IL145546A0 - Disodium salts, monohydrates, and ethanol solvates for delivering active agents - Google Patents
Disodium salts, monohydrates, and ethanol solvates for delivering active agentsInfo
- Publication number
- IL145546A0 IL145546A0 IL14554600A IL14554600A IL145546A0 IL 145546 A0 IL145546 A0 IL 145546A0 IL 14554600 A IL14554600 A IL 14554600A IL 14554600 A IL14554600 A IL 14554600A IL 145546 A0 IL145546 A0 IL 145546A0
- Authority
- IL
- Israel
- Prior art keywords
- active agents
- delivering active
- monohydrates
- ethanol
- disodium salts
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title abstract 8
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 title abstract 5
- 239000012453 solvate Substances 0.000 title abstract 4
- 239000013543 active substance Substances 0.000 title abstract 2
- 150000004682 monohydrates Chemical class 0.000 title 1
- 229940124447 delivery agent Drugs 0.000 abstract 3
- 125000003816 2-hydroxybenzoyl group Chemical group OC1=C(C(=O)*)C=CC=C1 0.000 abstract 2
- XRTHAPZDZPADIL-UHFFFAOYSA-N 8-[(5-chloro-2-hydroxybenzoyl)amino]octanoic acid Chemical compound OC(=O)CCCCCCCNC(=O)C1=CC(Cl)=CC=C1O XRTHAPZDZPADIL-UHFFFAOYSA-N 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 abstract 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- XUHVCHNJCBBXMP-UHFFFAOYSA-M sodium;10-[(2-hydroxybenzoyl)amino]decanoate Chemical compound [Na+].OC1=CC=CC=C1C(=O)NCCCCCCCCCC([O-])=O XUHVCHNJCBBXMP-UHFFFAOYSA-M 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12775499P | 1999-04-05 | 1999-04-05 | |
| US18614200P | 2000-03-01 | 2000-03-01 | |
| US18614300P | 2000-03-01 | 2000-03-01 | |
| US19128600P | 2000-03-21 | 2000-03-21 | |
| PCT/US2000/009390 WO2000059863A1 (en) | 1999-04-05 | 2000-04-05 | Disodium salts, monohydrates, and ethanol solvates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL145546A0 true IL145546A0 (en) | 2002-06-30 |
Family
ID=27494697
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14554600A IL145546A0 (en) | 1999-04-05 | 2000-04-05 | Disodium salts, monohydrates, and ethanol solvates for delivering active agents |
| IL145546A IL145546A (en) | 1999-04-05 | 2001-09-21 | Disodium salts, monohydrates and ethanol solvates for delivering active agents |
| IL166158A IL166158A (en) | 1999-04-05 | 2005-01-05 | Disodium salts, monohydrates and ethanol solvates for delivering active agents |
| IL180118A IL180118A (en) | 1999-04-05 | 2006-12-17 | Disodium salts, monohydrates and ethanol solvates for delivering active agents |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL145546A IL145546A (en) | 1999-04-05 | 2001-09-21 | Disodium salts, monohydrates and ethanol solvates for delivering active agents |
| IL166158A IL166158A (en) | 1999-04-05 | 2005-01-05 | Disodium salts, monohydrates and ethanol solvates for delivering active agents |
| IL180118A IL180118A (en) | 1999-04-05 | 2006-12-17 | Disodium salts, monohydrates and ethanol solvates for delivering active agents |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US20020065255A1 (de) |
| EP (1) | EP1175390B1 (de) |
| JP (2) | JP4588221B2 (de) |
| AT (1) | ATE288415T1 (de) |
| AU (1) | AU4216700A (de) |
| CA (1) | CA2369591C (de) |
| DE (1) | DE60017888T2 (de) |
| ES (1) | ES2235854T3 (de) |
| IL (4) | IL145546A0 (de) |
| NZ (1) | NZ534409A (de) |
| WO (1) | WO2000059863A1 (de) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| NZ509238A (en) | 1998-07-27 | 2003-07-25 | Emisphere Tech Inc | Pulmonary delivery of active agents the carrier containing acylated or sulfonated amino acids |
| US6440929B1 (en) | 1998-07-27 | 2002-08-27 | Emisphere Technologies, Inc. | Pulmonary delivery of active agents |
| IL140930A0 (en) | 1998-08-07 | 2002-02-10 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| US6991798B1 (en) | 1998-08-07 | 2006-01-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
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| US7279597B1 (en) | 1999-11-05 | 2007-10-09 | Emisphere Technologies, Inc. | Phenyl amine carboxylic acid compounds and compositions for delivering active agents |
| US7129274B1 (en) | 1999-11-05 | 2006-10-31 | Emisphere Technologies Inc. | Phenoxy carboxylic acid compounds and compositions for delivering active agents |
| US7151191B2 (en) | 2000-01-13 | 2006-12-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
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2000
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- 2000-04-05 AT AT00921909T patent/ATE288415T1/de active
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- 2000-04-05 EP EP00921909A patent/EP1175390B1/de not_active Expired - Lifetime
- 2000-04-05 CA CA2369591A patent/CA2369591C/en not_active Expired - Lifetime
- 2000-04-05 ES ES00921909T patent/ES2235854T3/es not_active Expired - Lifetime
- 2000-04-05 JP JP2000609376A patent/JP4588221B2/ja not_active Expired - Lifetime
- 2000-04-05 AU AU42167/00A patent/AU4216700A/en not_active Abandoned
- 2000-04-05 DE DE60017888T patent/DE60017888T2/de not_active Expired - Lifetime
- 2000-04-05 WO PCT/US2000/009390 patent/WO2000059863A1/en not_active Ceased
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2001
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- 2001-09-24 US US09/962,794 patent/US20020065255A1/en not_active Abandoned
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2003
- 2003-07-07 US US10/615,213 patent/US7384982B2/en not_active Expired - Lifetime
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2004
- 2004-11-09 JP JP2004325632A patent/JP4642435B2/ja not_active Expired - Lifetime
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2005
- 2005-01-05 IL IL166158A patent/IL166158A/en not_active IP Right Cessation
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2006
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2008
- 2008-04-29 US US12/111,750 patent/US7659311B2/en not_active Expired - Fee Related
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2009
- 2009-12-18 US US12/642,508 patent/US8003697B2/en not_active Expired - Fee Related
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2011
- 2011-03-22 US US13/053,641 patent/US8207227B2/en not_active Expired - Fee Related
-
2012
- 2012-05-25 US US13/481,310 patent/US8658695B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60017888T2 (de) | 2006-01-19 |
| JP4588221B2 (ja) | 2010-11-24 |
| AU4216700A (en) | 2000-10-23 |
| US7659311B2 (en) | 2010-02-09 |
| IL180118A (en) | 2010-12-30 |
| US8003697B2 (en) | 2011-08-23 |
| NZ534409A (en) | 2006-03-31 |
| CA2369591A1 (en) | 2000-10-12 |
| EP1175390A4 (de) | 2002-09-04 |
| US20020065255A1 (en) | 2002-05-30 |
| WO2000059863A1 (en) | 2000-10-12 |
| IL145546A (en) | 2007-10-31 |
| ATE288415T1 (de) | 2005-02-15 |
| IL166158A (en) | 2010-12-30 |
| IL180118A0 (en) | 2007-06-03 |
| EP1175390A1 (de) | 2002-01-30 |
| HK1045680A1 (en) | 2002-12-06 |
| ES2235854T3 (es) | 2005-07-16 |
| US20080269134A1 (en) | 2008-10-30 |
| US7384982B2 (en) | 2008-06-10 |
| IL166158A0 (en) | 2006-01-15 |
| US20100099621A1 (en) | 2010-04-22 |
| US20110251125A1 (en) | 2011-10-13 |
| DE60017888D1 (de) | 2005-03-10 |
| JP4642435B2 (ja) | 2011-03-02 |
| JP2002541132A (ja) | 2002-12-03 |
| US8658695B2 (en) | 2014-02-25 |
| EP1175390B1 (de) | 2005-02-02 |
| US20120264834A1 (en) | 2012-10-18 |
| US20040106825A1 (en) | 2004-06-03 |
| US8207227B2 (en) | 2012-06-26 |
| CA2369591C (en) | 2011-06-14 |
| JP2005068161A (ja) | 2005-03-17 |
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