ATE284204T1 - Lipidkomplexe von sehr unlöslichen platinkomplexen - Google Patents

Lipidkomplexe von sehr unlöslichen platinkomplexen

Info

Publication number
ATE284204T1
ATE284204T1 AT98903358T AT98903358T ATE284204T1 AT E284204 T1 ATE284204 T1 AT E284204T1 AT 98903358 T AT98903358 T AT 98903358T AT 98903358 T AT98903358 T AT 98903358T AT E284204 T1 ATE284204 T1 AT E284204T1
Authority
AT
Austria
Prior art keywords
complexes
lipid
insoluble platinum
insoluble
platinum complexes
Prior art date
Application number
AT98903358T
Other languages
English (en)
Inventor
Mathew Cherian
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ATE284204T1 publication Critical patent/ATE284204T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98903358T 1997-02-05 1998-01-28 Lipidkomplexe von sehr unlöslichen platinkomplexen ATE284204T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3737797P 1997-02-05 1997-02-05
PCT/US1998/000035 WO1998033481A1 (en) 1997-02-05 1998-01-28 Lipid complexes and liposomes of highly insoluble platinum complexes

Publications (1)

Publication Number Publication Date
ATE284204T1 true ATE284204T1 (de) 2004-12-15

Family

ID=21894020

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98903358T ATE284204T1 (de) 1997-02-05 1998-01-28 Lipidkomplexe von sehr unlöslichen platinkomplexen

Country Status (22)

Country Link
US (1) US6287593B2 (de)
EP (1) EP0975329B1 (de)
JP (1) JP2002513396A (de)
KR (1) KR100578705B1 (de)
CN (2) CN1191067C (de)
AT (1) ATE284204T1 (de)
AU (1) AU749220B2 (de)
BR (1) BR9815445A (de)
CA (1) CA2279279C (de)
DE (1) DE69828038T2 (de)
DK (1) DK0975329T3 (de)
EA (1) EA002630B1 (de)
ES (1) ES2234094T3 (de)
HK (1) HK1054201B (de)
HU (1) HUP0001266A3 (de)
IL (1) IL131008A (de)
NO (1) NO993750L (de)
NZ (1) NZ337502A (de)
PL (1) PL192633B1 (de)
PT (1) PT975329E (de)
UA (1) UA71540C2 (de)
WO (1) WO1998033481A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051246A1 (en) 1998-04-03 1999-10-14 Ajinomoto Co., Inc. Antitumor agents
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
US9186322B2 (en) * 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
JP2006525368A (ja) * 2003-05-02 2006-11-09 アロネックス，ファーマシューティカルズ，インコーポレーテッド 脂質白金錯体およびその使用方法
WO2004105732A1 (en) * 2003-05-20 2004-12-09 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising gemcitabine and a liposomal platinum complex
CA2526289A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising 5-fluorouracil or a derivative thereof and a liposomal platinum complex
EP1631278A4 (de) * 2003-05-20 2006-09-20 Aronex Pharmaceuticals Inc Kombinationschemotherapie mit capecitabin und einem liposomalen platinkomplex
JP2007504177A (ja) * 2003-09-02 2007-03-01 プリヴァ−ラケマ，エー．エス． 医薬組成物、その製造方法及び治療上の使用
EP1734937A1 (de) * 2004-03-26 2006-12-27 Cell Therapeutics Europe S.R.L. Nanoteilchen-formulierungen von platinverbindungen
WO2006084248A2 (en) * 2005-02-04 2006-08-10 Antigenics, Inc. Compositions comprising a platinum complex, lipid, and surfactant
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
CA2631243A1 (en) * 2005-12-08 2007-06-14 Wyeth Liposomal compositions
CZ300424B6 (cs) * 2006-06-20 2009-05-13 Pliva - Lachema A. S. Farmaceutická kompozice pro perorální podání
IN2012DN02576A (de) * 2009-09-21 2015-08-28 Jw Pharmaceutical Corportion
WO2012006101A2 (en) 2010-06-28 2012-01-12 The General Hospital Corporation Blood substitutes and uses thereof
CN102276674A (zh) * 2011-06-24 2011-12-14 天津大学 用于肿瘤靶向治疗的含半乳糖铂配合物及其制备方法
CN102286049A (zh) * 2011-06-24 2011-12-21 天津谷堆生物医药科技有限公司 用于肿瘤治疗的水溶性铂配合物及其制备方法
CN102286050A (zh) * 2011-06-24 2011-12-21 天津大学 用于肿瘤靶向治疗的含葡萄糖铂配合物及其制备方法
CN102716145A (zh) * 2012-06-20 2012-10-10 天津谷堆生物医药科技有限公司 含糖铂配合物在制备防治肿瘤药物的用途
EP2874605A1 (de) 2012-07-18 2015-05-27 Onyx Therapeutics, Inc. Liposomale zusammensetzungen von proteasomhemmern auf epoxyketonbasis
DK2892524T3 (da) 2012-09-04 2021-01-25 Eleison Pharmaceuticals LLC Forebyggelse af pulmonalt kræfttilbagefald med lipid-komplekseret cisplatin
US10039716B2 (en) 2013-03-13 2018-08-07 Mallinckrodt Llc Liposomal cisplatin compositions for cancer therapy
CN104546722B (zh) * 2015-02-10 2017-05-24 中国医学科学院医药生物技术研究所 米铂脂质体和制法
CN109678910B (zh) * 2016-01-25 2021-09-07 沈阳药科大学 一种化合物及其应用以及一种铂类配合物及其脂质体
JP2020500020A (ja) 2016-11-14 2020-01-09 ノバルティス アーゲー 融合誘導性タンパク質ｍｉｎｉｏｎに関連する組成物、方法、および治療上の使用
CN114652680A (zh) * 2020-12-24 2022-06-24 沈阳药科大学 制备脂质体的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0113508A1 (de) * 1982-11-04 1984-07-18 Inco Research & Development Center, Inc. Hydrophobische Platinverbindungen und ihre Herstellung
US5384127A (en) * 1985-10-18 1995-01-24 Board Of Regents, The University Of Texas System Stable liposomal formulations of lipophilic platinum compounds
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
CA1339034C (en) * 1988-08-22 1997-04-01 Paul A. Tremblay Platinum complexes of single isomer neoalkyl acids
US5393909A (en) * 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
JPH03200795A (ja) * 1989-12-28 1991-09-02 Nippon Kayaku Co Ltd 脂質親和性白金錯体及びそれを含有する製剤
US5843475A (en) * 1996-12-06 1998-12-01 Board Of Regents, The University Of Texas System Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes

Also Published As

Publication number Publication date
AU749220B2 (en) 2002-06-20
AU6015498A (en) 1998-08-25
CN1191067C (zh) 2005-03-02
HK1029059A1 (zh) 2001-03-23
KR100578705B1 (ko) 2006-05-12
CN1096263C (zh) 2002-12-18
NO993750D0 (no) 1999-08-03
CA2279279C (en) 2008-10-14
CN1264295A (zh) 2000-08-23
CN1422619A (zh) 2003-06-11
ES2234094T3 (es) 2005-06-16
HUP0001266A2 (hu) 2000-11-28
KR20000070771A (ko) 2000-11-25
NZ337502A (en) 2001-02-23
EA199900715A1 (ru) 2000-04-24
JP2002513396A (ja) 2002-05-08
DE69828038D1 (de) 2005-01-13
DK0975329T3 (da) 2005-03-14
EA002630B1 (ru) 2002-08-29
CA2279279A1 (en) 1998-08-06
DE69828038T2 (de) 2005-11-03
EP0975329B1 (de) 2004-12-08
NO993750L (no) 1999-08-03
IL131008A (en) 2003-06-24
EP0975329A1 (de) 2000-02-02
WO1998033481A1 (en) 1998-08-06
IL131008A0 (en) 2001-01-28
US20010010822A1 (en) 2001-08-02
HUP0001266A3 (en) 2001-02-28
PL334940A1 (en) 2000-03-27
US6287593B2 (en) 2001-09-11
HK1054201A1 (en) 2003-11-21
HK1054201B (zh) 2005-09-09
BR9815445A (pt) 2001-09-25
PL192633B1 (pl) 2006-11-30
UA71540C2 (uk) 2004-12-15
PT975329E (pt) 2005-03-31

Similar Documents

Publication Publication Date Title
ATE284204T1 (de) Lipidkomplexe von sehr unlöslichen platinkomplexen
DE69616523D1 (de) Verfahren zur baladung von lipidvesikeln
MY112093A (en) Cosmetic delivery system for salicylic acid and process for preparation of the same.
NO304982B1 (no) Fosfolipid, fosfatidyletanolamin, farmas°ytisk, nµrings eller kosmetisk blanding omfattende nevnte fosfolipid eller fosfatidyletanolamin
ATE223232T1 (de) Tocopherolzusammensetzungen zur abgabe von biologisch aktiven substanzen
FI971776A0 (fi) Yhdisteet ja koostumukset aktiivisten aineiden antamiseksi
ATE383169T1 (de) Komponente und zusammensetzungen zur verabreichung von wirkstoffen
DE69730218D1 (de) Fusogene liposomen
FR2740686B1 (fr) Formulation pharmaceutique lyophilisee stable
EP1226109A4 (de) Phenylamin-carbonsäure-verbindungen und zubereitungen zur verabreichung von wirkstoffen
ATE554750T1 (de) Hydrophobe pharmazeutische wirkstoffe enthaltende zubereitungen
FI960032L (fi) Farmaseuttisia koostumuksia vaikeasti liukenevia aktiiviaineita varten
IT1203515B (it) Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono
HUP0004396A2 (hu) A lipoprotein-oxidáció gátlására szolgáló, hatóanyagként hidroxilezett koleszterincsökkentő szert tartalmazó gyógyszerkészítmények
BG103552A (bg) Терапевтични средства
ATE252888T1 (de) Lipid haltige zusammenstellungen und deren verwendungen
KR950700725A (ko) 리포솜 조성물(liposome composition)
HUP9900506A2 (hu) Protrombinszármazékok
ATE226065T1 (de) Feste instant-release-darreichungsformen und verfahren zu ihrer herstellung
GR3029581T3 (en) Liposomes containing encapsulated proteins, method of preparing them and pharmaceutical and cosmetic preparations containing such liposomes
FI952738L (fi) Stabiiliproteiini, fosfolipidikoostumuksia ja menetelmiä
BR9811954A (pt) ácidos 3-aril-succinamido-hidroxâmicos, processos para sua produção e preparações farmacêuticas contendo estas substâncias
FR2753707B1 (fr) Complexes nucleopeptidiques, compositions cosmetologiques et pharmaceutiques les contenant et utilisations
AU632313B2 (en) New platinum complexes, their preparation and pharmaceutical compositions which contain them
FI893776A0 (fi) Transdermalt anvaendbara laekemedel innehaollande farmaceutiskt anvaendbara glykosider.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0975329

Country of ref document: EP

REN Ceased due to non-payment of the annual fee