IL112457A - Glycopeptide antibiotic derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents

Glycopeptide antibiotic derivatives, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL112457A
IL112457A IL11245795A IL11245795A IL112457A IL 112457 A IL112457 A IL 112457A IL 11245795 A IL11245795 A IL 11245795A IL 11245795 A IL11245795 A IL 11245795A IL 112457 A IL112457 A IL 112457A
Authority
IL
Israel
Prior art keywords
alkyl
alkoxy
halo
group
formula
Prior art date
Application number
IL11245795A
Other languages
English (en)
Other versions
IL112457A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL112457A0 publication Critical patent/IL112457A0/xx
Publication of IL112457A publication Critical patent/IL112457A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)
IL11245795A 1994-01-28 1995-01-26 Glycopeptide antibiotic derivatives, process for their preparation and pharmaceutical compositions containing them IL112457A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18939394A 1994-01-28 1994-01-28
US35641394A 1994-12-15 1994-12-15

Publications (2)

Publication Number Publication Date
IL112457A0 IL112457A0 (en) 1995-03-30
IL112457A true IL112457A (en) 2004-06-20

Family

ID=26885101

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11245795A IL112457A (en) 1994-01-28 1995-01-26 Glycopeptide antibiotic derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (30)

Country Link
US (1) US5843889A (de)
EP (3) EP1031576B1 (de)
JP (1) JP3756539B2 (de)
KR (1) KR100388867B1 (de)
CN (1) CN1071334C (de)
AT (3) ATE266042T1 (de)
AU (1) AU703106B2 (de)
BR (1) BR9500365A (de)
CA (3) CA2546625C (de)
CO (1) CO4600679A1 (de)
CZ (2) CZ292895B6 (de)
DE (3) DE69532013T2 (de)
DK (3) DK1016670T3 (de)
EG (1) EG25884A (de)
ES (3) ES2210274T3 (de)
FI (3) FI117095B (de)
HU (1) HU225164B1 (de)
IL (1) IL112457A (de)
MY (1) MY128335A (de)
NO (1) NO323103B1 (de)
NZ (1) NZ270387A (de)
PE (1) PE40996A1 (de)
PL (1) PL180961B1 (de)
PT (3) PT667353E (de)
RU (1) RU2145609C1 (de)
SG (1) SG52719A1 (de)
SI (2) SI1016670T1 (de)
TW (1) TW457248B (de)
UA (1) UA43323C2 (de)
YU (1) YU4995A (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
US5952466A (en) * 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
ID18900A (id) * 1996-11-21 1998-05-20 Lilly Co Eli Alkilasi menurun dari gliko peptida anti biotik
US5939382A (en) * 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5977063A (en) * 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5994297A (en) * 1997-08-22 1999-11-30 Eli Lilly And Company Therapy for Staphylococcus aureus
US6518242B1 (en) 1998-02-20 2003-02-11 Theravance, Inc. Derivatives of glycopeptide antibacterial agents
WO1999056760A1 (en) 1998-05-01 1999-11-11 Eli Lilly And Company N1-modified glycopeptides
US6710168B1 (en) * 1999-05-19 2004-03-23 The Trustees Of The University Of Princeton Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
CA2337103A1 (en) * 1998-07-14 2000-01-27 Robert Kerns Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
PT1140993E (pt) 1998-12-23 2003-10-31 Theravance Inc Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos
CA2726789A1 (en) 2000-02-05 2001-11-08 Theravance, Inc. Cyclodextrin containing glycopeptide antibiotic compositions
WO2001081373A2 (en) * 2000-04-25 2001-11-01 Merck & Co., Inc. Glycopeptide antibacterial compounds and methods of using same
AU2001259298A1 (en) 2000-05-02 2001-11-12 Advanced Medicine, Inc. Polyacid glycopeptide derivatives
JP4713810B2 (ja) * 2000-05-02 2011-06-29 セラヴァンス， インコーポレーテッド グリコペプチドに対する還元的アルキル化プロセス
WO2001098329A1 (en) 2000-06-22 2001-12-27 Theravance, Inc. Polyhydroxy glycopeptide derivatives
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
ES2302733T3 (es) 2000-06-22 2008-08-01 Theravance, Inc. Derivados carboxi-sacaridos de glucopeptido.
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
CA2497159A1 (en) * 2002-08-30 2004-03-11 K.U. Leuven Research And Development Glycopeptide antibiotic and semisynthetic derivatives thereof and their use as antiviral agents
WO2004091578A2 (en) 2003-04-09 2004-10-28 Biodelivery Sciences International, Inc. Novel encochleation methods, cochleates and methods of use
JP2006528704A (ja) 2003-05-27 2006-12-21 セラヴァンス インコーポレーテッド グリコペプチド抗細菌剤と組み合わせたポリエンマクロライド抗真菌剤の使用
DE602004010915T2 (de) * 2003-07-22 2008-12-11 Theravance, Inc., South San Francisco Verwendung eines antimykotischen echinocandin-mittels in kombination mit einem antibakteriellen glycopeptid-mittel
US8778874B2 (en) 2004-11-29 2014-07-15 National University Corporation Nagoya University Glycopeptide antibiotic monomer derivatives
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
CA2603421C (en) 2005-04-01 2013-05-21 James R. Gross Nonwoven material for acoustic insulation, and process for manufacture
JP5178520B2 (ja) 2005-09-22 2013-04-10 メディバス エルエルシー 固体ポリマー送達組成物およびその使用法
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
TW200808818A (en) * 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
CN101959900A (zh) * 2007-12-26 2011-01-26 盐野义制药株式会社 糖肽类抗生素糖基化衍生物
EP2260060A4 (de) 2008-04-01 2013-01-16 Univ Cornell Organisch lösliche chitosansalze und daraus hergestellte chitosan-abgeleitete biomaterialien
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途
EP2704688B1 (de) 2011-05-05 2019-07-10 Matinas BioPharma Nanotechnologies, Inc. Cochleatzusammensetzungen sowie verfahren zu ihrer herstellung und verwendung
KR102237887B1 (ko) 2013-03-15 2021-04-07 멜린타 서브시디어리 코프. 항생제를 사용하여 과체중 및 비만 환자에서 감염을 치료하는 방법
CN107759672A (zh) * 2013-08-19 2018-03-06 南京爱斯药业有限公司 万古霉素衍生物、制备方法及其应用
AU2014322817A1 (en) 2013-09-23 2016-04-21 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
EP3169345B1 (de) * 2014-07-17 2025-01-29 Melinta Therapeutics, LLC Hochreines oritavancin und verfahren zur herstellung davon
HRP20200101T1 (hr) 2014-11-06 2020-04-03 Xellia Pharmaceuticals Aps Glikopeptidni pripravci
WO2016103284A1 (en) * 2014-12-25 2016-06-30 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Glycopeptides and uses thereof
CN106188243B (zh) * 2015-05-05 2020-06-26 博瑞生物医药（苏州）股份有限公司 一种奥利万星的制备方法
CN106467570B (zh) * 2015-08-14 2020-04-07 正大天晴药业集团股份有限公司 糖肽类抗生素的还原烷基化方法
CN107434823B (zh) * 2016-05-26 2021-11-16 江苏恒瑞医药股份有限公司 一种奥利万星中间体a82846b的纯化方法
CN108409837B (zh) * 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
CN109053864B (zh) * 2018-07-10 2021-08-24 丽珠集团新北江制药股份有限公司 一种制备奥利万星的方法
CN109053865B (zh) * 2018-07-20 2021-04-13 丽珠集团新北江制药股份有限公司 一种羧基保护制备奥利万星的方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (23)

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US3067099A (en) * 1955-09-16 1962-12-04 Lilly Co Eli Vancomycin and method for its preparation
US3338786A (en) * 1966-07-29 1967-08-29 American Cyanamid Co Antibiotic av290 and production thereof
US4552886A (en) * 1982-06-07 1985-11-12 Eli Lilly And Company Fungicidal pyridylmethyl-amines
IT1173329B (it) * 1984-02-21 1987-06-24 Lepetit Spa Procedimento per la trasformazione quantitativa di teicoplanina a2 fattore 1 in teicoplanina a2 fattore 3
GB8415093D0 (en) * 1984-06-13 1984-07-18 Lepetit Spa Antibiotic l 17392
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
IL78597A0 (en) * 1985-04-25 1986-08-31 Lilly Co Eli Novel glycopeptide derivatives
US4648327A (en) * 1985-07-01 1987-03-10 Cubic Western Data Safe locking mechanism
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4946941A (en) * 1986-01-24 1990-08-07 Shionogi & Co., Ltd. Novel glycopeptide antibiotics
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
GB8701872D0 (en) * 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b
GB8726859D0 (en) * 1987-11-17 1987-12-23 Lepetit Spa 22-dechlorotei-coplanins
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CA1339808C (en) * 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
US5185320A (en) * 1989-04-03 1993-02-09 Gruppo Lepetit S.P.A. O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin
US5186725A (en) * 1989-12-11 1993-02-16 Martell Trevor J Abrasive products
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US5187082A (en) * 1990-08-16 1993-02-16 Eli Lilly And Company Process for producing A83850 antibiotics
EP0596929B1 (de) * 1991-07-29 1995-07-26 GRUPPO LEPETIT S.p.A. Amidderivate vom Antibiotikum A 40926

Also Published As

Publication number Publication date
AU1138995A (en) 1995-08-10
MY128335A (en) 2007-01-31
AU703106B2 (en) 1999-03-18
HU9500230D0 (en) 1995-03-28
HU225164B1 (en) 2006-07-28
DE69532013D1 (de) 2003-12-04
DK1016670T3 (da) 2004-01-05
PT1031576E (pt) 2004-08-31
ES2204444T3 (es) 2004-05-01
FI950374L (fi) 1995-07-29
FI20050512L (fi) 2005-05-13
DK0667353T3 (da) 2004-03-22
US5843889A (en) 1998-12-01
EP1031576A2 (de) 2000-08-30
KR950032274A (ko) 1995-12-20
CN1119649A (zh) 1996-04-03
CA2546910C (en) 2010-09-14
UA43323C2 (uk) 2001-12-17
PT667353E (pt) 2004-03-31
DK1031576T3 (da) 2004-08-16
SG52719A1 (en) 1998-09-28
JPH07258289A (ja) 1995-10-09
FI950374A0 (fi) 1995-01-27
EP1016670B1 (de) 2003-09-03
CZ292895B6 (cs) 2003-12-17
PL180961B1 (pl) 2001-05-31
EP0667353A1 (de) 1995-08-16
NZ270387A (en) 1996-11-26
PT1016670E (pt) 2003-12-31
CO4600679A1 (es) 1998-05-08
CA2546625A1 (en) 1995-07-29
CZ18495A3 (en) 1995-08-16
NO950298L (no) 1995-07-31
ATE248856T1 (de) 2003-09-15
DE69531709D1 (de) 2003-10-09
JP3756539B2 (ja) 2006-03-15
ATE266042T1 (de) 2004-05-15
SI0667353T1 (en) 2004-04-30
RU2145609C1 (ru) 2000-02-20
CA2141106A1 (en) 1995-07-29
EP1031576A3 (de) 2000-12-27
FI117097B (fi) 2006-06-15
EP0667353B1 (de) 2003-10-29
ATE253077T1 (de) 2003-11-15
NO950298D0 (no) 1995-01-26
IL112457A0 (en) 1995-03-30
FI20050513L (fi) 2005-05-13
ES2220335T3 (es) 2004-12-16
ES2210274T3 (es) 2004-07-01
CZ292921B6 (cs) 2004-01-14
CA2546910A1 (en) 1995-07-29
YU4995A (sh) 1998-07-10
DE69533004D1 (de) 2004-06-09
EP1031576B1 (de) 2004-05-06
KR100388867B1 (ko) 2003-10-08
CA2141106C (en) 2007-01-23
EG25884A (en) 2012-09-24
FI117096B (fi) 2006-06-15
TW457248B (en) 2001-10-01
PL306976A1 (en) 1995-08-07
DE69533004T2 (de) 2005-04-07
RU95101039A (ru) 1996-10-27
EP1016670A1 (de) 2000-07-05
HUT68715A (en) 1995-07-28
DE69531709T2 (de) 2004-07-15
CA2546625C (en) 2008-09-09
SI1016670T1 (en) 2004-02-29
DE69532013T2 (de) 2004-07-08
FI117095B (fi) 2006-06-15
CN1071334C (zh) 2001-09-19
BR9500365A (pt) 1995-10-17
NO323103B1 (no) 2007-01-02
PE40996A1 (es) 1996-10-14

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