IL128568A0 - Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia - Google Patents

Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia

Info

Publication number: IL128568A0
Authority: IL; Israel
Prior art keywords: neoplasia; treatment; cyclooxygenase; medicament; inhibitors
Prior art date: 1996-10-15

Application number

IL12856897A

Other languages

English (en)

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-15

Filing date

1997-10-14

Publication date

2000-01-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21843754&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL128568(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-10-14 Application filed by Searle & Co filed Critical Searle & Co

1997-10-14 Priority to IL15450197A priority Critical patent/IL154501A0/xx

2000-01-31 Publication of IL128568A0 publication Critical patent/IL128568A0/xx

Links

206010028980 Neoplasm Diseases 0.000 title abstract 2
230000009826 neoplastic cell growth Effects 0.000 title abstract 2
239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
230000002265 prevention Effects 0.000 title 1
229940034982 antineoplastic agent Drugs 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)

IL12856897A 1996-10-15 1997-10-14 Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia IL128568A0 (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
IL15450197A IL154501A0 (en)	1996-10-15	1997-10-14	Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2849496P	1996-10-15	1996-10-15
PCT/US1997/018670 WO1998016227A1 (fr)	1996-10-15	1997-10-14	Application d'inhibiteurs de la cyclogenase-2 au traitement et a la prevention du processus neoplasique

Publications (1)

Publication Number	Publication Date
IL128568A0 true IL128568A0 (en)	2000-01-31

Family

ID=21843754

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
IL12856897A IL128568A0 (en)	1996-10-15	1997-10-14	Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia
IL15450197A IL154501A0 (en)	1996-10-15	1997-10-14	Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia
IL16581604A IL165816A0 (en)	1996-10-15	2004-12-16	Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
IL15450197A IL154501A0 (en)	1996-10-15	1997-10-14	Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia
IL16581604A IL165816A0 (en)	1996-10-15	2004-12-16	Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia

Country Status (24)

Country	Link
EP (3)	EP1479385B1 (fr)
JP (1)	JP2001503395A (fr)
KR (1)	KR20000049138A (fr)
CN (2)	CN100558356C (fr)
AT (2)	ATE271385T1 (fr)
AU (1)	AU742645B2 (fr)
BR (1)	BR9712314A (fr)
CA (1)	CA2267186C (fr)
CZ (1)	CZ298022B6 (fr)
DE (2)	DE69729946T2 (fr)
DK (2)	DK1479385T3 (fr)
ES (2)	ES2224222T3 (fr)
HU (1)	HU227564B1 (fr)
IL (3)	IL128568A0 (fr)
NO (1)	NO326822B1 (fr)
NZ (3)	NZ506515A (fr)
PT (2)	PT1479385E (fr)
RO (1)	RO120172B1 (fr)
RU (1)	RU2239429C2 (fr)
SK (1)	SK284788B6 (fr)
TR (1)	TR199900827T2 (fr)
TW (1)	TWI235060B (fr)
UA (1)	UA67732C2 (fr)
WO (1)	WO1998016227A1 (fr)

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WO2002039958A2 (fr)	2000-11-03	2002-05-23	Tularik Inc.	Therapies combinees a base de pentafluorobenzenesulfonamides et d'agents antineoplasiques
DE60236273D1 (de)	2001-05-03	2010-06-17	Cornell Res Foundation Inc	Behandlung von krankheiten, die durch hpv verursacht werden
GB0112348D0 (en)	2001-05-19	2001-07-11	Smithkline Beecham Plc	Compounds
GB0112810D0 (en)	2001-05-25	2001-07-18	Glaxo Group Ltd	Pyrimidine derivatives
GB0112802D0 (en)	2001-05-25	2001-07-18	Glaxo Group Ltd	Pyrimidine derivatives
GB0119477D0 (en)	2001-08-09	2001-10-03	Glaxo Group Ltd	Pyrimidine derivatives
AR038957A1 (es)	2001-08-15	2005-02-02	Pharmacia Corp	Terapia de combinacion para el tratamiento del cancer
US20050043409A1 (en) *	2001-10-25	2005-02-24	Chen Ying-Nan Pan	Combinations comprising a selective cyclooxygenase-2 inhibitor
FR2835433B1 (fr) *	2002-02-01	2006-02-17	Richard Lab M	Utilisation de la 1-(-4-chlorobenzoyl)-5methoxy-2-methyl-1h- indole-3acetic 4-(acetylamino)phenylester pour la fabrication d'un medicament destine a inhiber exclusivement la cox2
NZ535951A (en) *	2002-03-15	2006-02-24	Pharmacia Corp	Crystalline parecoxib sodium
AU2003216920A1 (en)	2002-04-08	2003-10-20	Glaxo Group Limited	(2-((2-alkoxy)-phenyl)-cyclopent-1-enyl) aromatic carbo and heterocyclic acid and derivatives
ATE325115T1 (de)	2002-08-19	2006-06-15	Glaxo Group Ltd	Pyrimidinderivate als selektive cox-2-inhibitoren
GB0221443D0 (en)	2002-09-16	2002-10-23	Glaxo Group Ltd	Pyridine derivates
KR100484525B1 (ko) *	2002-10-15	2005-04-20	씨제이 주식회사	이소티아졸 유도체, 그 제조방법 및 약제학적 조성물
GB0225548D0 (en)	2002-11-01	2002-12-11	Glaxo Group Ltd	Compounds
PE20040844A1 (es)	2002-11-26	2004-12-30	Novartis Ag	Acidos fenilaceticos y derivados como inhibidores de la cox-2
SI1611112T1 (sl) *	2003-02-11	2012-12-31	Vernalis (R&D) Limited	Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov
GB0308466D0 (en)	2003-04-11	2003-05-21	Novartis Ag	Organic compounds
MX2007009888A (es)	2005-02-17	2007-10-16	Synta Pharmaceuticals Corp	Compuestos para el tratamiento de trastornos proliferativos.
ES2397085T3 (es)	2005-03-08	2013-03-04	Mitsui Norin Co., Ltd	Procedimientos y combinaciones de polifenol-coxib
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US5596008A (en)	1995-02-10	1997-01-21	G. D. Searle & Co.	3,4-Diaryl substituted pyridines for the treatment of inflammation
BR9607035A (pt)	1995-02-13	1997-11-04	Searle & Co	Isoxazois substituidos para o tratamento de inflamação
US5510368A (en)	1995-05-22	1996-04-23	Merck Frosst Canada, Inc.	N-benzyl-3-indoleacetic acids as antiinflammatory drugs
CA2223154A1 (fr) *	1995-06-02	1996-12-05	G.D. Searle & Co.	Derives heterocyclo-substitues d'acide hydroxamique utilises comme inhibiteurs de la cyclo-oxygenase-2 et de la 5-lipoxygenase
EP0859779A4 (fr)	1995-08-31	2000-04-12	Smithkline Beecham Corp	Enzyme de conversion d'interleukine et apoptose
ATE225343T1 (de)	1995-12-20	2002-10-15	Hoffmann La Roche	Matrix-metalloprotease inhibitoren

1997
- 1997-10-14 DE DE69729946T patent/DE69729946T2/de not_active Expired - Lifetime
- 1997-10-14 SK SK462-99A patent/SK284788B6/sk not_active IP Right Cessation
- 1997-10-14 ES ES97911746T patent/ES2224222T3/es not_active Expired - Lifetime
- 1997-10-14 ES ES04011516T patent/ES2308068T3/es not_active Expired - Lifetime
- 1997-10-14 NZ NZ506515A patent/NZ506515A/en not_active IP Right Cessation
- 1997-10-14 EP EP04011516A patent/EP1479385B1/fr not_active Expired - Lifetime
- 1997-10-14 CA CA002267186A patent/CA2267186C/fr not_active Expired - Fee Related
- 1997-10-14 IL IL12856897A patent/IL128568A0/xx not_active IP Right Cessation
- 1997-10-14 PT PT04011516T patent/PT1479385E/pt unknown
- 1997-10-14 EP EP08159064A patent/EP1977749A1/fr not_active Withdrawn
- 1997-10-14 PT PT97911746T patent/PT932402E/pt unknown
- 1997-10-14 AT AT97911746T patent/ATE271385T1/de active
- 1997-10-14 DK DK04011516T patent/DK1479385T3/da active
- 1997-10-14 CN CNB2005100062282A patent/CN100558356C/zh not_active Expired - Fee Related
- 1997-10-14 CZ CZ0117199A patent/CZ298022B6/cs not_active IP Right Cessation
- 1997-10-14 HU HU9904221A patent/HU227564B1/hu not_active IP Right Cessation
- 1997-10-14 KR KR1019990703225A patent/KR20000049138A/ko not_active Withdrawn
- 1997-10-14 UA UA99052704A patent/UA67732C2/uk unknown
- 1997-10-14 TW TW090122228A patent/TWI235060B/zh not_active IP Right Cessation
- 1997-10-14 TR TR1999/00827T patent/TR199900827T2/xx unknown
- 1997-10-14 WO PCT/US1997/018670 patent/WO1998016227A1/fr not_active Ceased
- 1997-10-14 NZ NZ334921A patent/NZ334921A/en not_active IP Right Cessation
- 1997-10-14 DE DE69738815T patent/DE69738815D1/de not_active Expired - Lifetime
- 1997-10-14 DK DK97911746T patent/DK0932402T3/da active
- 1997-10-14 RO RO99-00418A patent/RO120172B1/ro unknown
- 1997-10-14 JP JP51859198A patent/JP2001503395A/ja not_active Ceased
- 1997-10-14 EP EP97911746A patent/EP0932402B1/fr not_active Expired - Lifetime
- 1997-10-14 BR BR9712314-5A patent/BR9712314A/pt not_active Application Discontinuation
- 1997-10-14 AT AT04011516T patent/ATE399547T1/de active
- 1997-10-14 AU AU49048/97A patent/AU742645B2/en not_active Ceased
- 1997-10-14 RU RU99110192/15A patent/RU2239429C2/ru not_active IP Right Cessation
- 1997-10-14 IL IL15450197A patent/IL154501A0/xx not_active IP Right Cessation
- 1997-10-14 CN CNB971987548A patent/CN1332661C/zh not_active Expired - Fee Related
1999
- 1999-04-15 NO NO19991793A patent/NO326822B1/no not_active IP Right Cessation
2001
- 2001-02-07 NZ NZ509755A patent/NZ509755A/xx not_active IP Right Cessation
2004
- 2004-12-16 IL IL16581604A patent/IL165816A0/xx unknown

Also Published As

Publication number	Publication date
CN100558356C (zh)	2009-11-11
EP0932402A1 (fr)	1999-08-04
TWI235060B (en)	2005-07-01
HUP9904221A3 (en)	2000-12-28
EP1479385B1 (fr)	2008-07-02
CZ298022B6 (cs)	2007-05-30
ES2224222T3 (es)	2005-03-01
HK1025518A1 (en)	2000-11-17
BR9712314A (pt)	1999-08-31
AU742645B2 (en)	2002-01-10
PT932402E (pt)	2004-11-30
EP1479385A1 (fr)	2004-11-24
CN1332661C (zh)	2007-08-22
UA67732C2 (uk)	2004-07-15
DE69729946D1 (de)	2004-08-26
DK1479385T3 (da)	2008-08-04
EP0932402B1 (fr)	2004-07-21
KR20000049138A (ko)	2000-07-25
CA2267186C (fr)	2002-05-14
RU2239429C2 (ru)	2004-11-10
IL154501A0 (en)	2003-09-17
NZ509755A (en)	2002-09-27
NZ334921A (en)	2001-03-30
ATE399547T1 (de)	2008-07-15
DE69729946T2 (de)	2005-01-20
CN1660083A (zh)	2005-08-31
NZ506515A (en)	2002-05-31
IL165816A0 (en)	2006-01-15
TR199900827T2 (xx)	1999-07-21
WO1998016227A1 (fr)	1998-04-23
CZ117199A3 (cs)	1999-07-14
NO326822B1 (no)	2009-02-23
PT1479385E (pt)	2008-09-02
RO120172B1 (ro)	2005-10-28
HUP9904221A2 (hu)	2000-09-28
CN1244122A (zh)	2000-02-09
AU4904897A (en)	1998-05-11
ES2308068T3 (es)	2008-12-01
NO991793D0 (no)	1999-04-15
HU227564B1 (en)	2011-08-29
DE69738815D1 (de)	2008-08-14
CA2267186A1 (fr)	1998-04-23
EP1977749A1 (fr)	2008-10-08
NO991793L (no)	1999-04-15
SK284788B6 (sk)	2005-11-03
ATE271385T1 (de)	2004-08-15
JP2001503395A (ja)	2001-03-13
SK46299A3 (en)	2000-03-13
DK0932402T3 (da)	2004-11-08

Legal Events

Date	Code	Title
2005-03-20	FF	Patent granted
2005-05-17	KB	Patent renewed
2008-01-06	KB	Patent renewed
2012-10-31	MM9K	Patent not in force due to non-payment of renewal fees

Publication	Publication Date	Title
IL128568A0 (en)	2000-01-31	Use of cyclooxygenase-2 inhibitors for the manufacture of a medicament for the treatment and prevention of neoplasia
IL123002A0 (en)	1998-08-16	1-Phenyl-2- phenylacetoxy- ethanone derivatives
IL175398A0 (en)	2006-09-05	Steroidal compounds and pharmaceutical compositions containing them for treating oxidative stress and inflammation
GR3033127T3 (en)	2000-08-31	Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
LU91145I9 (fr)	2018-12-28
RU2088589C1 (en)	1997-08-27	Derivatives of 17 beta-substituted-4-aza-5-5 alpha-androstane-3-ones, methods of synthesis of compounds, pharmaceutical composition, compound 4
IL162214A0 (en)	2005-11-20	Pyridine derivatives and pharmaceutical compositions containing the same
SI0934065T1 (sl)	2007-02-28	Novi kriptoficinski derivati kot anti-neoplasticna sredstva
ZA941464B (en)	1994-09-27	Use of pregnane derivative
CA2289017A1 (fr)	1998-12-03	Utilisation d'oxydes d'azote ou de promedicament a base de ces oxydes pour la prevention et le traitement therapeutique du cancer
CA2301590A1 (fr)	1999-03-25	2-aminopyridines utilisees comme inhibiteurs de la cyclo-oxygenase 2
IL156140A0 (en)	2003-12-23	Use of substituted 6-dimethylaminomethyl-1-phenyl-cyclohexane compounds for treating urinary incontinence
IL158900A0 (en)	2004-05-12	Pharmaceutical compositions containing a tricyclic compound for the prevention or treatment of skin diseases
MY138319A (en)	2009-05-29	1,5-benzodiazepine derivatives