IL156872A0 - 6-substituted pyrido-pyrimidines - Google Patents

6-substituted pyrido-pyrimidines

Info

Publication number
IL156872A0
IL156872A0 IL15687202A IL15687202A IL156872A0 IL 156872 A0 IL156872 A0 IL 156872A0 IL 15687202 A IL15687202 A IL 15687202A IL 15687202 A IL15687202 A IL 15687202A IL 156872 A0 IL156872 A0 IL 156872A0
Authority
IL
Israel
Prior art keywords
pyrimidines
substituted pyrido
pyrido
substituted
Prior art date
Application number
IL15687202A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL156872A0 publication Critical patent/IL156872A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL15687202A 2001-02-12 2002-02-04 6-substituted pyrido-pyrimidines IL156872A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US33465401P 2001-11-30 2001-11-30
PCT/EP2002/001106 WO2002064594A2 (fr) 2001-02-12 2002-02-04 Pyrido-pyrimidines substituees en position 6

Publications (1)

Publication Number Publication Date
IL156872A0 true IL156872A0 (en) 2004-02-08

Family

ID=26953040

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15687202A IL156872A0 (en) 2001-02-12 2002-02-04 6-substituted pyrido-pyrimidines
IL156872A IL156872A (en) 2001-02-12 2003-07-10 Pyrido – pyrimidines 6 – transformed

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL156872A IL156872A (en) 2001-02-12 2003-07-10 Pyrido – pyrimidines 6 – transformed

Country Status (31)

Country Link
US (3) US6696566B2 (fr)
EP (1) EP1361880B1 (fr)
JP (1) JP4064818B2 (fr)
KR (1) KR100639772B1 (fr)
CN (1) CN100376571C (fr)
AR (1) AR035854A1 (fr)
AT (1) ATE305303T1 (fr)
AU (1) AU2002256615B2 (fr)
BR (1) BRPI0207172B8 (fr)
CA (1) CA2434834C (fr)
CZ (1) CZ20032416A3 (fr)
DE (1) DE60206363T2 (fr)
DK (1) DK1361880T3 (fr)
ES (1) ES2249574T3 (fr)
HR (1) HRP20030624B1 (fr)
HU (1) HU229604B1 (fr)
IL (2) IL156872A0 (fr)
JO (1) JO2410B1 (fr)
MA (1) MA26993A1 (fr)
MX (1) MXPA03007166A (fr)
MY (1) MY131518A (fr)
NO (1) NO326133B1 (fr)
NZ (1) NZ526961A (fr)
PA (1) PA8539201A1 (fr)
PE (1) PE20020976A1 (fr)
PL (1) PL366918A1 (fr)
RU (1) RU2269527C2 (fr)
SK (1) SK11322003A3 (fr)
WO (1) WO2002064594A2 (fr)
YU (1) YU63703A (fr)
ZA (1) ZA200305938B (fr)

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HU229604B1 (en) 2001-02-12 2014-02-28 Hoffmann La Roche 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them
ATE314370T1 (de) * 2002-01-22 2006-01-15 Warner Lambert Co 2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one
PL374544A1 (en) 2002-04-03 2005-10-31 F.Hoffmann-La Roche Ag Imidazo fused compounds
CA2492112A1 (fr) * 2002-08-06 2004-02-19 F. Hoffmann-La Roche Ag 6-alcoxy-pyrido-pyrimidines utilisees comme inhibiteurs de la map kinase p-38
US20040225077A1 (en) 2002-12-30 2004-11-11 Angiotech International Ag Drug delivery from rapid gelling polymer composition
RS53118B (sr) * 2003-02-26 2014-06-30 Sugen Inc. Aminoheteroaril jedinjenja kao inhibitori protein kinaze
EP1620105B1 (fr) * 2003-04-16 2007-01-10 F. Hoffmann-La Roche Ag Derives amines de (6-(phenoxy)-pyrido ¬3,4-d| pyrimidin-2-yle) en tant qu'inhibiteurs de la kinase p38 pour le traitement de conditions inflammatoires telles que la polyarthrite rhumatoide
BRPI0416030A (pt) * 2003-11-13 2007-01-02 Hoffmann La Roche pirido-7-pirimidin-7-onas substituìdas com hidroxialquila
US20090131430A1 (en) * 2004-11-23 2009-05-21 Palle Venkata P Pyrido'2,3-dipyrimidines as anti-inflammatory agents
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
EP1846403A1 (fr) * 2005-02-02 2007-10-24 Ranbaxy Laboratories Limited Derives azabicyclo utilises comme agents anti-inflammatoires
WO2006119504A2 (fr) * 2005-05-04 2006-11-09 Renovis, Inc. Composes heterocycliques fusionnes, leurs compositions et leurs utilisations
WO2007009911A1 (fr) * 2005-07-21 2007-01-25 F. Hoffmann-La Roche Ag Composes pyrido [2, 3-d] pyrimidine-2, 4-diamine utilises comme inhibiteurs de ptp1b
AU2006279992A1 (en) * 2005-08-09 2007-02-22 Irm Llc Compounds and compositions as protein kinase inhibitors
EP1917245A1 (fr) 2005-08-21 2008-05-07 Abbott GmbH & Co. KG Composes heterocycliques et leur utilisation en tant que partenaires de liaison des recepteurs 5-ht5
JO2783B1 (en) * 2005-09-30 2014-03-15 نوفارتيس ايه جي Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones
MX2008014908A (es) * 2006-05-26 2009-05-13 Toyama Chemical Co Ltd Compuesto heterociclico nuevo o sal del mismo e intermedio del mismo.
WO2008150260A1 (fr) * 2007-06-06 2008-12-11 Gpc Biotech, Inc. Inhibiteurs de kinase
WO2008078249A1 (fr) * 2006-12-21 2008-07-03 Ranbaxy Laboratories Limited Agents anti-inflammatoires
US8022085B2 (en) 2007-05-07 2011-09-20 Amgen Inc. Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof
WO2008151992A2 (fr) 2007-06-15 2008-12-18 F. Hoffmann-La Roche Ag Nouveau procédé de préparation de 3-amino-pentan-1,5-diol
US8367671B2 (en) 2008-03-21 2013-02-05 Amgen Inc. Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents
EP2112150B1 (fr) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Inhibiteurs Raf améliorés
JP2012505927A (ja) * 2008-10-22 2012-03-08 エフ．ホフマン−ラ ロシュ アーゲー Ｊｎｋのピリミジニルピリドン阻害剤
WO2010071846A2 (fr) 2008-12-19 2010-06-24 Afraxis, Inc. Composés pour traiter des états neuropsychiatriques
EP2486037A4 (fr) 2009-10-09 2013-01-16 Afraxis Inc 8-ethyl-6-(aryl)pyrido[2,3-d]pyrimidin-7(8h)-ones pour le traitement de troubles de snc
JP5797664B2 (ja) * 2009-12-18 2015-10-21 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイションＴｅｍｐｌｅ Ｕｎｉｖｅｒｓｉｔｙ−Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ 置換ピリド［２，３−ｄ］ピリミジン−７（８Ｈ）−オン及びそれらの治療用の使用
CA2954189A1 (fr) 2014-07-26 2016-02-04 Sunshine Lake Pharma Co., Ltd. 2-amino-pyrido [2,3-d] pyrimidin -7 (8h)-one utilises en tant qu'inhibiteurs de cdk et utilisations de ceux-ci
PL3468604T3 (pl) * 2016-06-08 2021-07-12 Support-Venture Gmbh Kombinacje farmaceutyczne do leczenia nowotworu złośliwego
BR112019002610A2 (pt) 2016-08-15 2019-07-02 Pfizer piridopirimidinonas inibidoras de cdk2/4/6
PE20190421A1 (es) * 2016-08-17 2019-03-19 Support Venture Gmbh Metodo para prevenir o tratar la perdida de la audicion
US11117858B2 (en) 2017-01-11 2021-09-14 The General Hospital Corporation Voltage gated sodium channel imaging agents
UA127245C2 (uk) 2017-04-04 2023-06-21 Кінарус Аг Способи запобігання або лікування офтальмологічних захворювань
EP3676267A4 (fr) * 2017-08-31 2021-04-14 Dana Farber Cancer Institute, Inc. Inhibiteurs d'egfr et/ou de her2 et procédés d'utilisation
WO2019071144A1 (fr) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. Utilisation d'inhibiteurs de p38 pour réduire l'expression de dux4
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
US12312346B2 (en) 2018-06-27 2025-05-27 Tufts Medical Center, Inc. Pyridopyrimidine compounds and methods of their use
EP3820526B1 (fr) 2018-07-13 2024-01-24 Kinarus AG Combinaisons d'agonistes de ppar et d'inhibiteurs de la kinase p38 pour la prévention ou le traitement de maladies fibrotiques
TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合
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CA2286909A1 (fr) 1997-04-16 1998-10-22 Abbott Laboratories Composes de 4-aminopyrido¬2,3-d|pyrimidine 5,7-disubstitues et leur utilisation comme inhibiteurs de l'adenosine kinase
CA2286592A1 (fr) 1997-04-16 1998-10-22 Abbott Laboratories Composes de 4-aminopyridol[2,3-d]pyrimidine a trisubstitution 5,6,7
EE200000706A (et) 1998-05-26 2002-06-17 Warner-Lambert Company Bitsüklilised pürimidiinid ja bitsüklilised 3,4-dihüdropürimidiinid kui rakkude proliferatsiooni inhibiitorid
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US7053070B2 (en) * 2000-01-25 2006-05-30 Warner-Lambert Company Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
EE200200506A (et) * 2000-03-06 2004-02-16 Warner-Lambert Company 5-alküülpürido[2,3-d]pürimidiinid kui türosiinkinaasi inhibiitorid
US6518276B2 (en) * 2000-08-31 2003-02-11 Syntex (U.S.A.) Llc 7-oxo-pyridopyrimidines (II)
HU229604B1 (en) * 2001-02-12 2014-02-28 Hoffmann La Roche 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them
ATE314370T1 (de) * 2002-01-22 2006-01-15 Warner Lambert Co 2-(pyridin-2-ylamino)-pyrido(2,3-d)pyrimidin-7- one

Also Published As

Publication number Publication date
NO326133B1 (no) 2008-10-06
CA2434834A1 (fr) 2002-08-22
HK1066170A1 (en) 2005-03-18
YU63703A (sh) 2006-05-25
MXPA03007166A (es) 2003-11-18
AU2002256615B2 (en) 2007-09-13
ZA200305938B (en) 2005-01-26
ATE305303T1 (de) 2005-10-15
CZ20032416A3 (cs) 2004-07-14
BRPI0207172B1 (pt) 2019-04-09
RU2269527C2 (ru) 2006-02-10
NO20033540L (no) 2003-08-11
DE60206363T2 (de) 2006-07-06
WO2002064594A2 (fr) 2002-08-22
NO20033540D0 (no) 2003-08-11
EP1361880A2 (fr) 2003-11-19
JP2004525896A (ja) 2004-08-26
JO2410B1 (en) 2007-06-17
JP4064818B2 (ja) 2008-03-19
US20070135458A1 (en) 2007-06-14
WO2002064594A3 (fr) 2003-01-09
SK11322003A3 (en) 2004-10-05
RU2003125887A (ru) 2005-03-20
US20040116698A1 (en) 2004-06-17
ES2249574T3 (es) 2006-04-01
KR20040018254A (ko) 2004-03-02
PL366918A1 (en) 2005-02-07
CN1503672A (zh) 2004-06-09
US6696566B2 (en) 2004-02-24
BRPI0207172B8 (pt) 2021-05-25
NZ526961A (en) 2005-03-24
MA26993A1 (fr) 2004-12-20
PE20020976A1 (es) 2002-10-29
DK1361880T3 (da) 2006-01-23
HU229604B1 (en) 2014-02-28
EP1361880B1 (fr) 2005-09-28
PA8539201A1 (es) 2004-08-31
HRP20030624A2 (en) 2005-06-30
MY131518A (en) 2007-08-30
US7169794B2 (en) 2007-01-30
HUP0303458A3 (en) 2012-12-28
BR0207172A (pt) 2004-03-30
US20030171584A1 (en) 2003-09-11
AR035854A1 (es) 2004-07-21
US7449581B2 (en) 2008-11-11
CN100376571C (zh) 2008-03-26
DE60206363D1 (de) 2006-02-09
HUP0303458A2 (hu) 2004-01-28
HRP20030624B1 (en) 2007-03-31
CA2434834C (fr) 2010-09-14
IL156872A (en) 2009-07-20
KR100639772B1 (ko) 2006-10-30

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