IL149100A0 - Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase - Google Patents

Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase

Info

Publication number: IL149100A0
Authority: IL; Israel
Prior art keywords: heteroalkylamino; inhibitors; protein kinase; substituted bicyclic; nitrogen heterocycles
Prior art date: 1999-10-21

Application number

IL14910000A

Other languages

English (en)

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-21

Filing date

2000-10-13

Publication date

2002-11-10

2000-10-13 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2002-11-10 Publication of IL149100A0 publication Critical patent/IL149100A0/xx

Links

239000003112 inhibitor Substances 0.000 title 1
229910052757 nitrogen Inorganic materials 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 1
102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title 1
108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
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Diabetes (AREA)
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Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Tropical Medicine & Parasitology (AREA)
Reproductive Health (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
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IL14910000A 1999-10-21 2000-10-13 Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase IL149100A0 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US16080399P	1999-10-21	1999-10-21
US21374300P	2000-06-22	2000-06-22
PCT/EP2000/010088 WO2001029042A1 (en)	1999-10-21	2000-10-13	Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase

Publications (1)

Publication Number	Publication Date
IL149100A0 true IL149100A0 (en)	2002-11-10

Family

ID=26857240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL14910000A IL149100A0 (en)	1999-10-21	2000-10-13	Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase

Country Status (26)

Country	Link
US (1)	US6451804B1 (de)
EP (1)	EP1228070B1 (de)
JP (1)	JP3961830B2 (de)
KR (1)	KR100523120B1 (de)
CN (1)	CN1171889C (de)
AR (1)	AR026084A1 (de)
AT (1)	ATE353329T1 (de)
AU (1)	AU776250B2 (de)
BR (1)	BR0015243A (de)
CA (1)	CA2388142C (de)
CZ (1)	CZ20021744A3 (de)
DE (1)	DE60033307T2 (de)
ES (1)	ES2280247T3 (de)
HR (1)	HRP20020328A2 (de)
HU (1)	HUP0203564A3 (de)
IL (1)	IL149100A0 (de)
MA (1)	MA26837A1 (de)
MX (1)	MXPA02003950A (de)
NO (1)	NO20021781L (de)
NZ (1)	NZ518119A (de)
PE (1)	PE20010758A1 (de)
PL (1)	PL357502A1 (de)
RU (1)	RU2265606C2 (de)
TR (1)	TR200201057T2 (de)
WO (1)	WO2001029042A1 (de)
YU (1)	YU29102A (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU763839B2 (en)	1998-05-26	2003-07-31	Warner-Lambert Company	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
EP1492790A1 (de) *	2002-04-03	2005-01-05	F. Hoffmann-La Roche Ag	Imidazokondensierte verbindungen
KR20040103972A (ko) *	2002-04-19	2004-12-09	스미스클라인 비참 코포레이션	신규 화합물
DE60310730T2 (de)	2002-07-09	2007-05-16	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege
US7196090B2 (en)	2002-07-25	2007-03-27	Warner-Lambert Company	Kinase inhibitors
CA2492112A1 (en) *	2002-08-06	2004-02-19	F. Hoffmann-La Roche Ag	6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors
US7084270B2 (en) *	2002-08-14	2006-08-01	Hoffman-La Roche Inc.	Pyrimido compounds having antiproliferative activity
TW200413381A (en) *	2002-11-04	2004-08-01	Hoffmann La Roche	Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
US7112676B2 (en)	2002-11-04	2006-09-26	Hoffmann-La Roche Inc.	Pyrimido compounds having antiproliferative activity
BR0316375A (pt) *	2002-11-18	2005-10-04	Hoffmann La Roche	Diazinopirimidinas
JP2006522756A (ja)	2003-04-10	2006-10-05	エフ．ホフマン−ラ　ロシュ　アーゲー	ピリミド化合物
MXPA06001098A (es)	2003-07-29	2006-04-24	Irm Llc	Compuestos y composiciones utiles como inhibidores de proteina cinasa.
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
KR100853974B1 (ko)	2004-08-31	2008-08-25	에프. 호프만-라 로슈 아게	7-아미노-3-페닐 디히드로피리미도[4,5-ｄ]피리미디논의아미드 유도체, 그의 제조 방법 및 약학제로서의 용도
BRPI0514738A (pt)	2004-08-31	2008-06-24	Hoffmann La Roche	derivados de amida de 3-fenil-diidropirimido[4,5-d]pirimidinonas, sua fabricação e aplicação como agentes farmacêuticos
WO2006038112A1 (en) *	2004-10-01	2006-04-13	Warner-Lambert Company Llc	Use of kinase inhibitors to promote neochondrogenesis
EP1831215A1 (de) *	2004-11-23	2007-09-12	Ranbaxy Laboratories Limited	Pyrido[2,3-d]pyrimidine als entzüngungshemmende mittel
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP1846403A1 (de) *	2005-02-02	2007-10-24	Ranbaxy Laboratories Limited	Azabicycloderivate als entzündungshemmende mittel
CN101341116A (zh) *	2005-12-22	2009-01-07	巴斯夫欧洲公司	制备o-烷基化环状氨基醇的方法
JP2009525292A (ja)	2006-01-31	2009-07-09	エフ．ホフマン−ラロシュアーゲー	７ｈ−ピリド［３，４−ｄ］ピリミジン−８−オン、それらの製造及びプロテインキナーゼ阻害剤としての使用
ES2301380B1 (es)	2006-08-09	2009-06-08	Laboratorios Almirall S.A.	Nuevos derivados de 1,7-naftiridina.
ES2320955B1 (es)	2007-03-02	2010-03-16	Laboratorios Almirall S.A.	Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es)	2007-04-26	2010-09-23	Laboratorios Almirall S.A.	Nuevos derivados de 4,8-difenilpoliazanaftaleno.
RU2340327C1 (ru) *	2007-05-03	2008-12-10	Лев Давидович Раснецов	Офтальмологический гель и способ его приготовления
EP1992344A1 (de)	2007-05-18	2008-11-19	Institut Curie	P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind
GB2452696B (en) *	2007-08-02	2009-09-23	Cambridge Entpr Ltd	3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
EP2108641A1 (de) *	2008-04-11	2009-10-14	Laboratorios Almirall, S.A.	Neue substituierte Spiro[Cycloalkyl-1,3'-indo]-2'(1'H)-on-Derivate und ihre Verwendung als p38 mitogen-activated Kinase Inhibitoren
EP2113503A1 (de)	2008-04-28	2009-11-04	Laboratorios Almirall, S.A.	Neue substituierte Indolin-2-on- Derivate und ihre Verwendung als p39 mitogen-activated Kinase Inhibitoren
AU2010301449B2 (en)	2009-09-30	2013-03-14	Toray Industries, Inc.	2,3-dihydro-1H-indene-2-ylurea derivative and pharmaceutical application of same
EP2322176A1 (de)	2009-11-11	2011-05-18	Almirall, S.A.	Neue 7-Phenyl-[1,2,4]triazol[4,3-a]pyridin-3(2H)on-Derivate
WO2011065800A2 (ko) *	2009-11-30	2011-06-03	주식회사 오스코텍	피리미딘 유도체, 이의 제조방법 및 이를 함유하는 약학적 조성물
US8754114B2 (en)	2010-12-22	2014-06-17	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
CN102816162B (zh) *	2011-06-10	2016-04-27	中国科学院广州生物医药与健康研究院	嘧啶并嘧啶酮类化合物及其药用组合物和应用
ES2704744T3 (es)	2012-06-13	2019-03-19	Incyte Holdings Corp	Compuestos tricíclicos sustituidos como inhibidores de FGFR
SMT202100451T1 (it) *	2012-07-11	2021-09-14	Blueprint Medicines Corp	Inibitori del recettore di crescita dei fibroblasti
US9388185B2 (en)	2012-08-10	2016-07-12	Incyte Holdings Corporation	Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
TWI647220B (zh)	2013-03-15	2019-01-11	美商西建卡爾有限責任公司	雜芳基化合物及其用途
MY181020A (en) *	2013-03-15	2020-12-16	Sanofi Sa	Heteroaryl compounds and uses thereof
EA035095B1 (ru)	2013-04-19	2020-04-27	Инсайт Холдингс Корпорейшн	Бициклические гетероциклы в качестве ингибиторов fgfr
CA2928042C (en)	2013-10-25	2022-05-10	Blueprint Medicines Corporation	Inhibitors of the fibroblast growth factor receptor
MA38393B1 (fr) *	2014-03-13	2018-11-30	Sanofi Sa	Composés hétéroaryle et utilisations associées
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
MX373169B (es)	2015-02-20	2020-04-24	Incyte Holdings Corp	Heterociclos bicíclicos como inhibidores de receptores del factor de crecimiento fibroblástico (fgfr).
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (en)	2015-02-20	2016-08-25	Incyte Corporation	Bicyclic heterocycles as fgfr4 inhibitors
US10308656B2 (en) *	2015-08-18	2019-06-04	Arizona Board Of Regents On Behalf Of The University Of Arizona	Small molecule inhibitors of Ku70/80 and uses thereof
KR20180002053A (ko)	2016-06-28	2018-01-05	한미약품 주식회사	신규한 헤테로시클릭 유도체 화합물 및 이의 용도
WO2018004258A1 (ko) *	2016-06-28	2018-01-04	한미약품 주식회사	신규한 헤테로시클릭 유도체 화합물 및 이의 용도
WO2018053373A1 (en)	2016-09-16	2018-03-22	The General Hospital Corporation	Uses of satl-inducible kinase (sik) inhibitors for treating osteoporosis
BR112019017741A2 (pt)	2017-02-28	2020-04-07	Dana Farber Cancer Inst Inc	usos de pirimidopirimidinonas como inibidores de sik
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019071147A1 (en)	2017-10-05	2019-04-11	Fulcrum Therapeutics, Inc.	INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD
CR20200590A (es)	2018-05-04	2021-04-26	Incyte Corp	Formas sólidas de un inhibidor de fgfr y procesos para prepararlas
MA52493A (fr)	2018-05-04	2021-03-10	Incyte Corp	Sels d'un inhibiteur de fgfr
MX2021007833A (es) *	2018-12-27	2021-10-26	Les Laboratoires Servier Sas	Inhibidores aza-heterobiciclicos de mat2a y metodos de uso en el tratamiento de cancer.
WO2020185532A1 (en)	2019-03-08	2020-09-17	Incyte Corporation	Methods of treating cancer with an fgfr inhibitor
WO2021007269A1 (en)	2019-07-09	2021-01-14	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
WO2021067374A1 (en)	2019-10-01	2021-04-08	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
TWI891666B (zh)	2019-10-14	2025-08-01	美商英塞特公司	作為ｆｇｆｒ抑制劑之雙環雜環
WO2021076728A1 (en)	2019-10-16	2021-04-22	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
GB201915828D0 (en)	2019-10-31	2019-12-18	Cancer Research Tech Ltd	Compounds, compositions and therapeutic uses thereof
EP4069696A1 (de)	2019-12-04	2022-10-12	Incyte Corporation	Tricyclische heterocyclen als fgfr-inhibitoren
BR112022010664A2 (pt)	2019-12-04	2022-08-16	Incyte Corp	Derivados de um inibidor de fgfr
WO2021146424A1 (en)	2020-01-15	2021-07-22	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
TW202304459A (zh)	2021-04-12	2023-02-01	美商英塞特公司	包含ｆｇｆｒ抑制劑及ｎｅｃｔｉｎ－４靶向劑之組合療法
WO2022261159A1 (en)	2021-06-09	2022-12-15	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
EP4352059A1 (de)	2021-06-09	2024-04-17	Incyte Corporation	Tricyclische heterocyclen als fgfr-inhibitoren

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8814352D0 (en)	1988-06-16	1988-07-20	Smith Kline French Lab	Chemical compounds
IL117923A (en)	1995-05-03	2000-06-01	Warner Lambert Co	Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
US6147080A (en) *	1996-12-18	2000-11-14	Vertex Pharmaceuticals Incorporated	Inhibitors of p38
ES2221213T3 (es) *	1997-10-20	2004-12-16	F. Hoffmann-La Roche Ag	Inhibidores de kinasa biciclicos.
AU763839B2 (en) *	1998-05-26	2003-07-31	Warner-Lambert Company	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
NZ510760A (en) *	1998-10-23	2003-08-29	F	Bicyclic nitrogen heterocycles

2000
- 2000-10-13 DE DE60033307T patent/DE60033307T2/de not_active Expired - Fee Related
- 2000-10-13 CN CNB008146624A patent/CN1171889C/zh not_active Expired - Fee Related
- 2000-10-13 HR HR20020328A patent/HRP20020328A2/hr not_active Application Discontinuation
- 2000-10-13 TR TR2002/01057T patent/TR200201057T2/xx unknown
- 2000-10-13 WO PCT/EP2000/010088 patent/WO2001029042A1/en not_active Ceased
- 2000-10-13 AT AT00967864T patent/ATE353329T1/de not_active IP Right Cessation
- 2000-10-13 AU AU77873/00A patent/AU776250B2/en not_active Ceased
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Publication number	Publication date
HRP20020328A2 (en)	2004-02-29
EP1228070B1 (de)	2007-02-07
CZ20021744A3 (cs)	2002-08-14
CN1171889C (zh)	2004-10-20
RU2002112753A (ru)	2004-01-20
CA2388142C (en)	2008-12-09
PE20010758A1 (es)	2001-07-21
MA26837A1 (fr)	2004-12-20
JP2003512378A (ja)	2003-04-02
AU776250B2 (en)	2004-09-02
MXPA02003950A (es)	2002-10-23
HUP0203564A3 (en)	2004-07-28
NO20021781D0 (no)	2002-04-16
EP1228070A1 (de)	2002-08-07
NZ518119A (en)	2004-02-27
WO2001029042A1 (en)	2001-04-26
YU29102A (sh)	2004-12-31
CA2388142A1 (en)	2001-04-26
KR100523120B1 (ko)	2005-10-20
AU7787300A (en)	2001-04-30
NO20021781L (no)	2002-04-18
DE60033307D1 (en)	2007-03-22
PL357502A1 (en)	2004-07-26
HUP0203564A2 (hu)	2003-02-28
ES2280247T3 (es)	2007-09-16
ATE353329T1 (de)	2007-02-15
KR20020038963A (ko)	2002-05-24
JP3961830B2 (ja)	2007-08-22
US6451804B1 (en)	2002-09-17
RU2265606C2 (ru)	2005-12-10
AR026084A1 (es)	2002-12-26
CN1382144A (zh)	2002-11-27
BR0015243A (pt)	2002-07-16
HK1051039A1 (en)	2003-07-18
TR200201057T2 (tr)	2002-09-23
DE60033307T2 (de)	2007-07-12

Publication	Publication Date	Title
IL149100A0 (en)	2002-11-10	Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase
IL149230A0 (en)	2002-11-10	Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase
AP9901565A0 (en)	1999-06-30	Substituted nitrogen containing heterocycles as inhibitors of p38 protein kinase
IL137041A0 (en)	2001-06-14	Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
IL141724A0 (en)	2002-03-10	INHIBITORS OF P38-α KINASE
PL344046A1 (en)	2001-09-24	Heterocyclic inhibitors of p38
PL344248A1 (en)	2001-10-22	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
IL161516A0 (en)	2004-09-27	Benzimidazoles useful as protein kinase inhibitors
EG24027A (en)	2008-03-26	Pyrrolotriazine inhibitors of kinases
PL351126A1 (en)	2003-03-24	Cyclic protein tyrosine kinase inhibitors
PL331221A1 (en)	1999-07-05	Heteroaromatic bicyclic compounds as inhibitors of propteinous tyrosine kinase
HUP0400300A3 (en)	2010-12-28	Pyrrolopyrimidines as protein kinase inhibitors
EP1085871A4 (de)	2001-10-04	Quinazolinonehemmendern von cgmp phosphodiesterase
AU2728201A (en)	2001-07-03	4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors
IL159506A0 (en)	2004-06-01	Pyrrolopyrimidines as protein kinase inhibitors
PL325122A1 (en)	1998-07-06	Bicyclic derivatives of 4-aralkylamino pyrididine as inhibitors of thyrosinic kinase
AU2002237657A1 (en)	2002-06-11	Indole-type inhibitors of p38 kinase
AU2576501A (en)	2001-06-18	Protein kinase inhibitors
AU2002252950A1 (en)	2002-09-04	Protein kinase d inhibitors and protein kinase 2 inhibitors as agents for inhibiting tumour cells and for stimulating angiogenesis
ZA200202540B (en)	2003-06-30	Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase.
SI0951467T1 (en)	2003-10-31	SUBSTITUTED NITROGEN CONTAINING HETEROCYCLES AS INHIBITORS OF p38 PROTEIN KINASE
HK1045839A (en)	2002-12-13	Indole-type derivatives as inhibitors of p38 kinase
HK1058792A (en)	2004-06-04	Indole-type inhibitors of p38 kinase
HK1058791A (en)	2004-06-04	Inhibitors of p38 kinase