IL186654A - Use of mtb72f fusion protein or nucleic acid encoded above to produce a remedy to prevent recurrence of tuberculosis in mammals with latent tuberculosis infection - Google Patents

Use of mtb72f fusion protein or nucleic acid encoded above to produce a remedy to prevent recurrence of tuberculosis in mammals with latent tuberculosis infection

Info

Publication number
IL186654A
IL186654A IL186654A IL18665407A IL186654A IL 186654 A IL186654 A IL 186654A IL 186654 A IL186654 A IL 186654A IL 18665407 A IL18665407 A IL 18665407A IL 186654 A IL186654 A IL 186654A
Authority
IL
Israel
Prior art keywords
fusion protein
tuberculosis
nucleic acid
latent
acid encoding
Prior art date
Application number
IL186654A
Other languages
English (en)
Hebrew (he)
Other versions
IL186654A0 (en
Original Assignee
Glaxosmithkline Biolog Sa
Infectious Disease Res Inst Idri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biolog Sa, Infectious Disease Res Inst Idri filed Critical Glaxosmithkline Biolog Sa
Publication of IL186654A0 publication Critical patent/IL186654A0/en
Publication of IL186654A publication Critical patent/IL186654A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL186654A 2005-04-29 2007-10-15 Use of mtb72f fusion protein or nucleic acid encoded above to produce a remedy to prevent recurrence of tuberculosis in mammals with latent tuberculosis infection IL186654A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67654905P 2005-04-29 2005-04-29
US77701706P 2006-02-27 2006-02-27
PCT/EP2006/004319 WO2006117240A2 (fr) 2005-04-29 2006-04-27 Nouvelle methode de prevention ou de traitement d'une infection par m tuberculosis

Publications (2)

Publication Number Publication Date
IL186654A0 IL186654A0 (en) 2008-01-20
IL186654A true IL186654A (en) 2013-04-30

Family

ID=36972897

Family Applications (2)

Application Number Title Priority Date Filing Date
IL186654A IL186654A (en) 2005-04-29 2007-10-15 Use of mtb72f fusion protein or nucleic acid encoded above to produce a remedy to prevent recurrence of tuberculosis in mammals with latent tuberculosis infection
IL215112A IL215112A (en) 2005-04-29 2011-09-13 Polypeptide Dispensing and Pharmaceutical Preparation @ which includes @ you @ b

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL215112A IL215112A (en) 2005-04-29 2011-09-13 Polypeptide Dispensing and Pharmaceutical Preparation @ which includes @ you @ b

Country Status (24)

Country Link
US (6) US8470338B2 (fr)
EP (3) EP1877426B1 (fr)
JP (4) JP5164830B2 (fr)
KR (4) KR20130110233A (fr)
CN (3) CN106390108B (fr)
AT (1) ATE543832T1 (fr)
AU (1) AU2006243357B2 (fr)
BR (1) BRPI0611347A2 (fr)
CA (2) CA2821389C (fr)
CY (1) CY1112851T1 (fr)
DK (3) DK2457926T3 (fr)
EA (1) EA012576B1 (fr)
ES (3) ES2381492T3 (fr)
HR (3) HRP20120331T1 (fr)
IL (2) IL186654A (fr)
MA (1) MA29678B1 (fr)
NO (3) NO340766B1 (fr)
NZ (1) NZ562729A (fr)
PH (1) PH12013502449A1 (fr)
PL (3) PL2426141T3 (fr)
PT (3) PT2426141E (fr)
SI (3) SI2457926T1 (fr)
WO (1) WO2006117240A2 (fr)
ZA (1) ZA200709209B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2457926T1 (sl) * 2005-04-29 2015-01-30 Glaxosmithkline Biologicals S.A. Nov postopek za preprečevanje ali zdravljenje infekcije z M. tuberculosis
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
EP2207035B1 (fr) * 2006-03-14 2013-10-16 Oregon Health and Science University Procédés pour détecter une infection de tuberculose à mycobactérie
US9717788B2 (en) 2007-03-02 2017-08-01 Glaxosmithkline Biologicals Sa Method of inducing an immune response against HIV employing HIV immunogens, adenoviral vectors encoding said immunogens, and adjuvant
CA2679410C (fr) * 2007-03-02 2017-01-17 Glaxosmithkline Biologicals S.A. Nouveau procede et nouvelles compositions
WO2009025820A2 (fr) * 2007-08-21 2009-02-26 Stc. Unm Dérivés isoniazide et éthionamide et activité améliorés de manière rationnelle par substitution isotopique sélective
WO2009158284A2 (fr) * 2008-06-26 2009-12-30 Mayo Foundation For Medical Education And Research Méthodes et matériaux de production de réponses immunitaires contre des polypeptides impliqués dans la résistance aux antibiotiques
PT2315834T (pt) 2008-07-25 2018-08-10 Glaxosmithkline Biologicals Sa A proteína rv2386c de tuberculose, composições e as suas utilizações
BRPI0916705A2 (pt) 2008-07-25 2015-11-10 Glaxo Group Ltd polipeptídeo isolado, polinucleotídeo isolado, composição farmacêutica, composição imunogênica, método para tratamento ou prevenção de tuberculose, e, usos de um polipeptídeo, e de um polinucleotídeo.
AU2009273130B2 (en) 2008-07-25 2014-10-16 Glaxo Group Limited Novel compositions and methods
GB0815872D0 (en) 2008-09-01 2008-10-08 Pasteur Institut Novel method and compositions
KR20170072366A (ko) 2009-04-24 2017-06-26 스태튼스 세룸 인스티튜트 재활성화를 예방하기 위한 결핵 백신
UA110103C2 (uk) 2010-01-27 2015-11-25 Ґлаксосмітклайн Байолоджікалз С.А. Модифікований туберкульозний антиген
DK2651436T3 (da) 2010-12-14 2016-06-20 Glaxosmithkline Biologicals Sa Mycobakterie antigen sammensætning.
GB201022007D0 (en) 2010-12-24 2011-02-02 Imp Innovations Ltd DNA-sensor
CN107296793A (zh) 2011-01-04 2017-10-27 阿尔西维尔法尔玛公司 适于治疗或预防结核的脂质体制剂
GB201116248D0 (en) 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
WO2013090897A1 (fr) * 2011-12-15 2013-06-20 The Trustees Of The University Of Pennsylvania Utilisation d'immunité adaptative pour détecter une résistance aux médicaments
BR112014017217B1 (pt) 2012-01-12 2023-01-17 Archivel Farma, S.L Agente e composição farmacêutica
MX385774B (es) 2012-08-03 2025-03-18 Infectious Disease Res Inst Composiciones para usarse en el tratamiento de una infección activa por mycobacterium tuberculosis.
GB2521573A (en) * 2012-09-27 2015-06-24 Chengdu Yongan Pharmaceutical Co; Ltd Modified BCG strains with reduced or eliminated activity of LSR2 and pharmaceutical composition comprising same
CN102993266B (zh) * 2012-11-30 2019-08-23 广州白云山拜迪生物医药有限公司 一种融合蛋白的纯化和复性方法
CN102994595B (zh) * 2012-11-30 2018-10-26 广州白云山拜迪生物医药有限公司 一种融合蛋白包涵体的制备方法
GB201405921D0 (en) * 2014-04-02 2014-05-14 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
US10335374B2 (en) 2014-12-04 2019-07-02 University System of Georgia, Valdosta State University Tablet composition for anti-tuberculosis antibiotics
US10672502B2 (en) * 2015-04-02 2020-06-02 Biodesy, Inc. Methods for determining protein structure using a surface-selective nonlinear optical technique
WO2016179231A1 (fr) * 2015-05-04 2016-11-10 Board Of Trustees Of Michigan State University Compositions et procédés pour l'inhibition de la croissance bactérienne
GB201513176D0 (en) * 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
EP3551222B1 (fr) 2016-12-07 2024-08-07 GlaxoSmithKline Biologicals SA Procede de fabrication d'une composition de liposome comprenant une saponine
US11717519B2 (en) 2017-04-21 2023-08-08 Washington University In St. Louis Use of fatty acid oxidation inhibitors as antimicrobials
WO2019178472A1 (fr) * 2018-03-16 2019-09-19 Washington University In St. Louis Utilisation d'inhibiteurs d'oxydation d'acides gras comme agents antimicrobiens
GB201707700D0 (en) 2017-05-12 2017-06-28 Glaxosmithkline Biologicals Sa Dried composition
WO2022119899A1 (fr) * 2020-12-02 2022-06-09 Shionogi & Co., Ltd. Médicament destiné au traitement d'une infection mycobactérienne, caractérisé par la combinaison d'un inhibiteur de cytochrome bc1 avec de la clarithromycine ou de l'azithromycine
AU2022339918A1 (en) 2021-08-31 2024-02-08 Vir Biotechnology, Inc. Tuberculosis vaccines
KR102534846B1 (ko) 2021-12-14 2023-05-19 재단법인 환동해산업연구원 결핵균에 항균 활성을 가지는 해조류 추출물
CN116162141B (zh) * 2022-11-30 2024-04-12 中国疾病预防控制中心传染病预防控制所 一种结核分枝杆菌抗原epcra013及其应用

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
US4769330A (en) 1981-12-24 1988-09-06 Health Research, Incorporated Modified vaccinia virus and methods for making and using the same
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4866034A (en) 1982-05-26 1989-09-12 Ribi Immunochem Research Inc. Refined detoxified endotoxin
US4436727A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
GB8508845D0 (en) 1985-04-04 1985-05-09 Hoffmann La Roche Vaccinia dna
US4777127A (en) 1985-09-30 1988-10-11 Labsystems Oy Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4877611A (en) 1986-04-15 1989-10-31 Ribi Immunochem Research Inc. Vaccine containing tumor antigens and adjuvants
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5811128A (en) 1986-10-24 1998-09-22 Southern Research Institute Method for oral or rectal delivery of microencapsulated vaccines and compositions therefor
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
GB8702816D0 (en) 1987-02-07 1987-03-11 Al Sumidaie A M K Obtaining retrovirus-containing fraction
CA1340522C (fr) 1987-03-10 1999-05-04 Heinz Dobeli Proteins hybrides renfermant des histidines voisines pour une purification amelioree
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
CA1331443C (fr) 1987-05-29 1994-08-16 Charlotte A. Kensil Adjuvant a saponine
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
WO1989001973A2 (fr) 1987-09-02 1989-03-09 Applied Biotechnology, Inc. Virus variolique recombinant d'immunisation contre des antigenes associes a une tumeur
AU2613988A (en) 1988-01-04 1989-08-01 E.I. Du Pont De Nemours And Company Multiple stage affinity process for isolation of specific cells from a cell mixture
AP129A (en) 1988-06-03 1991-04-17 Smithkline Biologicals S A Expression of retrovirus gag protein eukaryotic cells
US5215926A (en) 1988-06-03 1993-06-01 Cellpro, Inc. Procedure for designing efficient affinity cell separation processes
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
US5549910A (en) 1989-03-31 1996-08-27 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
US5725871A (en) 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
EP0487587A1 (fr) 1989-08-18 1992-06-03 Chiron Corporation Retrovirus de recombinaison apportant des constructions de vecteur a des cellules cibles
KR920007887B1 (ko) 1989-08-29 1992-09-18 스즈키 지도오샤 고오교오 가부시키가이샤 내연기관의 배기가스 정화장치
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
US5466468A (en) 1990-04-03 1995-11-14 Ciba-Geigy Corporation Parenterally administrable liposome formulation comprising synthetic lipids
WO1991016116A1 (fr) 1990-04-23 1991-10-31 Cellpro Incorporated Dispositif et procede d'immunoselection
SE466259B (sv) 1990-05-31 1992-01-20 Arne Forsgren Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
JP3218637B2 (ja) 1990-07-26 2001-10-15 大正製薬株式会社 安定なリポソーム水懸濁液
EP0468520A3 (en) 1990-07-27 1992-07-01 Mitsui Toatsu Chemicals, Inc. Immunostimulatory remedies containing palindromic dna sequences
JP2958076B2 (ja) 1990-08-27 1999-10-06 株式会社ビタミン研究所 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法
EP0553288B1 (fr) 1990-10-18 1997-06-18 Cellpro Incorporated Appareil et procede de separation de particules a l'aide d'un recipient pliable
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US6113914A (en) 1991-08-15 2000-09-05 Smithkline Beecham Biologicals (S.A.) Osp A proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines
US5240856A (en) 1991-10-23 1993-08-31 Cellpro Incorporated Apparatus for cell separation
US5756353A (en) 1991-12-17 1998-05-26 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol-and liposome-based delivery
ES2105262T3 (es) 1992-05-18 1997-10-16 Minnesota Mining & Mfg Dispositivo de suministro de farmaco a traves de las mucosas.
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
CA2138997C (fr) 1992-06-25 2003-06-03 Jean-Paul Prieels Composition vaccinale qui contient des adjuvants
JPH08505625A (ja) 1993-01-11 1996-06-18 ダナ−ファーバー キャンサー インスティチュート 細胞毒性ｔリンパ球応答の誘導
FR2702160B1 (fr) 1993-03-02 1995-06-02 Biovecteurs As Vecteurs particulaires synthétiques et procédé de préparation.
SG48309A1 (en) 1993-03-23 1998-04-17 Smithkline Beecham Biolog Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a
FR2704145B1 (fr) 1993-04-21 1995-07-21 Pasteur Institut Vecteur particulaire et composition pharmaceutique le contenant.
US5955077A (en) 1993-07-02 1999-09-21 Statens Seruminstitut Tuberculosis vaccine
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US5741516A (en) 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5551622A (en) 1994-07-13 1996-09-03 Yoon; Inbae Surgical stapler
WO1996002555A1 (fr) 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Oligonucleotides immunomodulateurs
FR2723849B1 (fr) 1994-08-31 1997-04-11 Biovector Therapeutics Sa Procede pour augmenter l'immunogenicite, produit obtenu et composition pharmaceutique
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5580579A (en) 1995-02-15 1996-12-03 Nano Systems L.L.C. Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
CA2220530A1 (fr) 1995-06-02 1996-12-05 Incyte Pharmaceuticals, Inc. Procede ameliore pour obtenir des sequences d'adn complementaire longues
US5738868A (en) 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
CN1154730C (zh) 1995-09-01 2004-06-23 科里克萨有限公司 用于结核病诊断的化合物和方法
CZ300688B6 (cs) 1995-09-01 2009-07-15 Corixa Corporation Polypeptid, farmaceutický prostredek a vakcína s jeho obsahem, zpusob prípravy a použití polypeptidu, molekula rekombinantní DNA a její použití, expresní vektor, hostitelská bunka, fúsní porotein a diagnostický kit
US6290969B1 (en) 1995-09-01 2001-09-18 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
EP0871747A1 (fr) 1996-01-02 1998-10-21 Chiron Viagene, Inc. Immunostimulation a mediation par cellules dendritiques modifiees par des genes
US5856462A (en) 1996-09-10 1999-01-05 Hybridon Incorporated Oligonucleotides having modified CpG dinucleosides
JP4111403B2 (ja) 1996-10-11 2008-07-02 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア 免疫刺激ポリヌクレオチド／免疫調節分子複合体
WO1998016645A2 (fr) 1996-10-11 1998-04-23 Corixa Corporation Composes et procedes pour diagnostiquer la tuberculose
US5655998A (en) 1996-12-03 1997-08-12 Yu; Chih-An Space walking exerciser
ES2227825T3 (es) 1997-04-01 2005-04-01 Corixa Corporation Composiciones inmunologicas aduvantes acuosas de monofosforil lipido a.
GB9727262D0 (en) 1997-12-24 1998-02-25 Smithkline Beecham Biolog Vaccine
ATE513042T1 (de) 1998-02-05 2011-07-15 Glaxosmithkline Biolog Sa Tumorassoziierte antigenderivate der mage-familie,nukleinsäuresequenzen, die dafür kodieren, zur herstellung von fusionsproteinen und zusammensetzungen zur impfung
KR100797876B1 (ko) 1998-04-07 2008-01-24 코릭사 코포레이션 마이코박테리움 튜베르쿨로시스 항원의 융합 단백질 및이의 용도
AU779978B2 (en) 1999-10-07 2005-02-24 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
US7472098B2 (en) 2000-02-14 2008-12-30 Ubs Financial Services, Inc. System and method for execution of trades made pursuant to stock option and purchase plans
DE60139963D1 (de) * 2000-06-20 2009-10-29 Corixa Corp Fusionsproteine aus mycobakterium tuberculosis
US20030143240A1 (en) 2000-06-27 2003-07-31 Cabezon-Silva Teresa Elisa Virginia Prostase protein vaccine comprising derivatised thiol residues and methods for producing said antigen
WO2002072792A2 (fr) * 2001-03-13 2002-09-19 Corixa Corporation Constructions de proteines de fusion heterologues comprenant un antigene de leishmania
ATE434637T1 (de) 2002-02-14 2009-07-15 Mitsui Chemicals Inc Polyesterharz und katalysator für die polyesterherstellung, verfahren zur herstellung von polyesterharz mit dem katalysator.
US7026465B2 (en) * 2002-02-15 2006-04-11 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis
GB0411411D0 (en) 2004-05-21 2004-06-23 Glaxosmithkline Biolog Sa Vaccines
US7301098B2 (en) 2005-01-19 2007-11-27 Panduit Corp. Communication channels with suppression cores
SI2457926T1 (sl) * 2005-04-29 2015-01-30 Glaxosmithkline Biologicals S.A. Nov postopek za preprečevanje ali zdravljenje infekcije z M. tuberculosis
JP4468858B2 (ja) 2005-06-01 2010-05-26 オリンパスイメージング株式会社 データ符号化装置、データ符号化方法、プログラム
US7296798B2 (en) 2006-01-31 2007-11-20 Matt Overfield Gameboard, games played on board and methods of play requiring strategy and luck
KR20170072366A (ko) * 2009-04-24 2017-06-26 스태튼스 세룸 인스티튜트 재활성화를 예방하기 위한 결핵 백신
CN104534426B (zh) 2009-07-21 2018-11-09 库柏技术公司 将发光二极管模块连接于散热器组件、反光件以及电路
DK2651436T3 (da) 2010-12-14 2016-06-20 Glaxosmithkline Biologicals Sa Mycobakterie antigen sammensætning.
US9119754B2 (en) 2011-10-08 2015-09-01 Michael Dennis Mattress overlay system with positionally adjustable, lateral ramp-wedge bolster structure
US9051890B2 (en) 2013-10-28 2015-06-09 Ford Global Technologies, Llc Method for estimating charge air cooler condensation storage with an intake oxygen sensor
US9903268B2 (en) 2015-04-02 2018-02-27 Ford Global Technologies, Llc Internal combustion engine with two-stage supercharging capability and with exhaust-gas aftertreatment arrangement, and method for operating an internal combustion engine
US9810514B2 (en) 2015-09-08 2017-11-07 Deufol Sunman Inc. Ammunition carrier consumer package

Also Published As

Publication number Publication date
EP2426141A3 (fr) 2012-08-15
JP2015057403A (ja) 2015-03-26
NO20075201L (no) 2008-01-25
CY1112851T1 (el) 2016-02-10
PL2426141T3 (pl) 2015-02-27
EA200702081A1 (ru) 2008-04-28
JP2008539187A (ja) 2008-11-13
CN102617739A (zh) 2012-08-01
KR20150036658A (ko) 2015-04-07
US9056913B2 (en) 2015-06-16
NO345071B1 (no) 2020-09-14
AU2006243357B2 (en) 2012-03-15
EA012576B1 (ru) 2009-10-30
CA2607715C (fr) 2015-11-24
JP5659207B2 (ja) 2015-01-28
DK2426141T3 (da) 2014-11-10
US8470338B2 (en) 2013-06-25
EP2457926B1 (fr) 2014-09-24
US20170196961A1 (en) 2017-07-13
BRPI0611347A2 (pt) 2010-08-31
US9655958B2 (en) 2017-05-23
JP2013040190A (ja) 2013-02-28
US20190030154A1 (en) 2019-01-31
DK1877426T3 (da) 2012-05-14
JP2012065650A (ja) 2012-04-05
DK2457926T3 (da) 2015-01-05
PH12013502449A1 (en) 2015-12-14
ES2524572T3 (es) 2014-12-10
KR20120089475A (ko) 2012-08-10
NZ562729A (en) 2009-10-30
EP1877426B1 (fr) 2012-02-01
CN106390108B (zh) 2020-09-08
CN106390108A (zh) 2017-02-15
KR20130110233A (ko) 2013-10-08
US10350283B2 (en) 2019-07-16
IL215112A (en) 2013-07-31
EP2426141B1 (fr) 2014-10-01
HRP20120331T1 (hr) 2012-05-31
HRP20141184T1 (en) 2015-03-13
CA2821389A1 (fr) 2006-11-09
KR101352806B1 (ko) 2014-02-17
NO340766B1 (no) 2017-06-19
WO2006117240A2 (fr) 2006-11-09
ES2381492T3 (es) 2012-05-28
CN101273055A (zh) 2008-09-24
KR20080021624A (ko) 2008-03-07
WO2006117240A3 (fr) 2007-01-18
MA29678B1 (fr) 2008-08-01
PT1877426E (pt) 2012-05-02
EP2426141A2 (fr) 2012-03-07
US20090123491A1 (en) 2009-05-14
EP2457926A1 (fr) 2012-05-30
US10105430B2 (en) 2018-10-23
PL2457926T3 (pl) 2015-03-31
CN101273055B (zh) 2016-03-16
CA2821389C (fr) 2015-11-17
US20140050776A1 (en) 2014-02-20
AU2006243357A1 (en) 2006-11-09
EP1877426A2 (fr) 2008-01-16
ZA200709209B (en) 2009-12-30
PL1877426T3 (pl) 2012-10-31
US20170065696A9 (en) 2017-03-09
NO340206B1 (no) 2017-03-20
US20190307872A1 (en) 2019-10-10
HRP20141125T1 (hr) 2015-01-02
PT2426141E (pt) 2014-11-25
SI1877426T1 (sl) 2012-06-29
NO20120381L (no) 2008-01-25
US20150231224A1 (en) 2015-08-20
SI2457926T1 (sl) 2015-01-30
JP5164830B2 (ja) 2013-03-21
ATE543832T1 (de) 2012-02-15
PT2457926E (pt) 2014-11-25
CA2607715A1 (fr) 2006-11-09
SI2426141T1 (sl) 2015-01-30
ES2524570T3 (es) 2014-12-10
NO20141158L (no) 2008-01-25
IL186654A0 (en) 2008-01-20
IL215112A0 (en) 2011-10-31
US10639361B2 (en) 2020-05-05

Similar Documents

Publication Publication Date Title
IL215112A0 (en) Fusion polypeptide and pharmaceutical composition comprising such
BRPI0518282A2 (pt) uso de uma quantidade terapeuticamente ou profilaticamente efetiva de um composto imunomodulatàrio
ID29181A (id) Kombinasi formoterol dan garam tiotropium
GB0008269D0 (en) Combination chemotherapy
BRPI0415953B8 (pt) formulação de dosagem de liberação controlada e conjunto de formas de dosagem de liberação controlada
JP2005537234A5 (fr)
DK1383752T3 (da) Deutererede 3-piperidinopropiophenoner samt lægemidler indeholdende disse forbindelser
DE602004029934D1 (de) Einen genetisch modifizierten antikörper gegen chemokin-rezeptor-ccr4 enthaltendes medikament
SE0300971D0 (sv) Nitric oxide in treatment of inflammation
WO2005044186A3 (fr) Formulations pharmaceutiques destinees a etre inhalees utilisant des agents dessechants et methodes d'administration desdites formulations pharmaceutiques
WO2005030109A3 (fr) Schema posologique pour l'administration d'antibiotiques de la classe des rifamycines
DE602006001699D1 (de) Stabile pharmazeutische Zusammensetzung mit Linezolid Form IV
UA98605C2 (ru) Новый способ предотвращения или лечения инфекции m. tuberculosis
SE0000303D0 (sv) Novel compounds
DE602005010844D1 (de) Pharmazeutische zusammensetzungen mit interferon-tau
NZ592114A (en) Composition comprising sortase anchored surface proteins of streptococcus uberis
CY1115823T1 (el) Νεα μεθοδος προληψης ή θεραπειας μολυνσης m. tuberculosis
SE0203817D0 (sv) New composition
BR0307196A (pt) Idraparinux (sanorg 34006) para tratamento e profilaxia secundária de eventos tromboembólicos venosos em pacientes com trombose venosa profunda
HRP20060325A2 (en) Combination of deramciclane and opoids as analgesics
SI1677808T1 (sl) Kombiniran pripravek za zdravljenje sepse
UY27472A1 (es) Metodo para la preparación de una composición farmacéutica que comprende un acido-5-amino-salicilico, para uso en el tratamiento de la colitis ulcerosa y enfermedad de crohn.

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees