IL107896A - Method for the production of apoliprotein ai-m and an expression vector enabling said production - Google Patents

Method for the production of apoliprotein ai-m and an expression vector enabling said production

Info

Publication number
IL107896A
IL107896A IL10789693A IL10789693A IL107896A IL 107896 A IL107896 A IL 107896A IL 10789693 A IL10789693 A IL 10789693A IL 10789693 A IL10789693 A IL 10789693A IL 107896 A IL107896 A IL 107896A
Authority
IL
Israel
Prior art keywords
apolipoprotein
promoter
apo
production
sequence coding
Prior art date
Application number
IL10789693A
Other languages
English (en)
Other versions
IL107896A0 (en
Original Assignee
Esperion Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esperion Therapeutics Inc filed Critical Esperion Therapeutics Inc
Publication of IL107896A0 publication Critical patent/IL107896A0/xx
Publication of IL107896A publication Critical patent/IL107896A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL10789693A 1992-12-11 1993-12-06 Method for the production of apoliprotein ai-m and an expression vector enabling said production IL107896A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9203753A SE9203753D0 (sv) 1992-12-11 1992-12-11 Expression system for producing apolipoprotein ai-m

Publications (2)

Publication Number Publication Date
IL107896A0 IL107896A0 (en) 1994-04-12
IL107896A true IL107896A (en) 2004-06-01

Family

ID=20388112

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10789693A IL107896A (en) 1992-12-11 1993-12-06 Method for the production of apoliprotein ai-m and an expression vector enabling said production

Country Status (22)

Country Link
US (1) US5721114A (cs)
EP (1) EP0677109B1 (cs)
JP (1) JP3899121B2 (cs)
AT (1) ATE191930T1 (cs)
AU (1) AU5663794A (cs)
CA (1) CA2150928C (cs)
CZ (1) CZ290865B6 (cs)
DE (1) DE69328442T2 (cs)
DK (1) DK0677109T3 (cs)
ES (1) ES2146646T3 (cs)
FI (1) FI952847A7 (cs)
GR (1) GR3033966T3 (cs)
HU (1) HU220193B (cs)
IL (1) IL107896A (cs)
MX (1) MX9307855A (cs)
NO (1) NO319497B1 (cs)
PL (1) PL175955B1 (cs)
PT (1) PT677109E (cs)
SE (1) SE9203753D0 (cs)
SK (1) SK76695A3 (cs)
WO (1) WO1994013819A1 (cs)
ZA (1) ZA939266B (cs)

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SE9603068D0 (sv) * 1996-08-23 1996-08-23 Pharmacia & Upjohn Ab Process for purifying a protein
SE9603303D0 (sv) 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a protein
SE9603304D0 (sv) * 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a compound
US6306433B1 (en) 1997-08-12 2001-10-23 Pharmacia Ab Method of preparing pharmaceutical compositions
US6037323A (en) 1997-09-29 2000-03-14 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6046166A (en) * 1997-09-29 2000-04-04 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6004925A (en) 1997-09-29 1999-12-21 J. L. Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6518412B1 (en) 1997-09-29 2003-02-11 Jean-Louis Dasseux Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
CN1297932A (zh) * 1999-11-30 2001-06-06 上海博容基因开发有限公司 一种新的多肽——人脂蛋白前体蛋白信号肽11和编码这种多肽的多核苷酸
US20020064820A1 (en) * 2000-03-13 2002-05-30 Jean-Michel Dayer Apo-A-I regulation of T-cell signaling
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US7217785B2 (en) * 2001-05-09 2007-05-15 The Regents Of The University Of California Cysteine-containing peptides having antioxidant properties
WO2003026492A2 (en) * 2001-09-28 2003-04-03 Esperion Therapeutics Inc. Prevention and treatment of restenosis by local administration of drug
US7470659B2 (en) * 2001-12-07 2008-12-30 The Regents Of The University Of California Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
US20030229062A1 (en) * 2001-12-07 2003-12-11 The Regents Of The University Of California Treatments for age-related macular degeneration (AMD)
JP2005511713A (ja) * 2001-12-07 2005-04-28 ザ・リージェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア 加齢性黄斑変性についての処置
US7223726B2 (en) * 2002-01-14 2007-05-29 The Regents Of The University Of California Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same
US20100204103A1 (en) * 2002-05-08 2010-08-12 The Regents Of The University Of California Helical synthetic peptides that stimulate cellular cholesterol efflux
PL374126A1 (en) * 2002-05-17 2005-10-03 Esperion Therapeutics, Inc. Methods and copositions for the treatment of ischemic reperfusion
AU2003239489A1 (en) 2002-05-17 2003-12-02 Esperion Therapeutics, Inc. Method of treating dyslipidemic disorders
EP2402300B1 (en) 2003-01-23 2016-05-25 Esperion Therapeutics Inc. Hydroxyl compounds and compositions for cholesterol management and related uses
US20070065906A1 (en) * 2003-03-05 2007-03-22 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Process for producing heterologous protein in e. coli
EP1706131A4 (en) * 2003-12-15 2009-08-12 Univ California THE CELLULAR CHOLESTEROL EFFLUX STIMULATING HELICULAR SYNTHETIC PEPTIDES
US8926958B2 (en) * 2004-04-06 2015-01-06 Cedars-Sinai Medical Center Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein A-I and apolipoprotein A-I milano
KR100560102B1 (ko) 2004-06-25 2006-03-13 한국생명공학연구원 프로아포리포단백질 ａ－ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제
CN1320119C (zh) * 2004-12-09 2007-06-06 复旦大学 人载脂蛋白ApoAⅠ在毕赤氏酵母胞内表达的方法
ATE533488T1 (de) 2005-08-22 2011-12-15 Melior Pharmaceuticals I Inc Verfahren und formulierungen zur modulierung von lyn-kinaseaktivität und behandlung assoziierter erkrankungen
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US20070254832A1 (en) * 2006-02-17 2007-11-01 Pressler Milton L Methods for the treatment of macular degeneration and related eye conditions
CN101489577B (zh) 2006-06-01 2013-10-16 蒙特利尔心脏病学研究所 治疗心瓣膜病的方法和化合物
DE102006044841A1 (de) 2006-09-22 2008-04-03 Wacker Chemie Ag Signalpeptid zur Produktion von rekombinanten Proteinen
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DE102006050332A1 (de) 2006-10-25 2008-04-30 Wacker Chemie Ag DNS-Konstrukt und Verfahren zur fermentativen Herstellung von Fusionsproteinen
MX2009008135A (es) * 2007-01-31 2009-08-12 Nutrition 21 Inc Uso de histidinato de cromo para tratamiento de alteraciones cardiometabolicas.
JP2010518860A (ja) * 2007-02-20 2010-06-03 メリオール・ファーマスーティカルズ・ワン・インコーポレイテッド Ｌｙｎキナーゼの活性化剤の同定方法
ES2579229T3 (es) 2007-03-13 2016-08-08 Jds Therapeutics, Llc Procedimientos y composiciones para la liberación sostenida de cromo
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AU2008279242A1 (en) * 2007-07-23 2009-01-29 Melior Discovery, Inc. Methods of activating IRS-1 and AKT
JP5600065B2 (ja) * 2007-10-23 2014-10-01 ザ クリーブランド クリニック ファウンデーション オキシダント耐性アポリポ蛋白質ａ−１および類似ペプチド
US8552184B2 (en) * 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
CA3029724A1 (en) 2008-11-10 2010-05-14 Muthiah Manoharan Lipids and compositions for the delivery of therapeutics
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DE102009053566B4 (de) * 2009-11-11 2014-08-14 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Mikroorganismen mit gesteigerter Sucrosemutaseaktivität
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EP2512449B1 (en) 2009-12-18 2019-08-07 The University of British Columbia Methods and compositions for delivery of nucleic acids
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US20130158055A1 (en) 2010-05-28 2013-06-20 Andrew G. Reaume Prevention Of Pancreatic Beta Cell Degeneration
NZ605079A (en) 2010-06-03 2015-08-28 Alnylam Pharmaceuticals Inc Biodegradable lipids for the delivery of active agents
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DE68917379T2 (de) * 1988-05-31 1994-12-01 Mitsubishi Chem Ind Verfahren zur Herstellung von Proteinen, die ähnlich dem natürlich-menschlichen Apolipoprotein-E sind.
DE3819463A1 (de) * 1988-06-08 1989-12-14 Behringwerke Ag Expressionsvektoren zur herstellung unfusionierter proteine in mikroorganismen
US5223407A (en) * 1988-08-31 1993-06-29 Allelix Inc. Excretion of heterologous proteins from e. coli
IT1229996B (it) * 1989-04-20 1991-09-20 Cesare Sirtori Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine.
DE68916444T2 (de) * 1989-10-31 1994-11-03 Schering Corp., Kenilworth, N.J. Sekretorische e-coli-stämme.
DE4009268A1 (de) * 1990-03-22 1991-09-26 Consortium Elektrochem Ind Sekretion von hirudinderivaten
SE9103701D0 (sv) * 1991-12-13 1991-12-13 Kabi Pharmacia Ab Apolipoprotein

Also Published As

Publication number Publication date
ZA939266B (en) 1994-08-08
DE69328442T2 (de) 2000-09-07
FI952847A0 (fi) 1995-06-09
DK0677109T3 (da) 2000-07-17
WO1994013819A1 (en) 1994-06-23
DE69328442D1 (de) 2000-05-25
CA2150928C (en) 2005-02-08
HU220193B (hu) 2001-11-28
NO952297D0 (no) 1995-06-09
GR3033966T3 (en) 2000-11-30
SK76695A3 (en) 1996-02-07
FI952847L (fi) 1995-06-09
FI952847A7 (fi) 1995-06-09
SE9203753D0 (sv) 1992-12-11
PL175955B1 (pl) 1999-03-31
IL107896A0 (en) 1994-04-12
MX9307855A (es) 1994-06-30
HU9501680D0 (en) 1995-08-28
PT677109E (pt) 2000-07-31
CA2150928A1 (en) 1994-06-23
EP0677109B1 (en) 2000-04-19
JP3899121B2 (ja) 2007-03-28
PL309292A1 (en) 1995-10-02
NO952297L (no) 1995-06-09
ES2146646T3 (es) 2000-08-16
US5721114A (en) 1998-02-24
CZ290865B6 (cs) 2002-11-13
HUT71697A (en) 1996-01-29
JPH08506723A (ja) 1996-07-23
NO319497B1 (no) 2005-08-22
EP0677109A1 (en) 1995-10-18
CZ148795A3 (en) 1996-01-17
ATE191930T1 (de) 2000-05-15
AU5663794A (en) 1994-07-04

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