IL116178A - Indole derivative process for preparing it and pharmaceutical composition containing the same - Google Patents

Indole derivative process for preparing it and pharmaceutical composition containing the same

Info

Publication number
IL116178A
IL116178A IL11617895A IL11617895A IL116178A IL 116178 A IL116178 A IL 116178A IL 11617895 A IL11617895 A IL 11617895A IL 11617895 A IL11617895 A IL 11617895A IL 116178 A IL116178 A IL 116178A
Authority
IL
Israel
Prior art keywords
lower alkoxy
indole derivative
preparing
pharmaceutical composition
same
Prior art date
Application number
IL11617895A
Other languages
English (en)
Other versions
IL116178A0 (en
Original Assignee
Dainippon Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co filed Critical Dainippon Pharmaceutical Co
Publication of IL116178A0 publication Critical patent/IL116178A0/xx
Publication of IL116178A publication Critical patent/IL116178A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL11617895A 1994-11-29 1995-11-28 Indole derivative process for preparing it and pharmaceutical composition containing the same IL116178A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP06321402 1994-11-29

Publications (2)

Publication Number Publication Date
IL116178A0 IL116178A0 (en) 1996-01-31
IL116178A true IL116178A (en) 2000-07-26

Family

ID=18132155

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11617895A IL116178A (en) 1994-11-29 1995-11-28 Indole derivative process for preparing it and pharmaceutical composition containing the same

Country Status (28)

Country Link
US (1) US5817689A (de)
EP (1) EP0801059B1 (de)
JP (1) JP3100165B2 (de)
KR (1) KR100388747B1 (de)
CN (1) CN1070477C (de)
AT (1) ATE202559T1 (de)
AU (1) AU688165B2 (de)
BR (1) BR9509827A (de)
CA (1) CA2206307A1 (de)
CY (1) CY2247B1 (de)
CZ (1) CZ290871B6 (de)
DE (1) DE69521529T2 (de)
DK (1) DK0801059T3 (de)
ES (1) ES2159648T3 (de)
FI (1) FI972275A7 (de)
GR (1) GR3036148T3 (de)
HU (1) HUT77308A (de)
IL (1) IL116178A (de)
NO (1) NO309648B1 (de)
NZ (1) NZ295749A (de)
PL (1) PL181963B1 (de)
PT (1) PT801059E (de)
RO (1) RO118426B1 (de)
RU (1) RU2137759C1 (de)
SK (1) SK281865B6 (de)
TW (1) TW349091B (de)
WO (1) WO1996016938A1 (de)
ZA (1) ZA9510130B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20010580A1 (es) * 1999-09-03 2001-05-25 Takeda Chemical Industries Ltd Composicion farmaceutica para tratar la diabetes
US6458824B1 (en) * 1999-11-30 2002-10-01 Dainippon Pharmaceutical Co., Ltd. Solid preparation
NZ519086A (en) * 1999-11-30 2003-11-28 Dainippon Pharmaceutical Co Solid preparation
JP2004331500A (ja) * 2001-02-16 2004-11-25 Dainippon Pharmaceut Co Ltd 血中濃度制御製剤
EP2335700A1 (de) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur
AU2003225277A1 (en) * 2002-05-02 2003-11-17 Robert Harris Lipid removal from the body
KR20050010512A (ko) * 2002-06-12 2005-01-27 스미또모 세이야꾸 가부시키가이샤 인돌, 인다졸 및 벤즈아졸류
RS20050532A (sr) 2003-01-14 2007-12-31 Arena Pharmaceuticals Inc., Derivati 1,2,3-trisupstituisanog arila i heteroarila kao modulatori metabolizma za profilaksu i tretman poremećaja povezanih sa njim, kao što su dijebetes i hiperglikemija
SI1599468T1 (sl) * 2003-01-14 2008-02-29 Arena Pharm Inc 1,2,3-trisubstituirani arilni in heteroarilni derivati kot modulatorji metabolizma ter profilaksa in zdravljenje motenj v zvezi z njim, kot diabetesain hiperglikemije
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
WO2004089936A1 (ja) * 2003-04-10 2004-10-21 Dainippon Pharmaceutical Co., Ltd. ヘテロアリールスルホン酸アニリド誘導体及びそれを含有する医薬組成物
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
EP2428516A1 (de) * 2003-11-19 2012-03-14 Metabasis Therapeutics, Inc. Neue Phosphor enthaltende Thyromimetika
CN1922174A (zh) 2004-02-20 2007-02-28 贝林格尔·英格海姆国际有限公司 病毒聚合酶抑制剂
MY148521A (en) 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
CA2618682C (en) * 2005-08-12 2011-06-21 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
CN103221410B (zh) 2010-09-22 2017-09-15 艾尼纳制药公司 Gpr119受体调节剂和对与其相关的障碍的治疗
ES2394349B1 (es) 2012-08-29 2013-11-04 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar
WO2015199097A1 (ja) * 2014-06-24 2015-12-30 花王株式会社 Ｕｃｐ－１発現促進剤
US10758519B2 (en) 2014-06-24 2020-09-01 Kao Corporation UCP-1 expression promoter
JP6660668B2 (ja) * 2014-06-24 2020-03-11 花王株式会社 Ｕｃｐ−１発現促進剤
CA3002540C (en) 2015-01-06 2023-11-07 Arena Pharmaceuticals, Inc. Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor
JP6838744B2 (ja) 2015-06-22 2021-03-03 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩
JP7397011B2 (ja) 2018-06-06 2023-12-12 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｓ１ｐ１受容体に関連する状態を治療する方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB861428A (en) * 1958-07-14 1961-02-22 Searle & Co Improvements in or relating to indole derivatives
US4055658A (en) * 1976-05-17 1977-10-25 Mead Johnson & Company Cyanomethylphenethanolamines
US4338333A (en) * 1979-06-16 1982-07-06 Beecham Group Limited Ethanamine derivatives their preparation and use in pharmaceutical compositions
FR2541999B1 (fr) * 1983-03-04 1986-09-19 Bristol Myers Co Phenethanolamines et leurs utilisations
JPH06345731A (ja) * 1992-04-28 1994-12-20 Dainippon Pharmaceut Co Ltd ２−〔２−（インドール−３−イル）エチルアミノ〕−１−フェニルエタノール誘導体
JPH0634531A (ja) * 1992-07-14 1994-02-08 Yokogawa Electric Corp 赤外線水分計

Also Published As

Publication number Publication date
AU688165B2 (en) 1998-03-05
CN1070477C (zh) 2001-09-05
PT801059E (pt) 2001-10-30
ES2159648T3 (es) 2001-10-16
SK281865B6 (sk) 2001-08-06
IL116178A0 (en) 1996-01-31
DE69521529D1 (de) 2001-08-02
AU3936695A (en) 1996-06-19
CN1174549A (zh) 1998-02-25
TW349091B (en) 1999-01-01
FI972275A0 (fi) 1997-05-29
MX9703858A (es) 1997-09-30
HUT77308A (hu) 1998-03-30
NO309648B1 (no) 2001-03-05
CZ165597A3 (en) 1997-11-12
SK65697A3 (en) 1998-01-14
EP0801059A4 (de) 1998-01-21
KR100388747B1 (ko) 2004-03-30
DE69521529T2 (de) 2001-10-11
FI972275L (fi) 1997-05-29
US5817689A (en) 1998-10-06
RU2137759C1 (ru) 1999-09-20
CA2206307A1 (en) 1996-06-06
NZ295749A (en) 1998-05-27
RO118426B1 (ro) 2003-05-30
CZ290871B6 (cs) 2002-11-13
NO972427D0 (no) 1997-05-28
PL320461A1 (en) 1997-09-29
NO972427L (no) 1997-07-28
FI972275A7 (fi) 1997-05-29
WO1996016938A1 (en) 1996-06-06
ATE202559T1 (de) 2001-07-15
BR9509827A (pt) 1997-09-30
JP3100165B2 (ja) 2000-10-16
EP0801059B1 (de) 2001-06-27
EP0801059A1 (de) 1997-10-15
HK1003886A1 (en) 1998-11-13
DK0801059T3 (da) 2001-09-24
PL181963B1 (pl) 2001-10-31
ZA9510130B (en) 1996-06-11
CY2247B1 (en) 2003-07-04
GR3036148T3 (en) 2001-09-28

Similar Documents

Publication Publication Date Title
AU688165B2 (en) Indole derivative
DK1029861T3 (da) Benzisothiazol-piperazinylderivat og dets anvendelse som neuroleptikum
HU9202105D0 (en) Tetrahydro-pyrrholo(1,2-a)pyrazine-4-spiro-3'-pyrrholidine derivatives method for producing them and pharmaceutical preparatives containing them
DK0458551T3 (da) Spiro-isoquinolin-pyrrolidiner og analoge deraf, som er anvendelige som aldosereduktase-inhibitorer.
HUT52065A (en) Process for producing substituted imidazol derivatives and pharmaceutical compositions containing them
HUT50337A (en) Process for producing benzoxazine derivatives and pharmaceutical compositions comprising the compounds
HU902555D0 (en) Process for producing thiazole derivatives and fungicide preparatives containing thiazoles
FI940011A0 (fi) Mono- ja bis-alkyyliaminoantrasykliinit
GR3023381T3 (en) Process for preparing trans-piperidine-2,5-dicarboxylates
CA2042112A1 (en) N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
HU905000D0 (en) Process for producing compounds suitable for treatment of gastric ulcer
GR3023800T3 (en) Agent acting on the central nervous system, process for its preparation and pharmaceutical compositions containing it
ZA957699B (en) Bicyclic oxazole and thiazole substituted ethers
HUT50833A (en) Process for producing indolo/3,2-1-de/ /1,4/-oxazino/2,3,4-ij/ /1,5/-naphthyridine derivatives
GR3030952T3 (en) Salmycins, a process for their preparation and their use as a pharmaceutical.
HUT53638A (en) Process for producing 15-amino-substituted 20,21-dinoreburnamenie derivatives and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees