IL128771A0 - An agent for enhancing the activity of glutathione reductase containing troglitazone and use thereof - Google Patents
An agent for enhancing the activity of glutathione reductase containing troglitazone and use thereofInfo
- Publication number
- IL128771A0 IL128771A0 IL12877197A IL12877197A IL128771A0 IL 128771 A0 IL128771 A0 IL 128771A0 IL 12877197 A IL12877197 A IL 12877197A IL 12877197 A IL12877197 A IL 12877197A IL 128771 A0 IL128771 A0 IL 128771A0
- Authority
- IL
- Israel
- Prior art keywords
- enhancing
- activity
- agent
- glutathione reductase
- reductase containing
- Prior art date
Links
- 108010063907 Glutathione Reductase Proteins 0.000 title 1
- 102100036442 Glutathione reductase, mitochondrial Human genes 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 title 1
- 229960001641 troglitazone Drugs 0.000 title 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24191096 | 1996-09-12 | ||
| PCT/JP1997/003199 WO1998010760A1 (fr) | 1996-09-12 | 1997-09-11 | Potentialisateur d'activite de glutathione-reductase contenant de la troglitazone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL128771A0 true IL128771A0 (en) | 2000-01-31 |
Family
ID=17081372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12877197A IL128771A0 (en) | 1996-09-12 | 1997-09-11 | An agent for enhancing the activity of glutathione reductase containing troglitazone and use thereof |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0958818A1 (cs) |
| KR (1) | KR20000036035A (cs) |
| CN (1) | CN1235543A (cs) |
| AU (1) | AU723354B2 (cs) |
| CA (1) | CA2265656A1 (cs) |
| CZ (1) | CZ74199A3 (cs) |
| HU (1) | HUP0002941A3 (cs) |
| ID (1) | ID21778A (cs) |
| IL (1) | IL128771A0 (cs) |
| NO (1) | NO991205L (cs) |
| NZ (1) | NZ334577A (cs) |
| WO (1) | WO1998010760A1 (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AP2001002036A0 (en) * | 1998-07-21 | 2001-03-31 | Smithkline Beecham Plc | Use of glucose uptake enhancer for reducing apoptosis. |
| US6613785B2 (en) | 1998-07-21 | 2003-09-02 | Smithkline Beecham Plc | Use of glucose uptake enhancer for reducing post-ischemic injury of the heart |
| MA26662A1 (fr) * | 1998-07-21 | 2004-12-20 | Smithkline Beecham Plc | Derives de thiazolidinedione, compositions pharmaceutiques les contenant et leur utilisation |
| WO2000007582A2 (en) * | 1998-08-06 | 2000-02-17 | Warner-Lambert Company | Use of thiazolidinedione derivatives for the treatment or prevention of cataracts |
| US6379664B1 (en) | 1998-09-29 | 2002-04-30 | Board Of Regents University Of Nebraska-Lincoln | Composition and method for the prevention and treatment of oxidative damage in ocular tissues |
| AU3073600A (en) * | 1999-01-19 | 2000-08-07 | Sankyo Company Limited | Inhibitor for nerve cell death due to glutamic acid cytotoxicity |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
| JPS6136284A (ja) * | 1984-07-27 | 1986-02-20 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造方法 |
| JPH0653738B2 (ja) * | 1985-02-26 | 1994-07-20 | 三共株式会社 | チアゾリジン誘導体 |
| JPS62234085A (ja) * | 1985-12-18 | 1987-10-14 | Sankyo Co Ltd | チアゾリジン誘導体を有効成分とする糖尿病性合併症治療剤 |
| WO1988000182A1 (fr) * | 1986-07-07 | 1988-01-14 | Teijin Limited | ESTER D'ETHYLE DE gamma-L-GLUTAMYL-L-CYSTEINE ET MEDICAMENT LE CONTENANT EN TANT QU'INGREDIENT ACTIF |
| JP2553090B2 (ja) * | 1987-07-21 | 1996-11-13 | 帝人株式会社 | 組織グルタチオンレベル向上剤 |
| JPH05202042A (ja) * | 1992-01-24 | 1993-08-10 | Sankyo Co Ltd | 糖尿病性合併症治療剤 |
| JPH0651189A (ja) * | 1992-08-04 | 1994-02-25 | Kyocera Corp | オートフォーカス一眼レフカメラの近接撮影機構 |
| JP2945220B2 (ja) * | 1992-10-23 | 1999-09-06 | 旭カーボン株式会社 | ハード系高ストラクチャーカーボンブラック |
-
1997
- 1997-09-11 ID IDW990076A patent/ID21778A/id unknown
- 1997-09-11 CN CN97199335A patent/CN1235543A/zh active Pending
- 1997-09-11 WO PCT/JP1997/003199 patent/WO1998010760A1/ja not_active Ceased
- 1997-09-11 KR KR1019997002023A patent/KR20000036035A/ko not_active Withdrawn
- 1997-09-11 CZ CZ99741A patent/CZ74199A3/cs unknown
- 1997-09-11 AU AU42195/97A patent/AU723354B2/en not_active Ceased
- 1997-09-11 IL IL12877197A patent/IL128771A0/xx unknown
- 1997-09-11 EP EP97940341A patent/EP0958818A1/en not_active Withdrawn
- 1997-09-11 CA CA002265656A patent/CA2265656A1/en not_active Abandoned
- 1997-09-11 NZ NZ334577A patent/NZ334577A/en unknown
- 1997-09-11 HU HU0002941A patent/HUP0002941A3/hu unknown
-
1999
- 1999-03-11 NO NO991205A patent/NO991205L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0002941A2 (hu) | 2001-08-28 |
| AU723354B2 (en) | 2000-08-24 |
| NZ334577A (en) | 2001-03-30 |
| WO1998010760A1 (fr) | 1998-03-19 |
| EP0958818A1 (en) | 1999-11-24 |
| NO991205D0 (no) | 1999-03-11 |
| CA2265656A1 (en) | 1998-03-19 |
| KR20000036035A (ko) | 2000-06-26 |
| AU4219597A (en) | 1998-04-02 |
| CZ74199A3 (cs) | 1999-07-14 |
| ID21778A (id) | 1999-07-22 |
| CN1235543A (zh) | 1999-11-17 |
| HUP0002941A3 (en) | 2001-11-28 |
| NO991205L (no) | 1999-05-11 |
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