IL108562A - 7, 8-diaryl-1,2,3,4- terahydropyrazolo- £5,1-c| £1,2,4| triazine derivatives, methods for the preparation thereof and pharmaceutical compositions containing them - Google Patents

7, 8-diaryl-1,2,3,4- terahydropyrazolo- £5,1-c| £1,2,4| triazine derivatives, methods for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number: IL108562A
Authority: IL; Israel
Prior art keywords: alkyl; suitable substituent; terahydropyrazolo; diaryl; preparation
Prior art date: 1993-02-26

Application number

IL108562A

Other languages

English (en)

Other versions

IL108562A0 (en

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-26

Filing date

1994-02-04

Publication date

1997-06-10

1994-02-04 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1994-05-30 Publication of IL108562A0 publication Critical patent/IL108562A0/xx

1997-06-10 Publication of IL108562A publication Critical patent/IL108562A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
150000003918 triazines Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
125000001424 substituent group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

IL108562A 1993-02-26 1994-02-04 7, 8-diaryl-1,2,3,4- terahydropyrazolo- £5,1-c| £1,2,4| triazine derivatives, methods for the preparation thereof and pharmaceutical compositions containing them IL108562A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939303993A GB9303993D0 (en)	1993-02-26	1993-02-26	New heterocyclic derivatives

Publications (2)

Publication Number	Publication Date
IL108562A0 IL108562A0 (en)	1994-05-30
IL108562A true IL108562A (en)	1997-06-10

Family

ID=10731142

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL108562A IL108562A (en)	1993-02-26	1994-02-04	7, 8-diaryl-1,2,3,4- terahydropyrazolo- £5,1-c\| £1,2,4\| triazine derivatives, methods for the preparation thereof and pharmaceutical compositions containing them

Country Status (20)

Country	Link
US (1)	US5670503A (es)
EP (1)	EP0686156B1 (es)
JP (1)	JP3569917B2 (es)
KR (1)	KR100313615B1 (es)
CN (1)	CN1041929C (es)
AT (1)	ATE220677T1 (es)
AU (1)	AU681625B2 (es)
CA (1)	CA2156919A1 (es)
DE (1)	DE69430988T2 (es)
DK (1)	DK0686156T3 (es)
ES (1)	ES2176235T3 (es)
GB (1)	GB9303993D0 (es)
HU (1)	HUT70832A (es)
IL (1)	IL108562A (es)
MX (1)	MX9401408A (es)
PT (1)	PT686156E (es)
RU (1)	RU2124517C1 (es)
TW (1)	TW260669B (es)
WO (1)	WO1994019350A1 (es)
ZA (1)	ZA94787B (es)

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AU736854B2 (en)	1996-04-25	2001-08-02	Nissan Chemical Industries Ltd.	Ethylene derivatives and pesticides containing said derivatives
EP1019394A1 (en)	1997-05-22	2000-07-19	G.D. Searle & Co.	PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS
US6979686B1 (en)	2001-12-07	2005-12-27	Pharmacia Corporation	Substituted pyrazoles as p38 kinase inhibitors
US6514977B1 (en) *	1997-05-22	2003-02-04	G.D. Searle & Company	Substituted pyrazoles as p38 kinase inhibitors
DE69835518T2 (de)	1997-06-12	2007-08-09	Aventis Pharma Ltd., West Malling	Imidazolyl-cyclische acetale
AU7966198A (en)	1997-06-13	1998-12-30	Smithkline Beecham Corporation	Novel pyrazole and pyrazoline substituted compounds
ATE293603T1 (de) *	1997-10-14	2005-05-15	Mitsubishi Pharma Corp	Piperazin-verbindungen und ihre medizinische verwendung
AU1924699A (en)	1997-12-19	1999-07-12	Smithkline Beecham Corporation	Compounds of heteroaryl substituted imidazole, their pharmaceutical compositionsand uses
US6858617B2 (en)	1998-05-26	2005-02-22	Smithkline Beecham Corporation	Substituted imidazole compounds
CA2341370A1 (en) *	1998-08-20	2000-03-02	Smithkline Beecham Corporation	Novel substituted triazole compounds
DE69914357T2 (de)	1998-11-04	2004-11-11	Smithkline Beecham Corp.	Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
WO2001015525A1 (en) *	1999-08-31	2001-03-08	Fujisawa Pharmaceutical Co., Ltd.	Organ preservatives
ES2237470T3 (es) *	1999-11-10	2005-08-01	Ortho-Mcneil Pharmaceutical, Inc.	2-aril-3-(heteroaril)-imidazo(1,2-alfa)pirimidinas sustituidas; y composiciones farmaceuticas y procedimientos asociados.
US7253169B2 (en) *	1999-11-12	2007-08-07	Gliamed, Inc.	Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) *	1999-11-12	2002-07-09	Gpi Nil Holdings, Inc.	AZA compounds, pharmaceutical compositions and methods of use
EP1233950B1 (en)	1999-11-23	2005-10-05	Smithkline Beecham Corporation	3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/P39 kINASE INHIBITORS
JP2003514900A (ja)	1999-11-23	2003-04-22	スミスクライン・ビーチャム・コーポレイション	ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物
ATE281439T1 (de)	1999-11-23	2004-11-15	Smithkline Beecham Corp	3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p38-kinase-inhibitoren
US6759410B1 (en)	1999-11-23	2004-07-06	Smithline Beecham Corporation	3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
CN100525768C (zh)	2000-10-23	2009-08-12	史密丝克莱恩比彻姆公司	新化合物
RU2316556C2 (ru) *	2000-11-17	2008-02-10	Бристол-Маерс Сквибб Компани	СПОСОБЫ ЛЕЧЕНИЯ СОСТОЯНИЙ, ОБУСЛОВЛЕННЫХ p38 КИНАЗАМИ, И ПИРРОЛОТРИАЗИНОВЫЕ СОЕДИНЕНИЯ, ПРИМЕНИМЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗ
WO2002064592A1 (en) *	2000-12-28	2002-08-22	Neurocrine Biosciences, Inc.	Tricyclic crf receptor antagonists
SK287857B6 (sk) *	2001-05-24	2012-01-04	Eli Lilly And Company	Novel pyrrole derivatives as pharmaceutical agents
US6821971B2 (en) *	2001-09-20	2004-11-23	The Procter & Gamble Company	Fused pyrazolone compounds which inhibit the release of inflammatory cytokines
KR20040103972A (ko)	2002-04-19	2004-12-09	스미스클라인 비참 코포레이션	신규 화합물
ES2278170T3 (es)	2002-07-09	2007-08-01	BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG	Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias.
EP1572113B1 (en) *	2002-08-26	2017-05-17	Takeda Pharmaceutical Company Limited	Calcium receptor modulating compound and use thereof
AU2004210127B2 (en)	2003-01-27	2009-10-01	Merck Sharp & Dohme Corp.	Substituted pyrazoles, compositions containing such compounds and methods of use
NZ551405A (en) *	2004-06-04	2009-06-26	Merck & Co Inc	Pyrazole derivatives, compositions containing such compounds and methods of use
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
US20080096905A1 (en)	2005-03-25	2008-04-24	Glaxo Group Limited	Process For Preparing Pyrido[2,3-D]Pyrimidin-7-One And 3,4-Dihydropyrimido{4,5-D}Pyrimidin-2(1H)-One Derivatives
US7423042B2 (en)	2005-03-25	2008-09-09	Glaxo Group Limited	Compounds
MY145343A (en)	2005-03-25	2012-01-31	Glaxo Group Ltd	Novel compounds
PE20061193A1 (es)	2005-03-25	2006-12-02	Glaxo Group Ltd	DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38
CN101300232A (zh) *	2005-07-26	2008-11-05	默克公司	合成取代的吡唑的方法
EP1992344A1 (en)	2007-05-18	2008-11-19	Institut Curie	P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
US20110195962A1 (en) *	2007-08-16	2011-08-11	Alcon Research, Ltd.	Use of multi-pharmacophore compounds to treat nasal disorders
JP2010540451A (ja) *	2007-09-20	2010-12-24	ワイス・エルエルシー	ピラゾロ［５，１−ｃ］［１，２，４］トリアジン、その調製法および使用法
CN101441969B (zh)	2007-11-23	2010-07-28	清华大学	场发射像素管
CN101441972B (zh)	2007-11-23	2011-01-26	鸿富锦精密工业（深圳）有限公司	场发射像素管
EP2402344A1 (en) *	2010-06-29	2012-01-04	Basf Se	Pyrazole fused bicyclic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH06502178A (ja) *	1990-12-31	1994-03-10	藤沢薬品工業株式会社	イミダゾトリアジン誘導体
US5356897A (en) *	1991-09-09	1994-10-18	Fujisawa Pharmaceutical Co., Ltd.	3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

1993
- 1993-02-26 GB GB939303993A patent/GB9303993D0/en active Pending
1994
- 1994-02-04 ZA ZA94787A patent/ZA94787B/xx unknown
- 1994-02-04 IL IL108562A patent/IL108562A/xx not_active IP Right Cessation
- 1994-02-09 PT PT94906381T patent/PT686156E/pt unknown
- 1994-02-09 KR KR1019950703609A patent/KR100313615B1/ko not_active Expired - Fee Related
- 1994-02-09 DE DE69430988T patent/DE69430988T2/de not_active Expired - Fee Related
- 1994-02-09 JP JP51881094A patent/JP3569917B2/ja not_active Expired - Fee Related
- 1994-02-09 US US08/505,284 patent/US5670503A/en not_active Expired - Fee Related
- 1994-02-09 CA CA002156919A patent/CA2156919A1/en not_active Abandoned
- 1994-02-09 DK DK94906381T patent/DK0686156T3/da active
- 1994-02-09 HU HU9402459A patent/HUT70832A/hu unknown
- 1994-02-09 ES ES94906381T patent/ES2176235T3/es not_active Expired - Lifetime
- 1994-02-09 EP EP94906381A patent/EP0686156B1/en not_active Expired - Lifetime
- 1994-02-09 RU RU95117872A patent/RU2124517C1/ru active
- 1994-02-09 AU AU60108/94A patent/AU681625B2/en not_active Ceased
- 1994-02-09 WO PCT/JP1994/000213 patent/WO1994019350A1/en not_active Ceased
- 1994-02-09 AT AT94906381T patent/ATE220677T1/de not_active IP Right Cessation
- 1994-02-09 CN CN94191768A patent/CN1041929C/zh not_active Expired - Fee Related
- 1994-02-18 TW TW083101366A patent/TW260669B/zh active
- 1994-02-24 MX MX9401408A patent/MX9401408A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3569917B2 (ja)	2004-09-29
AU681625B2 (en)	1997-09-04
HUT70832A (en)	1995-11-28
KR100313615B1 (ko)	2002-05-30
MX9401408A (es)	1994-08-31
CN1120840A (zh)	1996-04-17
KR960701055A (ko)	1996-02-24
ES2176235T3 (es)	2002-12-01
GB9303993D0 (en)	1993-04-14
HU9402459D0 (en)	1994-11-28
DK0686156T3 (da)	2002-11-11
PT686156E (pt)	2002-12-31
AU6010894A (en)	1994-09-14
IL108562A0 (en)	1994-05-30
EP0686156B1 (en)	2002-07-17
EP0686156A1 (en)	1995-12-13
ATE220677T1 (de)	2002-08-15
ZA94787B (en)	1994-09-08
CA2156919A1 (en)	1994-09-01
JPH08507056A (ja)	1996-07-30
DE69430988T2 (de)	2002-11-28
RU2124517C1 (ru)	1999-01-10
WO1994019350A1 (en)	1994-09-01
US5670503A (en)	1997-09-23
DE69430988D1 (de)	2002-08-22
TW260669B (es)	1995-10-21
CN1041929C (zh)	1999-02-03

Legal Events

Date	Code	Title
1998-01-04	FF	Patent granted
1998-04-05	KB	Patent renewed
2000-08-13	KB	Patent renewed
2004-11-10	RH1	Patent not in force
2006-02-21	HC	Change of name of proprietor(s)

Publication	Publication Date	Title
IL108562A (en)	1997-06-10	7, 8-diaryl-1,2,3,4- terahydropyrazolo- £5,1-c\| £1,2,4\| triazine derivatives, methods for the preparation thereof and pharmaceutical compositions containing them
MX9800577A (es)	1998-04-30	Derivados de 4,5-diaril oxazol.
GR3034542T3 (en)	2001-01-31	4,5-diaryloxazole derivatives
IL109395A0 (en)	1994-07-31	Heterocyclic derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
IL107426A (en)	1997-07-13	3-HALO-8-ARALKOXY (OR ARALKYLAMINO) IMIDAZO £1, 2-a\| PYRIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
IL124537A0 (en)	1998-12-06	Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
IL142649A0 (en)	2002-03-10	Azole derivatives
IL101785A0 (en)	1992-12-30	Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
MX9700308A (es)	1997-05-31	Derivados heterobiciclicos.
IL98872A0 (en)	1992-07-15	Pyrazolopyridine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
GB9602029D0 (en)	1996-04-03	New heterocyclic compounds
ES2006623A6 (es)	1989-05-01	Procedimiento de preparacion de nuevos derivados de amino 5,6,7,8-tetrahidro-(2,3b)-nafto-furano.
AUPN952696A0 (en)	1996-05-23	New heterocyclic compounds
TW334428B (en)	1998-06-21	Novel benzodiazepine derivatives
IL92010A (en)	1993-06-10	Pyrrolidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same