IL137965A - Method for producing spherical pellets with a polymeric coating - Google Patents

Method for producing spherical pellets with a polymeric coating

Info

Publication number
IL137965A
IL137965A IL13796599A IL13796599A IL137965A IL 137965 A IL137965 A IL 137965A IL 13796599 A IL13796599 A IL 13796599A IL 13796599 A IL13796599 A IL 13796599A IL 137965 A IL137965 A IL 137965A
Authority
IL
Israel
Prior art keywords
grains
encased
polymer dispersion
prostane
polymeric coating
Prior art date
Application number
IL13796599A
Other languages
English (en)
Other versions
IL137965A0 (en
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL137965A0 publication Critical patent/IL137965A0/xx
Publication of IL137965A publication Critical patent/IL137965A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
    • A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glanulating (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
IL13796599A 1998-02-24 1999-02-24 Method for producing spherical pellets with a polymeric coating IL137965A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19808634A DE19808634A1 (de) 1998-02-24 1998-02-24 Mantel für eine pharmazeutische Zusammensetzung
PCT/EP1999/001100 WO1999043303A1 (de) 1998-02-24 1999-02-24 Verfahren zur herstellung von ummantelten, sphärischen granulatkörnern

Publications (2)

Publication Number Publication Date
IL137965A0 IL137965A0 (en) 2001-10-31
IL137965A true IL137965A (en) 2005-11-20

Family

ID=7859315

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13796599A IL137965A (en) 1998-02-24 1999-02-24 Method for producing spherical pellets with a polymeric coating

Country Status (18)

Country Link
US (1) US6723372B1 (cs)
EP (1) EP1058542B1 (cs)
JP (1) JP2002504506A (cs)
KR (1) KR100623542B1 (cs)
AT (1) ATE303133T1 (cs)
AU (1) AU753261B2 (cs)
CA (1) CA2321969C (cs)
CZ (1) CZ299252B6 (cs)
DE (2) DE19808634A1 (cs)
DK (1) DK1058542T3 (cs)
ES (1) ES2247786T3 (cs)
HU (1) HU226066B1 (cs)
IL (1) IL137965A (cs)
NO (1) NO20004225L (cs)
PL (1) PL193071B1 (cs)
RU (1) RU2209060C2 (cs)
SK (1) SK284062B6 (cs)
WO (1) WO1999043303A1 (cs)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19828881A1 (de) 1998-06-22 1999-12-23 Schering Ag Oxidationsinhibitor bei Prostan-Derivaten
US8323692B2 (en) 2002-02-21 2012-12-04 Valeant International Bermuda Controlled release dosage forms
ATE341312T1 (de) * 2003-05-20 2006-10-15 Ethypharm Sa Orale pharmazeutische zusammensetzung mit verzögerter freisetzung
US8318230B2 (en) * 2005-05-02 2012-11-27 Henkel Ag & Co. Kgaa Use of debranched starch in extrusion-spheronization pharmaceutical pellets
WO2007063946A1 (ja) 2005-11-30 2007-06-07 Fujifilm Ri Pharma Co., Ltd. アミロイドの凝集及び／又は沈着に起因する疾患の診断薬及び治療薬
RU2702690C2 (ru) * 2015-08-13 2019-10-09 БИОЛИНГУС АйПи ЛЛСи Способ получения продуктов, содержащих стабилизированные активные вещества, и композиций, содержащих таковые
CN106822013B (zh) * 2015-11-30 2020-05-12 北京泰德制药股份有限公司 前列环素类似物缓释制剂

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA935093A (en) * 1969-07-28 1973-10-09 Eurand S.R.L. Method of preparing granules with controlled release of the active substance contained therein
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
US5286494A (en) * 1986-07-02 1994-02-15 Schering Aktiengesellschaft Medicinal agents with sustained action
DE3622487A1 (de) * 1986-07-02 1988-01-14 Schering Ag Arzneimittel mit verzoegerter wirkstoffabgabe
IT1227899B (it) * 1988-12-23 1991-05-14 Poli Ind Chimica Spa Rivestimento totale o parziale di principi attivi farmaceutici e relative composizioni
US5286493A (en) * 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
JP3277342B2 (ja) * 1992-09-02 2002-04-22 武田薬品工業株式会社 徐放性マイクロカプセルの製造法
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
DE4236025A1 (de) * 1992-10-24 1994-04-28 Merck Patent Gmbh Orale Arzneiformen
US5376384A (en) * 1992-12-23 1994-12-27 Kinaform Technology, Inc. Delayed, sustained-release pharmaceutical preparation
FI94926C (fi) * 1993-11-12 1995-11-27 Leiras Oy Menetelmä klodronaattivalmisteen valmistamiseksi
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
RU2117475C1 (ru) * 1995-11-02 1998-08-20 Химико-фармацевтическое акционерное общество открытого типа "Октябрь" Водная акриловая дисперсия для производства энтеральных лекарственных форм
JPH10139659A (ja) * 1996-09-10 1998-05-26 Freunt Ind Co Ltd 球形粒子群、その製造方法及びそれを用いた球形粒子製剤

Also Published As

Publication number Publication date
DK1058542T3 (da) 2006-01-02
SK12422000A3 (sk) 2001-04-09
NO20004225L (no) 2000-09-28
KR100623542B1 (ko) 2006-09-13
RU2209060C2 (ru) 2003-07-27
CA2321969C (en) 2007-04-10
EP1058542A1 (de) 2000-12-13
JP2002504506A (ja) 2002-02-12
DE59912501D1 (de) 2005-10-06
PL342315A1 (en) 2001-06-04
IL137965A0 (en) 2001-10-31
US6723372B1 (en) 2004-04-20
ATE303133T1 (de) 2005-09-15
KR20010041210A (ko) 2001-05-15
HUP0100752A2 (hu) 2001-08-28
CA2321969A1 (en) 1999-09-02
AU753261B2 (en) 2002-10-10
CZ299252B6 (cs) 2008-05-28
SK284062B6 (sk) 2004-09-08
EP1058542B1 (de) 2005-08-31
DE19808634A1 (de) 1999-08-26
AU2835299A (en) 1999-09-15
HU226066B1 (en) 2008-04-28
NO20004225D0 (no) 2000-08-23
WO1999043303A1 (de) 1999-09-02
CZ20003088A3 (cs) 2000-11-15
PL193071B1 (pl) 2007-01-31
ES2247786T3 (es) 2006-03-01

Similar Documents

Publication Publication Date Title
DE69829655T2 (de) Biofunktionelle polymere im überkritischem fluid hergestellt
EP1000615A3 (en) Preparation of pharmaceutically active particles
CA2228610A1 (en) Controlled release products
WO2002053599A3 (en) Biodegradable oxidized cellulose esters
EP0761213A3 (en) Method of production of sustained-release preparation
WO1995024929A3 (en) Polymeric gene delivery system
CA2514446A1 (en) Composition comprising a mixture of active principles, and method of preparation
CA2127352A1 (en) Pharmaceutical preparation in the form of an effervescent and/or disintegrating tablet or an instant granulate, and process for producing it
CA2331785A1 (en) Process for microgel preparation
IL137965A (en) Method for producing spherical pellets with a polymeric coating
NZ335364A (en) Pellets having a core 250-355 um coated with an antifungal and a polymer, pharmaceutical, and process
CA2561109A1 (en) Gastric retention system
AU2001277570A1 (en) Oral pharmaceutical composition with controlled release and prolonged absorption
ES2148300T3 (es) Microcapsulas para la liberacion controlada de acido acetilsalicilico.
RU92004344A (ru) Устойчивые лекарственные формы с регулируемым выделением, имеющие акриловые полимерные покрытия, и способ их получения
WO1990007859A3 (en) Method of controlling release of sucralose in chewing gum and gum produced thereby
EP0979648A3 (en) Microspheres of esters of hyaluronic acid for controlled release of an active
WO1996011675A3 (fr) Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
DE69434258D1 (de) Mikroverkapselte 1,2-benzazole
DE69929439D1 (de) Polyakrylsäure-granulate mit gesteuerter freigabe und verfahren zu dessen herstellung
DE59305700D1 (de) Verfahren zur Herstellung von festen pharmazeutischen Retardformen
DE3884214D1 (de) Verfahren zur herstellung einer festen form mit beibehaltender freisetzung aus einer funktionellen aktiven komposition und die bei dem verfahren erhaltene dosierungsform.
IL145755A0 (en) Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix
WO1990007864A3 (en) Method of controlling release of clycyrrhizin in chewing gum and gum produced thereby
EP0735049A3 (en) Humectant, antistatic agent, dispersant and film-forming agent with polysaccharide as an effective principle; Process for the production of polysaccharides and Klebsiella strain

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees