IL111905A - Compositions for lowering serum cholesterol levels containing 2, 6-di-alkyl-4-silyl-phenol derivatives - Google Patents

Compositions for lowering serum cholesterol levels containing 2, 6-di-alkyl-4-silyl-phenol derivatives

Info

Publication number
IL111905A
IL111905A IL11190594A IL11190594A IL111905A IL 111905 A IL111905 A IL 111905A IL 11190594 A IL11190594 A IL 11190594A IL 11190594 A IL11190594 A IL 11190594A IL 111905 A IL111905 A IL 111905A
Authority
IL
Israel
Prior art keywords
group
phenol
methyl
alkyl
butyl
Prior art date
Application number
IL11190594A
Other languages
English (en)
Other versions
IL111905A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL111905A0 publication Critical patent/IL111905A0/xx
Publication of IL111905A publication Critical patent/IL111905A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
IL11190594A 1993-12-10 1994-12-07 Compositions for lowering serum cholesterol levels containing 2, 6-di-alkyl-4-silyl-phenol derivatives IL111905A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16528193A 1993-12-10 1993-12-10

Publications (2)

Publication Number Publication Date
IL111905A0 IL111905A0 (en) 1995-03-15
IL111905A true IL111905A (en) 2001-04-30

Family

ID=22598245

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11190594A IL111905A (en) 1993-12-10 1994-12-07 Compositions for lowering serum cholesterol levels containing 2, 6-di-alkyl-4-silyl-phenol derivatives

Country Status (16)

Country Link
EP (3) EP0732928B1 (de)
JP (1) JPH09511222A (de)
CN (1) CN1092517C (de)
AT (2) ATE285238T1 (de)
AU (1) AU681731B2 (de)
CA (1) CA2177968C (de)
DE (2) DE69434720T2 (de)
DK (2) DK1468692T3 (de)
ES (2) ES2233937T3 (de)
HU (1) HU220761B1 (de)
IL (1) IL111905A (de)
NO (1) NO311868B1 (de)
NZ (1) NZ276285A (de)
PT (2) PT1468692E (de)
WO (1) WO1995015760A1 (de)
ZA (1) ZA949663B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
IL164568A0 (en) 1997-05-14 2005-12-18 Atherogenics Inc Compounds and methods for the inhibition of the expression of vcam-1
ES2190592T3 (es) * 1997-06-24 2003-08-01 Aventis Pharma Inc Fenoles y tiofenoles alquil-4-sililheterociclicos como agentes antioxidantes.
JP2002506443A (ja) * 1997-06-25 2002-02-26 アベンティス・ファーマスーティカルズ・インコーポレイテッド ２，６−ジ−ｔ−ブチル−４−［（ジメチル−４−メトキシフェニルシリル）メチルオキシ］フェノール及び２，６−ジ−ｔ−ブチル−４−［（ジメチル−２−メトキシフェニルシリル）メチルオキシ］フェノール
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
CA2294247C (en) 1997-07-01 2004-10-26 Atherogenics, Inc. Antioxidant enhancement of therapy for hyperproliferative conditions
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
CN1332849A (zh) * 1998-11-09 2002-01-23 埃瑟若詹尼克斯公司 降低血浆胆固醇水平的方法和组合物
US6821738B2 (en) 1999-01-20 2004-11-23 The Board Of Regents For Oklahoma State University Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
WO2002040021A2 (en) 2000-11-17 2002-05-23 Idenix (Cayman) Limited Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
CN1596240A (zh) 2001-12-19 2005-03-16 阿特罗吉尼克斯公司 查耳酮衍生物及其治疗疾病的用途
US6960683B2 (en) 2002-07-12 2005-11-01 Atherogenics, Inc. Salt forms of poorly soluble probucol esters and ethers
WO2004108094A2 (en) 2003-06-06 2004-12-16 Atherogenics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) * 2003-10-17 2005-05-06 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
WO2008118948A1 (en) 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE349046B (de) * 1966-12-23 1972-09-18 C Guevne
FR2230376A1 (en) * 1973-05-24 1974-12-20 Gueyne Jean Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity
FR2308372A2 (fr) * 1975-04-21 1976-11-19 Cortial Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif
US4670421A (en) * 1982-07-12 1987-06-02 American Cyanamid Company Antiatherosclerotic silanes
US4900757A (en) * 1988-12-08 1990-02-13 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents

Also Published As

Publication number Publication date
CN1092517C (zh) 2002-10-16
NO962415D0 (no) 1996-06-07
DE69434720D1 (de) 2006-06-01
EP1468693A2 (de) 2004-10-20
CN1140995A (zh) 1997-01-22
DK1468692T3 (da) 2006-08-28
PT1468692E (pt) 2006-09-29
DE69434720T2 (de) 2007-05-16
EP1468692B1 (de) 2006-04-26
WO1995015760A1 (en) 1995-06-15
NO962415L (no) 1996-06-07
HU220761B1 (hu) 2002-05-28
CA2177968A1 (en) 1995-06-15
HU9601590D0 (en) 1996-08-28
EP0732928B1 (de) 2004-12-22
PT732928E (pt) 2005-03-31
AU1049995A (en) 1995-06-27
ZA949663B (en) 1995-08-15
ES2263094T3 (es) 2006-12-01
AU681731B2 (en) 1997-09-04
ES2233937T3 (es) 2005-06-16
NZ276285A (en) 2004-11-26
CA2177968C (en) 2000-03-28
ATE324113T1 (de) 2006-05-15
EP1468692A2 (de) 2004-10-20
DE69434198D1 (de) 2005-01-27
DE69434198T2 (de) 2005-12-29
JPH09511222A (ja) 1997-11-11
EP0732928A1 (de) 1996-09-25
IL111905A0 (en) 1995-03-15
NO311868B1 (no) 2002-02-11
EP1468692A3 (de) 2004-11-03
ATE285238T1 (de) 2005-01-15
HUT74015A (en) 1996-10-28
EP1468693A3 (de) 2004-11-03
DK0732928T3 (da) 2005-04-18

Similar Documents

Publication Publication Date Title
AU639576B2 (en) Novel 2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents
US5677291A (en) Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols
EP0732928B1 (de) Verfahren zur senkung des serumcholesterinspiegels mit 2,6-dialkyl-4 silyl-phenol derivaten
AU639807B2 (en) Novel bis(4-(2,6-di-alkyl)phenol)silane derivatives as antiatherosclerotic agents
US5304668A (en) Bis-[4-(2,6-di-alkyl)phenolisilane derivatives as antiatherosclerotic agents

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees