IL123036A - 1-phenyl-8-substituted-1,3,8-triaza-spiro¬4.5¾decan-4-one derivatives their preparation and pharmaceutical compositions containing them - Google Patents

1-phenyl-8-substituted-1,3,8-triaza-spiro¬4.5¾decan-4-one derivatives their preparation and pharmaceutical compositions containing them

Info

Publication number: IL123036A
Authority: IL; Israel
Prior art keywords: triaza; spiro; phenyl; derivatives; substituted
Prior art date: 1997-01-30

Application number

IL12303698A

Other languages

English (en)

Other versions

IL123036A0 (en

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-30

Filing date

1998-01-23

Publication date

2000-12-06

1998-01-23 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1998-09-24 Publication of IL123036A0 publication Critical patent/IL123036A0/xx

2000-12-06 Publication of IL123036A publication Critical patent/IL123036A/xx

Links

239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Rheumatology (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Photoreceptors In Electrophotography (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Lubricants (AREA)

IL12303698A 1997-01-30 1998-01-23 1-phenyl-8-substituted-1,3,8-triaza-spiro¬4.5¾decan-4-one derivatives their preparation and pharmaceutical compositions containing them IL123036A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97101409		1997-01-30
EP97119311		1997-11-05

Publications (2)

Publication Number	Publication Date
IL123036A0 IL123036A0 (en)	1998-09-24
IL123036A true IL123036A (en)	2000-12-06

Family

ID=26145196

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12303698A IL123036A (en)	1997-01-30	1998-01-23	1-phenyl-8-substituted-1,3,8-triaza-spiro¬4.5¾decan-4-one derivatives their preparation and pharmaceutical compositions containing them

Country Status (34)

Country	Link
US (1)	US6071925A (de)
EP (1)	EP0856514B1 (de)
JP (1)	JP3292457B2 (de)
KR (1)	KR100274107B1 (de)
CN (1)	CN1113881C (de)
AR (1)	AR011576A1 (de)
AT (1)	ATE202105T1 (de)
AU (1)	AU730147B2 (de)
BR (1)	BR9800524B1 (de)
CA (1)	CA2226058C (de)
CO (1)	CO4920223A1 (de)
CZ (1)	CZ27398A3 (de)
DE (1)	DE69800896T2 (de)
DK (1)	DK0856514T3 (de)
EA (1)	EA001357B1 (de)
ES (1)	ES2158622T3 (de)
GR (1)	GR3036523T3 (de)
HR (1)	HRP980043B1 (de)
HU (1)	HUP9800138A3 (de)
ID (1)	ID19773A (de)
IL (1)	IL123036A (de)
MA (1)	MA26470A1 (de)
NO (1)	NO310026B1 (de)
NZ (1)	NZ329627A (de)
PE (1)	PE59999A1 (de)
PL (1)	PL324571A1 (de)
PT (1)	PT856514E (de)
SG (1)	SG71077A1 (de)
SI (1)	SI0856514T1 (de)
TR (1)	TR199800085A2 (de)
TW (1)	TW457238B (de)
UY (1)	UY24865A1 (de)
YU (1)	YU2098A (de)
ZA (1)	ZA98570B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE212635T1 (de) *	1997-12-05	2002-02-15		1,3,8-triazaspiro(4,5)decan-4-on-derivate
SI0921125T1 (en) *	1997-12-05	2002-04-30	F. Hoffmann-La Roche Ag	1,3,8-Triazaspiro(4,5)decan-4-on derivatives
US6166209A (en) *	1997-12-11	2000-12-26	Hoffmann-La Roche Inc.	Piperidine derivatives
US6277991B1 (en)	1998-05-18	2001-08-21	Novo Nordisk A/S	1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
PT963985E (pt)	1998-06-12	2003-06-30	Hoffmann La Roche	Derivados de di- ou triaza-espiro(4,5)decano
PT963987E (pt) *	1998-06-12	2003-01-31	Hoffmann La Roche	Spiro(piperidina-4,1'-pirrolo(3,4-c)pirrolo)
US6262066B1 (en) *	1998-07-27	2001-07-17	Schering Corporation	High affinity ligands for nociceptin receptor ORL-1
ID29137A (id) *	1998-07-27	2001-08-02	Schering Corp	Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
CO5150201A1 (es) *	1998-09-07	2002-04-29	Hoffmann La Roche	Derivados de piperidina
DE69923744T2 (de) *	1998-10-23	2006-02-23	Pfizer Inc.	1,3,8-Triazaspiro[4,5] decanon Verbindungen als orl1-receptor Agonisten
WO2000031061A1 (en) *	1998-11-20	2000-06-02	Banyu Pharmaceutical Co., Ltd.	2-oxoimidazole derivatives
GB9900078D0 (en) *	1999-01-05	1999-02-24	Zeneca Ltd	Chemical compounds
GB9914024D0 (en) *	1999-06-17	1999-08-18	Zeneca Ltd	Chemical compounds
AU1382901A (en) *	1999-11-17	2001-05-30	Novo Nordisk A/S	Novel triazaspirodecanones with high affinity for opioid receptor subtypes
US6686370B2 (en)	1999-12-06	2004-02-03	Euro-Celtique S.A.	Triazospiro compounds having nociceptin receptor affinity
WO2001072710A1 (en) *	2000-03-31	2001-10-04	Nippon Shinyaku Co., Ltd.	Heterocycle derivatives and drugs
CA2443868C (en) *	2001-04-10	2011-01-25	Ortho-Mcneil Pharmaceutical, Inc.	1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders
US20030040479A1 (en) *	2001-07-02	2003-02-27	Omeros Corporation	Rotational intrathecal analgesia method and device
JP2005502619A (ja)	2001-07-02	2005-01-27	オメロスコーポレイション	オピオイドレセプター様レセプター１アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
JP4056977B2 (ja)	2002-03-29	2008-03-05	田辺三菱製薬株式会社	睡眠障害治療薬
US6995168B2 (en)	2002-05-31	2006-02-07	Euro-Celtique S.A.	Triazaspiro compounds useful for treating or preventing pain
JP4712384B2 (ja) *	2002-09-09	2011-06-29	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体
EP1628978A2 (de) *	2003-05-23	2006-03-01	Zealand Pharma A/S	Triaza-spiro-verbindungen als nociceptin-analoga und deren verwendung
AR045939A1 (es)	2003-09-25	2005-11-16	Solvay Pharm Bv	Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos
US20060178390A1 (en) *	2004-08-02	2006-08-10	Alfonzo Jordan	1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
DE102006046745A1 (de) *	2006-09-29	2008-04-03	Grünenthal GmbH	Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
US8703948B2 (en) *	2006-11-28	2014-04-22	Janssen Pharmaceutica Nv	Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
BRPI0808025A2 (pt)	2007-03-01	2014-06-24	Mitsubishi Tanabe Pharma Corp	Composto de benzimidazol e uso farmacêutico do mesmo
CA2683598C (en) *	2007-04-09	2015-11-17	Janssen Pharmaceutica Nv	1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
TW201016675A (en) *	2008-09-16	2010-05-01	Mitsubishi Tanabe Pharma Corp	Crystalline benzoimidazole compound and salt thereof
CN108883103A (zh) *	2015-12-02	2018-11-23	阿斯特来亚治疗有限责任公司	哌啶基痛敏肽受体化合物
US10112924B2 (en)	2015-12-02	2018-10-30	Astraea Therapeutics, Inc.	Piperdinyl nociceptin receptor compounds
CN106397225A (zh) *	2016-09-04	2017-02-15	王际菊	一种手性化合物的制备方法
CN106467476A (zh) *	2016-09-04	2017-03-01	王际菊	一种左旋胺基化合物的合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US488082A (en) *		1892-12-13		Automatic gut-off for gas bxxenees
JPS5212171A (en) *	1975-07-17	1977-01-29	Yoshitomi Pharmaceut Ind Ltd	Process for preparation of cyclohexane derivatives
US4076821A (en) *	1976-02-27	1978-02-28	Yoshitomi Pharmaceutical Industries, Ltd.	4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof
US4160836A (en) *	1976-05-17	1979-07-10	Janssen Pharmaceutica N.V.	Antiemetic 1-(benzothiazolylalkyl)piperidine derivatives
US4329353A (en) *	1980-10-22	1982-05-11	Janssen Pharmaceutica, N.V.	1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
SU1095878A3 (ru) *	1980-10-22	1984-05-30	Жансен Фармасетика Н.В. (Фирма)	Способ получени производных 1-(4-арилциклогексил)пиперидина или их фармацевтически пригодных солей или их стереоизомерных форм
US4374245A (en) *	1982-04-09	1983-02-15	Hoechst-Roussel Pharmaceuticals Inc.	8-[3-(6-Fluoro-1,2-benzisoxazol-3-yl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
JPS6012357B2 (ja) *	1984-01-23	1985-04-01	吉富製薬株式会社	脂環式誘導体
US4707484A (en) *	1986-11-25	1987-11-17	Hoffmann-La Roche Inc.	Substituted piperidinomethylindolone and cyclopent(b)indolone derivatives
US5153225A (en) *	1986-12-10	1992-10-06	Bayer Aktiengesellschaft	Substituted basic 2-aminotetralin in pharmaceuticals
DE3718317A1 (de) *	1986-12-10	1988-06-16	Bayer Ag	Substituierte basische 2-aminotetraline
US5039804A (en) *	1989-12-13	1991-08-13	Glaxo Inc.	Preparation of substituted alkali metal piperidine-4-carboxylates
DE4135473A1 (de) *	1991-10-28	1993-04-29	Bayer Ag	Triazaspirodecanon-methylchromane
DE4405178A1 (de) *	1994-02-18	1995-08-24	Hoechst Ag	Substituierte 1,3,8-Triaza-spiro(4,5)-decan-4-on-Derivate als Vorstufen zur Herstellung von Pharmazeutika

1997
- 1997-12-31 CA CA002226058A patent/CA2226058C/en not_active Expired - Fee Related
1998
- 1998-01-07 SG SG1998000062A patent/SG71077A1/en unknown
- 1998-01-15 YU YU2098A patent/YU2098A/sh unknown
- 1998-01-20 TR TR1998/00085A patent/TR199800085A2/xx unknown
- 1998-01-20 US US09/009,457 patent/US6071925A/en not_active Expired - Fee Related
- 1998-01-21 PT PT98100970T patent/PT856514E/pt unknown
- 1998-01-21 AT AT98100970T patent/ATE202105T1/de active
- 1998-01-21 SI SI9830035T patent/SI0856514T1/xx unknown
- 1998-01-21 DK DK98100970T patent/DK0856514T3/da active
- 1998-01-21 EP EP98100970A patent/EP0856514B1/de not_active Expired - Lifetime
- 1998-01-21 DE DE69800896T patent/DE69800896T2/de not_active Expired - Lifetime
- 1998-01-21 ES ES98100970T patent/ES2158622T3/es not_active Expired - Lifetime
- 1998-01-22 ID IDP980073A patent/ID19773A/id unknown
- 1998-01-23 NZ NZ329627A patent/NZ329627A/xx unknown
- 1998-01-23 IL IL12303698A patent/IL123036A/xx not_active IP Right Cessation
- 1998-01-23 ZA ZA98570A patent/ZA98570B/xx unknown
- 1998-01-23 CN CN98103687A patent/CN1113881C/zh not_active Expired - Fee Related
- 1998-01-26 NO NO980332A patent/NO310026B1/no not_active IP Right Cessation
- 1998-01-26 HU HU9800138A patent/HUP9800138A3/hu unknown
- 1998-01-27 PE PE1998000056A patent/PE59999A1/es not_active Application Discontinuation
- 1998-01-27 JP JP01371198A patent/JP3292457B2/ja not_active Expired - Fee Related
- 1998-01-27 AR ARP980100349A patent/AR011576A1/es active IP Right Grant
- 1998-01-27 HR HR980043A patent/HRP980043B1/xx not_active IP Right Cessation
- 1998-01-28 MA MA24950A patent/MA26470A1/fr unknown
- 1998-01-28 CO CO98003944A patent/CO4920223A1/es unknown
- 1998-01-29 AU AU52809/98A patent/AU730147B2/en not_active Ceased
- 1998-01-29 UY UY24865A patent/UY24865A1/es unknown
- 1998-01-29 PL PL98324571A patent/PL324571A1/xx unknown
- 1998-01-29 CZ CZ98273A patent/CZ27398A3/cs unknown
- 1998-01-30 BR BRPI9800524-3A patent/BR9800524B1/pt not_active IP Right Cessation
- 1998-01-30 EA EA199800108A patent/EA001357B1/ru not_active IP Right Cessation
- 1998-01-30 KR KR1019980002475A patent/KR100274107B1/ko not_active Expired - Fee Related
- 1998-02-04 TW TW087101434A patent/TW457238B/zh not_active IP Right Cessation
2001
- 2001-09-05 GR GR20010401383T patent/GR3036523T3/el unknown

Also Published As

Publication number	Publication date
PE59999A1 (es)	1999-07-01
MA26470A1 (fr)	2004-12-20
DE69800896T2 (de)	2002-03-28
TW457238B (en)	2001-10-01
ZA98570B (en)	1998-07-30
KR100274107B1 (ko)	2000-12-15
EP0856514A1 (de)	1998-08-05
ATE202105T1 (de)	2001-06-15
TR199800085A3 (tr)	1998-08-21
AU5280998A (en)	1998-08-06
AU730147B2 (en)	2001-03-01
HUP9800138A3 (en)	1999-03-01
ID19773A (id)	1998-07-30
UY24865A1 (es)	2000-12-29
CN1191862A (zh)	1998-09-02
JP3292457B2 (ja)	2002-06-17
BR9800524B1 (pt)	2008-11-18
DK0856514T3 (da)	2001-09-17
US6071925A (en)	2000-06-06
EA001357B1 (ru)	2001-02-26
CA2226058A1 (en)	1998-07-30
SG71077A1 (en)	2000-03-21
AR011576A1 (es)	2000-08-30
NO980332D0 (no)	1998-01-26
DE69800896D1 (de)	2001-07-19
CA2226058C (en)	2008-01-29
NO310026B1 (no)	2001-05-07
TR199800085A2 (xx)	1998-08-21
CZ27398A3 (cs)	1998-08-12
KR19980070900A (ko)	1998-10-26
YU2098A (sh)	2001-03-07
CO4920223A1 (es)	2000-05-29
JPH10212290A (ja)	1998-08-11
PT856514E (pt)	2001-10-31
GR3036523T3 (en)	2001-12-31
HRP980043B1 (en)	2001-12-31
IL123036A0 (en)	1998-09-24
EP0856514B1 (de)	2001-06-13
CN1113881C (zh)	2003-07-09
NZ329627A (en)	1999-11-29
HRP980043A2 (en)	1998-12-31
EA199800108A1 (ru)	1998-10-29
HUP9800138A2 (hu)	1998-09-28
BR9800524A (pt)	2000-03-14
ES2158622T3 (es)	2001-09-01
PL324571A1 (en)	1998-08-03
HU9800138D0 (en)	1998-03-30
SI0856514T1 (en)	2001-08-31
NO980332L (no)	1998-07-31

Legal Events

Date	Code	Title
2001-04-30	FF	Patent granted
2001-07-24	KB	Patent renewed
2004-09-27	RH1	Patent not in force

Publication	Publication Date	Title
IL123036A (en)	2000-12-06	1-phenyl-8-substituted-1,3,8-triaza-spiro¬4.5¾decan-4-one derivatives their preparation and pharmaceutical compositions containing them
IL134961A0 (en)	2001-05-20	Carboxamidothiazole derivatives, preparation, pharmaceutical compositions containing them
HUP0002272A3 (en)	2002-03-28	Aroyl-piperazine derivatives, their preparation pharmaceutical compositions containing them and their use
IL123648A0 (en)	1998-10-30	1,4-Benzothiazepine-1,1-dioxides their preparation and pharmaceutical compositions containing them
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