IL133613A - Epothilone derivatives and pharmaceutical compositions containing same - Google Patents

Epothilone derivatives and pharmaceutical compositions containing same

Info

Publication number: IL133613A
Authority: IL; Israel
Prior art keywords: alkyl; group; substituted; aryl; cycloalkyl
Prior art date: 1997-07-08

Application number

IL13361398A

Other languages

English (en)

Other versions

IL133613A0 (en

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-08

Filing date

1998-06-16

Publication date

2005-11-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26729990&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL133613(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-06-16 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2001-04-30 Publication of IL133613A0 publication Critical patent/IL133613A0/xx

2005-11-20 Publication of IL133613A publication Critical patent/IL133613A/xx

Links

150000003883 epothilone derivatives Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
125000000547 substituted alkyl group Chemical group 0.000 abstract 5
125000003118 aryl group Chemical group 0.000 abstract 4
125000000753 cycloalkyl group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000003107 substituted aryl group Chemical group 0.000 abstract 2
-1 1-methyl-2-(substituted-4-thiazolyl)ethenyl Chemical group 0.000 abstract 1
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
102220046301 rs148061139 Human genes 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)

IL13361398A 1997-07-08 1998-06-16 Epothilone derivatives and pharmaceutical compositions containing same IL133613A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US5195197P	1997-07-08	1997-07-08
US6752497P	1997-12-04	1997-12-04
PCT/US1998/012550 WO1999002514A2 (en)	1997-07-08	1998-06-16	Epothilone derivatives

Publications (2)

Publication Number	Publication Date
IL133613A0 IL133613A0 (en)	2001-04-30
IL133613A true IL133613A (en)	2005-11-20

Family

ID=26729990

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL13361398A IL133613A (en)	1997-07-08	1998-06-16	Epothilone derivatives and pharmaceutical compositions containing same

Country Status (32)

Country	Link
US (10)	US6605599B1 (pl)
EP (4)	EP1531153A1 (pl)
JP (2)	JP4090514B2 (pl)
KR (1)	KR100569041B1 (pl)
CN (1)	CN100384834C (pl)
AR (1)	AR013358A1 (pl)
AT (2)	ATE426598T1 (pl)
AU (1)	AU731497B2 (pl)
BG (1)	BG64952B1 (pl)
BR (1)	BRPI9810555A8 (pl)
CA (1)	CA2296012C (pl)
CO (1)	CO4940501A1 (pl)
CZ (1)	CZ297904B6 (pl)
DE (2)	DE69840693D1 (pl)
DK (1)	DK1019389T3 (pl)
EE (1)	EE04566B1 (pl)
EG (1)	EG24464A (pl)
ES (2)	ES2322807T3 (pl)
GE (1)	GEP20032897B (pl)
HU (1)	HU227444B1 (pl)
ID (1)	ID23771A (pl)
IL (1)	IL133613A (pl)
LV (1)	LV12569B (pl)
MY (1)	MY124151A (pl)
NO (1)	NO322494B1 (pl)
NZ (1)	NZ501198A (pl)
PE (1)	PE104599A1 (pl)
PL (1)	PL197404B1 (pl)
RO (1)	RO120340B1 (pl)
TR (1)	TR200000065T2 (pl)
TW (1)	TW562802B (pl)
WO (1)	WO1999002514A2 (pl)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
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CA2273083C (en)	1996-12-03	2012-09-18	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
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1998
- 1998-05-26 US US09/084,542 patent/US6605599B1/en not_active Ceased
- 1998-06-16 EE EEP200000013A patent/EE04566B1/xx not_active IP Right Cessation
- 1998-06-16 DE DE69840693T patent/DE69840693D1/de not_active Expired - Lifetime
- 1998-06-16 CA CA002296012A patent/CA2296012C/en not_active Expired - Lifetime
- 1998-06-16 DE DE69832294T patent/DE69832294T2/de not_active Expired - Lifetime
- 1998-06-16 NZ NZ501198A patent/NZ501198A/en not_active IP Right Cessation
- 1998-06-16 EP EP04028581A patent/EP1531153A1/en not_active Withdrawn
- 1998-06-16 EP EP98930300A patent/EP1019389B1/en not_active Expired - Lifetime
- 1998-06-16 TR TR2000/00065T patent/TR200000065T2/xx unknown
- 1998-06-16 ES ES04021059T patent/ES2322807T3/es not_active Expired - Lifetime
- 1998-06-16 BR BRPI9810555A patent/BRPI9810555A8/pt active Search and Examination
- 1998-06-16 WO PCT/US1998/012550 patent/WO1999002514A2/en not_active Ceased
- 1998-06-16 AT AT04021059T patent/ATE426598T1/de not_active IP Right Cessation
- 1998-06-16 CN CNB988069067A patent/CN100384834C/zh not_active Expired - Fee Related
- 1998-06-16 IL IL13361398A patent/IL133613A/xx not_active IP Right Cessation
- 1998-06-16 HU HU0103111A patent/HU227444B1/hu not_active IP Right Cessation
- 1998-06-16 CZ CZ20000058A patent/CZ297904B6/cs not_active IP Right Cessation
- 1998-06-16 ID IDW20000002A patent/ID23771A/id unknown
- 1998-06-16 EP EP04028580A patent/EP1526133A1/en not_active Withdrawn
- 1998-06-16 RO RO99-01332A patent/RO120340B1/ro unknown
- 1998-06-16 EP EP04021059A patent/EP1493738B1/en not_active Expired - Lifetime
- 1998-06-16 AT AT98930300T patent/ATE309236T1/de active
- 1998-06-16 ES ES98930300T patent/ES2251088T3/es not_active Expired - Lifetime
- 1998-06-16 KR KR1020007000120A patent/KR100569041B1/ko not_active Expired - Lifetime
- 1998-06-16 GE GEAP19985171A patent/GEP20032897B/en unknown
- 1998-06-16 AU AU79720/98A patent/AU731497B2/en not_active Ceased
- 1998-06-16 DK DK98930300T patent/DK1019389T3/da active
- 1998-06-16 JP JP50867399A patent/JP4090514B2/ja not_active Expired - Fee Related
- 1998-06-16 PL PL338003A patent/PL197404B1/pl unknown
- 1998-07-02 TW TW087110722A patent/TW562802B/zh not_active IP Right Cessation
- 1998-07-07 CO CO98038387A patent/CO4940501A1/es unknown
- 1998-07-07 EG EG79298A patent/EG24464A/xx active
- 1998-07-07 PE PE1998000604A patent/PE104599A1/es not_active Application Discontinuation
- 1998-07-08 AR ARP980103322A patent/AR013358A1/es active IP Right Grant
- 1998-07-08 MY MYPI98003121A patent/MY124151A/en unknown
2000
- 2000-01-07 NO NO20000076A patent/NO322494B1/no not_active IP Right Cessation
- 2000-01-10 BG BG104068A patent/BG64952B1/bg unknown
- 2000-02-02 LV LVP-00-17A patent/LV12569B/en unknown
2003
- 2003-04-03 US US10/405,886 patent/US7125899B2/en not_active Expired - Lifetime
2006
- 2006-08-30 US US11/512,623 patent/US7241755B2/en not_active Expired - Lifetime
2007
- 2007-06-13 JP JP2007156260A patent/JP4885067B2/ja not_active Expired - Fee Related
- 2007-06-15 US US11/763,636 patent/US8536327B2/en not_active Expired - Fee Related
2009
- 2009-08-11 US US12/539,498 patent/USRE41893E1/en not_active Expired - Lifetime
- 2009-08-11 US US12/539,496 patent/USRE41895E1/en not_active Expired - Lifetime
- 2009-08-11 US US12/539,492 patent/USRE41911E1/en not_active Expired - Lifetime
2010
- 2010-09-15 US US12/882,769 patent/USRE43003E1/en not_active Expired - Fee Related
2013
- 2013-08-14 US US13/966,613 patent/US8921542B2/en not_active Expired - Fee Related
2014
- 2014-11-25 US US14/553,081 patent/US20150080440A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO20000076D0 (no)	2000-01-07
US20030220295A1 (en)	2003-11-27
KR20010021562A (ko)	2001-03-15
US20130331564A1 (en)	2013-12-12
AU731497B2 (en)	2001-03-29
EP1531153A1 (en)	2005-05-18
BR9810555A (pt)	2000-08-15
USRE41895E1 (en)	2010-10-26
US8536327B2 (en)	2013-09-17
PL197404B1 (pl)	2008-03-31
USRE43003E1 (en)	2011-12-06
CZ200058A3 (cs)	2001-01-17
DK1019389T3 (da)	2006-01-16
JP4090514B2 (ja)	2008-05-28
IL133613A0 (en)	2001-04-30
CZ297904B6 (cs)	2007-04-25
HUP0103111A3 (en)	2003-01-28
BG104068A (en)	2000-09-29
DE69832294D1 (de)	2005-12-15
PL338003A1 (en)	2000-09-25
US7125899B2 (en)	2006-10-24
US20150080440A1 (en)	2015-03-19
DE69840693D1 (de)	2009-05-07
JP2007291121A (ja)	2007-11-08
JP4885067B2 (ja)	2012-02-29
EP1019389B1 (en)	2005-11-09
USRE41911E1 (en)	2010-11-02
EP1019389A2 (en)	2000-07-19
JP2002512634A (ja)	2002-04-23
EP1493738A1 (en)	2005-01-05
WO1999002514A3 (en)	2001-05-10
US8921542B2 (en)	2014-12-30
PE104599A1 (es)	2000-01-19
ATE309236T1 (de)	2005-11-15
EE200000013A (et)	2000-08-15
NO322494B1 (no)	2006-10-16
ATE426598T1 (de)	2009-04-15
GEP20032897B (en)	2003-02-25
TR200000065T2 (tr)	2000-11-21
ES2322807T3 (es)	2009-06-29
EE04566B1 (et)	2005-12-15
CO4940501A1 (es)	2000-07-24
EG24464A (en)	2009-07-16
ID23771A (id)	2000-05-11
AU7972098A (en)	1999-02-08
HK1031731A1 (zh)	2001-06-22
US20070255055A1 (en)	2007-11-01
CA2296012A1 (en)	1999-01-21
KR100569041B1 (ko)	2006-04-10
LV12569A (en)	2000-11-20
RO120340B1 (ro)	2005-12-30
CN100384834C (zh)	2008-04-30
EP1019389A4 (en)	2001-11-07
BG64952B1 (bg)	2006-10-31
US7241755B2 (en)	2007-07-10
NO20000076L (no)	2000-01-07
HU227444B1 (en)	2011-06-28
ES2251088T3 (es)	2006-04-16
HUP0103111A2 (hu)	2002-04-29
EP1493738B1 (en)	2009-03-25
AR013358A1 (es)	2000-12-27
LV12569B (en)	2001-04-20
MY124151A (en)	2006-06-30
US6605599B1 (en)	2003-08-12
US20060287371A1 (en)	2006-12-21
CN1270589A (zh)	2000-10-18
TW562802B (en)	2003-11-21
CA2296012C (en)	2008-10-21
DE69832294T2 (de)	2006-05-24
BRPI9810555A8 (pt)	2017-09-19
USRE41893E1 (en)	2010-10-26
HK1026905A1 (en)	2000-12-29
NZ501198A (en)	2001-09-28
EP1526133A1 (en)	2005-04-27
WO1999002514A2 (en)	1999-01-21

Legal Events

Date	Code	Title	Description
2006-02-21	FF	Patent granted
2008-08-10	KB	Patent renewed
2012-04-30	EXTF	Application for patent extension filed
2012-06-28	KB	Patent renewed
2014-11-30	EXTG	Extension of patent term granted	Free format text: PRODUCT NAME: IXABEPILONE Extension date: 20200928
2017-01-31	MM9K	Patent not in force due to non-payment of renewal fees

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