ZA949663B - Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols - Google Patents

Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols

Info

Publication number: ZA949663B
Authority: ZA; South Africa
Prior art keywords: silyl; phenols; dialkyl; cholesterol levels; serum cholesterol
Prior art date: 1993-12-10

Application number

ZA949663A

Other languages

English (en)

Inventor

Simon J T Mao

Mark T Yates

Roger A Parker

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-10

Filing date

1994-12-05

Publication date

1995-08-15

1994-12-05 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1995-08-15 Publication of ZA949663B publication Critical patent/ZA949663B/xx

Links

HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000002947 alkylene group Chemical group 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
-1 hydroxy, methoxy, ethoxy Chemical group 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Saccharide Compounds (AREA)

ZA949663A 1993-12-10 1994-12-05 Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols ZA949663B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16528193A	1993-12-10	1993-12-10

Publications (1)

Publication Number	Publication Date
ZA949663B true ZA949663B (en)	1995-08-15

Family

ID=22598245

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA949663A ZA949663B (en)	1993-12-10	1994-12-05	Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols

Country Status (16)

Country	Link
EP (3)	EP1468692B1 (de)
JP (1)	JPH09511222A (de)
CN (1)	CN1092517C (de)
AT (2)	ATE285238T1 (de)
AU (1)	AU681731B2 (de)
CA (1)	CA2177968C (de)
DE (2)	DE69434198T2 (de)
DK (2)	DK0732928T3 (de)
ES (2)	ES2233937T3 (de)
HU (1)	HU220761B1 (de)
IL (1)	IL111905A (de)
NO (1)	NO311868B1 (de)
NZ (1)	NZ276285A (de)
PT (2)	PT1468692E (de)
WO (1)	WO1995015760A1 (de)
ZA (1)	ZA949663B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA200800375A1 (ru)	1997-05-14	2008-06-30	Атеродженикс, Инк.	Соединения и способы ингибирования экспрессии vcam-1
US6670398B2 (en)	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
HUP0002775A3 (en) *	1997-06-24	2001-08-28	Aventis Pharmaceuticals Inc Br	Alkyl-4-silyl-furane or tiophene substituted phenols and thiophenols and pharmaceutical compositions thereof
US6133467A (en) *	1997-06-25	2000-10-17	Hoechst Marion Roussel, Inc.	2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
JP2002506443A (ja) *	1997-06-25	2002-02-26	アベンティス・ファーマスーティカルズ・インコーポレイテッド	２，６−ジ−ｔ−ブチル−４−［（ジメチル−４−メトキシフェニルシリル）メチルオキシ］フェノール及び２，６−ジ−ｔ−ブチル−４−［（ジメチル−２−メトキシフェニルシリル）メチルオキシ］フェノール
KR20010020611A (ko)	1997-07-01	2001-03-15	아테로제닉스, 인코포레이티드	항산화제에 의한 과증식질병 치료의 향상
CA2350316A1 (en) *	1998-11-09	2000-05-18	Atherogenics, Inc.	Methods and compositions to lower plasma cholesterol levels
US6887712B1 (en)	1998-11-09	2005-05-03	Atherogenics, Inc.	Methods and compositions to lower plasma cholesterol levels
US6821738B2 (en)	1999-01-20	2004-11-23	The Board Of Regents For Oklahoma State University	Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
WO2002040021A2 (en)	2000-11-17	2002-05-23	Idenix (Cayman) Limited	Methods for inhibiting the transmission of hiv using topically applied substituted 6-benzyl-4-oxopyrimidines
CN1596240A (zh)	2001-12-19	2005-03-16	阿特罗吉尼克斯公司	查耳酮衍生物及其治疗疾病的用途
AU2003253887A1 (en)	2002-07-12	2004-02-02	Atherogenics, Inc.	Novel salt forms of poorly soluble probucol esters and ethers
WO2004108094A2 (en)	2003-06-06	2004-12-16	Atherogenics, Inc.	Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) *	2003-10-17	2005-05-06	Amylin Pharmaceuticals, Inc.	Silyl phenols for promoting vascular health
WO2005112914A2 (en)	2004-04-20	2005-12-01	Atherogenics, Inc.	Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
JP2010522762A (ja)	2007-03-26	2010-07-08	サルトリア・フアーマシユーテイカルズ・エル・エル・シー	糖尿病の治療のための方法及びプロブコール誘導体の組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE349046B (de) *	1966-12-23	1972-09-18	C Guevne
FR2230376A1 (en) *	1973-05-24	1974-12-20	Gueyne Jean	Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity
FR2308372A2 (fr) *	1975-04-21	1976-11-19	Cortial	Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif
US4670421A (en) *	1982-07-12	1987-06-02	American Cyanamid Company	Antiatherosclerotic silanes
US4900757A (en) *	1988-12-08	1990-02-13	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
US5155250A (en) *	1990-07-05	1992-10-13	Merrell Dow Pharmaceuticals Inc.	2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents
NZ238807A (en) *	1990-07-05	1994-03-25	Merrell Dow Pharma	Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions

1994
- 1994-11-03 DE DE69434198T patent/DE69434198T2/de not_active Expired - Fee Related
- 1994-11-03 NZ NZ276285A patent/NZ276285A/en not_active IP Right Cessation
- 1994-11-03 DK DK95901141T patent/DK0732928T3/da active
- 1994-11-03 EP EP04016883A patent/EP1468692B1/de not_active Expired - Lifetime
- 1994-11-03 DK DK04016883T patent/DK1468692T3/da active
- 1994-11-03 PT PT04016883T patent/PT1468692E/pt unknown
- 1994-11-03 AU AU10499/95A patent/AU681731B2/en not_active Ceased
- 1994-11-03 PT PT95901141T patent/PT732928E/pt unknown
- 1994-11-03 HU HU9601590A patent/HU220761B1/hu not_active IP Right Cessation
- 1994-11-03 AT AT95901141T patent/ATE285238T1/de not_active IP Right Cessation
- 1994-11-03 EP EP95901141A patent/EP0732928B1/de not_active Expired - Lifetime
- 1994-11-03 JP JP7516186A patent/JPH09511222A/ja not_active Ceased
- 1994-11-03 DE DE69434720T patent/DE69434720T2/de not_active Expired - Lifetime
- 1994-11-03 AT AT04016883T patent/ATE324113T1/de not_active IP Right Cessation
- 1994-11-03 EP EP04016884A patent/EP1468693A3/de not_active Withdrawn
- 1994-11-03 CN CN94194438A patent/CN1092517C/zh not_active Expired - Fee Related
- 1994-11-03 WO PCT/US1994/012702 patent/WO1995015760A1/en not_active Ceased
- 1994-11-03 CA CA002177968A patent/CA2177968C/en not_active Expired - Fee Related
- 1994-11-03 ES ES95901141T patent/ES2233937T3/es not_active Expired - Lifetime
- 1994-11-03 ES ES04016883T patent/ES2263094T3/es not_active Expired - Lifetime
- 1994-12-05 ZA ZA949663A patent/ZA949663B/xx unknown
- 1994-12-07 IL IL11190594A patent/IL111905A/en not_active IP Right Cessation
1996
- 1996-06-07 NO NO19962415A patent/NO311868B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69434720T2 (de)	2007-05-16
NZ276285A (en)	2004-11-26
DE69434198T2 (de)	2005-12-29
ATE324113T1 (de)	2006-05-15
EP1468692A2 (de)	2004-10-20
EP1468692A3 (de)	2004-11-03
NO962415D0 (no)	1996-06-07
CN1140995A (zh)	1997-01-22
DE69434720D1 (de)	2006-06-01
NO962415L (no)	1996-06-07
EP1468693A2 (de)	2004-10-20
JPH09511222A (ja)	1997-11-11
CN1092517C (zh)	2002-10-16
EP1468693A3 (de)	2004-11-03
EP0732928A1 (de)	1996-09-25
ATE285238T1 (de)	2005-01-15
CA2177968A1 (en)	1995-06-15
PT732928E (pt)	2005-03-31
ES2233937T3 (es)	2005-06-16
HUT74015A (en)	1996-10-28
HU220761B1 (hu)	2002-05-28
NO311868B1 (no)	2002-02-11
HU9601590D0 (en)	1996-08-28
IL111905A (en)	2001-04-30
DK1468692T3 (da)	2006-08-28
EP0732928B1 (de)	2004-12-22
CA2177968C (en)	2000-03-28
IL111905A0 (en)	1995-03-15
AU1049995A (en)	1995-06-27
DE69434198D1 (de)	2005-01-27
WO1995015760A1 (en)	1995-06-15
AU681731B2 (en)	1997-09-04
DK0732928T3 (da)	2005-04-18
EP1468692B1 (de)	2006-04-26
PT1468692E (pt)	2006-09-29
ES2263094T3 (es)	2006-12-01

Publication	Publication Date	Title
HUT74015A (en)	1996-10-28	Method of lowering serum cholesterol levels with 2,6-dialkyl-4-silyl-phenols
AU1163492A (en)	1992-08-27	3-benzylidene-1-carbamoyl-2-pyrrolidone analog
CA2046051A1 (en)	1992-01-06	2,6-di-alkyl-4-silyl-phenols as antiatherosclerotic agents
PH30430A (en)	1997-05-09	Method for lowering serum cholesterol
LU91196I2 (fr)	2005-10-31	Picoxystrobin et ses dérivlés pharmaceutiquement acceptables(ACANTO).
ATE202702T1 (de)	2001-07-15	Verwendung von oestrogenagonisten und - antagonisten zur herstellung eines medikaments zur behandlung von atherosklerose, unabhängig von lipidsenkung
EP0632031A4 (de)	1995-02-08
ATE181066T1 (de)	1999-06-15	Zwischenverbindungen zur herstellung von thioalkylthio cephalosporinderivaten
DK0490566T3 (da)	1994-11-14	Fremstilling og anvendelse af N-iodpropargyloxycarbonylaminosyreestere og derivater som antimikrobielle midler
PL309874A1 (en)	1996-02-05	Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
AU598229B2 (en)	1990-06-21	Novel indenothiazole derivatives and process for their preparation
NZ218243A (en)	1990-03-27	B-carboline derivatives and pharmaceutical compositions
EP0712398A1 (de)	1996-05-22	Benzopyrane und diese enthaltende pharmazeutische zusammenstellungen
EP0335979A4 (en)	1992-02-26	Thienopyrimidine derivatives
TW350757B (en)	1999-01-21	Benzisoxazole derivatives and pesticidal compositions containing them
AU5910690A (en)	1991-01-24	Method of treating diabetes mellitus
CA2089366A1 (en)	1992-02-21	Penem compounds
NO960308L (no)	1996-03-13	Terapeutisk aktive benzoksaziner og benzotioanoner
WO1993019024A3 (en)	1993-10-28	Mercapto-acetamide derivatives
ATE143591T1 (de)	1996-10-15	Verwendung von bis-(p- hydroxyphenylthio)methanderivaten zur hemmung der fortschreitenden entwicklung von insulinabhängingem diabetes mellitus
IL101379A0 (en)	1992-11-15	Light screening compositions containing isoxazolones,certain such novel compounds and their preparation
AU8292787A (en)	1988-06-23	Fluorine-containing macrolide compounds and their use
AU1317688A (en)	1988-09-22	Benzoxazine derivatives and processes for preparation thereof