BRPI9810555A8 - Derivados epotilona - Google Patents

Derivados epotilona

Info

Publication number
BRPI9810555A8
BRPI9810555A8 BRPI9810555A BR9810555A BRPI9810555A8 BR PI9810555 A8 BRPI9810555 A8 BR PI9810555A8 BR PI9810555 A BRPI9810555 A BR PI9810555A BR 9810555 A BR9810555 A BR 9810555A BR PI9810555 A8 BRPI9810555 A8 BR PI9810555A8
Authority
BR
Brazil
Prior art keywords
alkyl
group
substituted
aryl
cycloalkyl
Prior art date
Application number
BRPI9810555A
Other languages
English (en)
Other versions
BR9810555A (pt
Inventor
D Vite Gregory
M Borzilleri Robert
Kim Soong-Hoon
A Johnson James
Original Assignee
Bristol Myers Squibb Co
R Pharm Us Operating Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26729990&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI9810555(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co, R Pharm Us Operating Llc filed Critical Bristol Myers Squibb Co
Publication of BR9810555A publication Critical patent/BR9810555A/pt
Publication of BRPI9810555A8 publication Critical patent/BRPI9810555A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

DERIVADOS EPOTILONA A presente invenção refere-se a compostos de fórmula V caracterizado pelo fato de que: Q é selecionado do grupo que consiste de G é selecionado do grupo que consiste de alquila, alquila substituída, arila substituída ou insubstituída, heterociclo, W é O ou NR15; X é O ou H,H; Y é selecionado do grupo que consiste de O; H,OR16; OR17, OR17; NOR18; H,NOR19; H,NR20R21; H,H; ou CHR22; OR17OR17 pode ser um cetal cíclico; Z1, e Z2 são selecionados do grupo que consiste de CH2, O, NR23, S, ou SO2, onde apenas um de Z1 e Z2 pode ser um heteroátomo; B1 e B2 são selecionados do grupo que consiste de OR24, ou OCOR25, ou O2CNR26R27; quando B1 é H e Y é OH,H, os mesmos podem formar um anel cetal ou acetal de seis membros; D é selecionado do grupo que consiste de NR28R29, NR30COR31 ou heterociclo saturado; R1, R2, R3, R4, R5, R6, R7, R13, R14, R18, R19, R20, R21, R22, R26, e R27 são selecionados do grupo que consiste de H, alquila, alquila substituída, ou arila e quando R1 e R2 são alquila podem ser unidas para formar uma cicloalquila; R3 e R4 são alquila podem ser unidas para formar uma cicloalquila; R9, R10, R16, R17, R24, R25 e R31, são selecionados do grupo que consiste de H, alquila ou alquila substituída; R8, R11, R12, R28, R30, R32, R33 e R30 são selecionados do grupo que consiste de H, alquila, alquila substituída, arila, arila substituída, cicloalquila, ou heterociclo; R15, R23 e R29 são selecionados do grupo que consiste de H, alquila, alquila substituída, arila, arila substituída, cicloalquila, heterociclo, R32C=O, R33SO2, hidróxi, O-alquila ou alquila O-substituída; os sais farmaceuticamente aceitáveis dos mesmos e quaisquer hidratos, solvatos ou geométricos, óticos e estereoisômeros dos mesmos, desde que os compostos onde W e X são ambos O; e R1, R2, R7 são H; e R3, R4, R6 são metila; e R8 é H ou metila; e Z1, e Z2, são CH2; e G é 1-metil-2-(4-tiazolil-substituída) etenila Q é como definido acima sejam excluídos.
BRPI9810555A 1997-07-08 1998-06-16 Derivados epotilona BRPI9810555A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5195197P 1997-07-08 1997-07-08
US6752497P 1997-12-04 1997-12-04
PCT/US1998/012550 WO1999002514A2 (en) 1997-07-08 1998-06-16 Epothilone derivatives

Publications (2)

Publication Number Publication Date
BR9810555A BR9810555A (pt) 2000-08-15
BRPI9810555A8 true BRPI9810555A8 (pt) 2017-09-19

Family

ID=26729990

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9810555A BRPI9810555A8 (pt) 1997-07-08 1998-06-16 Derivados epotilona

Country Status (32)

Country Link
US (10) US6605599B1 (pt)
EP (4) EP1531153A1 (pt)
JP (2) JP4090514B2 (pt)
KR (1) KR100569041B1 (pt)
CN (1) CN100384834C (pt)
AR (1) AR013358A1 (pt)
AT (2) ATE426598T1 (pt)
AU (1) AU731497B2 (pt)
BG (1) BG64952B1 (pt)
BR (1) BRPI9810555A8 (pt)
CA (1) CA2296012C (pt)
CO (1) CO4940501A1 (pt)
CZ (1) CZ297904B6 (pt)
DE (2) DE69840693D1 (pt)
DK (1) DK1019389T3 (pt)
EE (1) EE04566B1 (pt)
EG (1) EG24464A (pt)
ES (2) ES2322807T3 (pt)
GE (1) GEP20032897B (pt)
HU (1) HU227444B1 (pt)
ID (1) ID23771A (pt)
IL (1) IL133613A (pt)
LV (1) LV12569B (pt)
MY (1) MY124151A (pt)
NO (1) NO322494B1 (pt)
NZ (1) NZ501198A (pt)
PE (1) PE104599A1 (pt)
PL (1) PL197404B1 (pt)
RO (1) RO120340B1 (pt)
TR (1) TR200000065T2 (pt)
TW (1) TW562802B (pt)
WO (1) WO1999002514A2 (pt)

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JP4885067B2 (ja) 2012-02-29
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USRE41911E1 (en) 2010-11-02
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