IL115590A - Pharmaceutical formulation comprising a growth hormone and isoleucine - Google Patents

Pharmaceutical formulation comprising a growth hormone and isoleucine

Info

Publication number: IL115590A
Authority: IL; Israel
Prior art keywords: isoleucine; growth hormone; pharmaceutical formulation; dissolved; formulation
Prior art date: 1994-10-13

Application number

IL11559095A

Other languages

English (en)

Other versions

IL115590A0 (en

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-13

Filing date

1995-10-12

Publication date

2000-02-29

1995-10-12 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1996-01-19 Publication of IL115590A0 publication Critical patent/IL115590A0/xx

2000-02-29 Publication of IL115590A publication Critical patent/IL115590A/xx

Links

102000018997 Growth Hormone Human genes 0.000 title abstract 2
108010051696 Growth Hormone Proteins 0.000 title abstract 2
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 title abstract 2
239000000122 growth hormone Substances 0.000 title abstract 2
229960000310 isoleucine Drugs 0.000 title abstract 2
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
239000000654 additive Substances 0.000 abstract 1
230000000996 additive effect Effects 0.000 abstract 1
239000006172 buffering agent Substances 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
230000006240 deamidation Effects 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL11559095A 1994-10-13 1995-10-12 Pharmaceutical formulation comprising a growth hormone and isoleucine IL115590A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/322,837 US5631225A (en)	1994-10-13	1994-10-13	Pharmaceutical formulation

Publications (2)

Publication Number	Publication Date
IL115590A0 IL115590A0 (en)	1996-01-19
IL115590A true IL115590A (en)	2000-02-29

Family

ID=23256650

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11559095A IL115590A (en)	1994-10-13	1995-10-12	Pharmaceutical formulation comprising a growth hormone and isoleucine

Country Status (11)

Country	Link
US (1)	US5631225A (es)
EP (1)	EP0785796B1 (es)
JP (1)	JP4064454B2 (es)
KR (1)	KR970706839A (es)
AT (1)	ATE214614T1 (es)
AU (1)	AU699345B2 (es)
DE (1)	DE69525955T2 (es)
ES (1)	ES2173197T3 (es)
IL (1)	IL115590A (es)
WO (1)	WO1996011703A1 (es)
ZA (1)	ZA958604B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6022858A (en) *	1991-12-20	2000-02-08	Novo Nordisk A/S	Pharmaceutical formulation of human-growth hormone pretreated with zinc salt
US6673335B1 (en)	1992-07-08	2004-01-06	Nektar Therapeutics	Compositions and methods for the pulmonary delivery of aerosolized medicaments
US6582728B1 (en)	1992-07-08	2003-06-24	Inhale Therapeutic Systems, Inc.	Spray drying of macromolecules to produce inhaleable dry powders
ATE220327T1 (de) *	1992-09-29	2002-07-15	Inhale Therapeutic Syst	Pulmonale abgabe von aktiven fragmenten des parathormons
ES2218543T3 (es)	1994-03-07	2004-11-16	Nektar Therapeutics	Procedimiento y preparacion para la administracion de insulina por via pulmonar.
US20030113273A1 (en) *	1996-06-17	2003-06-19	Patton John S.	Methods and compositions for pulmonary delivery of insulin
NZ285664A (en) *	1994-05-18	1998-07-28	Inhale Therapeutic Syst	Dry powder interferon composition adapted for pulmonary delivery
US6290991B1 (en) *	1994-12-02	2001-09-18	Quandrant Holdings Cambridge Limited	Solid dose delivery vehicle and methods of making same
US20030035778A1 (en) *	1997-07-14	2003-02-20	Robert Platz	Methods and compositions for the dry powder formulation of interferon
US6309623B1 (en) *	1997-09-29	2001-10-30	Inhale Therapeutic Systems, Inc.	Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en)	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en)	1997-09-29	2003-05-20	Inhale Therapeutic Systems, Inc.	Methods of spray drying pharmaceutical compositions
WO2001034181A2 (en) *	1999-11-09	2001-05-17	Rappold Hoerbrand Gudrun	Methods of treating short stature disorders related to the short stature homeobox-containing (shox) gene
US7442388B2 (en)	2000-05-10	2008-10-28	Weers Jeffry G	Phospholipid-based powders for drug delivery
US7871598B1 (en)	2000-05-10	2011-01-18	Novartis Ag	Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en)	2000-05-10	2013-03-26	Novartis Ag	Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
WO2002011695A2 (en) *	2000-08-07	2002-02-14	Inhale Therapeutic Systems, Inc.	Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation
US7368102B2 (en)	2001-12-19	2008-05-06	Nektar Therapeutics	Pulmonary delivery of aminoglycosides
US7951368B2 (en) *	2007-06-25	2011-05-31	Amgen Inc.	Compositions of specific binding agents to hepatocyte growth factor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4056520A (en) *	1972-03-31	1977-11-01	Research Corporation	Clinically active bovine growth hormone fraction
US4563352A (en) *	1982-10-04	1986-01-07	The Salk Institute For Biological Studies	Human pancreatic GRF
JPS5967228A (ja) *	1982-10-07	1984-04-16	Green Cross Corp:The	寒冷不溶性グロブリンの凍結乾燥方法
US4917685A (en) *	1986-05-16	1990-04-17	International Minerals & Chem. Corp.	Delivery device for the administration of stabilized growth promoting hormones
ATE82506T1 (de) *	1987-08-21	1992-12-15	Imcera Group Inc	Stabilisierung von wachstumshormonen.
US5096885A (en) *	1988-04-15	1992-03-17	Genentech, Inc.	Human growth hormone formulation
EP0374120A3 (en) *	1988-12-13	1991-07-31	Monsanto Company	Comosition for controlled release of polypeptides
US5137872A (en) *	1989-09-18	1992-08-11	Pitman-Moore, Inc.	Growth hormone-releasing factor analogs
DK204791D0 (da) *	1991-12-20	1991-12-20	Novo Nordisk As	Hidtil ukendt farmaceutisk praeparat
SK279641B6 (sk) *	1991-12-20	1999-01-11	Novo Nordisk A/S	Stabilizovaný farmaceutický prípravok obsahujúci r
SE9201073D0 (sv) *	1992-04-03	1992-04-03	Kabi Pharmacia Ab	Protein formulation
MD1699F2 (ro) *	1992-07-31	2001-07-31	Genentech, Inc.	Compoziţie apoasă a hormonului somatotrop uman şi procedeu de prevenire a denaturării ei

1994
- 1994-10-13 US US08/322,837 patent/US5631225A/en not_active Expired - Lifetime
1995
- 1995-10-12 ZA ZA958604A patent/ZA958604B/xx unknown
- 1995-10-12 IL IL11559095A patent/IL115590A/xx not_active IP Right Cessation
- 1995-10-13 DE DE69525955T patent/DE69525955T2/de not_active Expired - Lifetime
- 1995-10-13 ES ES95933346T patent/ES2173197T3/es not_active Expired - Lifetime
- 1995-10-13 AU AU36053/95A patent/AU699345B2/en not_active Ceased
- 1995-10-13 AT AT95933346T patent/ATE214614T1/de not_active IP Right Cessation
- 1995-10-13 WO PCT/DK1995/000409 patent/WO1996011703A1/en not_active Ceased
- 1995-10-13 EP EP95933346A patent/EP0785796B1/en not_active Expired - Lifetime
- 1995-10-13 JP JP51286296A patent/JP4064454B2/ja not_active Expired - Fee Related
- 1995-10-13 KR KR1019970702430A patent/KR970706839A/ko not_active Abandoned

Also Published As

Publication number	Publication date
EP0785796A1 (en)	1997-07-30
JP4064454B2 (ja)	2008-03-19
EP0785796B1 (en)	2002-03-20
ATE214614T1 (de)	2002-04-15
KR970706839A (ko)	1997-12-01
WO1996011703A1 (en)	1996-04-25
JPH10507182A (ja)	1998-07-14
AU699345B2 (en)	1998-12-03
ZA958604B (en)	1996-05-14
DE69525955T2 (de)	2002-11-07
DE69525955D1 (de)	2002-04-25
US5631225A (en)	1997-05-20
IL115590A0 (en)	1996-01-19
ES2173197T3 (es)	2002-10-16
AU3605395A (en)	1996-05-06

Legal Events

Date	Code	Title
2000-06-29	FF	Patent granted
2000-10-31	KB	Patent renewed
2002-02-10	KB	Patent renewed
2006-08-01	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL115590A0 (en)	1996-01-19	Pharmaceutical formulation comprising a growth hormone and isoleucine
HU9401831D0 (en)	1994-09-28	Stabilized pharmaceutical formulations comprising growth hormone and asparagine
IL115591A0 (en)	1996-01-19	Pharmaceutical formulation comprising a growth hormone and valine
EP1197222A3 (en)	2004-02-04	A stabilized pharmaceutical formulation comprising growth hormone and histidine
BG106046A (en)	2002-05-31	Pharmaceutical compositions of ertythropoietin
IE882671L (en)	1989-03-05	Stabilised human protein formulation
EP1308170A3 (en)	2004-03-03	Dried blood factor composition comprising trehalose
ATE261742T1 (de)	2004-04-15	Pulmonale verabreichung von medikamenten in aerosolform
ZA200007415B (en)	2002-04-02	Amino acid derivatives and drugs containing the same as the active ingredient.
IL115592A0 (en)	1996-01-19	Pharmaceutical formulation comprising a growth hormone and leucine
MX9800309A (es)	1998-07-31	Formulacion farmaceutica estabilizada que comprende una hormona del crecimiento y un peptido que comprende al menos un residuo de aminoacido basico y al menos un residuo de aminoacido acido.
MX9800358A (es)	1998-07-31	Formulacion farmaceutica estabilizada que comprende una hormona del crecimiento pretratada con zinc y opcionalmente lisina o iones calcio.
AU8375891A (en)	1992-03-19	Antioxidant system based on a basic amino acid in combination with a tocopherol or derivative thereof and a nonthiolated polypeptide, and compositions containing the same
AU1879097A (en)	1997-09-16	Fragments of cr1 and their use