NO326822B1 - Anvendelse av cyklooksygenase-2 inhibitorer for fremstilling av et medikament for behandling av neoplasi - Google Patents

Anvendelse av cyklooksygenase-2 inhibitorer for fremstilling av et medikament for behandling av neoplasi Download PDF

Info

Publication number: NO326822B1
Authority: NO; Norway
Prior art keywords: pyrazol; cancer; trifluoromethyl; difluoromethyl; compound
Prior art date: 1996-10-15

Application number

NO19991793A

Other languages

English (en)

Norwegian (no)

Other versions

NO991793L (no

NO991793D0 (no

Inventor

Jaime L Masferrer

Gary B Gordon

Karen Seibert

Original Assignee

Searle Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-15

Filing date

1999-04-15

Publication date

2009-02-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21843754&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO326822(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-04-15 Application filed by Searle Llc filed Critical Searle Llc

1999-04-15 Publication of NO991793L publication Critical patent/NO991793L/no

1999-04-15 Publication of NO991793D0 publication Critical patent/NO991793D0/no

2009-02-23 Publication of NO326822B1 publication Critical patent/NO326822B1/no

Links

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IQDSXWRQCKDBMW-NSFJATOBSA-N vintriptol Chemical compound C([C@@H](C[C@@](O)(CC)C1)C[C@@]2(C3=C(OC)C=C4N(C)[C@H]5[C@@]([C@@H]([C@]6(CC)C=CCN7CC[C@]5([C@H]67)C4=C3)O)(O)C(=O)N[C@@H](CC=3C4=CC=CC=C4NC=3)C(=O)OCC)C(=O)OC)N1CCC1=C2NC2=CC=CC=C12 IQDSXWRQCKDBMW-NSFJATOBSA-N 0.000 description 1
229950003415 vintriptol Drugs 0.000 description 1
238000001262 western blot Methods 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
229960000641 zorubicin Drugs 0.000 description 1
FBTUMDXHSRTGRV-ALTNURHMSA-N zorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(\C)=N\NC(=O)C=1C=CC=CC=1)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 FBTUMDXHSRTGRV-ALTNURHMSA-N 0.000 description 1

Classifications

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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/42—Oxazoles
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- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)

NO19991793A 1996-10-15 1999-04-15 Anvendelse av cyklooksygenase-2 inhibitorer for fremstilling av et medikament for behandling av neoplasi NO326822B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2849496P	1996-10-15	1996-10-15
PCT/US1997/018670 WO1998016227A1 (fr)	1996-10-15	1997-10-14	Application d'inhibiteurs de la cyclogenase-2 au traitement et a la prevention du processus neoplasique

Publications (3)

Publication Number	Publication Date
NO991793L NO991793L (no)	1999-04-15
NO991793D0 NO991793D0 (no)	1999-04-15
NO326822B1 true NO326822B1 (no)	2009-02-23

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NO19991793A NO326822B1 (no)	1996-10-15	1999-04-15	Anvendelse av cyklooksygenase-2 inhibitorer for fremstilling av et medikament for behandling av neoplasi

Country Status (24)

Country	Link
EP (3)	EP1479385B1 (fr)
JP (1)	JP2001503395A (fr)
KR (1)	KR20000049138A (fr)
CN (2)	CN100558356C (fr)
AT (2)	ATE399547T1 (fr)
AU (1)	AU742645B2 (fr)
BR (1)	BR9712314A (fr)
CA (1)	CA2267186C (fr)
CZ (1)	CZ298022B6 (fr)
DE (2)	DE69729946T2 (fr)
DK (2)	DK0932402T3 (fr)
ES (2)	ES2308068T3 (fr)
HU (1)	HU227564B1 (fr)
IL (3)	IL128568A0 (fr)
NO (1)	NO326822B1 (fr)
NZ (3)	NZ334921A (fr)
PT (2)	PT932402E (fr)
RO (1)	RO120172B1 (fr)
RU (1)	RU2239429C2 (fr)
SK (1)	SK284788B6 (fr)
TR (1)	TR199900827T2 (fr)
TW (1)	TWI235060B (fr)
UA (1)	UA67732C2 (fr)
WO (1)	WO1998016227A1 (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6512121B2 (en)	1998-09-14	2003-01-28	G.D. Searle & Co.	Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
WO1996038418A1 (fr)	1995-06-02	1996-12-05	G.D. Searle & Co.	Derives heterocyclo-substitues d'acide hydroxamique utilises comme inhibiteurs de la cyclo-oxygenase-2 et de la 5-lipoxygenase
US20040072889A1 (en)	1997-04-21	2004-04-15	Pharmacia Corporation	Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia
NZ333399A (en)	1997-12-24	2000-05-26	Sankyo Co	Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis
US6294558B1 (en)	1999-05-31	2001-09-25	Pfizer Inc.	Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
US6727238B2 (en)	1998-06-11	2004-04-27	Pfizer Inc.	Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
CN1398189A (zh) *	1998-12-23	2003-02-19	G.D.西尔公司	用于治疗肿瘤形成的放疗与cox－2抑制剂的联合治疗
US20020103141A1 (en) *	1998-12-23	2002-08-01	Mckearn John P.	Antiangiogenic combination therapy for the treatment of cancer
US20040122011A1 (en) *	1998-12-23	2004-06-24	Pharmacia Corporation	Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US20040053900A1 (en) *	1998-12-23	2004-03-18	Pharmacia Corporation	Method of using a COX-2 inhibitor and an aromatase inhibitor as a combination therapy
US6649645B1 (en) *	1998-12-23	2003-11-18	Pharmacia Corporation	Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
ATE425749T1 (de) *	1999-01-27	2009-04-15	Cornell Res Foundation Inc	Behandlung von mit her-2/neu-uberexprimierung einhergehendem krebs
WO2001000229A1 (fr) *	1999-06-24	2001-01-04	Pharmacia Corporation	Combinaison d'antagonistes du facteur de necrose des tumeurs (tnf) et d'inhibiteurs de cox-2 pour le traitement des inflammations
CA2380078C (fr) *	1999-07-29	2008-05-06	Tularik Inc.	Therapie d'association comprenant l'administration de pentafluorobenzenesulfonamides
US7189745B1 (en)	1999-11-22	2007-03-13	Smithkline Beecham Corporation	Compounds
EP1253921A4 (fr) *	2000-01-28	2004-10-13	Merck & Co Inc	Traitement ou prevention du cancer de la prostate avec un medicament inhibiteur selectif de cox-2
GB0003224D0 (en)	2000-02-11	2000-04-05	Glaxo Group Ltd	Chemical compounds
GB0005357D0 (en)	2000-03-06	2000-04-26	Smithkline Beecham Plc	Compounds
AU2001275004A1 (en) *	2000-06-01	2001-12-11	Pharmacia Corporation	Use of cox2 inhibitors for treating skin injury from exposure to ultraviolet radiation
GB0021494D0 (en)	2000-09-01	2000-10-18	Glaxo Group Ltd	Chemical comkpounds
WO2002024680A1 (fr)	2000-09-21	2002-03-28	Smithkline Beecham P.L.C.	Derives d'imidazole en tant qu'inhibiteurs de la raf kinase
US6822001B2 (en)	2000-11-03	2004-11-23	Tularik Inc.	Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents
DE60236273D1 (de)	2001-05-03	2010-06-17	Cornell Res Foundation Inc	Behandlung von krankheiten, die durch hpv verursacht werden
GB0112348D0 (en)	2001-05-19	2001-07-11	Smithkline Beecham Plc	Compounds
GB0112810D0 (en)	2001-05-25	2001-07-18	Glaxo Group Ltd	Pyrimidine derivatives
GB0112802D0 (en)	2001-05-25	2001-07-18	Glaxo Group Ltd	Pyrimidine derivatives
GB0119477D0 (en)	2001-08-09	2001-10-03	Glaxo Group Ltd	Pyrimidine derivatives
AR038957A1 (es)	2001-08-15	2005-02-02	Pharmacia Corp	Terapia de combinacion para el tratamiento del cancer
DE60224299T2 (de) *	2001-10-25	2008-12-11	Novartis Ag	Kombinationsmedikationen mit einem selektiven cyclooxygenase-2-inhibitor
FR2835433B1 (fr) *	2002-02-01	2006-02-17	Richard Lab M	Utilisation de la 1-(-4-chlorobenzoyl)-5methoxy-2-methyl-1h- indole-3acetic 4-(acetylamino)phenylester pour la fabrication d'un medicament destine a inhiber exclusivement la cox2
AU2003220180A1 (en) *	2002-03-15	2003-09-29	Pharmacia Corporation	Crystalline parecoxib sodium
AR039391A1 (es)	2002-04-08	2005-02-16	Glaxo Group Ltd	Compuesto de ciclopenteno, composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento
AU2003258630A1 (en)	2002-08-19	2004-03-11	Glaxo Group Limited	Pyrimidine derivatives as selective cox-2 inhibitors
GB0221443D0 (en)	2002-09-16	2002-10-23	Glaxo Group Ltd	Pyridine derivates
KR100484525B1 (ko) *	2002-10-15	2005-04-20	씨제이 주식회사	이소티아졸 유도체, 그 제조방법 및 약제학적 조성물
GB0225548D0 (en)	2002-11-01	2002-12-11	Glaxo Group Ltd	Compounds
AR042206A1 (es)	2002-11-26	2005-06-15	Novartis Ag	Acidos fenilaceticos y derivados
SI1611112T1 (sl) *	2003-02-11	2012-12-31	Vernalis (R&D) Limited	Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov
GB0308466D0 (en)	2003-04-11	2003-05-21	Novartis Ag	Organic compounds
SG164378A1 (en)	2005-02-17	2010-09-29	Synta Pharmaceuticals Corp	Compounds for the treatment of proliferative disorders
CA2600276C (fr) *	2005-03-08	2013-01-08	Mitsui Norin Co., Ltd	Methodes et combinaisons polyphenol-coxib
CU23511B6 (es) *	2006-02-28	2010-04-13	Biorec B V	Combinación farmacéutica para el tratamiento y/o quimiosensibilización de tumores refractarios a drogas anticancerígenas
JPWO2010007943A1 (ja) *	2008-07-17	2012-01-05	旭化成ファーマ株式会社	含窒素複素環化合物
KR20110055682A (ko) *	2008-08-22	2011-05-25	노파르티스 아게	간독성과 연관된 ｈｌａ 대립형질을 보유하지 않은 환자에서 ｃｏｘ-2 의존성 장애의 치료를 위한 ｃｏｘ-2 억제제의 용도
US10525040B2 (en)	2015-06-29	2020-01-07	Nantbio, Inc.	Compositions and methods of Rit1 inhibition

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU33730B (en)	1967-04-18	1978-02-28	Farmaceutici Italia	Process for preparing a novel antibiotic substance and salts thereof
US4012448A (en)	1976-01-15	1977-03-15	Stanford Research Institute	Synthesis of adriamycin and 7,9-epiadriamycin
ATE167473T1 (de) *	1990-08-20	1998-07-15	Eisai Co Ltd	Sulfonamid-derivate
KR0145953B1 (ko)	1991-07-19	1998-08-17	제임스 클리프튼 보올딩	슈퍼옥사이드의 불균화촉매로서 효과적인 질소를 포함하는 마크로사이클 릭리간드의 망간착물
US5604260A (en)	1992-12-11	1997-02-18	Merck Frosst Canada Inc.	5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2
EP0679157B1 (fr)	1993-01-15	1997-11-19	G.D. Searle & Co.	Nouveaux thiophenes 3,4-diaryle et leurs analogues utilises comme agents anti-inflammatoires
US5409944A (en)	1993-03-12	1995-04-25	Merck Frosst Canada, Inc.	Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase
CA2161789A1 (fr)	1993-05-13	1994-11-24	Jacques Yves Gauthier	Derives de substitution en 2 du 3,4-diarylthiofene, inhibiteurs de la cyclooxygenase
US5380738A (en)	1993-05-21	1995-01-10	Monsanto Company	2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US5474995A (en)	1993-06-24	1995-12-12	Merck Frosst Canada, Inc.	Phenyl heterocycles as cox-2 inhibitors
PT673937E (pt) *	1993-09-10	2004-04-30	Eisai Co Ltd	Derivados biciclicos heterociclicos de sulfonamida e de ester sulfonico
US5344991A (en)	1993-10-29	1994-09-06	G.D. Searle & Co.	1,2 diarylcyclopentenyl compounds for the treatment of inflammation
US5466823A (en) *	1993-11-30	1995-11-14	G.D. Searle & Co.	Substituted pyrazolyl benzenesulfonamides
US5434178A (en)	1993-11-30	1995-07-18	G.D. Searle & Co.	1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
RO118291B1 (ro) *	1993-11-30	2003-04-30	Searle & Co	Derivati de pirazol 1,3,4,5 - tetrasubstituiti si compozitie farmaceutica care ii contine
US5475018A (en)	1993-11-30	1995-12-12	G. D. Searle & Co.	1,5-diphenyl pyrazole compounds for treatment of inflammation
US5393790A (en)	1994-02-10	1995-02-28	G.D. Searle & Co.	Substituted spiro compounds for the treatment of inflammation
US5486534A (en)	1994-07-21	1996-01-23	G. D. Searle & Co.	3,4-substituted pyrazoles for the treatment of inflammation
WO1996003392A1 (fr)	1994-07-27	1996-02-08	G.D. Searle & Co.	Thiazoles substitues destines au traitement de l'inflammation
US5620999A (en)	1994-07-28	1997-04-15	Weier; Richard M.	Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
US5616601A (en)	1994-07-28	1997-04-01	Gd Searle & Co	1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation
US5521213A (en)	1994-08-29	1996-05-28	Merck Frosst Canada, Inc.	Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
US5739166A (en)	1994-11-29	1998-04-14	G.D. Searle & Co.	Substituted terphenyl compounds for the treatment of inflammation
US5596008A (en)	1995-02-10	1997-01-21	G. D. Searle & Co.	3,4-Diaryl substituted pyridines for the treatment of inflammation
US5686470A (en)	1995-02-10	1997-11-11	Weier; Richard M.	2, 3-substituted pyridines for the treatment of inflammation
ATE223390T1 (de)	1995-02-13	2002-09-15	Searle & Co	Substituierte isoxazole zur behandlung von entzündung
US5510368A (en)	1995-05-22	1996-04-23	Merck Frosst Canada, Inc.	N-benzyl-3-indoleacetic acids as antiinflammatory drugs
WO1996038418A1 (fr) *	1995-06-02	1996-12-05	G.D. Searle & Co.	Derives heterocyclo-substitues d'acide hydroxamique utilises comme inhibiteurs de la cyclo-oxygenase-2 et de la 5-lipoxygenase
JPH11511463A (ja)	1995-08-31	1999-10-05	スミスクライン・ビーチャム・コーポレイション	インターロイキン変換酵素およびアポプトーシス
ATE225343T1 (de)	1995-12-20	2002-10-15	Hoffmann La Roche	Matrix-metalloprotease inhibitoren

1997
- 1997-10-14 WO PCT/US1997/018670 patent/WO1998016227A1/fr not_active Ceased
- 1997-10-14 NZ NZ334921A patent/NZ334921A/en not_active IP Right Cessation
- 1997-10-14 AU AU49048/97A patent/AU742645B2/en not_active Ceased
- 1997-10-14 TW TW090122228A patent/TWI235060B/zh not_active IP Right Cessation
- 1997-10-14 SK SK462-99A patent/SK284788B6/sk not_active IP Right Cessation
- 1997-10-14 RU RU99110192/15A patent/RU2239429C2/ru not_active IP Right Cessation
- 1997-10-14 EP EP04011516A patent/EP1479385B1/fr not_active Expired - Lifetime
- 1997-10-14 CA CA002267186A patent/CA2267186C/fr not_active Expired - Fee Related
- 1997-10-14 CN CNB2005100062282A patent/CN100558356C/zh not_active Expired - Fee Related
- 1997-10-14 HU HU9904221A patent/HU227564B1/hu not_active IP Right Cessation
- 1997-10-14 KR KR1019990703225A patent/KR20000049138A/ko not_active Withdrawn
- 1997-10-14 AT AT04011516T patent/ATE399547T1/de active
- 1997-10-14 DE DE69729946T patent/DE69729946T2/de not_active Expired - Lifetime
- 1997-10-14 UA UA99052704A patent/UA67732C2/uk unknown
- 1997-10-14 NZ NZ506515A patent/NZ506515A/en not_active IP Right Cessation
- 1997-10-14 AT AT97911746T patent/ATE271385T1/de active
- 1997-10-14 CZ CZ0117199A patent/CZ298022B6/cs not_active IP Right Cessation
- 1997-10-14 TR TR1999/00827T patent/TR199900827T2/xx unknown
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- 1997-10-14 DK DK97911746T patent/DK0932402T3/da active
- 1997-10-14 EP EP08159064A patent/EP1977749A1/fr not_active Withdrawn
- 1997-10-14 BR BR9712314-5A patent/BR9712314A/pt not_active Application Discontinuation
- 1997-10-14 ES ES04011516T patent/ES2308068T3/es not_active Expired - Lifetime
- 1997-10-14 PT PT04011516T patent/PT1479385E/pt unknown
- 1997-10-14 JP JP51859198A patent/JP2001503395A/ja not_active Ceased
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- 1997-10-14 CN CNB971987548A patent/CN1332661C/zh not_active Expired - Fee Related
- 1997-10-14 EP EP97911746A patent/EP0932402B1/fr not_active Expired - Lifetime
- 1997-10-14 IL IL12856897A patent/IL128568A0/xx not_active IP Right Cessation
- 1997-10-14 DE DE69738815T patent/DE69738815D1/de not_active Expired - Lifetime
- 1997-10-14 DK DK04011516T patent/DK1479385T3/da active
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1999
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2001
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Also Published As

Publication number	Publication date
DK0932402T3 (da)	2004-11-08
CZ298022B6 (cs)	2007-05-30
HUP9904221A2 (hu)	2000-09-28
WO1998016227A1 (fr)	1998-04-23
DK1479385T3 (da)	2008-08-04
EP1977749A1 (fr)	2008-10-08
CA2267186C (fr)	2002-05-14
UA67732C2 (uk)	2004-07-15
RO120172B1 (ro)	2005-10-28
ATE399547T1 (de)	2008-07-15
CA2267186A1 (fr)	1998-04-23
EP1479385B1 (fr)	2008-07-02
NZ506515A (en)	2002-05-31
NO991793L (no)	1999-04-15
EP1479385A1 (fr)	2004-11-24
AU4904897A (en)	1998-05-11
ATE271385T1 (de)	2004-08-15
CN1660083A (zh)	2005-08-31
CZ117199A3 (cs)	1999-07-14
NZ334921A (en)	2001-03-30
ES2224222T3 (es)	2005-03-01
DE69729946D1 (de)	2004-08-26
AU742645B2 (en)	2002-01-10
KR20000049138A (ko)	2000-07-25
SK284788B6 (sk)	2005-11-03
TWI235060B (en)	2005-07-01
BR9712314A (pt)	1999-08-31
CN100558356C (zh)	2009-11-11
EP0932402A1 (fr)	1999-08-04
NZ509755A (en)	2002-09-27
IL154501A0 (en)	2003-09-17
HUP9904221A3 (en)	2000-12-28
IL128568A0 (en)	2000-01-31
JP2001503395A (ja)	2001-03-13
EP0932402B1 (fr)	2004-07-21
ES2308068T3 (es)	2008-12-01
CN1332661C (zh)	2007-08-22
HU227564B1 (en)	2011-08-29
RU2239429C2 (ru)	2004-11-10
NO991793D0 (no)	1999-04-15
SK46299A3 (en)	2000-03-13
DE69738815D1 (de)	2008-08-14
HK1025518A1 (en)	2000-11-17
IL165816A0 (en)	2006-01-15
PT932402E (pt)	2004-11-30
DE69729946T2 (de)	2005-01-20
PT1479385E (pt)	2008-09-02
CN1244122A (zh)	2000-02-09
TR199900827T2 (xx)	1999-07-21

Legal Events

Date	Code	Title	Description
2013-05-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
CN100558356C (zh)	2009-11-11	应用环加氧酶-2抑制剂治疗和预防肿瘤形成的方法
US5972986A (en)	1999-10-26	Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
EP0393575B1 (fr)	1994-03-16	Composition pour le traitement de néoplasia contenant un agent antinéoplastique et un agent protecteur réduisant les effets secondaires
US6025353A (en)	2000-02-15	Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents
WO1998016227A9 (fr)	1998-07-30	Application d'inhibiteurs de la cyclogenase-2 au traitement et a la prevention du processus neoplasique
ZA200103200B (en)	2002-05-07	Substituted benzopyran analogs for the treatment of inflammation.
CN1247470A (zh)	2000-03-15	使用环加氧酶－2抑制剂作为抗血管发生剂的方法
EP3773654B1 (fr)	2023-09-20	Compositions médicamenteuses polypharmaceutiques et méthodes associées
NZ517374A (en)	2003-10-31	Method of using cycloozygenase-2 inhibitors to prevent a neoplasia that produces a prostaglandin
HUP9903342A2 (hu)	2000-02-28	Ciklooxigenáz-2 inhibitorok alkalmazása angiogenezissel kapcsolatos rendellenességek kezelésére és megelőzésére szolgáló gyógyászati készítmények előállítására
IL154502A (en)	2004-09-27	Use of cyclooxygenase-2 inhibitors in the preparation of medicaments for treating angiogenesis-related disorders