IL114968A - 1,4-dihydropyridine compounds and pharmaceutical compositions containing them - Google Patents

1,4-dihydropyridine compounds and pharmaceutical compositions containing them

Info

Publication number: IL114968A
Authority: IL; Israel
Prior art keywords: pct; pharmaceutical compositions; compositions containing; dihydropyridine compounds; sec
Prior art date: 1994-08-24

Application number

IL11496895A

Other languages

English (en)

Other versions

IL114968A0 (en

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-24

Filing date

1995-08-17

Publication date

1999-08-17

1995-08-17 Application filed by Pfizer filed Critical Pfizer

1995-12-08 Publication of IL114968A0 publication Critical patent/IL114968A0/xx

1999-08-17 Publication of IL114968A publication Critical patent/IL114968A/xx

Links

YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
101800004538 Bradykinin Proteins 0.000 abstract 1
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
102100035792 Kininogen-1 Human genes 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Oncology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

IL11496895A 1994-08-24 1995-08-17 1,4-dihydropyridine compounds and pharmaceutical compositions containing them IL114968A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/JP1994/001398 WO1996006083A1 (fr)	1994-08-24	1994-08-24	2-(piperazinyl-1-carbonylmethyl)-1,4-dihydropyridines utilisees comme antagonistes de bradykinine

Publications (2)

Publication Number	Publication Date
IL114968A0 IL114968A0 (en)	1995-12-08
IL114968A true IL114968A (en)	1999-08-17

Family

ID=14098614

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11496895A IL114968A (en)	1994-08-24	1995-08-17	1,4-dihydropyridine compounds and pharmaceutical compositions containing them

Country Status (21)

Country	Link
US (1)	US5859011A (fr)
EP (1)	EP0777653B1 (fr)
JP (1)	JP3001978B2 (fr)
KR (1)	KR100235285B1 (fr)
CN (1)	CN1087737C (fr)
AT (1)	ATE204567T1 (fr)
AU (1)	AU689587B2 (fr)
CA (1)	CA2198231C (fr)
DE (1)	DE69522332T2 (fr)
DK (1)	DK0777653T3 (fr)
ES (1)	ES2159637T3 (fr)
FI (1)	FI970745A0 (fr)
GR (1)	GR3036907T3 (fr)
IL (1)	IL114968A (fr)
MX (1)	MX9701363A (fr)
MY (1)	MY115372A (fr)
NO (1)	NO970806L (fr)
NZ (1)	NZ285155A (fr)
TW (1)	TW500722B (fr)
WO (2)	WO1996006083A1 (fr)
ZA (1)	ZA977057B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4345062A1 (de) *	1993-12-31	1995-07-13	Hoechst Ag	Verwendung von Bradykinin-Antagonisten zur Herstellung von Arzneimitteln zur Behandlung von Viruserkrankungen
MX9701245A (es) *	1996-02-19	1998-04-30	Pfizer	Compuestos de 1,4 dihidropiridina.
TNSN97037A1 (fr) *	1996-02-19	2005-03-15	Pfizer	Derives de 1,4 -dihydropyridine, procede pour leur preparation et compositions pharmaceutiques les contenant.
JP3823388B2 (ja) *	1996-09-04	2006-09-20	カシオ計算機株式会社	印刷装置
JPH11106375A (ja) *	1997-08-18	1999-04-20	Pfizer Pharmaceut Inc	ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物
KR100579792B1 (ko)	1998-05-13	2006-05-12	동화약품공업주식회사	신규 2,5-피리딘디카복실산 유도체
EP1110962A1 (fr) *	1999-12-10	2001-06-27	Pfizer Inc.	Procede pour la preparation de composes 1,4-dihydropyridines
DK1106614T3 (da) *	1999-12-10	2004-04-13	Pfizer	5-leddede, heteroarylsubstituerede 1,4-dihydropyridinforbindelser som bradykininantagonister
DE60001535T2 (de) *	1999-12-10	2003-10-02	Pfizer Inc., New York	Substituierte 1,4-Dihydropyridinverbindungen zur Verwendung als Bradykininantagonisten
US6653313B2 (en)	2000-08-10	2003-11-25	Warner-Lambert Company Llc	1,4-dihydropyridine compounds as bradykinin antagonists
PT2813502T (pt)	2013-06-14	2017-04-06	Dompé Farm S P A	Antagonistas do recetor da bradicinina e composições farmacêuticas que os contêm

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5162497A (en) *	1987-09-24	1992-11-10	The Administrators Of The Tulane Educational Fund	Bradykinin analogs with non-peptide bond
US5120750A (en) *	1989-01-17	1992-06-09	Synphar Laboratories, Inc.	Generation of 1,4-dihydropyridine derivatives
US5610142A (en) *	1992-10-08	1997-03-11	Scios Inc.	Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids

1994
- 1994-08-24 WO PCT/JP1994/001398 patent/WO1996006083A1/fr not_active Ceased
1995
- 1995-05-26 AT AT95918113T patent/ATE204567T1/de not_active IP Right Cessation
- 1995-05-26 KR KR1019970701151A patent/KR100235285B1/ko not_active Expired - Fee Related
- 1995-05-26 AU AU24166/95A patent/AU689587B2/en not_active Ceased
- 1995-05-26 DK DK95918113T patent/DK0777653T3/da active
- 1995-05-26 MX MX9701363A patent/MX9701363A/es not_active IP Right Cessation
- 1995-05-26 EP EP95918113A patent/EP0777653B1/fr not_active Expired - Lifetime
- 1995-05-26 JP JP8507896A patent/JP3001978B2/ja not_active Expired - Fee Related
- 1995-05-26 ES ES95918113T patent/ES2159637T3/es not_active Expired - Lifetime
- 1995-05-26 CN CN95194758A patent/CN1087737C/zh not_active Expired - Fee Related
- 1995-05-26 DE DE69522332T patent/DE69522332T2/de not_active Expired - Fee Related
- 1995-05-26 WO PCT/IB1995/000400 patent/WO1996006082A1/fr not_active Ceased
- 1995-05-26 US US08/793,561 patent/US5859011A/en not_active Expired - Fee Related
- 1995-05-26 CA CA002198231A patent/CA2198231C/fr not_active Expired - Fee Related
- 1995-07-11 TW TW084107170A patent/TW500722B/zh not_active IP Right Cessation
- 1995-08-17 IL IL11496895A patent/IL114968A/xx not_active IP Right Cessation
- 1995-08-22 MY MYPI95002477A patent/MY115372A/en unknown
- 1995-08-23 ZA ZA9707057A patent/ZA977057B/xx unknown
1997
- 1997-02-21 NO NO970806A patent/NO970806L/no not_active Application Discontinuation
- 1997-02-21 FI FI970745A patent/FI970745A0/fi not_active Application Discontinuation
- 1997-02-24 NZ NZ285155A patent/NZ285155A/en unknown
2001
- 2001-10-16 GR GR20010401777T patent/GR3036907T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1996006082A1 (fr)	1996-02-29
GR3036907T3 (en)	2002-01-31
NO970806D0 (no)	1997-02-21
MY115372A (en)	2003-05-31
NO970806L (no)	1997-04-21
CN1087737C (zh)	2002-07-17
AU2416695A (en)	1996-03-14
CN1156449A (zh)	1997-08-06
FI970745A7 (fi)	1997-02-21
JP3001978B2 (ja)	2000-01-24
MX9701363A (es)	1997-05-31
NZ285155A (en)	1998-06-26
JPH09510992A (ja)	1997-11-04
EP0777653B1 (fr)	2001-08-22
US5859011A (en)	1999-01-12
ES2159637T3 (es)	2001-10-16
DK0777653T3 (da)	2001-10-08
IL114968A0 (en)	1995-12-08
KR970705555A (ko)	1997-10-09
CA2198231A1 (fr)	1996-02-29
CA2198231C (fr)	1999-12-07
AU689587B2 (en)	1998-04-02
DE69522332T2 (de)	2002-01-03
FI970745A0 (fi)	1997-02-21
ZA977057B (en)	1997-02-24
WO1996006083A1 (fr)	1996-02-29
DE69522332D1 (de)	2001-09-27
KR100235285B1 (ko)	2000-02-01
TW500722B (en)	2002-09-01
ATE204567T1 (de)	2001-09-15
EP0777653A1 (fr)	1997-06-11

Legal Events

Date	Code	Title
1999-12-22	FF	Patent granted
2000-08-31	KB	Patent renewed
2001-10-31	KB	Patent renewed
2006-06-18	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
PL315636A1 (en)	1996-11-25	Cosmetic or pharmaceutic compositions containing magnipherine or its derivatives
IL124537A0 (en)	1998-12-06	Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
ZA918044B (en)	1992-07-29	Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines of piperazines,and compositions and methods of use thereof
SE9504661D0 (sv)	1995-12-22	New compounds
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
DK41193D0 (da)	1993-04-07	Ionkanalaabnere
IL133825A0 (en)	2001-04-30	Substituted 6-phenylphenanthridines, medicaments containing same and use thereof
GR3035414T3 (en)	2001-05-31	Novel imidazole derivatives, their preparation and therapeutic applications.
EP0482410A3 (en)	1992-09-09	Anti-microbial compounds, including substituted 2-cyclohexyl-amine derivatives and their preparation
GR3035621T3 (en)	2001-06-29	New pyrimidone derivatives with antifungal activity
AU3563695A (en)	1996-05-31	Novel piperidine derivatives with paf antagonist activity
TR199801268T2 (xx)	1998-10-21	Ta�ikinin antagonistleri olarak 3-Azetidinilalkilpiperidinler veya pirolidinler.
IL114241A0 (en)	1995-10-31	Thiazolidine derivatives their preparation and compositions containing them
IL114968A0 (en)	1995-12-08	1,4-dihydropyridine compounds
IL116526A (en)	1999-11-30	Piperazinediones their preparation and pharmaceutical and veterinary compositions containing them
AU693241B2 (en)	1998-06-25	New 3-substituted 3h-2,3-benzodiazepine derivatives, their preparation and use as medicaments
AU699021B2 (en)	1998-11-19	N-substituted azabicycloheptane derivatives, the preperation and use thereof
TW252979B (fr)	1995-08-01
SE9504662D0 (sv)	1995-12-22	New compounds
ZA935045B (en)	1994-02-07	Pharmacologically active alfa-(tertiary-aminomethyl)-ben-zenemethanol derivatives
ZA955941B (en)	1996-02-21	Derivatives of imidazo(1,2-a)indeno(1,2-e)pyrazine-2-carboxylic acid their preparation and medicaments containing them
AU3809095A (en)	1996-05-23	6-polyfluoroalkoxy and 6-polyfluoroalkyl-2-aminobenzothiazole derivatives
SI0805817T1 (fr)	2001-12-31
TR199800958A2 (xx)	1998-12-21	Herbisidal 3,5-Difloropridinleri.