IL160085A0 - Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain - Google Patents

Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain

Info

Publication number: IL160085A0
Authority: IL; Israel
Prior art keywords: dihydroisomorphine; dihydromorphine; hydromorphone; treating; compositions
Prior art date: 2001-07-27

Application number

IL16008502A

Other languages

English (en)

Original Assignee

Euro Celtique Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-27

Filing date

2002-07-24

Publication date

2004-06-20

2002-07-24 Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa

2004-06-20 Publication of IL160085A0 publication Critical patent/IL160085A0/xx

Links

IJVCSMSMFSCRME-NOSXKOESSA-N (4r,4ar,7r,7ar,12bs)-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol Chemical compound O([C@H]1[C@@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-NOSXKOESSA-N 0.000 title abstract 4
IJVCSMSMFSCRME-KBQPJGBKSA-N Dihydromorphine Chemical compound O([C@H]1[C@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-KBQPJGBKSA-N 0.000 title abstract 4
WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical class O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
229930182478 glucoside Natural products 0.000 abstract 3
150000008131 glucosides Chemical class 0.000 abstract 3
229930182480 glucuronide Natural products 0.000 abstract 3
-1 glucuronide derivatives of hydromorphone Chemical class 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/033—Uronic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

IL16008502A 2001-07-27 2002-07-24 Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain IL160085A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US30784501P	2001-07-27	2001-07-27
PCT/US2002/023553 WO2003011881A2 (en)	2001-07-27	2002-07-24	Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain

Publications (1)

Publication Number	Publication Date
IL160085A0 true IL160085A0 (en)	2004-06-20

Family

ID=23191416

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
IL16008502A IL160085A0 (en)	2001-07-27	2002-07-24	Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain
IL160085A IL160085A (en)	2001-07-27	2004-01-27	Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
IL160085A IL160085A (en)	2001-07-27	2004-01-27	Sugar derivatives of hydromorphone, dihydromorphine and dihydroisomorphine, compositions thereof and uses for treating or preventing pain

Country Status (14)

Country	Link
US (1)	US6740641B2 (da)
EP (1)	EP1412368B1 (da)
JP (1)	JP4679055B2 (da)
AT (1)	ATE371665T1 (da)
AU (1)	AU2002329634B2 (da)
CA (1)	CA2455774C (da)
CY (1)	CY1107813T1 (da)
DE (1)	DE60222137T2 (da)
DK (1)	DK1412368T3 (da)
ES (1)	ES2292806T3 (da)
IL (2)	IL160085A0 (da)
MX (1)	MXPA04000825A (da)
PT (1)	PT1412368E (da)
WO (1)	WO2003011881A2 (da)

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US20070066537A1 (en) *	2002-02-22	2007-03-22	New River Pharmaceuticals Inc.	Compounds and compositions for prevention of overdose of oxycodone
US20060014697A1 (en) *	2001-08-22	2006-01-19	Travis Mickle	Pharmaceutical compositions for prevention of overdose or abuse
US7169752B2 (en) *	2003-09-30	2007-01-30	New River Pharmaceuticals Inc.	Compounds and compositions for prevention of overdose of oxycodone
US7338939B2 (en) *	2003-09-30	2008-03-04	New River Pharmaceuticals Inc.	Abuse-resistant hydrocodone compounds
US7105486B2 (en) *	2002-02-22	2006-09-12	New River Pharmaceuticals Inc.	Abuse-resistant amphetamine compounds
KR100822498B1 (ko) *	2002-02-22	2008-04-16	샤이어 엘엘씨	규제된 물질의 남용을 방지하기 위한 새로운 서방성 약학화합물
WO2003072735A2 (en) *	2002-02-22	2003-09-04	New River Pharmaceuticals Inc.	Use of peptide-drug conjugation to reduce inter-subject variability of drug serum levels
US7659253B2 (en) *	2002-02-22	2010-02-09	Shire Llc	Abuse-resistant amphetamine prodrugs
US7700561B2 (en) *	2002-02-22	2010-04-20	Shire Llc	Abuse-resistant amphetamine prodrugs
GB0218811D0 (en) *	2002-08-14	2002-09-18	Cenes Ltd	Salts of morphine-6-glucuronide
US8133881B2 (en)	2003-01-13	2012-03-13	Shire Llc	Carbohydrate conjugates to prevent abuse of controlled substances
SI1644019T2 (en) *	2003-05-29	2018-04-30	Shire Llc	Abuse resistant amphetamine compounds
EA008864B1 (ru) *	2003-09-30	2007-08-31	Нью Ривер Фармасьютикалз Инк.	Фармацевтические композиции для предотвращения передозировки или неправильного употребления лекарственных средств
JP5176188B2 (ja) *	2006-04-21	2013-04-03	ディーエスエムアイピーアセッツビー．ブイ．	オピオイド受容体拮抗薬の使用
US20080051380A1 (en)	2006-08-25	2008-02-28	Auerbach Alan H	Methods and compositions for treating cancer
FR2939436B1 (fr) *	2008-12-10	2010-12-17	Sanofi Aventis	Synthese de morphine-6-glucuronide ou de l'un de ses derives
US8716350B2 (en) *	2010-03-30	2014-05-06	Algynomics Inc.	Compositions and methods for the treatment of somatosensory disorders
US8716349B2 (en)	2010-03-30	2014-05-06	Algynomics Inc.	Compositions and methods for the treatment of somatosensory disorders
ES2566828T3 (es)	2010-09-21	2016-04-15	Purdue Pharma L.P.	Análogos de buprenorfina como agonistas y/o antagonistas del receptor opioide
SG11201401856VA (en)	2011-10-26	2014-05-29	Kempharm Inc	Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
EP2917182B1 (en)	2012-11-09	2018-01-03	Purdue Pharma LP	Benzomorphan analogs and the use thereof
WO2014087226A1 (en)	2012-12-07	2014-06-12	Purdue Pharma L.P.	Buprenorphine analogs as opiod receptor modulators
EP2931724B1 (en)	2012-12-14	2017-01-25	Purdue Pharma LP	Pyridonemorphinan analogs and biological activity on opioid receptors
WO2014091297A1 (en)	2012-12-14	2014-06-19	Purdue Pharma L.P.	Spirocyclic morphinans and their use
JP6182620B2 (ja)	2013-01-31	2017-08-16	パーデュー、ファーマ、リミテッド、パートナーシップ	ベンゾモルファン類似体およびその使用
US8969358B2 (en)	2013-03-15	2015-03-03	Purdue Pharma L.P.	Buprenorphine analogs
HU231191B1 (hu)	2013-04-15	2021-08-30	Szegedi Tudományegyetem	Izotóp tartalmú morfin molekulák
EP3087057A4 (en)	2013-12-26	2017-06-28	Purdue Pharma LP	Ring-contracted morphinans and the use thereof
WO2015097546A1 (en)	2013-12-26	2015-07-02	Purdue Pharma L.P.	Propellane-based compounds and their use as opioid receptor modulators
WO2015097548A1 (en)	2013-12-26	2015-07-02	Purdue Pharma L.P.	7-beta-alkyl analogs of orvinols
WO2015097547A1 (en)	2013-12-26	2015-07-02	Purdue Pharma L.P.	10-substituted morphinan hydantoins
WO2015097545A1 (en)	2013-12-26	2015-07-02	Purdue Pharma L.P.	Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
WO2015099863A1 (en)	2013-12-27	2015-07-02	Purdue Pharma L.P.	6-substituted and 7-substituted morphinan analogs and the use thereof
CA2950567A1 (en)	2014-05-27	2015-12-03	Purdue Pharma L.P.	Spirocyclic morphinans and use thereof
MA40171A (fr)	2014-06-13	2017-04-19	Purdue Pharma Lp	Dérivés d'azamophinan et leur utilisation
RU2683274C2 (ru)	2014-12-02	2019-03-27	Кемфарм, Инк.	Бензойная кислота, производные бензойной кислоты и конъюгаты гетероарилкарбоновой кислоты и оксиморфона, их пролекарства, способы получения и применение
MA41125A (fr)	2014-12-05	2017-10-10	Purdue Pharma Lp	Dérivés de 6.7-cyclomorphinane et leur utilisation
ITUB20154996A1 (it)	2015-10-27	2017-04-27	Nobili S P A	Attrezzatura per l?erogazione di un liquido di trattamento ad una rispettiva coltura o piantagione agricola.
UA124972C2 (uk)	2016-07-29	2021-12-22	Янссен Фармацевтика Нв	Способи лікування раку передміхурової залози
WO2018125716A1 (en)	2017-01-02	2018-07-05	Purdue Pharma L.P.	Morphinan derivatives and use thereof
WO2020012245A1 (en)	2018-07-13	2020-01-16	Alkermes Pharma Ireland Limited	Thienothiophene-naltrexone prodrugs for long-acting injectable compositions
US10799496B2 (en)	2018-07-13	2020-10-13	Alkermes Pharma Ireland Limited	Naphthylenyl compounds for long-acting injectable compositions and related methods
US10975099B2 (en)	2018-11-05	2021-04-13	Alkermes Pharma Ireland Limited	Thiophene compounds for long-acting injectable compositions and related methods
WO2024042226A2 (en) *	2022-08-25	2024-02-29	Biosynth Gmbh	Procedure for production of opioid-antagonist-releasing compounds and their use as a medicine

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ATE92497T1 (de)	1988-01-12	1993-08-15	Baker Norton Pharma	Glucuronsaeure-derivate von opioid-antagonisten.
FR2680786B1 (fr) *	1991-09-04	1995-03-10	Irepa	Procede de synthese de glucuronides d'epoxy-4,5 morphinanes.
EP0816375A1 (en) *	1995-11-29	1998-01-07	Rolabo Sl	Glycoconjugates of opiated substances
GB9711118D0 (en)	1997-05-29	1997-07-23	Rolabo Sl	Compound

2002
- 2002-07-22 US US10/199,526 patent/US6740641B2/en not_active Expired - Lifetime
- 2002-07-24 DK DK02765874T patent/DK1412368T3/da active
- 2002-07-24 AT AT02765874T patent/ATE371665T1/de active
- 2002-07-24 IL IL16008502A patent/IL160085A0/xx unknown
- 2002-07-24 CA CA2455774A patent/CA2455774C/en not_active Expired - Fee Related
- 2002-07-24 PT PT02765874T patent/PT1412368E/pt unknown
- 2002-07-24 EP EP02765874A patent/EP1412368B1/en not_active Expired - Lifetime
- 2002-07-24 AU AU2002329634A patent/AU2002329634B2/en not_active Ceased
- 2002-07-24 DE DE60222137T patent/DE60222137T2/de not_active Expired - Lifetime
- 2002-07-24 MX MXPA04000825A patent/MXPA04000825A/es active IP Right Grant
- 2002-07-24 JP JP2003517072A patent/JP4679055B2/ja not_active Expired - Fee Related
- 2002-07-24 WO PCT/US2002/023553 patent/WO2003011881A2/en not_active Ceased
- 2002-07-24 ES ES02765874T patent/ES2292806T3/es not_active Expired - Lifetime
2004
- 2004-01-27 IL IL160085A patent/IL160085A/en not_active IP Right Cessation
2007
- 2007-11-26 CY CY20071101510T patent/CY1107813T1/el unknown

Also Published As

Publication number	Publication date
DE60222137D1 (de)	2007-10-11
WO2003011881A3 (en)	2003-10-30
CA2455774A1 (en)	2003-02-13
EP1412368B1 (en)	2007-08-29
EP1412368A2 (en)	2004-04-28
JP2005500357A (ja)	2005-01-06
DK1412368T3 (da)	2008-01-02
ES2292806T3 (es)	2008-03-16
MXPA04000825A (es)	2004-05-17
JP4679055B2 (ja)	2011-04-27
CY1107813T1 (el)	2013-06-19
IL160085A (en)	2010-12-30
AU2002329634B2 (en)	2009-01-29
ATE371665T1 (de)	2007-09-15
CA2455774C (en)	2011-06-07
PT1412368E (pt)	2007-11-06
US20030050257A1 (en)	2003-03-13
WO2003011881A2 (en)	2003-02-13
DE60222137T2 (de)	2008-06-05
US6740641B2 (en)	2004-05-25

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