ZA9610080B - Screening assay for compounds stimulating somatostatin and insulin production. - Google Patents

Screening assay for compounds stimulating somatostatin and insulin production.

Info

Publication number: ZA9610080B
Authority: ZA; South Africa
Prior art keywords: insulin production; screening assay; compounds; binding; somatostatin
Prior art date: 1995-11-30

Application number

ZA9610080A

Other languages

English (en)

Inventor

Marc R Montminy

Bernard Peers

Original Assignee

Res Dev Foundation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-30

Filing date

1996-11-29

Publication date

1998-05-29

1996-11-29 Application filed by Res Dev Foundation filed Critical Res Dev Foundation

1998-05-29 Publication of ZA9610080B publication Critical patent/ZA9610080B/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 4
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
102000005157 Somatostatin Human genes 0.000 title abstract 2
108010056088 Somatostatin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
229960000553 somatostatin Drugs 0.000 title abstract 2
230000004936 stimulating effect Effects 0.000 title abstract 2
238000007423 screening assay Methods 0.000 title 1
108010048349 Steroidogenic Factor 1 Proteins 0.000 abstract 2
102100029856 Steroidogenic factor 1 Human genes 0.000 abstract 2
230000027455 binding Effects 0.000 abstract 2
238000012287 DNA Binding Assay Methods 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000003278 mimic effect Effects 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
230000000087 stabilizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Analytical Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Hematology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Cell Biology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Peptides Or Proteins (AREA)

ZA9610080A 1995-11-30 1996-11-29 Screening assay for compounds stimulating somatostatin and insulin production. ZA9610080B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US772295P	1995-11-30	1995-11-30

Publications (1)

Publication Number	Publication Date
ZA9610080B true ZA9610080B (en)	1998-05-29

Family

ID=21727790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9610080A ZA9610080B (en)	1995-11-30	1996-11-29	Screening assay for compounds stimulating somatostatin and insulin production.

Country Status (14)

Country	Link
US (1)	US5849493A (de)
EP (1)	EP0954598B1 (de)
JP (1)	JP2000501290A (de)
KR (1)	KR100456183B1 (de)
CN (1)	CN1117876C (de)
AT (1)	ATE321880T1 (de)
AU (1)	AU719614B2 (de)
CA (1)	CA2237717C (de)
DE (1)	DE69635998D1 (de)
IL (1)	IL124652A (de)
NZ (1)	NZ324951A (de)
RU (1)	RU2178714C2 (de)
WO (1)	WO1997020075A1 (de)
ZA (1)	ZA9610080B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5427905A (en)	1994-07-13	1995-06-27	Polaroid Corporation	Thermally processable image-recording material including reductone developing agent
US5849989A (en) *	1994-10-07	1998-12-15	Ontogeny, Inc.	Insulin promoter factor, and uses related thereto
US8778899B2 (en)	1999-06-01	2014-07-15	Sarah Ferber	Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US6774120B1 (en) *	1999-06-01	2004-08-10	Sarah Ferber	Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US6696256B1 (en)	2001-06-08	2004-02-24	Pandmics, Inc.	Method, array and kit for detecting activated transcription factors by hybridization array
US6924113B2 (en)	2001-06-08	2005-08-02	Panomics, Inc.	Method and kit for isolating DNA probes that bind to activated transcription factors
US6821737B2 (en)	2001-06-08	2004-11-23	Panomics, Inc.	Method for screening for drug candidates for modulating transcription factor activity
US7981842B2 (en)	2001-06-08	2011-07-19	Panomics, Inc.	Method for detecting transcription factor-protein interactions
US20040214166A1 (en) *	2001-06-08	2004-10-28	Xianqiang Li	Method for identifying a disease state based on a detected mixture of activated transcription factors
US6642003B2 (en)	2001-08-02	2003-11-04	Cedars-Sinai Medical Center	Human glucose-dependent insulin-secreting cell line
US20030143547A1 (en) *	2002-01-24	2003-07-31	Xianqiang Li	Method for identifying multiple activated transcription factors
US7141240B2 (en) *	2002-03-12	2006-11-28	Cedars-Sinai Medical Center	Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
EP1706134A2 (de) *	2004-01-20	2006-10-04	DeveloGen Aktiengesellschaft	Verwendung von proteinprodukten zur prophylaxe und therapie von pankreas-erkrankungen und/oder fettleibigkeit und/oder stoffwechselsyndrom
WO2011127194A1 (en)	2010-04-06	2011-10-13	The George Washington University	Compositions and methods for identifying autism spectrum disorders
US9205241B2 (en)	2011-07-12	2015-12-08	Warsaw Orthopedic, Inc.	Medical devices and methods comprising an adhesive material
US9132194B2 (en)	2011-07-12	2015-09-15	Warsaw Orthopedic, Inc.	Medical devices and methods comprising an adhesive sheet containing a drug depot
BR112015031253B1 (pt)	2013-06-13	2021-09-28	Orgenesis Ltd.	Método para produção de uma população de células transdiferenciada
MA41296A (fr)	2014-12-30	2017-11-07	Orgenesis Ltd	Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
US11530381B2 (en) *	2016-07-20	2022-12-20	The Johns Hopkins University	Oxygen gradient hydrogel drug screening
WO2018207179A1 (en)	2017-05-08	2018-11-15	Orgenesis Ltd.	Transdifferentiated cell populations and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0714438B1 (de) *	1993-08-16	2007-09-19	RESEARCH DEVELOPMENT FOUNDATION (a Nevada corporation)	Ein homeobox-faktor der insulin-expression in pankreatischen inselnzellen stimuliert
US5612455A (en) *	1994-07-05	1997-03-18	Tularik, Inc.	Nuclear factors and binding assay

1996
- 1996-11-27 AT AT96943530T patent/ATE321880T1/de not_active IP Right Cessation
- 1996-11-27 AU AU12749/97A patent/AU719614B2/en not_active Ceased
- 1996-11-27 JP JP9520666A patent/JP2000501290A/ja not_active Ceased
- 1996-11-27 KR KR10-1998-0704076A patent/KR100456183B1/ko not_active Expired - Fee Related
- 1996-11-27 IL IL12465296A patent/IL124652A/xx not_active IP Right Cessation
- 1996-11-27 US US08/757,316 patent/US5849493A/en not_active Expired - Lifetime
- 1996-11-27 RU RU98112015/14A patent/RU2178714C2/ru not_active IP Right Cessation
- 1996-11-27 NZ NZ324951A patent/NZ324951A/en not_active IP Right Cessation
- 1996-11-27 CN CN96198630A patent/CN1117876C/zh not_active Expired - Fee Related
- 1996-11-27 CA CA2237717A patent/CA2237717C/en not_active Expired - Fee Related
- 1996-11-27 DE DE69635998T patent/DE69635998D1/de not_active Expired - Lifetime
- 1996-11-27 WO PCT/US1996/019009 patent/WO1997020075A1/en not_active Ceased
- 1996-11-27 EP EP96943530A patent/EP0954598B1/de not_active Expired - Lifetime
- 1996-11-29 ZA ZA9610080A patent/ZA9610080B/xx unknown

Also Published As

Publication number	Publication date
WO1997020075A1 (en)	1997-06-05
NZ324951A (en)	1999-04-29
IL124652A0 (en)	1998-12-06
AU719614B2 (en)	2000-05-11
EP0954598B1 (de)	2006-03-29
ATE321880T1 (de)	2006-04-15
US5849493A (en)	1998-12-15
KR100456183B1 (ko)	2005-06-13
KR19990071797A (ko)	1999-09-27
RU2178714C2 (ru)	2002-01-27
JP2000501290A (ja)	2000-02-08
CA2237717A1 (en)	1997-06-05
CN1202936A (zh)	1998-12-23
EP0954598A4 (de)	2002-10-30
IL124652A (en)	2000-11-21
DE69635998D1 (de)	2006-05-18
CA2237717C (en)	2010-07-27
CN1117876C (zh)	2003-08-13
AU1274997A (en)	1997-06-19
EP0954598A1 (de)	1999-11-10

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IL124652A (en)	2000-11-21	Screening assay for compounds stimulating somatostatin and insulin production
IL184795A0 (en)	2007-12-03	Nucleic acids encoding a g-protein coupled receptor involved in sensory transduction
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DE69941701D1 (de)	2010-01-07	Mutanten von flt3-l und ihre verwendungen
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ATE250426T1 (de)	2003-10-15	Verwendung von verbindungen die an ein zytoplasmatischen dipeptidase binden zur potenzierung des immunantworts
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CA2111573A1 (en)	1993-10-28	Cadherin materials and methods
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ES2148967T3 (es)	2000-10-16	Sustancias y metodos destinados al diagnostico y al tratamiento de la pre-eclampsia.
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DE59800472D1 (de)	2001-03-22	Reaktionsmischung zur Abdichtung von Rohrverbindungen, Sanierverfahren und Verwendung
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