IL124652A - Screening assay for compounds stimulating somatostatin and insulin production - Google Patents

Screening assay for compounds stimulating somatostatin and insulin production

Info

Publication number: IL124652A
Authority: IL; Israel
Prior art keywords: insulin production; screening assay; compounds; binding; somatostatin
Prior art date: 1995-11-30

Application number

IL12465296A

Other languages

English (en)

Other versions

IL124652A0 (en

Inventor

Marc R Montminy

Bernard Peers

Original Assignee

Res Dev Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-30

Filing date

1996-11-27

Publication date

2000-11-21

1996-11-27 Application filed by Res Dev Foundation filed Critical Res Dev Foundation

1998-12-06 Publication of IL124652A0 publication Critical patent/IL124652A0/xx

2000-11-21 Publication of IL124652A publication Critical patent/IL124652A/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 4
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
102000005157 Somatostatin Human genes 0.000 title abstract 2
108010056088 Somatostatin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
229960000553 somatostatin Drugs 0.000 title abstract 2
230000004936 stimulating effect Effects 0.000 title abstract 2
238000007423 screening assay Methods 0.000 title 1
108010048349 Steroidogenic Factor 1 Proteins 0.000 abstract 2
102100029856 Steroidogenic factor 1 Human genes 0.000 abstract 2
230000027455 binding Effects 0.000 abstract 2
238000012287 DNA Binding Assay Methods 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000003278 mimic effect Effects 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
230000000087 stabilizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Analytical Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Hematology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Cell Biology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Peptides Or Proteins (AREA)

IL12465296A 1995-11-30 1996-11-27 Screening assay for compounds stimulating somatostatin and insulin production IL124652A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US772295P	1995-11-30	1995-11-30
PCT/US1996/019009 WO1997020075A1 (en)	1995-11-30	1996-11-27	Screening assay for compounds stimulating somatostatin and insulin production

Publications (2)

Publication Number	Publication Date
IL124652A0 IL124652A0 (en)	1998-12-06
IL124652A true IL124652A (en)	2000-11-21

Family

ID=21727790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12465296A IL124652A (en)	1995-11-30	1996-11-27	Screening assay for compounds stimulating somatostatin and insulin production

Country Status (14)

Country	Link
US (1)	US5849493A (de)
EP (1)	EP0954598B1 (de)
JP (1)	JP2000501290A (de)
KR (1)	KR100456183B1 (de)
CN (1)	CN1117876C (de)
AT (1)	ATE321880T1 (de)
AU (1)	AU719614B2 (de)
CA (1)	CA2237717C (de)
DE (1)	DE69635998D1 (de)
IL (1)	IL124652A (de)
NZ (1)	NZ324951A (de)
RU (1)	RU2178714C2 (de)
WO (1)	WO1997020075A1 (de)
ZA (1)	ZA9610080B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5427905A (en)	1994-07-13	1995-06-27	Polaroid Corporation	Thermally processable image-recording material including reductone developing agent
US5849989A (en) *	1994-10-07	1998-12-15	Ontogeny, Inc.	Insulin promoter factor, and uses related thereto
US6774120B1 (en) *	1999-06-01	2004-08-10	Sarah Ferber	Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US8778899B2 (en)	1999-06-01	2014-07-15	Sarah Ferber	Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US6924113B2 (en)	2001-06-08	2005-08-02	Panomics, Inc.	Method and kit for isolating DNA probes that bind to activated transcription factors
US6696256B1 (en) *	2001-06-08	2004-02-24	Pandmics, Inc.	Method, array and kit for detecting activated transcription factors by hybridization array
US6821737B2 (en)	2001-06-08	2004-11-23	Panomics, Inc.	Method for screening for drug candidates for modulating transcription factor activity
US7981842B2 (en)	2001-06-08	2011-07-19	Panomics, Inc.	Method for detecting transcription factor-protein interactions
US20040214166A1 (en) *	2001-06-08	2004-10-28	Xianqiang Li	Method for identifying a disease state based on a detected mixture of activated transcription factors
US6642003B2 (en)	2001-08-02	2003-11-04	Cedars-Sinai Medical Center	Human glucose-dependent insulin-secreting cell line
US20030143547A1 (en) *	2002-01-24	2003-07-31	Xianqiang Li	Method for identifying multiple activated transcription factors
US7141240B2 (en) *	2002-03-12	2006-11-28	Cedars-Sinai Medical Center	Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
EP1706134A2 (de) *	2004-01-20	2006-10-04	DeveloGen Aktiengesellschaft	Verwendung von proteinprodukten zur prophylaxe und therapie von pankreas-erkrankungen und/oder fettleibigkeit und/oder stoffwechselsyndrom
EP2558622A4 (de)	2010-04-06	2013-07-24	Univ George Washington	Zusammensetzungen und verfahren zur identifikation von störungen aus dem autismusspektrum
US9205241B2 (en)	2011-07-12	2015-12-08	Warsaw Orthopedic, Inc.	Medical devices and methods comprising an adhesive material
US9132194B2 (en)	2011-07-12	2015-09-15	Warsaw Orthopedic, Inc.	Medical devices and methods comprising an adhesive sheet containing a drug depot
JP6650393B2 (ja)	2013-06-13	2020-02-19	オージェネシスリミテッド	細胞の集団、分化転換の方法及びその使用方法
MA41296A (fr)	2014-12-30	2017-11-07	Orgenesis Ltd	Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
WO2018017657A1 (en) *	2016-07-20	2018-01-25	The Johns Hopkins University	Oxygen gradient hydrogel drug screening
EP3635106A4 (de)	2017-05-08	2021-01-06	Orgenesis Ltd.	Transdifferenzierte zellpopulationen und verfahren zur verwendung davon

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3802051B2 (ja) *	1993-08-16	2006-07-26	リサーチディベロップメントファンデーション	膵臓島細胞におけるインシュリン表現を刺激する新しいホメオボックス因子
US5612455A (en) *	1994-07-05	1997-03-18	Tularik, Inc.	Nuclear factors and binding assay

1996
- 1996-11-27 JP JP9520666A patent/JP2000501290A/ja not_active Ceased
- 1996-11-27 US US08/757,316 patent/US5849493A/en not_active Expired - Lifetime
- 1996-11-27 DE DE69635998T patent/DE69635998D1/de not_active Expired - Lifetime
- 1996-11-27 KR KR10-1998-0704076A patent/KR100456183B1/ko not_active Expired - Fee Related
- 1996-11-27 AU AU12749/97A patent/AU719614B2/en not_active Ceased
- 1996-11-27 RU RU98112015/14A patent/RU2178714C2/ru not_active IP Right Cessation
- 1996-11-27 AT AT96943530T patent/ATE321880T1/de not_active IP Right Cessation
- 1996-11-27 IL IL12465296A patent/IL124652A/xx not_active IP Right Cessation
- 1996-11-27 NZ NZ324951A patent/NZ324951A/en not_active IP Right Cessation
- 1996-11-27 EP EP96943530A patent/EP0954598B1/de not_active Expired - Lifetime
- 1996-11-27 CA CA2237717A patent/CA2237717C/en not_active Expired - Fee Related
- 1996-11-27 WO PCT/US1996/019009 patent/WO1997020075A1/en not_active Ceased
- 1996-11-27 CN CN96198630A patent/CN1117876C/zh not_active Expired - Fee Related
- 1996-11-29 ZA ZA9610080A patent/ZA9610080B/xx unknown

Also Published As

Publication number	Publication date
CN1117876C (zh)	2003-08-13
ZA9610080B (en)	1998-05-29
AU719614B2 (en)	2000-05-11
US5849493A (en)	1998-12-15
EP0954598B1 (de)	2006-03-29
CA2237717C (en)	2010-07-27
EP0954598A1 (de)	1999-11-10
JP2000501290A (ja)	2000-02-08
NZ324951A (en)	1999-04-29
KR100456183B1 (ko)	2005-06-13
CA2237717A1 (en)	1997-06-05
DE69635998D1 (de)	2006-05-18
IL124652A0 (en)	1998-12-06
AU1274997A (en)	1997-06-19
EP0954598A4 (de)	2002-10-30
RU2178714C2 (ru)	2002-01-27
CN1202936A (zh)	1998-12-23
KR19990071797A (ko)	1999-09-27
ATE321880T1 (de)	2006-04-15
WO1997020075A1 (en)	1997-06-05

Legal Events

Date	Code	Title
2001-04-30	FF	Patent granted
2001-07-24	KB	Patent renewed
2003-02-12	KB	Patent renewed
2006-12-27	KB	Patent renewed
2010-12-30	KB	Patent renewed
2015-06-30	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL124652A0 (en)	1998-12-06	Screening assay for compounds stimulating somatostatin and insulin production
IL184795A0 (en)	2007-12-03	Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction
DE3869969D1 (de)	1992-05-21	Versuchsmethode unter verwendung von partikeln mit assoziiertem, fluoreszierendem stoff.
ATE408422T1 (de)	2008-10-15	Methode zur hemmung immunstimulatorischer mit dna assoziierter antworten
HUT75825A (en)	1997-05-28	Protocadherin proteins and their uses
ID22852A (id)	1999-12-09	Bahan-bahan biokontrol antifungi, proses untuk membuatnya dan memperlakukannya
DE69941701D1 (de)	2010-01-07	Mutanten von flt3-l und ihre verwendungen
DK1870465T3 (da)	2010-05-17	Fremgangsmåde til chemokinreceptor 88C
DE58902183D1 (de)	1992-10-08	Verfahren zur reinigung von rohem, gasfoermigem chlorwasserstoff.
ATE250426T1 (de)	2003-10-15	Verwendung von verbindungen die an ein zytoplasmatischen dipeptidase binden zur potenzierung des immunantworts
CA2111573A1 (en)	1993-10-28	Cadherin materials and methods
DE69007997D1 (de)	1994-05-19	Sieb-Konstruktion zum Reinigung von elastomeren Materialien.
PT1137413E (pt)	2005-05-31	Antagonistas nao-peptidicos do receptor de glp-1 e metodos de utilizacao
DE3765125D1 (de)	1990-10-31	Seismischer schwingungserzeuger zur kombinierten erregung von kompressions- und schubwellen.
DE19681439T1 (de)	1998-07-23	Modifizierung von Polypeptidarzneimitteln zur Erhöhung des Elektrotransportflusses
DE69618095D1 (de)	2002-01-31	Vorrichtung zum Zuführen von flachen Materialien
ATE247530T1 (de)	2003-09-15	Verfahren zur verstärkung der farben von mineralen, die als edelsteine benutzt werden
DE69807136D1 (de)	2002-09-19	Verfahren zur Identifizierung von Substanzen, die die Bindung von TL2 (TRAIL) an TR5 hemmen oder stimulieren.
WO2002018941A3 (en)	2002-09-26	Screen for glutamate reuptake inhibitors, stimulators, and modulators
DE59800472D1 (de)	2001-03-22	Reaktionsmischung zur Abdichtung von Rohrverbindungen, Sanierverfahren und Verwendung
WO2000077208A3 (en)	2001-03-01	Gustatory receptors in drosophila
DE69013466D1 (de)	1994-11-24	Materialien zum Trennen von suspendierten Verunreinigungen Materialien zum Trennung von suspendierten Verunreinigungen.
DE3480943D1 (de)	1990-02-08	Verfahren zur errichtung von aus gussfaehigen materialien insbesondere beton bestehenden baukoerpern und vorrichtung zur durchfuehrung des verfahrens.
GB2299771B (en)	1998-04-15	Improved shale shaker
AU6451998A (en)	1998-09-22	Screening and treatment using complement regulator or receptor proteins