IL113767A - Neurotensin antagonist peptides process for their preparation and pharmaceutical compositions containing them - Google Patents

Neurotensin antagonist peptides process for their preparation and pharmaceutical compositions containing them

Info

Publication number: IL113767A
Authority: IL; Israel
Prior art keywords: pct; compound; radical; preparation; date nov
Prior art date: 1994-05-20

Application number

IL11376795A

Other languages

English (en)

Other versions

IL113767A0 (en

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-20

Filing date

1995-05-17

Publication date

1999-04-11

1995-05-17 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1995-08-31 Publication of IL113767A0 publication Critical patent/IL113767A0/xx

1999-04-11 Publication of IL113767A publication Critical patent/IL113767A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000004082 neurotensin receptor antagonist Substances 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
-1 nicotinoyl Chemical group 0.000 abstract 3
125000000539 amino acid group Chemical group 0.000 abstract 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
BLNWTAHYTCHDJH-UHFFFAOYSA-O hydroxy(oxo)azanium Chemical group O[NH+]=O BLNWTAHYTCHDJH-UHFFFAOYSA-O 0.000 abstract 1
229910052740 iodine Chemical group 0.000 abstract 1
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical compound [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C27/00—Processes involving the simultaneous production of more than one class of oxygen-containing compounds
- C07C27/20—Processes involving the simultaneous production of more than one class of oxygen-containing compounds by oxo-reaction
- C07C27/22—Processes involving the simultaneous production of more than one class of oxygen-containing compounds by oxo-reaction with the use of catalysts which are specific for this process
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/083—Neurotensin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/18—Kallidins; Bradykinins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Toxicology (AREA)
Psychiatry (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Zoology (AREA)
Immunology (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IL11376795A 1994-05-20 1995-05-17 Neurotensin antagonist peptides process for their preparation and pharmaceutical compositions containing them IL113767A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9406167A FR2720066B1 (fr)	1994-05-20	1994-05-20	Peptides antagonistes de la neurotensine.

Publications (2)

Publication Number	Publication Date
IL113767A0 IL113767A0 (en)	1995-08-31
IL113767A true IL113767A (en)	1999-04-11

Family

ID=9463378

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11376795A IL113767A (en)	1994-05-20	1995-05-17	Neurotensin antagonist peptides process for their preparation and pharmaceutical compositions containing them

Country Status (13)

Country	Link
US (1)	US5840682A (da)
EP (1)	EP0759934B1 (da)
JP (1)	JPH10500424A (da)
AT (1)	ATE178905T1 (da)
AU (1)	AU2619595A (da)
DE (1)	DE69509084T2 (da)
DK (1)	DK0759934T3 (da)
ES (1)	ES2132671T3 (da)
FR (1)	FR2720066B1 (da)
GR (1)	GR3029950T3 (da)
IL (1)	IL113767A (da)
WO (1)	WO1995032218A1 (da)
ZA (1)	ZA954026B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU728712C (en) *	1997-02-03	2001-07-19	Mallinckrodt, Inc.	Method for the detection and localization of malignant human tumours
DE10226921A1 (de) *	2002-06-17	2003-12-24	Bayer Ag	Antibakterielle Amid-Makrozyklen
DE10358824A1 (de) *	2003-12-16	2005-07-21	Bayer Healthcare Ag	Antibakterielle Makrozyklen mit substituiertem Biphenyl
DE102005014247A1 (de) *	2005-03-30	2006-10-05	Aicuris Gmbh & Co. Kg	Antibakterielle Amid-Makrozyklen VI
DE102005014245A1 (de) *	2005-03-30	2006-10-05	Aicuris Gmbh & Co. Kg	Antibakterielle Amid-Makrozyklen V
DE102005032781A1 (de) *	2005-07-14	2007-01-18	Aicuris Gmbh & Co. Kg	Antibakterielle Amid-Markozyklen VII
WO2010079158A1 (en)	2009-01-07	2010-07-15	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for the treatment, the prognostic assessment and the detection of breast cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4439359A (en) *	1982-07-02	1984-03-27	Merck & Co., Inc.	Cyclic octapeptide analogs of neurotensin
US5162497A (en) *	1987-09-24	1992-11-10	The Administrators Of The Tulane Educational Fund	Bradykinin analogs with non-peptide bond
US5430047A (en) *	1994-04-07	1995-07-04	Warner-Lambert Company	Neurotensin antagonists
FR2720065B1 (fr) *	1994-05-20	1996-06-28	Rhone Poulenc Rorer Sa	Métabolite de fermentation d'actinomycètes A 9738 intermédiaire pour la préparation d'antagonistes de la neurotensine.

1994
- 1994-05-20 FR FR9406167A patent/FR2720066B1/fr not_active Expired - Lifetime
1995
- 1995-05-17 ZA ZA954026A patent/ZA954026B/xx unknown
- 1995-05-17 DE DE69509084T patent/DE69509084T2/de not_active Expired - Fee Related
- 1995-05-17 ES ES95920949T patent/ES2132671T3/es not_active Expired - Lifetime
- 1995-05-17 US US08/737,695 patent/US5840682A/en not_active Expired - Fee Related
- 1995-05-17 JP JP7530094A patent/JPH10500424A/ja active Pending
- 1995-05-17 EP EP95920949A patent/EP0759934B1/fr not_active Expired - Lifetime
- 1995-05-17 DK DK95920949T patent/DK0759934T3/da active
- 1995-05-17 AT AT95920949T patent/ATE178905T1/de not_active IP Right Cessation
- 1995-05-17 WO PCT/FR1995/000643 patent/WO1995032218A1/fr not_active Ceased
- 1995-05-17 AU AU26195/95A patent/AU2619595A/en not_active Abandoned
- 1995-05-17 IL IL11376795A patent/IL113767A/xx active IP Right Grant
1999
- 1999-04-15 GR GR980400478T patent/GR3029950T3/el unknown

Also Published As

Publication number	Publication date
US5840682A (en)	1998-11-24
ZA954026B (en)	1996-03-06
EP0759934A1 (fr)	1997-03-05
DE69509084D1 (de)	1999-05-20
JPH10500424A (ja)	1998-01-13
EP0759934B1 (fr)	1999-04-14
ATE178905T1 (de)	1999-04-15
ES2132671T3 (es)	1999-08-16
WO1995032218A1 (fr)	1995-11-30
DE69509084T2 (de)	1999-08-12
FR2720066B1 (fr)	1996-06-28
GR3029950T3 (en)	1999-07-30
DK0759934T3 (da)	1999-08-02
AU2619595A (en)	1995-12-18
IL113767A0 (en)	1995-08-31
FR2720066A1 (fr)	1995-11-24

Legal Events

Date	Code	Title
1999-08-17	FF	Patent granted
2000-07-26	KB	Patent renewed
2000-08-31	KB	Patent renewed

Publication	Publication Date	Title
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JPS59205350A (ja)	1984-11-20	カルボキシアルキルペプチド誘導体
WO1995030687A1 (de)	1995-11-16	Neurokinin (tachykinin)-antagonisten
HUP0102900A2 (hu)	2002-01-28	Javított szilárd fázisú peptidszintézis és a szintézisben alkalmazható anyagok
ES8600769A1 (es)	1985-11-01	Procedimiento de preparar compuestos vinblastinicos y similares
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