IL128535A - Process for r-epimer enrichment of 16, 17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11 beta, 16 alpha, 17 alpha-triol-3,20-dione derivatives - Google Patents

Process for r-epimer enrichment of 16, 17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11 beta, 16 alpha, 17 alpha-triol-3,20-dione derivatives

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Publication number
IL128535A
IL128535A IL12853597A IL12853597A IL128535A IL 128535 A IL128535 A IL 128535A IL 12853597 A IL12853597 A IL 12853597A IL 12853597 A IL12853597 A IL 12853597A IL 128535 A IL128535 A IL 128535A
Authority
IL
Israel
Prior art keywords
alpha
derivatives
dien
triol
acyloxy
Prior art date
Application number
IL12853597A
Other languages
English (en)
Other versions
IL128535A0 (en
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Publication of IL128535A0 publication Critical patent/IL128535A0/xx
Publication of IL128535A publication Critical patent/IL128535A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL12853597A 1996-09-03 1997-08-29 Process for r-epimer enrichment of 16, 17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11 beta, 16 alpha, 17 alpha-triol-3,20-dione derivatives IL128535A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19635498A DE19635498A1 (de) 1996-09-03 1996-09-03 Verfahren zur Epimerenanreicherung
PCT/EP1997/004716 WO1998009982A1 (en) 1996-09-03 1997-08-29 Process for r-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11.beta.,16.alpha.,17.alpha.-triol-3,20-dione derivatives

Publications (2)

Publication Number Publication Date
IL128535A0 IL128535A0 (en) 2000-01-31
IL128535A true IL128535A (en) 2003-07-06

Family

ID=7804358

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12853597A IL128535A (en) 1996-09-03 1997-08-29 Process for r-epimer enrichment of 16, 17-acetal derivatives of 21-acyloxy pregan-1,4-dien-11 beta, 16 alpha, 17 alpha-triol-3,20-dione derivatives

Country Status (18)

Country Link
US (1) US6787533B1 (cs)
EP (1) EP0929566B1 (cs)
JP (1) JP3807509B2 (cs)
AT (1) ATE229539T1 (cs)
AU (1) AU736840B2 (cs)
CA (1) CA2264863C (cs)
CL (1) CL2004001297A1 (cs)
CY (2) CY2454B1 (cs)
CZ (1) CZ298789B6 (cs)
DE (2) DE19635498A1 (cs)
DK (1) DK0929566T3 (cs)
EE (1) EE03927B1 (cs)
ES (1) ES2188984T3 (cs)
HU (1) HU228766B1 (cs)
IL (1) IL128535A (cs)
PL (1) PL186063B1 (cs)
PT (1) PT929566E (cs)
WO (1) WO1998009982A1 (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264923B1 (en) * 1998-05-13 2001-07-24 3M Innovative Properties Company Medicinal aerosol formulation of ciclesonide and related compounds
DE10055820C1 (de) * 2000-11-10 2002-07-25 Byk Gulden Lomberg Chem Fab Verfahren zur Herstellung eines Glucocorticoids
DE60142920D1 (de) 2000-11-10 2010-10-07 Nycomed Gmbh Verfahren zur herstellung von 16,17-ä(cyclohexylmethylen)bis(oxy)ü -11,21-dihydroxy-pregna-1,4-dien-3,20-dion oder ihre 21-isobutyrat durch transketalisation
US20040235811A1 (en) 2002-10-08 2004-11-25 Sepracor Inc. Fatty acid modified forms of glucocorticoids
ES2312844T3 (es) 2002-12-12 2009-03-01 Nycomed Gmbh Medicamento de combinacion de r, r-formoterol y ciclesonida.
MY143936A (en) * 2003-03-27 2011-07-29 Nycomed Gmbh Process for preparing crystalline ciclesonide with defined particle size
WO2005025578A1 (en) 2003-09-16 2005-03-24 Altana Pharma Ag Use of ciclesonide for the treatment of respiratory diseases
PE20050941A1 (es) 2003-12-16 2005-11-08 Nycomed Gmbh Suspensiones acuosas de ciclesonida para nebulizacion
CN100345864C (zh) * 2004-10-29 2007-10-31 天津药业研究院有限公司 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体
WO2007056181A2 (en) * 2005-11-02 2007-05-18 Sicor, Inc. Process for the preparation of ciclesonide
EP1904514A2 (en) * 2006-02-08 2008-04-02 Sicor, Inc. Crystalline forms of ciclesonide
WO2008015696A2 (en) * 2006-05-23 2008-02-07 Cadila Healthcare Limited Process for preparing ciclesonide
WO2008062450A2 (en) * 2006-09-18 2008-05-29 Cadila Healthcare Limited Crystalline polymorphs of ciclesonide
EP2064227A2 (en) * 2006-09-19 2009-06-03 Cipla Ltd. Processes for the preparation of ciclesonide and its crystal form
JP2011513469A (ja) * 2008-03-13 2011-04-28 ファルマビオス ソシエタ ペル アチオニ プレグナン誘導体の製造法
IT1397499B1 (it) * 2009-01-09 2013-01-16 Farmabios Spa Processo per la preparazione di ciclesonide
US20100120737A1 (en) * 2008-11-10 2010-05-13 Martin Feth Amorphous ciclesonide
US9109005B2 (en) 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
RS62040B1 (sr) 2016-06-02 2021-07-30 Abbvie Inc Agonist receptora glukokortikoida i njegovi imunokonjugati
EP3658192B1 (en) 2017-12-01 2021-04-28 AbbVie Inc. Glucocorticoid receptor agonist and immunoconjugates thereof
CN109293730A (zh) * 2018-10-23 2019-02-01 山东泰华生物科技股份有限公司 一种环索奈德的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
US3992534A (en) * 1972-05-19 1976-11-16 Ab Bofors Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods
SE378110B (cs) * 1972-05-19 1975-08-18 Bofors Ab
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
PL164294B1 (pl) * 1990-12-20 1994-07-29 Inst Farmaceutyczny Sposób otrzymywania diastereoizomeru /22R/-16a , 17a-butylidenodioksy-11 ß 21-dihydroksy-1,4-pregnadien-3,20-dionu PL
US5482935A (en) 1993-01-05 1996-01-09 American Home Product Corporation Anti-atherosclerotic use of 17 alpha-dihydroequilin
CZ287877B6 (cs) * 1993-04-02 2001-03-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Prednisolonové deriváty a farmaceutické prostředky s jejich obsahem
WO1995024416A1 (de) 1994-03-09 1995-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue silylverbindungen und ihre verwendung

Also Published As

Publication number Publication date
PL331699A1 (en) 1999-08-02
AU736840B2 (en) 2001-08-02
ATE229539T1 (de) 2002-12-15
DE69717836T2 (de) 2003-09-18
US6787533B1 (en) 2004-09-07
EE03927B1 (et) 2002-12-16
DE19635498A1 (de) 1998-03-26
JP3807509B2 (ja) 2006-08-09
JP2000517330A (ja) 2000-12-26
CZ298789B6 (cs) 2008-01-30
EP0929566A1 (en) 1999-07-21
EP0929566B1 (en) 2002-12-11
ES2188984T3 (es) 2003-07-01
EE9900079A (et) 1999-10-15
CY2009010I1 (el) 2010-07-28
CY2009010I2 (el) 2010-07-28
CZ72799A3 (cs) 1999-09-15
CY2454B1 (en) 2005-06-03
CA2264863C (en) 2007-07-31
PL186063B1 (pl) 2003-09-30
HUP9904127A2 (hu) 2000-04-28
WO1998009982A1 (en) 1998-03-12
PT929566E (pt) 2003-04-30
CL2004001297A1 (es) 2005-04-15
IL128535A0 (en) 2000-01-31
DK0929566T3 (da) 2003-04-07
AU4456797A (en) 1998-03-26
HUP9904127A3 (en) 2001-02-28
DE69717836D1 (de) 2003-01-23
CA2264863A1 (en) 1998-03-12
HU228766B1 (hu) 2013-05-28

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