MA40171A - Dérivés d'azamophinan et leur utilisation - Google Patents

Dérivés d'azamophinan et leur utilisation

Info

Publication number
MA40171A
MA40171A MA040171A MA40171A MA40171A MA 40171 A MA40171 A MA 40171A MA 040171 A MA040171 A MA 040171A MA 40171 A MA40171 A MA 40171A MA 40171 A MA40171 A MA 40171A
Authority
MA
Morocco
Prior art keywords
azamophinan
derivatives
solvates
compounds
directed
Prior art date
Application number
MA040171A
Other languages
English (en)
Inventor
Jae Hyun Park
Laykea Tafesse
Original Assignee
Purdue Pharma Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Pharma Lp filed Critical Purdue Pharma Lp
Publication of MA40171A publication Critical patent/MA40171A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne des composés de formule (i), ainsi que des sels et solvates pharmaceutiquement acceptables de ceux-ci. Dans la formule (i), r
MA040171A 2014-06-13 2015-06-12 Dérivés d'azamophinan et leur utilisation MA40171A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462012060P 2014-06-13 2014-06-13

Publications (1)

Publication Number Publication Date
MA40171A true MA40171A (fr) 2017-04-19

Family

ID=54834434

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040171A MA40171A (fr) 2014-06-13 2015-06-12 Dérivés d'azamophinan et leur utilisation

Country Status (6)

Country Link
US (1) US10202382B2 (fr)
EP (1) EP3154972A4 (fr)
JP (1) JP6360915B2 (fr)
CA (1) CA2951697A1 (fr)
MA (1) MA40171A (fr)
WO (1) WO2015192053A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2917182B1 (fr) 2012-11-09 2018-01-03 Purdue Pharma LP Analogues de benzomorphane et leur utilisation
WO2015097548A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Analogues 7-bêta-alkyle d'orvinols
WO2015097545A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Morphinanes oxabicyclo[2.2.2]octane modulateurs des récepteurs aux opiacés
EP3087057A4 (fr) 2013-12-26 2017-06-28 Purdue Pharma LP Morphinanes à cycle contracté et leur utilisation
WO2015097547A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Hydantoïnes de morphinane substitués en position 10
WO2015099863A1 (fr) 2013-12-27 2015-07-02 Purdue Pharma L.P. Analogues de la morphinane 6-substitués et 7-substitués, et leurs utilisations
EP3089978B1 (fr) 2013-12-30 2018-08-29 Purdue Pharma L.P. Analogues de morphinane pyridone-sulfones utilisés comme ligands de récepteurs opioïdes
CA2950567A1 (fr) 2014-05-27 2015-12-03 Purdue Pharma L.P. Morphinanes spirocycliques et utilisation associee
MA40171A (fr) 2014-06-13 2017-04-19 Purdue Pharma Lp Dérivés d'azamophinan et leur utilisation
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
WO2018125716A1 (fr) 2017-01-02 2018-07-05 Purdue Pharma L.P. Dérivés de morphinane et leur utilisation
WO2020048829A1 (fr) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft Composés de 3,9-diazaspiro[5.5]undécane
WO2020048828A1 (fr) 2018-09-03 2020-03-12 Bayer Pharma Aktiengesellschaft Composés du 5-hétéroaryl-3,9-diazaspiro[5.5]undécane
EP4039331A4 (fr) * 2019-09-30 2024-01-17 Nippon Chemiphar Co., Ltd. Dérivé d'azépane
CN114292889B (zh) * 2022-03-14 2023-11-21 河南省医药科学研究院 一种紫穗槐花多糖的制备方法及其应用
EP4265663A1 (fr) 2022-04-21 2023-10-25 Covestro Deutschland AG Compositions de revêtement à deux composants à base de polyaspartate destinées à la fabrication de revêtements présentant de bonnes propriétés d'auto-cicatrisation et en même temps une faible adhérence

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3285922A (en) * 1962-01-26 1966-11-15 Research Corp N-cyclopropylmethyl-and -cyclobutyl-methyl-morphinans
US3300500A (en) * 1962-04-09 1967-01-24 Alkylmorphinan derivatives and production thereof
CA1093070A (fr) * 1978-02-10 1981-01-06 Michael P. Kotick Traduction non-disponible
HU196376B (en) * 1985-05-23 1988-11-28 Sandoz Ag Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds
NZ500590A (en) 1997-04-22 2001-11-30 Cocensys Inc Carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones and the use thereof
EP1032377B1 (fr) 1997-11-21 2010-11-17 Purdue Neuroscience Company 2-aminoacetamides substitues et leur utilisation
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
TW502019B (en) 1999-03-26 2002-09-11 Cocensys Inc Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof
DK1169060T3 (da) 1999-04-09 2006-01-16 Euro Celtique Sa Natriumkanalblokkerpræparater og anvendelse deraf
AR029489A1 (es) 2000-03-10 2003-07-02 Euro Celtique Sa Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento
AU4589701A (en) 2000-03-24 2001-10-08 Cocensys Inc Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof
AU4961001A (en) 2000-03-31 2001-10-15 Cocensys Inc Aminopyridines and their use as anticonvulsants and sodium channel blockers
JP2004538256A (ja) 2001-03-02 2004-12-24 ユーロ−セルティーク，エス．エイ． Ｎ−ブト−３−エチル＝ノルブプレノルフィン及び使用方法
IL159765A0 (en) 2001-07-16 2004-06-20 Euro Celtique Sa Aryl substituted thiazolidinone derivatives and pharmaceutical compositions containing the same
US6740641B2 (en) 2001-07-27 2004-05-25 Euro-Celtique, S.A. Sugar derivatives of hydromorphone, dihydromorphine and dihydromorphine, compositions thereof and uses for treating or preventing pain
AR037233A1 (es) 2001-09-07 2004-11-03 Euro Celtique Sa Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
AR036873A1 (es) 2001-09-07 2004-10-13 Euro Celtique Sa Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento
MXPA04008901A (es) 2002-03-13 2004-11-26 Euro Celtique Sa Pirimidinas arilo sustituidas y el uso de las mismas.
CA2492305A1 (fr) 2002-07-31 2004-02-05 Euro-Celtique S.A. Benzimidazoles aryle substituees et utilisation de ce compose comme bloqueurs de canal
US20040097569A1 (en) 2002-07-31 2004-05-20 Euro-Celtique S.A. Aryl substituted hydantoin compounds and their use as sodium channel blockers
US20040152696A1 (en) 2002-08-01 2004-08-05 Euro-Celtique S.A. 2-substituted bicyclic benzoheterocyclic compounds and their use as sodium channel blockers
PT1543010E (pt) 2002-09-25 2007-07-26 Euro Celtique Sa Hidromorfonas n-substituídas e a sua utilização
EP1554290B1 (fr) 2002-10-25 2009-09-30 Euro-Celtique S.A. Analogues et promedicaments de buprenorphine
US7202259B2 (en) 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US6958398B1 (en) 2002-12-30 2005-10-25 Euro-Celtique S.A. Methods for making thebaine or its acid salts
WO2005014849A2 (fr) 2003-07-03 2005-02-17 Euro-Celtique, S.A. Genes associes a des reponses a des douleurs neuropathiques
ES2433118T3 (es) 2006-11-01 2013-12-09 Purdue Pharma Lp Compuestos de fenilpropionamida y uso de los mismos
CN101878214A (zh) 2007-11-30 2010-11-03 普渡制药公司 苯并吗啡烷化合物
ES2449222T3 (es) 2008-07-30 2014-03-18 Purdue Pharma Lp Análogos de buprenorfina
US9119848B2 (en) * 2009-12-04 2015-09-01 Alkermes Pharma Ireland Limited Morphinan derivatives for the treatment of drug overdose
EP2582666B1 (fr) 2010-06-16 2014-08-13 Purdue Pharma L.P. Indoles à substitution aryle et leur utilisation en tant que bloqueur des canaux sodium
JP2013531687A (ja) 2010-07-16 2013-08-08 パーデュー、ファーマ、リミテッド、パートナーシップ ナトリウムチャネル遮断剤としてのピリジン化合物
AU2011303597A1 (en) 2010-09-17 2013-04-11 Purdue Pharma L.P. Pyridine compounds and the uses thereof
ES2566828T3 (es) 2010-09-21 2016-04-15 Purdue Pharma L.P. Análogos de buprenorfina como agonistas y/o antagonistas del receptor opioide
KR20130095772A (ko) 2010-10-05 2013-08-28 퍼듀 퍼머 엘피 나트륨 채널 차단제로서 퀴나졸린 화합물
EP2655330B1 (fr) 2010-12-22 2016-02-10 Purdue Pharma LP Pyridines substituées en tant que bloqueurs de canaux sodiques
SMT201700400T1 (it) * 2011-06-29 2017-09-07 Alkermes Inc Composti oppioidi ad azione periferica
EP3255041A1 (fr) 2011-09-02 2017-12-13 Purdue Pharma L.P. Pyrimidines utilisées comme bloqueurs de canaux sodiques
WO2013064883A1 (fr) 2011-10-31 2013-05-10 Purdue Pharma L.P. Composés hétéroaryliques comme agents de blocage des canaux sodiques
WO2013064884A1 (fr) 2011-10-31 2013-05-10 Purdue Pharma L.P. Amines quaternisées en tant que bloqueurs des canaux sodiques
US9133131B2 (en) 2011-11-15 2015-09-15 Purdue Pharma L.P. Pyrimidine diol amides as sodium channel blockers
EP2788358B1 (fr) 2011-12-08 2018-08-29 Purdue Pharma LP Analogues de buprénorphine quaternisés
WO2013136170A1 (fr) 2012-03-16 2013-09-19 Purdue Pharma L.P. Pyridines substituées en tant que bloqueurs des canaux sodiques
AR091027A1 (es) 2012-05-11 2014-12-30 Purdue Pharma Lp Analogos de benzomorfano y el usos de estos
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
EP2917182B1 (fr) 2012-11-09 2018-01-03 Purdue Pharma LP Analogues de benzomorphane et leur utilisation
WO2014087226A1 (fr) 2012-12-07 2014-06-12 Purdue Pharma L.P. Analogues de buprénorphine en tant que modulateurs d'un récepteur des opioïdes
ES2623262T3 (es) * 2012-12-14 2017-07-10 Purdue Pharma Lp Derivados de morfinano que contienen nitrógeno y el uso de los mismos
EP2931724B1 (fr) 2012-12-14 2017-01-25 Purdue Pharma LP Analogues de pyridonemorphinane et activité biologique sur des récepteurs des opioïdes
WO2014091297A1 (fr) 2012-12-14 2014-06-19 Purdue Pharma L.P. Morphinanes spirocycliques et leur utilisation
EP2935257B1 (fr) 2012-12-20 2018-02-07 Purdue Pharma LP Sulfonamides cycliques en tant que bloquants des canaux sodiques
WO2014102587A1 (fr) 2012-12-28 2014-07-03 Purdue Pharma L.P. Analogues de 7,8-cyclicmorphinane
US8946255B2 (en) 2012-12-28 2015-02-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
JP6182620B2 (ja) 2013-01-31 2017-08-16 パーデュー、ファーマ、リミテッド、パートナーシップ ベンゾモルファン類似体およびその使用
US9120786B2 (en) 2013-03-04 2015-09-01 Purdue Pharma, L.P. Triazine carboxamides as sodium channel blockers
WO2014135955A1 (fr) 2013-03-04 2014-09-12 Purdue Pharma L.P. Pyrimidine carboxamides à titre de bloqueurs des canaux sodiques
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
CA2939549C (fr) 2013-03-15 2020-08-18 Purdue Pharma L.P. Derives de carboxamide et leur utilisation
CN105246897B (zh) 2013-05-24 2017-12-26 罗德科技公司 阿片样缩酮化合物和其用途
US9359330B2 (en) 2013-08-26 2016-06-07 Purdue Pharma L.P. Substituted piperidines as sodium channel blockers
US9828348B2 (en) 2013-11-08 2017-11-28 Purdue Pharma L.P. Benzimidazole derivatives and use thereof
US9340504B2 (en) 2013-11-21 2016-05-17 Purdue Pharma L.P. Pyridine and piperidine derivatives as novel sodium channel blockers
US9695144B2 (en) 2013-12-23 2017-07-04 Purdue Pharma L.P. Dibenzazepine derivatives and use thereof
WO2015097548A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Analogues 7-bêta-alkyle d'orvinols
WO2015097547A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Hydantoïnes de morphinane substitués en position 10
WO2015097545A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Morphinanes oxabicyclo[2.2.2]octane modulateurs des récepteurs aux opiacés
WO2015097546A1 (fr) 2013-12-26 2015-07-02 Purdue Pharma L.P. Composés à base de propellane et utilisation de ces derniers en qualité de modulateurs de récepteurs d'opioïdes
EP3087057A4 (fr) 2013-12-26 2017-06-28 Purdue Pharma LP Morphinanes à cycle contracté et leur utilisation
US20160333020A1 (en) 2013-12-26 2016-11-17 Purdue Pharma L.P. 7-beta analogs of orvinols
WO2015099863A1 (fr) 2013-12-27 2015-07-02 Purdue Pharma L.P. Analogues de la morphinane 6-substitués et 7-substitués, et leurs utilisations
EP3089978B1 (fr) 2013-12-30 2018-08-29 Purdue Pharma L.P. Analogues de morphinane pyridone-sulfones utilisés comme ligands de récepteurs opioïdes
JP6526023B2 (ja) 2014-01-24 2019-06-05 パーデュー、ファーマ、リミテッド、パートナーシップ ピリジン類及びピリミジン類並びにその使用
AU2015217185B2 (en) 2014-02-12 2018-04-05 Purdue Pharma L.P. Isoquinoline derivatives and use thereof
US10730866B2 (en) 2014-04-07 2020-08-04 Purdue Pharma L.P. Indole derivatives and use thereof
CA2948144A1 (fr) 2014-05-06 2015-11-12 Purdue Pharma L.P. Analogues du benzomorphane et leur utilisation
CA2950567A1 (fr) 2014-05-27 2015-12-03 Purdue Pharma L.P. Morphinanes spirocycliques et utilisation associee
MA40171A (fr) 2014-06-13 2017-04-19 Purdue Pharma Lp Dérivés d'azamophinan et leur utilisation
WO2015192039A1 (fr) 2014-06-13 2015-12-17 Purdue Pharma L.P. Dérivés hétérocycliques de morphinan et leur utilisation
WO2016044546A1 (fr) 2014-09-17 2016-03-24 Purdue Pharma L.P. Analogues de benzomorphane et leur utilisation

Also Published As

Publication number Publication date
EP3154972A4 (fr) 2017-11-22
JP2017517559A (ja) 2017-06-29
CA2951697A1 (fr) 2015-12-17
EP3154972A1 (fr) 2017-04-19
US10202382B2 (en) 2019-02-12
JP6360915B2 (ja) 2018-07-18
WO2015192053A1 (fr) 2015-12-17
US20170107220A1 (en) 2017-04-20

Similar Documents

Publication Publication Date Title
MA40171A (fr) Dérivés d'azamophinan et leur utilisation
MA40170A (fr) Dérivés hétérocycliques de morphinan et leur utilisation
PH12019501321B1 (en) Use of pyrazolopyrimidine derivatives for the treatment of pi3k-delta related disorders
MA40058A (fr) Composés inhibiteurs de kinases se liant à tank
MD20160106A2 (ro) Compuşi aril sau heteroaril biciclici condensaţi şi utilizarea acestora ca inhibitori IRAK4
JO3317B1 (ar) مركبات تترا هيدروبيرولو ثيازين
AU2014267235A8 (en) Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
MA39749A (fr) Dérivés de pipéridine-dione
MA39866A (fr) Amides 2-amino-6-méthyl-4,4a,5,6-tétrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl-1,3-thiazol-4-yle
MX2017003930A (es) Derivados de aminotriazina utiles como compuestos inhibidores de la cinasa de union a tank.
CR20150470A (es) Derivados de triazolona de piridinilo y piridinilo fusionado
PH12017500095A1 (en) Imidazopyridazine compounds
AU2015292632B2 (en) Aldosterone synthase inhibitors
SA517381678B1 (ar) مركبات داي هيدرو بيريميدين-2-أون واستخدامها الطبي
JOP20190163B1 (ar) منشط nrf2
MX2015013224A (es) Inhibidores macrociclicos y biciclicos del virus de la hepatitis c.
IN2013MU03862A (fr)
EA201791099A1 (ru) Хинолин карбоксамиды для применения в лечении лейкоза
EA201491227A1 (ru) Новые производные морфолинила, подходящие для применения в качестве ингибиторов mogat-2
EA201790687A1 (ru) Хинолинкарбоксамиды для применения в лечении множественной миеломы
PH12016502480A1 (en) Compounds, pharmaceutical composition and their use in treating neurodegenerative diseases
JO3298B1 (ar) مشتقات جليكوبيرانوسيل-مستبدل و اندول-يوريا و استعمالاتهم كمثبطات sglt
IN2013MU03565A (fr)
IN2013MU02010A (fr)
MX2018002193A (es) Metodo de uso de quinoxalinilo-piperazinamida.