IL126295A - Piperazine and piperidine compounds, a method for their preparation, pharmaceutical compositions comprising them and their use is treating a cns disorder - Google Patents

Piperazine and piperidine compounds, a method for their preparation, pharmaceutical compositions comprising them and their use is treating a cns disorder

Info

Publication number
IL126295A
IL126295A IL12629598A IL12629598A IL126295A IL 126295 A IL126295 A IL 126295A IL 12629598 A IL12629598 A IL 12629598A IL 12629598 A IL12629598 A IL 12629598A IL 126295 A IL126295 A IL 126295A
Authority
IL
Israel
Prior art keywords
piperazine
treating
preparation
pharmaceutical compositions
piperidine compounds
Prior art date
Application number
IL12629598A
Other languages
English (en)
Other versions
IL126295A0 (en
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of IL126295A0 publication Critical patent/IL126295A0/xx
Publication of IL126295A publication Critical patent/IL126295A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
IL12629598A 1997-09-24 1998-09-18 Piperazine and piperidine compounds, a method for their preparation, pharmaceutical compositions comprising them and their use is treating a cns disorder IL126295A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97202950 1997-09-24

Publications (2)

Publication Number Publication Date
IL126295A0 IL126295A0 (en) 1999-05-09
IL126295A true IL126295A (en) 2003-02-12

Family

ID=8228755

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12629598A IL126295A (en) 1997-09-24 1998-09-18 Piperazine and piperidine compounds, a method for their preparation, pharmaceutical compositions comprising them and their use is treating a cns disorder

Country Status (30)

Country Link
US (2) US6090812A (de)
EP (1) EP0908458B1 (de)
JP (1) JP4191826B2 (de)
KR (1) KR100632188B1 (de)
CN (1) CN1093857C (de)
AR (1) AR017127A1 (de)
AT (1) ATE316529T1 (de)
AU (1) AU733526B2 (de)
BR (1) BR9803497A (de)
CA (1) CA2247734C (de)
CY (1) CY1107494T1 (de)
CZ (1) CZ296741B6 (de)
DE (1) DE69833297T2 (de)
DK (1) DK0908458T3 (de)
DZ (1) DZ2613A1 (de)
ES (1) ES2255127T3 (de)
HU (1) HU227422B1 (de)
ID (1) ID20895A (de)
IL (1) IL126295A (de)
NO (1) NO312835B1 (de)
NZ (1) NZ331984A (de)
PL (1) PL190622B1 (de)
PT (1) PT908458E (de)
RU (1) RU2197488C2 (de)
SI (1) SI0908458T1 (de)
SK (1) SK285205B6 (de)
TR (1) TR199801866A1 (de)
TW (1) TW530054B (de)
UA (1) UA66756C2 (de)
ZA (1) ZA988749B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6200994B1 (en) 1999-01-07 2001-03-13 American Home Products Corp 1,4-Disubstituted cyclohexane derivatives for the treatment of depression
ATE223406T1 (de) * 1999-01-07 2002-09-15 Wyeth Corp 1,4-disubstitutierte cyclohexanderivate zur behandlung von depression
DE10005150A1 (de) * 2000-02-07 2001-08-09 Merck Patent Gmbh Verfahren zur Herstellung von 5-Arylnicotinaldehyden
US6911448B2 (en) * 2000-05-12 2005-06-28 Solvay Pharmaceuticals B.V. Piperazine and piperidine compounds
DE10115922A1 (de) * 2001-03-30 2002-10-10 Bayer Ag Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
US7504395B2 (en) * 2001-07-20 2009-03-17 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder
US7435738B2 (en) 2003-08-18 2008-10-14 Solvay Pharmaceuticals, Inc. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7405216B2 (en) 2004-08-18 2008-07-29 Solvay Pharmaceuticals, B.V. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7423040B2 (en) 2005-02-18 2008-09-09 Irene Eijgendaal Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
US7964604B2 (en) 2005-02-18 2011-06-21 Solvay Pharmaceuticals B.V. Bifeprunox mesylate maintenance dose compositions and methods for using the same
AU2007247251B2 (en) 2006-05-02 2011-11-03 Solvay Pharmaceuticals B.V. N-oxides of pyridylmethylpiperazine and -piperidine derivatives
US20070275977A1 (en) * 2006-05-02 2007-11-29 Van Aar Marcel P N-oxides of pyridylmethyl -piperazine and -piperidine derivatives
US7786126B2 (en) 2006-06-16 2010-08-31 Solvay Pharmaceuticals B.V. Combination preparations comprising SLV308 and a dopamine agonist
US8106056B2 (en) 2006-06-16 2012-01-31 Solvay Pharmaceuticals B.V. Combination preparations comprising bifeprunox and a dopamine agonist
WO2011088838A1 (en) 2010-01-25 2011-07-28 H. Lundbeck A/S Novel 6,6a,7,8,9,10-hexahydro-4h-4,8,10a-triaza-acephenanthrylene derivatives as dopamine d2 ligands
US8877778B2 (en) * 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
US8921397B2 (en) 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds
JP7030776B2 (ja) 2016-07-20 2022-03-07 ノバルティス アーゲー アミノピリジン誘導体およびそれらの選択的ａｌｋ－２阻害剤としての使用
KR101665971B1 (ko) 2016-08-10 2016-10-13 (주)글로벌 로보틱스 차량용 발포패드 부착장치
BR112022009710A2 (pt) 2019-11-22 2022-08-09 Incyte Corp Terapia de combinação compreendendo um inibidor de alk2 e um inibidor de jak2
CA3187767A1 (en) 2020-06-16 2021-12-23 Incyte Corporation Alk2 inhibitors for the treatment of anemia

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0190472B1 (de) * 1984-12-21 1989-07-12 Duphar International Research B.V Arzneimittel mit antipsychotischer Wirkung
DE3586794T2 (de) 1984-12-21 1993-05-27 Duphar Int Res Arzneimittel mit psychotroper wirkung.
DK93087A (da) * 1986-02-27 1987-08-28 Duphar Int Res Hidtil ukendte aryl substituerede (n-piperidinyl)methyl- og (n-piperazinyl)methylazoler med antipsykotiske egenskaber
EP0508347A1 (de) * 1991-04-10 1992-10-14 Hoechst Aktiengesellschaft 5,7-Dihydroxy-2-Methyl-8-[4-(3-Hydroxy-1-(1-Propyl))Piperidinyl]-4H-1-Benzopyran-4-on, seine Herstellung und Verwendung
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
JPH05262765A (ja) * 1992-03-18 1993-10-12 Sumitomo Chem Co Ltd ベンゾフラン誘導体およびそれを有効成分とする除草剤
FR2692264B1 (fr) 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5332732A (en) * 1992-09-11 1994-07-26 Mcneilab, Inc. Thiophene and pyridine antipsychotic agents
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
RU2118322C1 (ru) * 1993-07-05 1998-08-27 Дюфар Интернэшнл Рисерч Б.В. 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
GB9314758D0 (en) * 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
EP0650964A1 (de) 1993-11-02 1995-05-03 Duphar International Research B.V 1- 2H-1-Benzopyran-2-on-8-yl -Piperazin Derivate
DE4425146A1 (de) 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
DE69615376T2 (de) * 1995-07-13 2002-09-05 Knoll Gmbh Piperazin-derivate als heilmittel
AU708053B2 (en) * 1996-03-29 1999-07-29 Duphar International Research B.V. Piperazine and piperidine compounds
DE19637237A1 (de) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate

Also Published As

Publication number Publication date
HU227422B1 (en) 2011-05-30
CN1220265A (zh) 1999-06-23
AU733526B2 (en) 2001-05-17
DE69833297T2 (de) 2006-07-20
ATE316529T1 (de) 2006-02-15
TR199801866A1 (xx) 1999-04-21
AU8607998A (en) 1999-04-15
NO312835B1 (no) 2002-07-08
SI0908458T1 (sl) 2006-06-30
AR017127A1 (es) 2001-08-22
BR9803497A (pt) 2000-05-02
JPH11302279A (ja) 1999-11-02
KR100632188B1 (ko) 2007-04-25
PL190622B1 (pl) 2005-12-30
DE69833297D1 (de) 2006-04-13
ES2255127T3 (es) 2006-06-16
IL126295A0 (en) 1999-05-09
CA2247734A1 (en) 1999-03-24
ZA988749B (en) 1999-03-26
KR19990029982A (ko) 1999-04-26
PL328754A1 (en) 1999-03-29
NO984380L (no) 1999-03-25
CA2247734C (en) 2007-08-07
NO984380D0 (no) 1998-09-21
US6090812A (en) 2000-07-18
PT908458E (pt) 2006-05-31
UA66756C2 (uk) 2004-06-15
EP0908458B1 (de) 2006-01-25
NZ331984A (en) 2000-02-28
JP4191826B2 (ja) 2008-12-03
CN1093857C (zh) 2002-11-06
HK1018272A1 (en) 1999-12-17
CZ303098A3 (cs) 1999-04-14
DZ2613A1 (fr) 2003-03-01
SK285205B6 (sk) 2006-08-03
CZ296741B6 (cs) 2006-06-14
SK129498A3 (en) 1999-04-13
DK0908458T3 (da) 2006-06-06
HU9802129D0 (en) 1998-11-30
HUP9802129A1 (hu) 2000-03-28
TW530054B (en) 2003-05-01
CY1107494T1 (el) 2013-03-13
RU2197488C2 (ru) 2003-01-27
ID20895A (id) 1999-03-25
EP0908458A1 (de) 1999-04-14
USRE41425E1 (en) 2010-07-06

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees