IL111083A0 - Tetraazacyclododecane macrocycle derivatives, pharmaceutical compositions and diagnostic compositions containing the same - Google Patents

Tetraazacyclododecane macrocycle derivatives, pharmaceutical compositions and diagnostic compositions containing the same

Info

Publication number: IL111083A0
Authority: IL; Israel
Prior art keywords: alkyl; branched; straight; same; compositions containing
Prior art date: 1993-09-30

Application number

IL11108394A

Other languages

English (en)

Original Assignee

Bracco Int Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-30

Filing date

1994-09-29

Publication date

1994-11-28

1994-09-29 Application filed by Bracco Int Bv filed Critical Bracco Int Bv

1994-11-28 Publication of IL111083A0 publication Critical patent/IL111083A0/xx

Links

239000000203 mixture Substances 0.000 title abstract 2
150000002678 macrocyclic compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052688 Gadolinium Inorganic materials 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
LGAILEFNHXWAJP-BMEPFDOTSA-N macrocycle Chemical group N([C@H]1[C@@H](C)CC)C(=O)C(N=2)=CSC=2CNC(=O)C(=C(O2)C)N=C2[C@H]([C@@H](C)CC)NC(=O)C2=CSC1=N2 LGAILEFNHXWAJP-BMEPFDOTSA-N 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Soft Magnetic Materials (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL11108394A 1993-09-30 1994-09-29 Tetraazacyclododecane macrocycle derivatives, pharmaceutical compositions and diagnostic compositions containing the same IL111083A0 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/129,870 US5358704A (en)	1993-09-30	1993-09-30	Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents

Publications (1)

Publication Number	Publication Date
IL111083A0 true IL111083A0 (en)	1994-11-28

Family

ID=22441998

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11108394A IL111083A0 (en)	1993-09-30	1994-09-29	Tetraazacyclododecane macrocycle derivatives, pharmaceutical compositions and diagnostic compositions containing the same

Country Status (14)

Country	Link
US (1)	US5358704A (fr)
EP (2)	EP1184377B1 (fr)
JP (1)	JP3949714B2 (fr)
KR (1)	KR960702447A (fr)
CN (1)	CN1115180A (fr)
AT (2)	ATE218554T1 (fr)
AU (1)	AU7623494A (fr)
CA (1)	CA2150452A1 (fr)
CZ (1)	CZ136995A3 (fr)
DE (2)	DE69430730T2 (fr)
HK (1)	HK1046131A1 (fr)
IL (1)	IL111083A0 (fr)
NO (1)	NO300131B1 (fr)
WO (1)	WO1995009161A1 (fr)

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DE4009119A1 (de) *	1990-03-19	1991-09-26	Schering Ag	1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4318369C1 (de) *	1993-05-28	1995-02-09	Schering Ag	Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
JPH0797340A (ja) *	1993-06-03	1995-04-11	Terumo Corp	Ｍｒｉ造影剤組成物
IT1269839B (it) *	1994-05-26	1997-04-15	Bracco Spa	Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
US6962686B2 (en) *	1994-10-12	2005-11-08	California Institute Of Technology	Cell-specific gene delivery vehicles
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AU6896796A (en) *	1995-08-17	1997-03-12	Monsanto Company	Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
US5900228A (en)	1996-07-31	1999-05-04	California Institute Of Technology	Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6495118B1 (en) *	1997-09-26	2002-12-17	Schering Aktiengesellschaft	Lipophilic metal complexes for necrosis and infarction imaging
DE19744004C1 (de) *	1997-09-26	1999-07-22	Schering Ag	Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6713046B1 (en)	1997-10-27	2004-03-30	Research Corporation Technologies	Magnetic resonance imaging agents for the delivery of therapeutic agents
AU752812B2 (en)	1997-11-17	2002-10-03	Research Corporation Technologies, Inc.	Magnetic resonance imaging agents for the detection of physiological agents
IT1297035B1 (it) *	1997-12-30	1999-08-03	Bracco Spa	Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6093382A (en) *	1998-05-16	2000-07-25	Bracco Research Usa Inc.	Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
US6056939A (en) *	1998-08-28	2000-05-02	Desreux; Jean F.	Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
AU2001276956A1 (en)	2000-07-17	2002-01-30	California Institute Of Technology	Macrocyclic mri contrast agents
WO2002028441A2 (fr)	2000-10-04	2002-04-11	California Institute Of Technology	Agents d'imagerie par resonance magnetique pour la detection et l'etiquetage in vivo de depots amyloides
US20030004236A1 (en) *	2001-04-20	2003-01-02	Meade Thomas J.	Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
US20020197648A1 (en) *	2001-05-02	2002-12-26	Silva Robin M.	High throughput screening methods using magnetic resonance imaging agents
US20030135108A1 (en) *	2001-05-02	2003-07-17	Silva Robin M.	High throughput screening methods using magnetic resonance imaging agents
US20040038303A1 (en) *	2002-04-08	2004-02-26	Unger Gretchen M.	Biologic modulations with nanoparticles
AU2003270347B2 (en) *	2002-09-06	2007-05-24	The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Backbone-substituted bifunctional dota ligands, complexes and compositions thereof, and methods of using same
EP1587547A2 (fr) *	2003-01-22	2005-10-26	The General Hospital Corporation	Agent de chelation metallique, a liaison amyloide
US7012140B1 (en) *	2003-07-14	2006-03-14	Board Of Regents, The University Of Texas System	Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
WO2005115105A2 (fr) *	2004-05-10	2005-12-08	Northwestern University	Agents de contraste pour imagerie a resonance magnetique sensibles a beta-glucoronidase qui s'auto-detruisent
CA2569461A1 (fr)	2004-06-09	2005-12-29	Kereos, Inc.	Derives lipophiles de monoamides chelates
SI1836239T1 (sl)	2005-01-13	2009-04-30	Cinv Ag	Kompozitni materiali, ki vsebujejo ogljikove nanodelce
AU2006303324A1 (en) *	2005-10-18	2007-04-26	Cinvention Ag	Thermoset particles and methods for production thereof
US20090317335A1 (en) *	2006-04-20	2009-12-24	Wenbin Lin	Hybrid Nanomaterials as Multimodal Imaging Contrast Agents
JP2010510252A (ja) *	2006-11-21	2010-04-02	バーンズジューイッシュホスピタル	キレート剤を用いるイメージング法
CN100459932C (zh) *	2007-01-15	2009-02-11	北京大学人民医院	一种mri分子影像探针及其制备方法
BRPI0806916A2 (pt) *	2007-01-19	2014-04-29	Cinv Ag	Implante poroso, não degradável feito por moldagem de pó
US20080206862A1 (en) *	2007-02-28	2008-08-28	Cinvention Ag	High surface cultivation system bag
BRPI0807993A2 (pt) *	2007-02-28	2014-06-17	Cinv Ag	Sistema de cultivo de alta superfície.
EP2072060A1 (fr)	2007-12-18	2009-06-24	Institut Curie	Procédés et compositions pour la préparation et l'utilisation de conjugués de toxines
US8580231B2 (en)	2008-05-23	2013-11-12	Northwestern University	Compositions and methods comprising magnetic resonance contrast agents
US20100029909A1 (en) *	2008-05-23	2010-02-04	Northwestern University	Compositions and methods comprising magnetic resonance contrast agents
CA2726050A1 (fr)	2008-05-30	2009-12-10	Siemens Medical Solutions Usa, Inc.	Obtention d'un indice therapeutique eleve par traitement medicamentaux cible guide par l'imagerie moleculaire
US20120093725A1 (en)	2009-04-10	2012-04-19	Inserm (Institut National De La Sante Et De La Recherche Medicale	Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies
US9272054B2 (en)	2010-12-03	2016-03-01	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Agents for the molecular imaging of serine-protease in human pathologies
US9598499B2 (en)	2010-12-30	2017-03-21	Institut National De La Santé Et De La Recherche Médicale (Inserm)	Antigen binding formats for use in therapeutic treatments or diagnostic assays
WO2013153138A1 (fr)	2012-04-11	2013-10-17	INSERM (Institut National de la Santé et de la Recherche Médicale)	Aptamère de métalloprotéinase matricielle 9 (mmp-9) et ses utilisations
EP2733153A1 (fr)	2012-11-15	2014-05-21	INSERM (Institut National de la Santé et de la Recherche Médicale)	Procédés pour la préparation d'immunoconjugués et leurs utilisations
EP3188716B1 (fr)	2014-09-03	2022-10-26	GeneSegues, Inc.	Nanoparticules thérapeutiques et compositions, procédés et systèmes associés
MX382574B (es)	2016-09-27	2025-03-13	Bayer Pharma AG	Método para producir la forma cristalina de modificación a de calcobutrol.
JP7693317B2 (ja)	2017-05-05	2025-06-17	センター・フォー・プローブ・デベロップメント・アンド・コマーシャライゼイション	二官能性キレートの薬物動態増強及びその使用
MA49398A (fr)	2017-05-05	2020-04-22	Eric Steven Burak	Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci
US10093741B1 (en)	2017-05-05	2018-10-09	Fusion Pharmaceuticals Inc.	IGF-1R monoclonal antibodies and uses thereof
US11607462B2 (en)	2017-05-16	2023-03-21	Northwestern University	Systems and methods for minimally-invasive assessment of toxicity-induced tissue injury

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EP0073456B1 (fr) *	1981-08-24	1985-11-27	Asahi Kasei Kogyo Kabushiki Kaisha	Complexes cobalt-tétraazaannulène et leur procédé de préparation
DE3276165D1 (de) *	1982-11-03	1987-06-04	Ciba Geigy Ag	Dibenzo(b,i)-1,4,8,11-tetraaza(14)annulenocobalt(iii) iodide
DE3562917D1 (en) *	1984-04-18	1988-06-30	Ciba Geigy Ag	Substituted dibenzotetraaza-û14¨-annulene metal complexes, process for their preparation and their use
US4899755A (en) *	1985-05-08	1990-02-13	The General Hospital Corporation	Hepatobiliary NMR contrast agents
US4880008A (en) *	1985-05-08	1989-11-14	The General Hospital Corporation	Vivo enhancement of NMR relaxivity
GB8603537D0 (en) *	1986-02-13	1986-03-19	Parker D	Conjugate compound
DE3625417C2 (de) *	1986-07-28	1998-10-08	Schering Ag	Tetraazacyclododecan-Derivate
DE4001655A1 (de) *	1990-01-18	1991-07-25	Schering Ag	6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
EP0511275A1 (fr) *	1990-01-19	1992-11-04	Nycomed Imaging As	Composes de chelation

1993
- 1993-09-30 US US08/129,870 patent/US5358704A/en not_active Expired - Lifetime
1994
- 1994-09-29 AT AT94926365T patent/ATE218554T1/de not_active IP Right Cessation
- 1994-09-29 AU AU76234/94A patent/AU7623494A/en not_active Abandoned
- 1994-09-29 CZ CZ951369A patent/CZ136995A3/cs unknown
- 1994-09-29 CA CA002150452A patent/CA2150452A1/fr not_active Abandoned
- 1994-09-29 EP EP01127327A patent/EP1184377B1/fr not_active Expired - Lifetime
- 1994-09-29 EP EP94926365A patent/EP0670832B1/fr not_active Expired - Lifetime
- 1994-09-29 CN CN94190738A patent/CN1115180A/zh active Pending
- 1994-09-29 JP JP51019495A patent/JP3949714B2/ja not_active Expired - Fee Related
- 1994-09-29 DE DE69430730T patent/DE69430730T2/de not_active Expired - Fee Related
- 1994-09-29 IL IL11108394A patent/IL111083A0/xx unknown
- 1994-09-29 KR KR1019950702155A patent/KR960702447A/ko not_active Withdrawn
- 1994-09-29 DE DE69434260T patent/DE69434260T2/de not_active Expired - Fee Related
- 1994-09-29 WO PCT/IB1994/000298 patent/WO1995009161A1/fr not_active Ceased
- 1994-09-29 AT AT01127327T patent/ATE288422T1/de not_active IP Right Cessation
1995
- 1995-05-29 NO NO952111A patent/NO300131B1/no unknown
2002
- 2002-09-06 HK HK02106580.1A patent/HK1046131A1/en unknown

Also Published As

Publication number	Publication date
NO300131B1 (no)	1997-04-14
DE69434260D1 (de)	2005-03-10
EP1184377B1 (fr)	2005-02-02
JPH08503967A (ja)	1996-04-30
HK1046131A1 (en)	2002-12-27
CZ136995A3 (en)	1995-12-13
CN1115180A (zh)	1996-01-17
DE69434260T2 (de)	2006-01-19
WO1995009161A1 (fr)	1995-04-06
US5358704A (en)	1994-10-25
JP3949714B2 (ja)	2007-07-25
NO952111D0 (no)	1995-05-29
AU7623494A (en)	1995-04-18
ATE288422T1 (de)	2005-02-15
ATE218554T1 (de)	2002-06-15
NO952111L (no)	1995-05-29
EP0670832B1 (fr)	2002-06-05
DE69430730T2 (de)	2003-02-06
CA2150452A1 (fr)	1995-04-06
EP1184377A1 (fr)	2002-03-06
KR960702447A (ko)	1996-04-27
DE69430730D1 (de)	2002-07-11
EP0670832A1 (fr)	1995-09-13

Publication	Publication Date	Title
AU7623494A (en)	1995-04-18	Hepatobiliary magnetic resonance contrast agents
GR3029603T3 (en)	1999-06-30	Cytotoxic stilbene derivatives and pharmaceutical composition containing them.
DE69024826D1 (de)	1996-02-29	Aza-Macrozyklen und Verfahren zu deren Herstellung
IE883844L (en)	1989-06-24	Macrocyclic chelating agents and chelates thereof
IL106164A0 (en)	1993-10-20	Polyazamacrocyclic compounds and their complexes with metal ions
IL114785A0 (en)	1995-11-27	Pyrrolocarbazoles their preparation and pharmaceutical compositions containing them
IL70905A0 (en)	1984-05-31	Carbacycline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
ATE156119T1 (de)	1997-08-15	2-formylpyridin-thiosemicarbazonderivate, ihre herstellung und ihre verwendung als antitumor mittel
WO1998006400A3 (fr)	1998-03-26	Produits pharmaceutiques preventifs et curatifs de maladies liees a des defaillances de cellules de l'endothelium vasculaire
NZ230128A (en)	1990-10-26	Dibenzooxepine-pyridinium and -pyrrolo derivatives and pharmaceutical compositions
IL111725A0 (en)	1995-01-24	3'-aziridino-anthracycline derivatives, their preparation and pharmaceutical compositions containing them
IL102409A0 (en)	1993-01-14	Mono and bis alkylamino-anthracyclines,their preparation and pharmaceutical compositions containing them
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ES8300116A1 (es)	1982-10-01	Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina
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MX9605046A (es)	1998-02-28	Derivados de adenosina.