IL106873A - Process for selective amplification of the production of the antibiotic substance EG 0722 Factor A - Google Patents

Process for selective amplification of the production of the antibiotic substance EG 0722 Factor A

Info

Publication number: IL106873A
Authority: IL; Israel
Prior art keywords: vitamin; antibiotic; fermentation; added; fish meal
Prior art date: 1992-09-10

Application number

IL10687393A

Other languages

English (en)

Hebrew (he)

Other versions

IL106873A0 (en

Inventor

Angelo Michele Rizzo

Luciano Gastaldo

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-10

Filing date

1993-09-02

Publication date

1998-08-16

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8209988&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL106873(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-09-02 Application filed by Lepetit Spa filed Critical Lepetit Spa

1993-12-28 Publication of IL106873A0 publication Critical patent/IL106873A0/xx

1998-08-16 Publication of IL106873A publication Critical patent/IL106873A/en

Links

238000000034 method Methods 0.000 title claims abstract description 25
101000655610 Planobispora rosea Thiocillin GE2270 Proteins 0.000 title claims abstract description 21
238000004519 manufacturing process Methods 0.000 title claims abstract description 18
238000000855 fermentation Methods 0.000 claims abstract description 43
230000004151 fermentation Effects 0.000 claims abstract description 43
229930003779 Vitamin B12 Natural products 0.000 claims abstract description 33
239000011715 vitamin B12 Substances 0.000 claims abstract description 33
235000019163 vitamin B12 Nutrition 0.000 claims abstract description 33
230000000694 effects Effects 0.000 claims abstract description 20
241001495389 Planobispora rosea Species 0.000 claims abstract description 7
229930003231 vitamin Natural products 0.000 claims abstract description 7
235000013343 vitamin Nutrition 0.000 claims abstract description 7
239000011782 vitamin Substances 0.000 claims abstract description 7
229940088594 vitamin Drugs 0.000 claims abstract description 7
150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 6
AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims description 32
235000019733 Fish meal Nutrition 0.000 claims description 13
239000004467 fishmeal Substances 0.000 claims description 12
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
241000766754 Agra Species 0.000 claims description 8
239000011365 complex material Substances 0.000 claims description 6
229910052757 nitrogen Inorganic materials 0.000 claims description 5
150000003839 salts Chemical class 0.000 claims description 5
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
229910052799 carbon Inorganic materials 0.000 claims description 4
YOZNUFWCRFCGIH-BYFNXCQMSA-L hydroxocobalamin Chemical compound O[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O YOZNUFWCRFCGIH-BYFNXCQMSA-L 0.000 claims description 4
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 3
229910052921 ammonium sulfate Inorganic materials 0.000 claims description 3
235000011130 ammonium sulphate Nutrition 0.000 claims description 3
125000004093 cyano group Chemical group *C#N 0.000 claims description 3
239000003446 ligand Substances 0.000 claims description 3
JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 claims description 3
235000007672 methylcobalamin Nutrition 0.000 claims description 3
239000011585 methylcobalamin Substances 0.000 claims description 3
OAJLVMGLJZXSGX-NDSREFPTSA-L (2r,3s,4s,5r)-2-(6-aminopurin-9-yl)-5-methanidyloxolane-3,4-diol;cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12 Chemical compound [Co+3].O[C@H]1[C@H](O)[C@@H]([CH2-])O[C@H]1N1C2=NC=NC(N)=C2N=C1.C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O OAJLVMGLJZXSGX-NDSREFPTSA-L 0.000 claims description 2
235000004867 hydroxocobalamin Nutrition 0.000 claims description 2
239000011704 hydroxocobalamin Substances 0.000 claims description 2
229960001103 hydroxocobalamin Drugs 0.000 claims description 2
230000003115 biocidal effect Effects 0.000 abstract description 14
239000003242 anti bacterial agent Substances 0.000 abstract description 6
229940088710 antibiotic agent Drugs 0.000 abstract description 6
FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
239000002609 medium Substances 0.000 description 24
238000007792 addition Methods 0.000 description 15
239000000463 material Substances 0.000 description 11
238000004128 high performance liquid chromatography Methods 0.000 description 9
235000010633 broth Nutrition 0.000 description 8
244000005700 microbiome Species 0.000 description 8
239000000284 extract Substances 0.000 description 7
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 7
239000000203 mixture Substances 0.000 description 7
230000015572 biosynthetic process Effects 0.000 description 5
238000002474 experimental method Methods 0.000 description 5
238000002955 isolation Methods 0.000 description 5
229920002472 Starch Polymers 0.000 description 4
229940041514 candida albicans extract Drugs 0.000 description 4
235000015097 nutrients Nutrition 0.000 description 4
239000008107 starch Substances 0.000 description 4
235000019698 starch Nutrition 0.000 description 4
239000000126 substance Substances 0.000 description 4
239000012138 yeast extract Substances 0.000 description 4
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 3
229930182566 Gentamicin Natural products 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
229910000019 calcium carbonate Inorganic materials 0.000 description 3
239000005018 casein Substances 0.000 description 3
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 3
235000021240 caseins Nutrition 0.000 description 3
JMDULECOHIXMNX-MZHFYNGJSA-N chembl1766417 Chemical compound C1([C@H](O)[C@H]2C=3SC=C(N=3)C=3SC=C(N=3)C3=NC(=CC=C3C=3SC=C(N=3)C(=O)N[C@H](C3=NC(=C(S3)C)C(=O)N[C@H](C3=NC(=C(S3)COC)C(=O)NCC(=O)N2)C(C)C)CC(=O)NC)C=2SC=C(N=2)C=2OC[C@H](N=2)C(=O)N2[C@@H](CCC2)C(N)=O)=CC=CC=C1 JMDULECOHIXMNX-MZHFYNGJSA-N 0.000 description 3
239000010941 cobalt Substances 0.000 description 3
229910017052 cobalt Inorganic materials 0.000 description 3
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 3
239000008103 glucose Substances 0.000 description 3
235000012054 meals Nutrition 0.000 description 3
235000013372 meat Nutrition 0.000 description 3
238000003786 synthesis reaction Methods 0.000 description 3
238000011282 treatment Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
108010077805 Bacterial Proteins Proteins 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
241000187722 Micromonospora echinospora Species 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
235000019764 Soybean Meal Nutrition 0.000 description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
238000012512 characterization method Methods 0.000 description 2
RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
239000003480 eluent Substances 0.000 description 2
239000001963 growth medium Substances 0.000 description 2
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 description 2
239000003112 inhibitor Substances 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
238000001243 protein synthesis Methods 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000004455 soybean meal Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
230000014616 translation Effects 0.000 description 2
DKHFLDXCKWDVMF-UPONEAKYSA-N (-)-chuangxinmycin Chemical compound S([C@H]([C@H]1C)C(O)=O)C2=CC=CC3=C2C1=CN3 DKHFLDXCKWDVMF-UPONEAKYSA-N 0.000 description 1
CGWBGDOPBYWJKZ-UHFFFAOYSA-N (1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid Chemical compound OC1CC(P(O)(O)=O)C(=O)N1O CGWBGDOPBYWJKZ-UHFFFAOYSA-N 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
244000063299 Bacillus subtilis Species 0.000 description 1
235000014469 Bacillus subtilis Nutrition 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
229930185938 Elsamicin Natural products 0.000 description 1
241000192125 Firmicutes Species 0.000 description 1
229930195503 Fortimicin Natural products 0.000 description 1
108010085026 GE 2270 A Proteins 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
ZHTRILQJTPJGNK-FYBAATNNSA-N Leinamycin Chemical compound N([C@@H](C=1SC=C(N=1)\C=C/C=C/C(=O)[C@H](O)/C=C(C)/CC1)C)C(=O)C[C@@]21S(=O)SC(=O)[C@]2(C)O ZHTRILQJTPJGNK-FYBAATNNSA-N 0.000 description 1
ZHTRILQJTPJGNK-UHFFFAOYSA-N Leinamycin Natural products C1CC(C)=CC(O)C(=O)C=CC=CC(N=2)=CSC=2C(C)NC(=O)CC21S(=O)SC(=O)C2(C)O ZHTRILQJTPJGNK-UHFFFAOYSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
229930191564 Monensin Natural products 0.000 description 1
241001302239 Mycobacterium tuberculosis complex Species 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
WKDDRNSBRWANNC-ATRFCDNQSA-N Thienamycin Chemical compound C1C(SCCN)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 WKDDRNSBRWANNC-ATRFCDNQSA-N 0.000 description 1
WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
238000012459 agar diffusion assay Methods 0.000 description 1
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
235000001014 amino acid Nutrition 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
229910021529 ammonia Inorganic materials 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
210000001557 animal structure Anatomy 0.000 description 1
239000002518 antifoaming agent Substances 0.000 description 1
BIDUPMYXGFNAEJ-APGVDKLISA-N astromicin Chemical compound O[C@@H]1[C@H](N(C)C(=O)CN)[C@@H](OC)[C@@H](O)[C@H](N)[C@H]1O[C@@H]1[C@H](N)CC[C@@H]([C@H](C)N)O1 BIDUPMYXGFNAEJ-APGVDKLISA-N 0.000 description 1
238000004166 bioassay Methods 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
238000013375 chromatographic separation Methods 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
229910001429 cobalt ion Inorganic materials 0.000 description 1
XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical compound [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
238000012258 culturing Methods 0.000 description 1
235000000639 cyanocobalamin Nutrition 0.000 description 1
239000011666 cyanocobalamin Substances 0.000 description 1
229960002104 cyanocobalamin Drugs 0.000 description 1
230000000881 depressing effect Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
HPVDVZANUAGIRR-ZAVMYBFASA-N elsamicin Chemical compound O[C@@H]1[C@@](C)(O)[C@@H](O)[C@@H](C)O[C@H]1OC1=CC=CC2=C(O)C(C(O3)=O)=C4C5=C3C=CC(C)=C5C(=O)OC4=C12 HPVDVZANUAGIRR-ZAVMYBFASA-N 0.000 description 1
-1 etc) Chemical compound 0.000 description 1
238000000605 extraction Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
229910052500 inorganic mineral Chemical class 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
239000011707 mineral Chemical class 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
239000003471 mutagenic agent Substances 0.000 description 1
231100000707 mutagenic chemical Toxicity 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
230000007170 pathology Effects 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
238000003359 percent control normalization Methods 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
239000012137 tryptone Substances 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Microbiology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Bipolar Transistors (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL10687393A 1992-09-10 1993-09-02 Process for selective amplification of the production of the antibiotic substance EG 0722 Factor A IL106873A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP92115451		1992-09-10

Publications (2)

Publication Number	Publication Date
IL106873A0 IL106873A0 (en)	1993-12-28
IL106873A true IL106873A (en)	1998-08-16

Family

ID=8209988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL10687393A IL106873A (en)	1992-09-10	1993-09-02	Process for selective amplification of the production of the antibiotic substance EG 0722 Factor A

Country Status (13)

Country	Link
EP (1)	EP0662145B1 (fr)
JP (1)	JP3458355B2 (fr)
KR (1)	KR100281661B1 (fr)
AT (1)	ATE147105T1 (fr)
CA (1)	CA2144331C (fr)
DE (1)	DE69307148T2 (fr)
DK (1)	DK0662145T3 (fr)
ES (1)	ES2096313T3 (fr)
GR (1)	GR3022960T3 (fr)
HU (1)	HU213751B (fr)
IL (1)	IL106873A (fr)
WO (1)	WO1994005798A1 (fr)
ZA (1)	ZA936544B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2242067A1 (fr) *	1996-02-14	1997-08-21	Versicor Inc.	Derives des facteurs c2a, d2 et e de l'antibiotique ge2270

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8821160D0 (en) *	1988-09-09	1988-10-12	Lepetit Spa	Antibiotic ge 2270

1993
- 1993-07-20 HU HU9500715A patent/HU213751B/hu not_active IP Right Cessation
- 1993-07-20 KR KR1019950700942A patent/KR100281661B1/ko not_active Expired - Fee Related
- 1993-07-20 JP JP50677894A patent/JP3458355B2/ja not_active Expired - Fee Related
- 1993-07-20 EP EP93917597A patent/EP0662145B1/fr not_active Expired - Lifetime
- 1993-07-20 WO PCT/EP1993/001907 patent/WO1994005798A1/fr not_active Ceased
- 1993-07-20 CA CA002144331A patent/CA2144331C/fr not_active Expired - Fee Related
- 1993-07-20 AT AT93917597T patent/ATE147105T1/de not_active IP Right Cessation
- 1993-07-20 DE DE69307148T patent/DE69307148T2/de not_active Expired - Fee Related
- 1993-07-20 DK DK93917597.2T patent/DK0662145T3/da active
- 1993-07-20 ES ES93917597T patent/ES2096313T3/es not_active Expired - Lifetime
- 1993-09-02 IL IL10687393A patent/IL106873A/en not_active IP Right Cessation
- 1993-09-06 ZA ZA936544A patent/ZA936544B/xx unknown
1997
- 1997-03-27 GR GR970400635T patent/GR3022960T3/el unknown

Also Published As

Publication number	Publication date
HU9500715D0 (en)	1995-04-28
ZA936544B (en)	1994-03-28
CA2144331C (fr)	2005-01-04
ATE147105T1 (de)	1997-01-15
KR100281661B1 (ko)	2001-02-15
WO1994005798A1 (fr)	1994-03-17
DE69307148T2 (de)	1997-05-22
IL106873A0 (en)	1993-12-28
AU4700493A (en)	1994-03-29
EP0662145B1 (fr)	1997-01-02
EP0662145A1 (fr)	1995-07-12
DK0662145T3 (da)	1997-01-20
JPH08501215A (ja)	1996-02-13
CA2144331A1 (fr)	1994-03-17
ES2096313T3 (es)	1997-03-01
GR3022960T3 (en)	1997-06-30
AU675076B2 (en)	1997-01-23
HUT71698A (en)	1996-01-29
DE69307148D1 (de)	1997-02-13
KR950703654A (ko)	1995-09-20
HU213751B (en)	1997-09-29
JP3458355B2 (ja)	2003-10-20

Legal Events

Date	Code	Title
1998-12-27	FF	Patent granted
1999-06-20	KB	Patent renewed
1999-07-14	HP	Change in proprietorship
2000-01-31	KB	Patent renewed
2003-11-23	KB	Patent renewed
2008-06-05	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
US2595499A (en)	1952-05-06	Process for production of vitamin b12
US5227295A (en)	1993-07-13	Process for isolating A83543 and its components
EP0185456B1 (fr)	1990-11-07	Composés antibiotiques/antitumoraux CL-1577D et CL-1577E, leur obtention et leur emploi
US5882900A (en)	1999-03-16	Process for the selective increase of production of antibiotic GE 2270 factor a by adding vitamin B12 to nutrient medium
US5223413A (en)	1993-06-29	Process for the preparation of vancomycin
JPH0491793A (ja)	1992-03-25	発酵法によるアミノ酸の製造法
CA2144331C (fr)	2005-01-04	Processus d'augmentation selective de la production du facteur a de l'antibiotique ge 2270
AU675076C (en)	1998-03-19	Process for the selective increase of production of antibiotic GE 2270 factor A
US4764602A (en)	1988-08-16	Antibiotics, and their production
EP0139465B1 (fr)	1990-05-16	L'antibiotique et son procédé de production
CA1152915A (fr)	1983-08-30	Antibiotiques c-14482 b.sub.1, b.sub.2 et b.sub.3
CA1193211A (fr)	1985-09-10	Procede de production de la mitomycine a par fermentation
US3991183A (en)	1976-11-09	Antibiotic produced by a species of micromonospora
US4249008A (en)	1981-02-03	3,4-Dihydro-4-hydroxy-5-(3-hydroxy-2-pyridinyl)-4-methyl-2H-pyrrole-2-carboxamide
US4091093A (en)	1978-05-23	Protease inhibitors
EP0413967B1 (fr)	1994-11-02	Antibiotique
US5126350A (en)	1992-06-30	Polycyclic aromatic antifungal compounds
CA1113874A (fr)	1981-12-08	Antibiotique bl580 zeta produit par le streptomyces hygroscopicus
US5364623A (en)	1994-11-15	Antibiotic produced by Bacillus subtilis ATCC 55422 capable of inhibiting bacteria
US4206283A (en)	1980-06-03	Protease inhibitors
EP0206068B1 (fr)	1992-10-28	Antibiotique TAN-749, sa production et son emploi
US4298599A (en)	1981-11-03	Novel antibiotic BN-235 substance, and process for the production thereof
KR960014621B1 (ko)	1996-10-19	신 균주 스트렙토마이세스 라벤도폴리아 dk-506 및 이를 이용한 아클라시노마이신 a의 제조와 분리정제 방법
JPS5924995B2 (ja)	1984-06-13	新規抗生物質ナナオマイシンｅおよびその製造法
JPH05320186A (ja)	1993-12-03	新規エバーメクチン誘導体、その製造方法ならびにその生産微生物