IL46160A0 - Isoquinoline derivatives and processes for their preparation - Google Patents

Isoquinoline derivatives and processes for their preparation

Info

Publication number
IL46160A0
IL46160A0 IL46160A IL4616074A IL46160A0 IL 46160 A0 IL46160 A0 IL 46160A0 IL 46160 A IL46160 A IL 46160A IL 4616074 A IL4616074 A IL 4616074A IL 46160 A0 IL46160 A0 IL 46160A0
Authority
IL
Israel
Prior art keywords
processes
preparation
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
IL46160A
Other languages
English (en)
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of IL46160A0 publication Critical patent/IL46160A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
IL46160A 1973-12-10 1974-11-29 Isoquinoline derivatives and processes for their preparation IL46160A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2361390A DE2361390A1 (de) 1973-12-10 1973-12-10 Isochinolinderivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
IL46160A0 true IL46160A0 (en) 1975-02-10

Family

ID=5900348

Family Applications (1)

Application Number Title Priority Date Filing Date
IL46160A IL46160A0 (en) 1973-12-10 1974-11-29 Isoquinoline derivatives and processes for their preparation

Country Status (18)

Country Link
US (1) US3985881A (cs)
JP (1) JPS5088077A (cs)
AT (1) AT351026B (cs)
BE (1) BE823027A (cs)
CA (1) CA1053675A (cs)
CH (1) CH605776A5 (cs)
CS (1) CS188933B2 (cs)
DD (1) DD115666A5 (cs)
DE (1) DE2361390A1 (cs)
DK (1) DK137007C (cs)
ES (1) ES432716A1 (cs)
FR (1) FR2253522B1 (cs)
GB (1) GB1447611A (cs)
HU (1) HU171483B (cs)
IL (1) IL46160A0 (cs)
NL (1) NL7416050A (cs)
SE (1) SE7415247L (cs)
ZA (1) ZA747820B (cs)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2504250A1 (de) * 1975-02-01 1976-08-05 Merck Patent Gmbh Tetrahydroisochinolin-derivate und verfahren zu ihrer herstellung
US4232160A (en) * 1978-10-18 1980-11-04 Miles Laboratories, Inc. Isoquinoline propionamides exhibiting analgesic properties
US4556712A (en) * 1981-05-20 1985-12-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
GB8601796D0 (en) * 1986-01-24 1986-02-26 Zambeletti Spa L Compounds
DE3713743A1 (de) * 1987-04-24 1988-11-17 Boehringer Ingelheim Kg Kondensierte bis-(3,4-dihydro-l-pyridinyl)methane, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ATE97893T1 (de) * 1988-02-19 1993-12-15 Smithkline Beecham Farma 1,2,3,4-tetrahydroisoquinoline, verfharen zu ihrer herstellung und ihre verwendung als kappa- rezeptor agonisten.
PT89780A (pt) * 1988-02-23 1989-10-04 Glaxo Group Ltd Processo para a preparacao de derivados da tetrahidroisoquinolina
DE3827727A1 (de) * 1988-08-16 1990-02-22 Boehringer Ingelheim Kg Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion
GB8827479D0 (en) * 1988-11-24 1988-12-29 Zambeletti Spa L Novel compounds
GB8916395D0 (en) * 1989-07-18 1989-09-06 Zambeletti Spa L Pharmaceuticals
US5389638A (en) * 1993-09-10 1995-02-14 Abbott Laboratories Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors
GB0225884D0 (en) * 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
US9604930B2 (en) * 2012-12-21 2017-03-28 Epizyme, Inc. Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof
CA2996813C (en) * 2015-09-01 2023-09-26 Merck Patent Gmbh Method for the production of praziquantel and precursors thereof
WO2017066705A1 (en) * 2015-10-14 2017-04-20 Aquinnah Pharmaceuticals, Inc. Compounds, compositions and methods of use against stress granules
RU2764243C2 (ru) 2017-09-22 2022-01-14 ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи Гетероциклические соединения в качестве ингибиторов PAD
CN111225915B (zh) 2017-10-18 2023-03-07 朱比兰特埃皮帕德有限公司 作为pad抑制剂的咪唑并吡啶化合物
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
RS65576B1 (sr) 2017-11-24 2024-06-28 Jubilant Episcribe Llc Heterociklična jedinjenja kao inhibitori prmt5
CN112105610B (zh) 2018-03-13 2024-01-26 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2612503A (en) * 1949-04-19 1952-09-30 Smith Kline French Lab Basic ether-substituted isoquinolines
US2640829A (en) * 1950-11-10 1953-06-02 Smith Kline French Lab Isoquinolyl heterocyclic ethers
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
US3483206A (en) * 1967-12-15 1969-12-09 Ciba Geigy Corp N-isoquinolylalkanoyl-n-arylamines
US3600394A (en) * 1968-05-17 1971-08-17 Searle & Co 2-aminoalkyl-3-arylisocarbostyrils

Also Published As

Publication number Publication date
GB1447611A (en) 1976-08-25
AT351026B (de) 1979-07-10
AU7625774A (en) 1976-06-10
PL93405B1 (cs) 1977-05-30
CH605776A5 (cs) 1978-10-13
ATA981974A (de) 1978-12-15
HU171483B (hu) 1978-01-28
FR2253522A1 (cs) 1975-07-04
DE2361390A1 (de) 1975-06-19
JPS5088077A (cs) 1975-07-15
SE7415247L (cs) 1975-06-11
DK639674A (cs) 1975-08-11
CA1053675A (en) 1979-05-01
DK137007B (da) 1978-01-02
DK137007C (da) 1978-06-05
DD115666A5 (cs) 1975-10-12
BE823027A (fr) 1975-06-06
US3985881A (en) 1976-10-12
ES432716A1 (es) 1977-03-01
NL7416050A (nl) 1975-06-12
ZA747820B (en) 1975-12-31
FR2253522B1 (cs) 1978-06-30
CS188933B2 (en) 1979-03-30

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