IL272776B2 - Method of rapidly achieving therapeutic concentrations of zolmitriptan for treatment of migraines and cluster headaches - Google Patents

Method of rapidly achieving therapeutic concentrations of zolmitriptan for treatment of migraines and cluster headaches

Info

Publication number
IL272776B2
IL272776B2 IL272776A IL27277620A IL272776B2 IL 272776 B2 IL272776 B2 IL 272776B2 IL 272776 A IL272776 A IL 272776A IL 27277620 A IL27277620 A IL 27277620A IL 272776 B2 IL272776 B2 IL 272776B2
Authority
IL
Israel
Prior art keywords
microns
microprojections
patch
zolmitriptan
group
Prior art date
Application number
IL272776A
Other languages
English (en)
Hebrew (he)
Other versions
IL272776B1 (en
IL272776A (en
Original Assignee
Zosano Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zosano Pharma Corp filed Critical Zosano Pharma Corp
Publication of IL272776A publication Critical patent/IL272776A/en
Publication of IL272776B1 publication Critical patent/IL272776B1/en
Publication of IL272776B2 publication Critical patent/IL272776B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
IL272776A 2017-08-23 2017-08-23 Method of rapidly achieving therapeutic concentrations of zolmitriptan for treatment of migraines and cluster headaches IL272776B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2017/048258 WO2019040063A1 (fr) 2017-08-23 2017-08-23 Procédé d'obtention rapide de concentrations thérapeutiques de zolmitriptan pour le traitement de migraines et de céphalées de horton

Publications (3)

Publication Number Publication Date
IL272776A IL272776A (en) 2020-04-30
IL272776B1 IL272776B1 (en) 2024-02-01
IL272776B2 true IL272776B2 (en) 2024-06-01

Family

ID=59829462

Family Applications (1)

Application Number Title Priority Date Filing Date
IL272776A IL272776B2 (en) 2017-08-23 2017-08-23 Method of rapidly achieving therapeutic concentrations of zolmitriptan for treatment of migraines and cluster headaches

Country Status (8)

Country Link
EP (1) EP3672570A1 (fr)
JP (2) JP7219384B2 (fr)
KR (2) KR20210155817A (fr)
CN (1) CN111050749A (fr)
AU (1) AU2017428907B2 (fr)
CA (2) CA3073442C (fr)
IL (1) IL272776B2 (fr)
WO (1) WO2019040063A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017143345A1 (fr) 2016-02-19 2017-08-24 Zp Opco, Inc. Procédé pour obtenir rapidement des concentrations thérapeutiques de triptans pour le traitement de migraines
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
US20220241571A1 (en) * 2019-06-06 2022-08-04 Kindeva Drug Delivery L.P. Microarray carrier for microarray applicator
AU2020306024B2 (en) * 2019-06-28 2025-02-27 Passport Technologies, Inc. Triptan microporation delivery system
CN114699510B (zh) * 2021-12-29 2024-07-16 浙江湃肽生物有限公司 一种司美格鲁肽微针阵列及其制备方法
JP2025521646A (ja) * 2022-06-24 2025-07-10 ヴァクセス テクノロジーズ インコーポレイテッド 薬剤パッチ用アプリケータ
CN115887903B (zh) * 2022-12-15 2024-09-27 太平洋康泰科学仪器(济南)有限公司 微针贴片给药组件及给药方法
CN120227361A (zh) * 2023-12-29 2025-07-01 珠海科瑞微医药科技有限公司 一种微针贴片的制备工艺及其制备得到的微针贴

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013177376A (ja) * 2012-02-09 2013-09-09 Hisamitsu Pharmaceut Co Inc マイクロニードル用ゾルミトリプタン含有コーティング組成物及びマイクロニードルデバイス

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5080646A (en) 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5147296A (en) 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
CA2253549C (fr) 1996-06-18 2005-10-25 Alza Corporation Dispositif d'amelioration d'apport ou d'echantillonnage d'agents transdermiques
US5743960A (en) 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5916524A (en) 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5738728A (en) 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
US5741554A (en) 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
DE69806963T2 (de) 1997-12-11 2002-11-21 Alza Corp., Mountain View Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
CA2313698C (fr) 1997-12-11 2008-04-15 Alza Corporation Dispositif renforcant le flux d'agents transdermiques
ES2314995T3 (es) 1997-12-11 2009-03-16 Alza Corporation Dispositivo para mejorar el flujo de agentes tansdermicos.
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
ES2253278T3 (es) 1999-12-10 2006-06-01 Alza Corporation Dispositivo y procedimiento para mejorar la perforacion cutanea con microprotuberancias.
DE60138411D1 (de) 2000-10-13 2009-05-28 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
PL360978A1 (en) 2000-10-13 2004-09-20 Alza Corporation Microblade array impact applicator
ATE416692T1 (de) 2000-10-13 2008-12-15 Alza Corp Mikronadelelementhalter für schlagapplikator
NZ525551A (en) 2000-10-26 2005-09-30 Alza Corp Transdermal drug delivery devices having coated microprotrusions
WO2002074173A1 (fr) 2001-03-16 2002-09-26 Alza Corporation Procede et appareil de revetement de microprojections de perçage de peau
ATE444773T1 (de) 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
ES2377647T3 (es) 2003-10-31 2012-03-29 Alza Corporation Aplicador auto-actuado para ordenamiento de microproyecciones
US7556821B2 (en) 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
AU2007225056A1 (en) 2006-03-15 2007-09-20 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia
WO2008115586A1 (fr) * 2007-03-21 2008-09-25 Alza Corporation Appareil et procédé d'administration transdermique d'un agoniste de triptane
EP3027263A1 (fr) 2013-07-30 2016-06-08 ZP Opco, Inc. Applicateur extra-plat de tampon de micro-aiguilles
WO2017143345A1 (fr) * 2016-02-19 2017-08-24 Zp Opco, Inc. Procédé pour obtenir rapidement des concentrations thérapeutiques de triptans pour le traitement de migraines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013177376A (ja) * 2012-02-09 2013-09-09 Hisamitsu Pharmaceut Co Inc マイクロニードル用ゾルミトリプタン含有コーティング組成物及びマイクロニードルデバイス

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KELLERMAN DONALD J ET AL,, RAPID SYSTEMIC DELIVERY OF ZOLMITRIPTAN USING AN ADHESIVE DERMALLY APPLIED MICROARRAY, 25 July 2017 (2017-07-25) *

Also Published As

Publication number Publication date
JP2021500397A (ja) 2021-01-07
IL272776B1 (en) 2024-02-01
CN111050749A (zh) 2020-04-21
WO2019040063A1 (fr) 2019-02-28
KR102340393B1 (ko) 2021-12-17
AU2017428907A1 (en) 2020-03-05
CA3073442A1 (fr) 2019-02-28
EP3672570A1 (fr) 2020-07-01
CA3223555A1 (fr) 2019-02-28
KR20210155817A (ko) 2021-12-23
KR20200032170A (ko) 2020-03-25
AU2017428907B2 (en) 2021-12-16
CA3073442C (fr) 2024-02-06
JP7219384B2 (ja) 2023-02-08
JP7602732B2 (ja) 2024-12-19
IL272776A (en) 2020-04-30
JP2023033378A (ja) 2023-03-10

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