (en) * 1996-01-10 1996-03-13 Nycomed Imaging As Contrast media
EP0877630B1 (fr) 1996-01-10 2005-03-23 Amersham Health AS Milieu de contraste
WO1998044910A1 (fr) 1997-04-09 1998-10-15 Philipp Lang NOUVELLE TECHNIQUE DE CONTROLE DE L'ADMINISTRATION DE MEDICAMENTS NON VULNERANTE $i(IN VIVO)
US6337215B1 (en) * 1997-12-01 2002-01-08 International Business Machines Corporation Magnetic particles having two antiparallel ferromagnetic layers and attached affinity recognition molecules
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
EP1118009A1 (fr) * 1998-09-28 2001-07-25 Nycomed Imaging As Procede d'imagerie par resonance magnetique
US6283448B1 (en) * 2000-04-19 2001-09-04 Daniel Webster Denton Offset butterfly valve
JP5078212B2 (ja) 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
DE60137953D1 (de) * 2000-10-06 2009-04-23 Life Technologies Corp Zellen mit spektraler signatur sowie verfahren zu ihrer herstellung und nutzung
US20050059031A1 (en) * 2000-10-06 2005-03-17 Quantum Dot Corporation Method for enhancing transport of semiconductor nanocrystals across biological membranes
US20090060992A1 (en) * 2002-05-08 2009-03-05 University Of Central Florida Research Foundation, Inc., Preparation of magneto-vesicles with DOPE/DDAB layers
EP1590006B1 (fr) 2003-02-04 2010-09-08 Bracco Suisse SA Agents de contraste pour ultrasons et procede pour leur elaboration
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
DE10331439B3 (de) * 2003-07-10 2005-02-03 Micromod Partikeltechnologie Gmbh Magnetische Nanopartikel mit verbesserten Magneteigenschaften
CA2547024C (fr) * 2003-12-22 2013-12-17 Bracco Research Sa Systeme de microvesicule remplie de gaz pour l'imagerie de contraste
ES2531751T3 (es) * 2003-12-22 2015-03-18 Bracco Suisse Sa Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste
US20050260137A1 (en) * 2004-05-18 2005-11-24 General Electric Company Contrast agents for magnetic resonance imaging
US7229690B2 (en) * 2004-07-26 2007-06-12 Massachusetts Institute Of Technology Microspheres including nanoparticles
WO2006018433A1 (fr) 2004-08-18 2006-02-23 Bracco Research Sa Composition renfermant des microvesicules remplies de gaz, destinee a l'imagerie de contraste
WO2006028129A1 (fr) * 2004-09-10 2006-03-16 Toray Industries, Inc. Préparation thérapeutique
US20070264199A1 (en) * 2005-09-26 2007-11-15 Labhasetwar Vinod D Magnetic nanoparticle composition and methods for using the same
US8361494B2 (en) * 2006-03-10 2013-01-29 The Trustees Of The University Of Pennsylvania Biomimetic iron-oxide-containing lipoprotein and related materials
AU2007293888B2 (en) 2006-09-05 2013-05-02 Bracco Suisse S.A. Gas-filled microvesicles with polymer-modified lipids
WO2008074804A2 (fr) 2006-12-18 2008-06-26 Colorobbia Italia S.P.A. Nanoparticules magnétiques pour l'application en hyperthermie, sa préparation et son utilisation dans des produits de construction ayant une application pharmacologique
US8784659B2 (en) * 2007-08-08 2014-07-22 General Electric Company Method for controlling microbial biofilm in aqueous systems
WO2009145813A1 (fr) * 2008-03-04 2009-12-03 Qd Vision, Inc. Particules comprenant des nanoparticules, leurs utilisations, et procédés
FR2934953B1 (fr) * 2008-08-14 2011-01-21 Commissariat Energie Atomique Nanoemulsions de nanocristaux
FR2934955B1 (fr) 2008-08-14 2011-07-08 Commissariat Energie Atomique Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions
FR2934954B1 (fr) 2008-08-14 2011-07-22 Commissariat Energie Atomique Emulsion fluorescente de vert d'indocyanine
EP2346532B1 (fr) * 2008-10-07 2020-10-07 Bracco Suisse SA Construction de ciblage comprenant un anticorps anti-polymere et des microvesicules se liant à ceux-ci
EP2475717A4 (fr) 2009-09-09 2015-01-07 Qd Vision Inc Particules comprenant des nanoparticules, leurs utilisations, et procédés
WO2011031876A1 (fr) 2009-09-09 2011-03-17 Qd Vision, Inc. Formulations comprenant des nanoparticules
JP5678565B2 (ja) * 2009-12-08 2015-03-04 Jnc株式会社 磁性微粒子およびその製造方法
US20110217379A1 (en) * 2010-03-08 2011-09-08 Davis Llp Magnetic nanomaterials and methods for chemoembolisation
KR101174470B1 (ko) 2010-04-08 2012-08-16 한국세라믹기술원 자성 실리카 리포좀 나노입자 및 이의 제조방법
TWI428284B (zh) * 2010-11-05 2014-03-01 國立中正大學 Sea urchin iron oxide and its manufacturing method
US8895068B2 (en) 2010-12-15 2014-11-25 General Electric Company Nanoparticle composition and associated methods thereof
US8889103B2 (en) 2010-12-15 2014-11-18 General Electric Company Diagnostic agent composition and associated methods thereof
WO2012136813A2 (fr) 2011-04-07 2012-10-11 Universitetet I Oslo Agents pour un diagnostic par radar médical
JP6313329B2 (ja) 2012-12-21 2018-04-18 ブラッコ・スイス・ソシエテ・アノニムＢｒａｃｃｏ Ｓｕｉｓｓｅ ＳＡ ガス封入マイクロベシクル
JP2018520113A (ja) * 2015-05-26 2018-07-26 インテザイン テクノロジーズ， インコーポレイテッド 磁性造影剤としての鉄安定化ミセル
FR3103376B1 (fr) * 2019-11-26 2021-11-12 Univ Bordeaux Ferrofluide huileux biocompatible et procédé de préparation

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4331645A (en) * 1981-04-20 1982-05-25 Reynolds Metals Company Alumina from alkali metal-aluminum chloride complexes
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
JPS6072830A (ja) * 1983-09-29 1985-04-24 Kao Corp ベシクル用組成物
GB8408127D0 (en) * 1984-03-29 1984-05-10 Nyegaard & Co As Contrast agents
US4728575A (en) * 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
DE3515373A1 (de) * 1985-04-27 1986-11-06 Merck Patent Gmbh, 6100 Darmstadt Stickstoffhaltige heterocyclen
US4675173A (en) * 1985-05-08 1987-06-23 Molecular Biosystems, Inc. Method of magnetic resonance imaging of the liver and spleen
JPS6295134A (ja) * 1985-10-21 1987-05-01 Nippon Saafuakutanto Kogyo Kk リポソ−ムの製造法
DE3619746A1 (de) * 1986-06-12 1987-12-17 Basf Ag Superparamagnetische feststoffteilchen
US4951675A (en) * 1986-07-03 1990-08-28 Advanced Magnetics, Incorporated Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging
US5262176A (en) * 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
DK175531B1 (da) * 1986-12-15 2004-11-22 Nexstar Pharmaceuticals Inc Leveringsvehikel med amphiphil-associeret aktiv bestanddel
US4929589A (en) * 1986-12-29 1990-05-29 Aluminum Company Of America Metal oxide/hydroxide particles coated with phosphate esters
US5124289A (en) * 1986-12-29 1992-06-23 Aluminum Company Of America Surface treated permeable inorganic membranes and process of making same
US4994429A (en) * 1986-12-29 1991-02-19 Aluminum Company Of America Active material useful as adsorbent comprising metal oxide/hydroxide particles reacted with phosphorus-containing organic acid group of organic compound having unreacted acid group
US4983566A (en) * 1987-03-09 1991-01-08 Aluminum Company Of America Surface-modified adsorbent comprising metal oxide/hydroxide particles reacted with one or more perfluorinated organic acids
US5000960A (en) * 1987-03-13 1991-03-19 Micro-Pak, Inc. Protein coupling to lipid vesicles
DE3709851A1 (de) * 1987-03-24 1988-10-06 Silica Gel Gmbh Adsorptions Te Nmr-diagnostische fluessigkeitszusammensetzungen
JPH0720857B2 (ja) * 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
US5230882A (en) * 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
GB9007052D0 (en) * 1990-03-29 1990-05-30 Skua Investments Ltd Pharmaceutical formulations
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
CA2046997C (fr) * 1990-07-16 2000-12-12 Hiroshi Kikuchi Liposomes
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
JP3272736B2 (ja) * 1991-01-31 2002-04-08 協和醗酵工業株式会社 リポソーム製剤
CA2064683A1 (fr) * 1992-03-26 1993-09-27 Krishna Mohan Rao Kallury Formation d'enzymes thermostables possedant une extraordinaire tolerance a la chaleur par immobilisation sur des matrices de phospholipides
US5411730A (en) * 1993-07-20 1995-05-02 Research Corporation Technologies, Inc. Magnetic microparticles
US5494744A (en) * 1994-10-12 1996-02-27 Kimberly-Clark Corporation Method of applying a protein coating to a substrate and article thereof
BR112012010988B1 (pt) * 2009-11-10 2019-06-18 Microphyt Reator fotossintético adaptado para a cultura de microrganismos fotossintéticos, particularmente algas,invólucro de reação para o mesmo, método para cultura demicrorganismos fotossintéticos, particularmente algas e método para a manufatura de um invólucro de reação

Also Published As

Publication number Publication date
NO941311D0 (no) 1994-04-12
FI941677L (fi) 1994-04-12
US5464696A (en) 1995-11-07
CN1076205C (zh) 2001-12-19
EP0607401A1 (fr) 1994-07-27
US5545395A (en) 1996-08-13
HU221805B1 (hu) 2003-01-28
NO307244B1 (no) 2000-03-06
JPH07503976A (ja) 1995-04-27
WO1994004197A1 (fr) 1994-03-03
NO941311L (no) 1994-04-12
DE69305730T2 (de) 1997-05-28
DE69305730D1 (de) 1996-12-05
CA2119654C (fr) 2001-02-06
FI941677A0 (fi) 1994-04-12
IS1648B (is) 1997-03-25
FI941677A7 (fi) 1994-04-12
ES2094558T3 (es) 1997-01-16
AU4705493A (en) 1994-03-15
IL106493A0 (en) 1993-11-15
JP2968588B2 (ja) 1999-10-25
IS4058A (is) 1994-02-14
ATE144714T1 (de) 1996-11-15
EP0607401B1 (fr) 1996-10-30
KR100307773B1 (ko) 2001-12-28
US5587199A (en) 1996-12-24
HUT75149A (en) 1997-04-28
CN1089470A (zh) 1994-07-20
NZ254791A (en) 1996-11-26
GR3022288T3 (en) 1997-04-30
HU9401038D0 (en) 1994-07-28
CA2119654A1 (fr) 1994-03-03
DK0607401T3 (da) 1996-11-25
AU660108B2 (en) 1995-06-08
MX9304924A (es) 1994-08-31

Similar Documents

Publication Publication Date Title
IL106493A0 (en) Particles for nmr imaging and their manufacture
ZA945038B (en) Image contrast enhancing composition
JP2001316217A (ja) 水性透明組成物
TR199901448T1 (xx) Oral siklosporin form�lasyonlar�.
IE811215L (en) Rapamycin composition
ATE191733T1 (de) Verminderung des beschlagens in polyurethanschaum mittels phosphatestern
IL126412A0 (en) Method of t-weighted magnetic resonance imaging of res organs
WO2001028587A3 (fr) Porteurs magnetiques cibles composes de fer et de matieres poreuses pour l'administration ciblee d'agents biologiquement actifs
ZA9210076B (en) A cosmetic or dermatological composition containing a diol ester
CA2048115A1 (fr) Aimant a magnetisation continue
US8273727B2 (en) Lipid-analogous phosphoric triesters
EP0384976A3 (en) Glycerophospholipid composition having enhanced surface-active properties
JPS63307709A (ja) 多極磁石集合体
Gair Three-dimensional spatial field and force distributions in axial field machines using a computed tomography method (three dimensional spatial field distributions)
JPS5716101A (en) Magnetic powder covered by lubricating layer
RU98107636A (ru) Стабилизированные фосфолипидные композиции
JPS60186008A (ja) リング状磁性成形体の製造方法
Syrovoj Accuracy of direct problems in the paraxial theory of relativistic electron beams
Kind The highest order common sense
ATE287181T1 (de) Verfahren zur erzeugung einer dreidimensional wahrnehmbaren filmsequenz aus einem film

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees