IL131008A - Lipid complexes and liposomes of highly insoluble platinum complex dicarboxylate - Google Patents

Lipid complexes and liposomes of highly insoluble platinum complex dicarboxylate

Info

Publication number
IL131008A
IL131008A IL13100898A IL13100898A IL131008A IL 131008 A IL131008 A IL 131008A IL 13100898 A IL13100898 A IL 13100898A IL 13100898 A IL13100898 A IL 13100898A IL 131008 A IL131008 A IL 131008A
Authority
IL
Israel
Prior art keywords
dicarboxylate
liposomes
platinum complex
lipid complexes
highly insoluble
Prior art date
Application number
IL13100898A
Other languages
English (en)
Other versions
IL131008A0 (en
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of IL131008A0 publication Critical patent/IL131008A0/xx
Publication of IL131008A publication Critical patent/IL131008A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL13100898A 1997-02-05 1998-01-28 Lipid complexes and liposomes of highly insoluble platinum complex dicarboxylate IL131008A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3737797P 1997-02-05 1997-02-05
PCT/US1998/000035 WO1998033481A1 (en) 1997-02-05 1998-01-28 Lipid complexes and liposomes of highly insoluble platinum complexes

Publications (2)

Publication Number Publication Date
IL131008A0 IL131008A0 (en) 2001-01-28
IL131008A true IL131008A (en) 2003-06-24

Family

ID=21894020

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13100898A IL131008A (en) 1997-02-05 1998-01-28 Lipid complexes and liposomes of highly insoluble platinum complex dicarboxylate

Country Status (22)

Country Link
US (1) US6287593B2 (de)
EP (1) EP0975329B1 (de)
JP (1) JP2002513396A (de)
KR (1) KR100578705B1 (de)
CN (2) CN1096263C (de)
AT (1) ATE284204T1 (de)
AU (1) AU749220B2 (de)
BR (1) BR9815445A (de)
CA (1) CA2279279C (de)
DE (1) DE69828038T2 (de)
DK (1) DK0975329T3 (de)
EA (1) EA002630B1 (de)
ES (1) ES2234094T3 (de)
HK (1) HK1054201B (de)
HU (1) HUP0001266A3 (de)
IL (1) IL131008A (de)
NO (1) NO993750D0 (de)
NZ (1) NZ337502A (de)
PL (1) PL192633B1 (de)
PT (1) PT975329E (de)
UA (1) UA71540C2 (de)
WO (1) WO1998033481A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100598474B1 (ko) 1998-04-03 2006-07-11 아지노모토 가부시키가이샤 항종양제
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
US9186322B2 (en) * 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
US20070160656A1 (en) * 2003-05-02 2007-07-12 Dziewiszek Krzysztof J Lipid platinum complexes and methods of use thereof
US20080050425A1 (en) * 2003-05-20 2008-02-28 Jonathan Lewis Combination Chemotherapy Comprising 5-Fluorouracil or a Derivative Thereof and a Liposomal Platinum Complex
AU2003239510A1 (en) * 2003-05-20 2005-01-21 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising gemcitabine and a liposomal platinum complex
AU2003233586A1 (en) * 2003-05-20 2005-01-21 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising capecitabine and a liposomal platinum complex
JP2007504177A (ja) * 2003-09-02 2007-03-01 プリヴァ−ラケマ，エー．エス． 医薬組成物、その製造方法及び治療上の使用
CA2560900A1 (en) * 2004-03-26 2005-10-06 Cell Therapeutics Europe S.R.L. Nanoparticle formulations of platinum compounds
WO2006084248A2 (en) * 2005-02-04 2006-08-10 Antigenics, Inc. Compositions comprising a platinum complex, lipid, and surfactant
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
AU2006321796A1 (en) * 2005-12-08 2007-06-14 Wyeth Liposomal compositions
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
EP2481396A4 (de) * 2009-09-21 2014-03-05 Jw Pharmaceutical Corp Oxaliplatin-nanopartikel und herstellungsverfahren dafür
WO2012006101A2 (en) 2010-06-28 2012-01-12 The General Hospital Corporation Blood substitutes and uses thereof
CN102276674A (zh) * 2011-06-24 2011-12-14 天津大学 用于肿瘤靶向治疗的含半乳糖铂配合物及其制备方法
CN102286050A (zh) * 2011-06-24 2011-12-21 天津大学 用于肿瘤靶向治疗的含葡萄糖铂配合物及其制备方法
CN102286049A (zh) * 2011-06-24 2011-12-21 天津谷堆生物医药科技有限公司 用于肿瘤治疗的水溶性铂配合物及其制备方法
CN102716145A (zh) * 2012-06-20 2012-10-10 天津谷堆生物医药科技有限公司 含糖铂配合物在制备防治肿瘤药物的用途
JP2015524411A (ja) 2012-07-18 2015-08-24 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． エポキシケトン系プロテアソーム阻害剤のリポソーム組成物
PL2892524T3 (pl) 2012-09-04 2021-10-25 Eleison Pharmaceuticals, Llc Zapobieganie nawrotom płucnym przy użyciu cisplatyny w kompleksie z lipidami
US10039716B2 (en) 2013-03-13 2018-08-07 Mallinckrodt Llc Liposomal cisplatin compositions for cancer therapy
CN104546722B (zh) * 2015-02-10 2017-05-24 中国医学科学院医药生物技术研究所 米铂脂质体和制法
CN109678910B (zh) * 2016-01-25 2021-09-07 沈阳药科大学 一种化合物及其应用以及一种铂类配合物及其脂质体
EP3538546B1 (de) 2016-11-14 2025-01-08 Novartis AG Zusammensetzungen, methoden und therapeutische verwendungen des fusogenen proteins minion
CN114652680A (zh) * 2020-12-24 2022-06-24 沈阳药科大学 制备脂质体的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113508A1 (de) 1982-11-04 1984-07-18 Inco Research & Development Center, Inc. Hydrophobische Platinverbindungen und ihre Herstellung
US5384127A (en) * 1985-10-18 1995-01-24 Board Of Regents, The University Of Texas System Stable liposomal formulations of lipophilic platinum compounds
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
CA1339034C (en) * 1988-08-22 1997-04-01 Paul A. Tremblay Platinum complexes of single isomer neoalkyl acids
US5393909A (en) 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
JPH03200795A (ja) 1989-12-28 1991-09-02 Nippon Kayaku Co Ltd 脂質親和性白金錯体及びそれを含有する製剤
US5843475A (en) * 1996-12-06 1998-12-01 Board Of Regents, The University Of Texas System Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes

Also Published As

Publication number Publication date
CN1422619A (zh) 2003-06-11
EA199900715A1 (ru) 2000-04-24
PT975329E (pt) 2005-03-31
NO993750L (no) 1999-08-03
IL131008A0 (en) 2001-01-28
HK1054201B (zh) 2005-09-09
JP2002513396A (ja) 2002-05-08
HK1054201A1 (en) 2003-11-21
DK0975329T3 (da) 2005-03-14
ES2234094T3 (es) 2005-06-16
BR9815445A (pt) 2001-09-25
KR20000070771A (ko) 2000-11-25
US20010010822A1 (en) 2001-08-02
AU6015498A (en) 1998-08-25
EP0975329A1 (de) 2000-02-02
AU749220B2 (en) 2002-06-20
HUP0001266A2 (hu) 2000-11-28
CN1191067C (zh) 2005-03-02
DE69828038T2 (de) 2005-11-03
HK1029059A1 (zh) 2001-03-23
NZ337502A (en) 2001-02-23
UA71540C2 (uk) 2004-12-15
US6287593B2 (en) 2001-09-11
EP0975329B1 (de) 2004-12-08
NO993750D0 (no) 1999-08-03
HUP0001266A3 (en) 2001-02-28
CA2279279A1 (en) 1998-08-06
KR100578705B1 (ko) 2006-05-12
DE69828038D1 (de) 2005-01-13
PL334940A1 (en) 2000-03-27
CN1096263C (zh) 2002-12-18
EA002630B1 (ru) 2002-08-29
CA2279279C (en) 2008-10-14
WO1998033481A1 (en) 1998-08-06
CN1264295A (zh) 2000-08-23
ATE284204T1 (de) 2004-12-15
PL192633B1 (pl) 2006-11-30

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Legal Events

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MM9K Patent not in force due to non-payment of renewal fees