IL63110A - Indole and indoline derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

Indole and indoline derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL63110A
Authority: IL; Israel
Prior art keywords: carbon atoms; alkyl; indole; hydrogen; indoline derivatives
Prior art date: 1980-06-18

Application number

IL63110A

Other languages

English (en)

Original Assignee

May & Baker Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-06-18

Filing date

1981-06-17

Publication date

1986-10-31

1981-06-17 Application filed by May & Baker Ltd filed Critical May & Baker Ltd

1986-10-31 Publication of IL63110A publication Critical patent/IL63110A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Obesity (AREA)
Hematology (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IL63110A 1980-06-18 1981-06-17 Indole and indoline derivatives,their preparation and pharmaceutical compositions containing them IL63110A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8019948		1980-06-18

Publications (1)

Publication Number	Publication Date
IL63110A true IL63110A (en)	1986-10-31

Family

ID=10514138

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL63110A IL63110A (en)	1980-06-18	1981-06-17	Indole and indoline derivatives,their preparation and pharmaceutical compositions containing them

Country Status (22)

Country	Link
US (1)	US4493843A (de)
EP (1)	EP0042298B1 (de)
JP (1)	JPS5728048A (de)
KR (1)	KR850001470B1 (de)
AT (1)	ATE9329T1 (de)
AU (1)	AU539678B2 (de)
CA (1)	CA1149811A (de)
DE (1)	DE3165998D1 (de)
DK (1)	DK264281A (de)
ES (4)	ES503097A0 (de)
FI (1)	FI811889A7 (de)
GB (1)	GB2078736B (de)
GR (1)	GR75701B (de)
HK (2)	HK92684A (de)
HU (1)	HU183480B (de)
IE (1)	IE52102B1 (de)
IL (1)	IL63110A (de)
MY (2)	MY8500975A (de)
NZ (1)	NZ197441A (de)
PH (1)	PH16357A (de)
SG (2)	SG68984G (de)
ZA (1)	ZA814057B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000015612A1 (en) *	1998-08-26	2000-03-23	Aventis Pharma Limited	Aza-bicycles which modulate the inhibition of cell adhesion
GB9818641D0 (en) *	1998-08-26	1998-10-21	Rh Ne Poulenc Rorer Limited	Chemical compounds
AU2050001A (en) *	1999-12-16	2001-06-25	Eli Lilly And Company	Synthesis of indole-containing spla2 inhibitors
AU2003247390A1 (en)	2002-05-22	2003-12-12	Errant Gene Therapeutics, Llc.	Histone deacetylase inhibitors based on alphachalcogenmethylcarbonyl compounds
DE602005012380D1 (de) *	2004-03-15	2009-03-05	Lilly Co Eli	4-(5-(aminomethyl)-indol-1-ylmethyl)benzamidderivate und verwandte verbindungen als opioidrezeptorantagonisten zur behandlung von fettleibigkeit
JP6217561B2 (ja) *	2014-08-21	2017-10-25	信越化学工業株式会社	新規オニウム塩化合物及びレジスト組成物並びにパターン形成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3076814A (en) *	1954-04-28	1963-02-05	Upjohn Co	Novel process for the preparation of tryptophols and to novel compounds produced therein
DE2237361A1 (de) *	1972-07-29	1974-02-14	Boehringer Mannheim Gmbh	(5-indolyloxy)-essigsaeure-derivate und verfahren zur herstellung derselben
US3992392A (en) *	1973-04-27	1976-11-16	The Ohio State University Research Foundation	Synthesis of indoles from anilines and intermediates therein
US3901899A (en) *	1973-04-27	1975-08-26	Univ Ohio State Res Found	Synthesis of indoles from anilines and intermediates therein
US3950343A (en) *	1973-11-06	1976-04-13	Ayerst, Mckenna And Harrison Ltd.	Pyrroloisoquinoline derivatives
US4070470A (en) *	1974-06-24	1978-01-24	Otsuka Pharmaceutical Co., Ltd.	Platelet aggregation inhibiting carbostyrils, their compositions and method of use
DE2909779A1 (de) *	1979-03-13	1980-09-18	Thomae Gmbh Dr K	Neue indolderivate, deren herstellung und deren verwendung als arzneimittel

1981
- 1981-06-16 EP EP81302699A patent/EP0042298B1/de not_active Expired
- 1981-06-16 KR KR1019810002197A patent/KR850001470B1/ko not_active Expired
- 1981-06-16 GB GB8118439A patent/GB2078736B/en not_active Expired
- 1981-06-16 ES ES503097A patent/ES503097A0/es active Granted
- 1981-06-16 FI FI811889A patent/FI811889A7/fi not_active Application Discontinuation
- 1981-06-16 DE DE8181302699T patent/DE3165998D1/de not_active Expired
- 1981-06-16 AU AU71864/81A patent/AU539678B2/en not_active Ceased
- 1981-06-16 DK DK264281A patent/DK264281A/da not_active Application Discontinuation
- 1981-06-16 HU HU811777A patent/HU183480B/hu unknown
- 1981-06-16 AT AT81302699T patent/ATE9329T1/de not_active IP Right Cessation
- 1981-06-16 NZ NZ197441A patent/NZ197441A/en unknown
- 1981-06-16 ZA ZA814057A patent/ZA814057B/xx unknown
- 1981-06-17 GR GR65248A patent/GR75701B/el unknown
- 1981-06-17 IL IL63110A patent/IL63110A/xx unknown
- 1981-06-17 PH PH25767A patent/PH16357A/en unknown
- 1981-06-17 IE IE1344/81A patent/IE52102B1/en unknown
- 1981-06-17 CA CA000380032A patent/CA1149811A/en not_active Expired
- 1981-06-18 JP JP9453481A patent/JPS5728048A/ja active Pending
1982
- 1982-05-21 US US06/380,838 patent/US4493843A/en not_active Expired - Fee Related
- 1982-05-31 ES ES512705A patent/ES512705A0/es active Granted
- 1982-05-31 ES ES512704A patent/ES8303332A1/es not_active Expired
- 1982-05-31 ES ES512706A patent/ES512706A0/es active Granted
1984
- 1984-09-25 SG SG689/84A patent/SG68984G/en unknown
- 1984-11-22 HK HK926/84A patent/HK92684A/xx unknown
1985
- 1985-10-05 SG SG730/85A patent/SG73085G/en unknown
- 1985-11-21 HK HK924/85A patent/HK92485A/xx unknown
- 1985-12-30 MY MY975/85A patent/MY8500975A/xx unknown
1986
- 1986-12-30 MY MY409/86A patent/MY8600409A/xx unknown

Also Published As

Publication number	Publication date
IE52102B1 (en)	1987-06-24
ES512704A0 (es)	1983-02-01
KR850001470B1 (ko)	1985-10-10
GB2078736A (en)	1982-01-13
ZA814057B (en)	1982-07-28
EP0042298B1 (de)	1984-09-12
SG73085G (en)	1986-05-02
MY8500975A (en)	1985-12-31
EP0042298A1 (de)	1981-12-23
ES8300091A1 (es)	1982-10-01
ATE9329T1 (de)	1984-09-15
PH16357A (en)	1983-09-05
ES8303332A1 (es)	1983-02-01
HU183480B (en)	1984-05-28
IE811344L (en)	1981-12-18
DE3165998D1 (de)	1984-10-18
MY8600409A (en)	1986-12-31
ES8305327A1 (es)	1983-04-01
ES512706A0 (es)	1983-04-01
CA1149811A (en)	1983-07-12
JPS5728048A (en)	1982-02-15
GB2078736B (en)	1984-03-07
ES8303333A1 (es)	1983-02-01
KR830006205A (ko)	1983-09-20
ES503097A0 (es)	1982-10-01
FI811889L (fi)	1981-12-19
FI811889A7 (fi)	1981-12-19
GR75701B (de)	1984-08-02
AU7186481A (en)	1981-12-24
AU539678B2 (en)	1984-10-11
US4493843A (en)	1985-01-15
HK92684A (en)	1984-11-30
HK92485A (en)	1985-11-29
NZ197441A (en)	1984-11-09
ES512705A0 (es)	1983-02-01
SG68984G (en)	1985-03-15
DK264281A (da)	1981-12-19

Publication	Publication Date	Title
EP0110814A3 (en)	1985-07-24	Beta-carbolines, process for their preparation and pharmaceutical compositions containing them
ES8403910A1 (es)	1984-04-01	Procedimiento para la preparacion de nitratos de amino-deso-xi-1.4;3.6-dianhidro-hexito,asi como de sus sales de adicionacida farmacologicamente inocuas
IL63110A (en)	1986-10-31	Indole and indoline derivatives,their preparation and pharmaceutical compositions containing them
ES8407033A1 (es)	1984-08-16	Un procedimiento para la preparacion de derivados de benzotiazolina.
ES8302733A1 (es)	1982-12-01	Un procedimiento para preparar nuevos derivados de antraci- clina
ZA794155B (en)	1980-08-27	New aminoglycosides derived from desoxystreptamine,and their salts,their preparation process,their application as medicaments and the pharmaceutical compounds containing them
ES8105268A1 (es)	1981-06-01	Procedimiento para preparar derivados de acido acilaminoben-zoico
ES8506011A1 (es)	1985-06-16	Procedimiento para la obtencion de un derivado de tetrahidrobenzotiazol
ES444091A1 (es)	1977-04-16	Un metodo de preparar nuevos derivados de 10-piperazinodi- benzo (b, f) itepina polisustituidos.
DE3160968D1 (en)	1983-10-27	Cardenolide-bis-digitoxoside derivatives, process for their preparation and their utilization as medicines
DE3060792D1 (en)	1982-10-28	Dithiepinno (1,4)(2,3-c) pyrrol derivatives, their preparation and pharmaceutical compositions containing them
HUT50833A (en)	1990-03-28	Process for producing indolo/3,2-1-de/ /1,4/-oxazino/2,3,4-ij/ /1,5/-naphthyridine derivatives
DE3564106D1 (en)	1988-09-08	4-phenylaminopyridine derivatives, process of the preparation thereof and pharmaceutical compositions containing them
IL71430A0 (en)	1984-07-31	Iminosulfonamides and process for their production,pharmaceutical compositions containing such compounds and the use thereof
EP0093049A3 (en)	1984-02-08	Dithiino (1,4) (2,3-c) pyrrole derivatives, their preparation and pharmaceutical compositions containing them