IL148309A0 - Use of retigabine for the treatment of neuropathic pain - Google Patents
Use of retigabine for the treatment of neuropathic painInfo
- Publication number
- IL148309A0 IL148309A0 IL14830900A IL14830900A IL148309A0 IL 148309 A0 IL148309 A0 IL 148309A0 IL 14830900 A IL14830900 A IL 14830900A IL 14830900 A IL14830900 A IL 14830900A IL 148309 A0 IL148309 A0 IL 148309A0
- Authority
- IL
- Israel
- Prior art keywords
- retigabine
- treatment
- neuropathic pain
- neuropathic
- pain
- Prior art date
Links
- PCOBBVZJEWWZFR-UHFFFAOYSA-N ezogabine Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 PCOBBVZJEWWZFR-UHFFFAOYSA-N 0.000 title 1
- 208000004296 neuralgia Diseases 0.000 title 1
- 208000021722 neuropathic pain Diseases 0.000 title 1
- 229960003312 retigabine Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/406,135 US6117900A (en) | 1999-09-27 | 1999-09-27 | Use of retigabine for the treatment of neuropathic pain |
| PCT/EP2000/009284 WO2001022953A2 (fr) | 1999-09-27 | 2000-09-22 | Utilisation de retigabine pour le traitement de douleurs neuropathiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL148309A0 true IL148309A0 (en) | 2002-09-12 |
Family
ID=23606675
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14830900A IL148309A0 (en) | 1999-09-27 | 2000-09-22 | Use of retigabine for the treatment of neuropathic pain |
| IL148309A IL148309A (en) | 1999-09-27 | 2002-02-21 | Use of retigabine to treat neopathic pain |
| IL187030A IL187030A (en) | 1999-09-27 | 2007-10-30 | Use of retigabine for the preparation of drugs for the treatment of non-allodinia pain, hyperalgesic pain, pseudoassay, pain due to diabetes, pain associated with sympathetic dystrophy of reflexes, vulvodynia, paraesthesia, pain due to activation of pressure and pain due to spinal cord injury |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL148309A IL148309A (en) | 1999-09-27 | 2002-02-21 | Use of retigabine to treat neopathic pain |
| IL187030A IL187030A (en) | 1999-09-27 | 2007-10-30 | Use of retigabine for the preparation of drugs for the treatment of non-allodinia pain, hyperalgesic pain, pseudoassay, pain due to diabetes, pain associated with sympathetic dystrophy of reflexes, vulvodynia, paraesthesia, pain due to activation of pressure and pain due to spinal cord injury |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6117900A (fr) |
| EP (1) | EP1223927B1 (fr) |
| JP (1) | JP2003510273A (fr) |
| KR (1) | KR100730829B1 (fr) |
| CN (2) | CN101444498A (fr) |
| AR (1) | AR026163A1 (fr) |
| AT (1) | ATE288748T1 (fr) |
| AU (1) | AU777764B2 (fr) |
| BG (1) | BG65795B1 (fr) |
| BR (1) | BR0014293A (fr) |
| CA (2) | CA2659048A1 (fr) |
| CZ (1) | CZ295980B6 (fr) |
| DE (1) | DE50009504D1 (fr) |
| DK (1) | DK1223927T3 (fr) |
| EE (1) | EE05073B1 (fr) |
| ES (1) | ES2237461T3 (fr) |
| HK (1) | HK1052471A1 (fr) |
| HR (1) | HRP20020234A2 (fr) |
| HU (1) | HUP0202853A3 (fr) |
| IL (3) | IL148309A0 (fr) |
| IS (1) | IS6303A (fr) |
| MX (1) | MXPA02003179A (fr) |
| NO (1) | NO329744B1 (fr) |
| NZ (1) | NZ517616A (fr) |
| PL (1) | PL200847B1 (fr) |
| PT (1) | PT1223927E (fr) |
| RS (1) | RS50091B (fr) |
| RU (1) | RU2264813C2 (fr) |
| SI (1) | SI1223927T1 (fr) |
| SK (1) | SK286057B6 (fr) |
| TR (1) | TR200200706T2 (fr) |
| TW (1) | TWI257304B (fr) |
| UA (1) | UA72550C2 (fr) |
| WO (1) | WO2001022953A2 (fr) |
| ZA (1) | ZA200202449B (fr) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001268353A1 (en) * | 2000-06-09 | 2001-12-17 | The Regents Of The University Of California | Method of treating pain using nalbuphine and opioid antagonists |
| TWI287984B (en) | 2000-10-17 | 2007-10-11 | Wyeth Corp | Pharmaceutical composition for modulating bladder function |
| US6589986B2 (en) * | 2000-12-20 | 2003-07-08 | Wyeth | Methods of treating anxiety disorders |
| WO2002061075A1 (fr) * | 2001-02-01 | 2002-08-08 | Takeda Chemical Industries, Ltd. | Proteine de recepteur couple aux proteines g et adn correspondant |
| CA2438868A1 (fr) | 2001-02-20 | 2002-09-19 | Valentin K. Gribkoff | Modulateurs de canaux potassiques kcnq et leur utilisation dans le traitement de la migraine et de maladies liees a la migraine d'un point de vue mecanistique |
| AR033095A1 (es) * | 2001-04-04 | 2003-12-03 | Wyeth Corp | Metodos para el tratamiento de motilidad gastrica hiperactiva |
| US20080039461A1 (en) * | 2002-09-05 | 2008-02-14 | Protter Andrew A | Treatment of pain by inhibition of p38 map kinase |
| JP2006503025A (ja) * | 2002-09-05 | 2006-01-26 | サイオス インク. | p38MAPキナーゼの抑制による疼痛治療 |
| US7632866B2 (en) * | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
| WO2004054511A2 (fr) * | 2002-12-13 | 2004-07-01 | The Regents Of The University Of California | Traitement de la douleur avec des combinaisons de nalbuphine et d'autres agonistes de recepteurs kappa-opioides et antagonistes de recepteurs opioides |
| MXPA05006463A (es) * | 2002-12-27 | 2005-08-26 | Lundbeck & Co As H | Derivados de 1,2,4-triaminobenceno, utiles para tratar transtornos del sistema nervioso central. |
| KR20050089862A (ko) * | 2002-12-27 | 2005-09-08 | 하. 룬트벡 아크티에 셀스카브 | 중추신경계 장애의 치료에 유용한 1,2,4-트리아미노벤젠유도체 |
| EP1631546A1 (fr) * | 2003-04-25 | 2006-03-08 | H. Lundbeck A/S | Derives indole et indoline substitues |
| US20050089559A1 (en) * | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
| TWI357901B (en) | 2004-03-12 | 2012-02-11 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivati |
| EP1861394A1 (fr) | 2005-03-03 | 2007-12-05 | H.Lundbeck A/S | Derives de pyridine substitues |
| US7960436B2 (en) * | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US20080045534A1 (en) * | 2006-08-18 | 2008-02-21 | Valeant Pharmaceuticals North America | Derivatives of 1,3-diamino benzene as potassium channel modulators |
| BRPI0716715B1 (pt) * | 2006-08-23 | 2021-07-06 | Xenon Pharmaceuticals, Inc | Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula |
| US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| CA2670966A1 (fr) * | 2006-11-28 | 2008-06-05 | Valeant Pharmaceuticals International | Analogues de 1,4-diamino retigabine bicycliques en tant que modulateurs de canaux potassiques |
| US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| US8765815B2 (en) | 2007-09-20 | 2014-07-01 | Ramot At Tel-Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
| US20100120906A1 (en) * | 2008-07-18 | 2010-05-13 | Valeant Pharmaceuticals International | Modified release formulation and methods of use |
| US20100323015A1 (en) * | 2008-07-18 | 2010-12-23 | Biljana Nadjsombati | Modified release formulation and methods of use |
| US20100323016A1 (en) * | 2008-07-18 | 2010-12-23 | Biljana Nadjsombati | Modified release formulation and methods of use |
| DE102009013613A1 (de) | 2009-03-17 | 2010-09-23 | Ratiopharm Gmbh | Trockenverarbeitung von Retigabin |
| DE102009013611A1 (de) | 2009-03-17 | 2010-09-23 | Ratiopharm Gmbh | Festes Retigabin in nicht-kristalliner Form |
| DE102009013612A1 (de) | 2009-03-17 | 2010-09-23 | Ratiopharm Gmbh | Retigabin-Tabletten, bevorzugt mit modifizierter Freisetzung |
| IT1398282B1 (it) * | 2009-07-30 | 2013-02-22 | Difass S A Ora Farmapros S P A | Composizione comprendente acido alfa-lipoico e carnosina per il trattamento della sindrome dell arto fantasma |
| US20110087650A1 (en) * | 2009-10-06 | 2011-04-14 | Johnson Controls Technology Company | Creation and use of causal relationship models in building management systems and applications |
| TR201002473A2 (tr) * | 2010-03-31 | 2011-09-21 | Mustafa Nevzat �La� Sanay�� A.�. | Herpes zoster hastalığının bır opiat reseptör antagonist kullanılarak tedavi yöntemi. |
| RU2446795C1 (ru) * | 2011-03-31 | 2012-04-10 | Федеральное государственное учреждение "Московский научно-исследовательский онкологический институт им. П.А. Герцена Министерства здравоохранения и социального развития Российской Федерации" ФГУ "МНИОИ им. П.А. Герцена "Минздравсоцразвития России" | Способ предотвращения фантомного болевого синдрома после ампутации конечностей |
| CN102531966B (zh) * | 2011-12-23 | 2013-07-24 | 山东创新药物研发有限公司 | 瑞替加滨的晶型d及其制备方法 |
| US20130310385A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants |
| US9320725B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a gabapentinoid |
| US9345689B2 (en) * | 2012-05-18 | 2016-05-24 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N, N-dimethyl-4-phenyl-4,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and an anticonvulsant |
| CN103271899A (zh) * | 2012-12-30 | 2013-09-04 | 北京阜康仁生物制药科技有限公司 | 瑞替加滨粉碎粒度在制剂中的应用 |
| CN105919990A (zh) * | 2016-06-29 | 2016-09-07 | 青岛云天生物技术有限公司 | 用于预防和治疗神经病理性疼痛的药物组合物及其用途 |
| CN106176715A (zh) * | 2016-06-29 | 2016-12-07 | 青岛云天生物技术有限公司 | 一种神经病理性疼痛治疗用药物组合物及其用途 |
| WO2019014547A1 (fr) | 2017-07-14 | 2019-01-17 | Texas Tech University System | Carbamates de pyridine fonctionnalisés présentant une activité neuroprotectrice améliorée |
| CA3077659A1 (fr) | 2017-10-09 | 2019-04-18 | Ramot At Tel-Aviv University Ltd. | Modulateurs de canaux trpv1 et ioniques potassiques et leurs utilisations |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| WO2021092439A1 (fr) | 2019-11-08 | 2021-05-14 | Xenon Pharmaceuticals Inc. | Méthodes de traitement de troubles dépressifs |
| IL304920A (en) | 2021-02-09 | 2023-10-01 | Xenon Pharmaceuticals Inc | A voltage-gated potassium channel opener for use in the treatment of anhedonia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4200259A1 (de) * | 1992-01-08 | 1993-07-15 | Asta Medica Ag | Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung |
| DE19539861A1 (de) * | 1995-10-26 | 1997-04-30 | Asta Medica Ag | Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen |
| GB9915414D0 (en) * | 1999-07-01 | 1999-09-01 | Glaxo Group Ltd | Medical use |
-
1999
- 1999-09-27 US US09/406,135 patent/US6117900A/en not_active Expired - Lifetime
-
2000
- 2000-09-21 TW TW089119495A patent/TWI257304B/zh not_active IP Right Cessation
- 2000-09-22 SI SI200030641T patent/SI1223927T1/xx unknown
- 2000-09-22 IL IL14830900A patent/IL148309A0/xx active IP Right Grant
- 2000-09-22 CZ CZ2002989A patent/CZ295980B6/cs not_active IP Right Cessation
- 2000-09-22 TR TR2002/00706T patent/TR200200706T2/xx unknown
- 2000-09-22 CA CA002659048A patent/CA2659048A1/fr not_active Abandoned
- 2000-09-22 HU HU0202853A patent/HUP0202853A3/hu unknown
- 2000-09-22 RS YUP-203/02A patent/RS50091B/sr unknown
- 2000-09-22 EP EP00969283A patent/EP1223927B1/fr not_active Expired - Lifetime
- 2000-09-22 UA UA2002043557A patent/UA72550C2/uk unknown
- 2000-09-22 NZ NZ517616A patent/NZ517616A/xx not_active IP Right Cessation
- 2000-09-22 SK SK292-2002A patent/SK286057B6/sk not_active IP Right Cessation
- 2000-09-22 DE DE50009504T patent/DE50009504D1/de not_active Expired - Lifetime
- 2000-09-22 KR KR1020027003903A patent/KR100730829B1/ko not_active Expired - Fee Related
- 2000-09-22 CN CNA2008101752753A patent/CN101444498A/zh active Pending
- 2000-09-22 EE EEP200200145A patent/EE05073B1/xx not_active IP Right Cessation
- 2000-09-22 CN CNB008133042A patent/CN100522155C/zh not_active Expired - Fee Related
- 2000-09-22 ES ES00969283T patent/ES2237461T3/es not_active Expired - Lifetime
- 2000-09-22 DK DK00969283T patent/DK1223927T3/da active
- 2000-09-22 HR HR20020234A patent/HRP20020234A2/hr not_active Application Discontinuation
- 2000-09-22 JP JP2001526165A patent/JP2003510273A/ja not_active Ceased
- 2000-09-22 PL PL353393A patent/PL200847B1/pl not_active IP Right Cessation
- 2000-09-22 RU RU2002109240/15A patent/RU2264813C2/ru not_active IP Right Cessation
- 2000-09-22 WO PCT/EP2000/009284 patent/WO2001022953A2/fr not_active Ceased
- 2000-09-22 CA CA002384504A patent/CA2384504C/fr not_active Expired - Fee Related
- 2000-09-22 HK HK03104879.5A patent/HK1052471A1/zh unknown
- 2000-09-22 AT AT00969283T patent/ATE288748T1/de active
- 2000-09-22 MX MXPA02003179A patent/MXPA02003179A/es active IP Right Grant
- 2000-09-22 BR BR0014293-0A patent/BR0014293A/pt not_active Application Discontinuation
- 2000-09-22 PT PT00969283T patent/PT1223927E/pt unknown
- 2000-09-22 AU AU79061/00A patent/AU777764B2/en not_active Ceased
- 2000-09-26 AR ARP000105028A patent/AR026163A1/es unknown
-
2002
- 2002-02-21 IL IL148309A patent/IL148309A/en not_active IP Right Cessation
- 2002-02-27 BG BG106450A patent/BG65795B1/bg unknown
- 2002-03-18 IS IS6303A patent/IS6303A/is unknown
- 2002-03-21 NO NO20021418A patent/NO329744B1/no not_active IP Right Cessation
- 2002-03-27 ZA ZA200202449A patent/ZA200202449B/xx unknown
-
2007
- 2007-10-30 IL IL187030A patent/IL187030A/en active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |