IL68769A - Pharmaceutical compositions containing insulin for oral administration - Google Patents

Pharmaceutical compositions containing insulin for oral administration

Info

Publication number: IL68769A
Authority: IL; Israel
Prior art keywords: acid; oral administration; pharmaceutical compositions; compositions containing; insulin
Prior art date: 1983-05-23

Application number

IL68769A

Other languages

English (en)

Other versions

IL68769A0 (en

Inventor

Kidron Miriam

Ziv Ehud

Eldor Amiram

Original Assignee

Hadassah Med Org

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-23

Filing date

1983-05-23

Publication date

1986-02-28

1983-05-23 Application filed by Hadassah Med Org filed Critical Hadassah Med Org

1983-05-23 Priority to IL68769A priority Critical patent/IL68769A/xx

1983-09-30 Publication of IL68769A0 publication Critical patent/IL68769A0/xx

1984-05-09 Priority to DK229484A priority patent/DK167240B1/da

1984-05-09 Priority to US06/608,462 priority patent/US4579730A/en

1984-05-14 Priority to CA000454266A priority patent/CA1223200A/fr

1984-05-21 Priority to EP84401049A priority patent/EP0127535B1/fr

1984-05-21 Priority to AT84401049T priority patent/ATE49125T1/de

1984-05-21 Priority to DE8484401049T priority patent/DE3480903D1/de

1984-05-23 Priority to JP59104386A priority patent/JPH0678238B2/ja

1986-02-28 Publication of IL68769A publication Critical patent/IL68769A/xx

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
102000004877 Insulin Human genes 0.000 title abstract 3
108090001061 Insulin Proteins 0.000 title abstract 3
229940125396 insulin Drugs 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
239000003613 bile acid Substances 0.000 abstract 2
BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 abstract 1
RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 abstract 1
239000004380 Cholic acid Substances 0.000 abstract 1
108010007979 Glycocholic Acid Proteins 0.000 abstract 1
RFDAIACWWDREDC-UHFFFAOYSA-N Na salt-Glycocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCC(O)=O)C)C1(C)C(O)C2 RFDAIACWWDREDC-UHFFFAOYSA-N 0.000 abstract 1
229940124158 Protease/peptidase inhibitor Drugs 0.000 abstract 1
BHTRKEVKTKCXOH-UHFFFAOYSA-N Taurochenodesoxycholsaeure Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)CC2 BHTRKEVKTKCXOH-UHFFFAOYSA-N 0.000 abstract 1
WBWWGRHZICKQGZ-UHFFFAOYSA-N Taurocholic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)C(O)C2 WBWWGRHZICKQGZ-UHFFFAOYSA-N 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
-1 alkali metal salt Chemical class 0.000 abstract 1
229960001091 chenodeoxycholic acid Drugs 0.000 abstract 1
RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 abstract 1
BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 abstract 1
229960002471 cholic acid Drugs 0.000 abstract 1
235000019416 cholic acid Nutrition 0.000 abstract 1
KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 abstract 1
RFDAIACWWDREDC-FRVQLJSFSA-N glycocholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 RFDAIACWWDREDC-FRVQLJSFSA-N 0.000 abstract 1
229940099347 glycocholic acid Drugs 0.000 abstract 1
210000000936 intestine Anatomy 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000000137 peptide hydrolase inhibitor Substances 0.000 abstract 1
210000002784 stomach Anatomy 0.000 abstract 1
BHTRKEVKTKCXOH-AYSJQVDDSA-N taurochenodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)C1C2C2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)CC1 BHTRKEVKTKCXOH-AYSJQVDDSA-N 0.000 abstract 1
WBWWGRHZICKQGZ-GIHLXUJPSA-N taurocholic acid Chemical compound C([C@@H]1C[C@H]2O)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@H](O)C1 WBWWGRHZICKQGZ-GIHLXUJPSA-N 0.000 abstract 1
RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 abstract 1
229960001661 ursodiol Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Botany (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

IL68769A 1983-05-23 1983-05-23 Pharmaceutical compositions containing insulin for oral administration IL68769A (en)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
IL68769A IL68769A (en)	1983-05-23	1983-05-23	Pharmaceutical compositions containing insulin for oral administration
DK229484A DK167240B1 (da)	1983-05-23	1984-05-09	Farmaceutisk praeparat til oral administration af insulin
US06/608,462 US4579730A (en)	1983-05-23	1984-05-09	Pharmaceutical compositions containing insulin
CA000454266A CA1223200A (fr)	1983-05-23	1984-05-14	Produits pharmaceutiques a teneur d'insuline
EP84401049A EP0127535B1 (fr)	1983-05-23	1984-05-21	Compositions pharmaceutiques contenant de l'insuline
AT84401049T ATE49125T1 (de)	1983-05-23	1984-05-21	Pharmazeutische zusammensetzungen mit gehalt an insulin.
DE8484401049T DE3480903D1 (de)	1983-05-23	1984-05-21	Pharmazeutische zusammensetzungen mit gehalt an insulin.
JP59104386A JPH0678238B2 (ja)	1983-05-23	1984-05-23	インシュリンを含む薬剤組成物

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL68769A IL68769A (en)	1983-05-23	1983-05-23	Pharmaceutical compositions containing insulin for oral administration

Publications (2)

Publication Number	Publication Date
IL68769A0 IL68769A0 (en)	1983-09-30
IL68769A true IL68769A (en)	1986-02-28

Family

ID=11054289

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL68769A IL68769A (en)	1983-05-23	1983-05-23	Pharmaceutical compositions containing insulin for oral administration

Country Status (8)

Country	Link
US (1)	US4579730A (fr)
EP (1)	EP0127535B1 (fr)
JP (1)	JPH0678238B2 (fr)
AT (1)	ATE49125T1 (fr)
CA (1)	CA1223200A (fr)
DE (1)	DE3480903D1 (fr)
DK (1)	DK167240B1 (fr)
IL (1)	IL68769A (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9259456B2 (en)	2005-09-06	2016-02-16	Oramed Pharmaceuticals Inc.	Methods and compositions for oral administration of proteins
US10058593B2 (en)	2008-03-26	2018-08-28	Oramed Ltd.	Methods and compositions for oral administration of proteins
US10342764B2 (en)	2012-02-01	2019-07-09	Oramed Ltd.	Protease inhibitor-containing compositions, compositions comprising same, and methods for producing and using same
US10350162B2 (en)	2008-05-05	2019-07-16	Oramed Ltd.	Methods and compositions for oral administration of exenatide
US10398762B2 (en)	2012-01-03	2019-09-03	Oramed Ltd.	Methods and compositions for treating diabetes
US10967051B2 (en)	2013-01-03	2021-04-06	Oramed Ltd.	Methods and compositions for treating NAFLD, hepatic steatosis, and sequelae thereof

Families Citing this family (144)

* Cited by examiner, † Cited by third party
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IL99699A (en)	1990-10-10	2002-04-21	Autoimmune Inc	Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
EP0533938A4 (en) *	1991-02-19	1993-06-16	Tsumura & Co.	Composition for rectal administration of difficultly absorbable peptide
IT1245890B (it) *	1991-04-12	1994-10-25	Alfa Wassermann Spa	Formulazioni farmaceutiche per uso orale gastroresistenti contenenti acidi biliari.
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1983
- 1983-05-23 IL IL68769A patent/IL68769A/xx unknown
1984
- 1984-05-09 DK DK229484A patent/DK167240B1/da not_active IP Right Cessation
- 1984-05-09 US US06/608,462 patent/US4579730A/en not_active Expired - Fee Related
- 1984-05-14 CA CA000454266A patent/CA1223200A/fr not_active Expired
- 1984-05-21 DE DE8484401049T patent/DE3480903D1/de not_active Expired - Lifetime
- 1984-05-21 EP EP84401049A patent/EP0127535B1/fr not_active Expired - Lifetime
- 1984-05-21 AT AT84401049T patent/ATE49125T1/de not_active IP Right Cessation
- 1984-05-23 JP JP59104386A patent/JPH0678238B2/ja not_active Expired - Lifetime

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Also Published As

Publication number	Publication date
CA1223200A (fr)	1987-06-23
EP0127535A3 (en)	1987-01-14
DE3480903D1 (de)	1990-02-08
IL68769A0 (en)	1983-09-30
DK229484A (da)	1984-11-24
US4579730A (en)	1986-04-01
ATE49125T1 (de)	1990-01-15
EP0127535A2 (fr)	1984-12-05
JPS6069028A (ja)	1985-04-19
JPH0678238B2 (ja)	1994-10-05
DK167240B1 (da)	1993-09-27
DK229484D0 (da)	1984-05-09
EP0127535B1 (fr)	1990-01-03

Legal Events

Date	Code	Title	Description
1997-11-20	KB	Patent renewed

Publication	Publication Date	Title
IL68769A (en)	1986-02-28	Pharmaceutical compositions containing insulin for oral administration
IL67572A (en)	1992-08-18	Trans-2-aza bicyclo(3.(3+n).o)alkane-3-carboxylic acid derivatives,processes for their preparation and pharmaceutical compositions containing them
DK0843558T3 (da)	2003-03-03	Sammensætning til forstærket optagelse af polære lægemidler fra colon
DE3460577D1 (en)	1986-10-09	Sodium salt of ursodeoxycholic sulphate
PL334566A1 (en)	2000-03-13	Treatment of sclerosis multiplex by oral and inhalatory administration of a copolymer-1
GR3002299T3 (en)	1992-12-30	Composition of pregnanolole comprising a stable oil-in-water emulsion
PL309777A1 (en)	1995-11-13	Novel ileum and colon specific steroid derivatives
IL52127A0 (en)	1977-07-31	Novel phosphonous acid derivatives their preparation and pharmaceutical compositions containing them
ZA93727B (en)	1994-08-03	New parathormone fragments, process for the preparation thereof and pharmaceutical compositions containing them.
AU1879597A (en)	1997-09-16	Tetraether lipids and liposomes containing said lipids, and use of the same
IL87122A0 (en)	1988-12-30	Substituted thienoinidazole derivatives,process for the preparation thereof,pharmaceutical compositions containing them,and the use thereof as inhibitors of gastric acid secretion,as gastroprotectives and as medicaments for intestinal inflammations
NZ210667A (en)	1988-08-30	16-phenoxyprostatrienoic acid derivatives, their stereoisomers and pharmaceutical compositions containing such
DE3262109D1 (en)	1985-03-14	Salts of cholic acids, process for their preparation and therapeutic compositions containing them as active principles
IL63022A (en)	1984-04-30	Nonapeptide having gonadoliberine activity,its preparation and compositions containing it
IL80679A (en)	1992-03-29	16,17-acetalsubstituted pregnane 21-oic acid derivatives,process for their preparation and pharmaceutical compositions containing them
IL51548A (en)	1980-06-30	Pharmaceutical compositions containing 4-hydroxy-2-quinolinone-3-carboxylic acid esters,certain such novel comounds and their preparation
IL62509A0 (en)	1981-05-20	Monohydrated isophthalic acid picolylamide,its preparation and pharmaceutical compositions containing it
IL71905A0 (en)	1984-09-30	Bicyclo(3.2.1)octanecarboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
GB8804188D0 (en)	1988-03-23	Pharmaceutical compositions
NZ189151A (en)	1981-05-15	Peptide derivatives of phosphonic acid and pharmaceutical compositions
GB1459485A (en)	1976-12-22	Medicament pack for the oral treatment with oestrogen
AU7927987A (en)	1988-04-14	Pharmaceutical peptide compositions, also containing poly-d-3-hydroxybutyric acid and calcium acetate/glycerol adduct
AU2503488A (en)	1989-05-18	Substituted thienoimidazole derivatives, processes for their preparation, pharmaceutical preparations containing them and their use as inhibitors of gastric acid secretion
IT1254688B (it)	1995-09-28	Composizioni farmaceutiche somministrabili per via orale a rilascio mirato contenenti acido ursodesossicolico ed acido chenodesossicolico.
ATE34382T1 (de)	1988-06-15	Substituierte dipeptide, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische zusammensetzungen und verfahren zur herstellung dieser pharmazeutischen zusammensetzungen.