IL73334A - Blood substitutes,their preparation and pharmaceutical compositions containing them - Google Patents

Blood substitutes,their preparation and pharmaceutical compositions containing them

Info

Publication number: IL73334A
Authority: IL; Israel
Prior art keywords: haemoglobin; preparation; pharmaceutical compositions; compositions containing; molecular weight
Prior art date: 1983-10-28

Application number

IL73334A

Other languages

English (en)

Other versions

IL73334A0 (en

Original Assignee

Fisons Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-10-28

Filing date

1984-10-26

Publication date

1989-03-31

1984-10-26 Application filed by Fisons Plc filed Critical Fisons Plc

1985-01-31 Publication of IL73334A0 publication Critical patent/IL73334A0/xx

1989-03-31 Publication of IL73334A publication Critical patent/IL73334A/xx

Links

239000003633 blood substitute Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
239000003446 ligand Substances 0.000 abstract 2
INAPMGSXUVUWAF-GCVPSNMTSA-N [(2r,3s,5r,6r)-2,3,4,5,6-pentahydroxycyclohexyl] dihydrogen phosphate Chemical compound OC1[C@H](O)[C@@H](O)C(OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-GCVPSNMTSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
150000004676 glycans Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1
229920001282 polysaccharide Polymers 0.000 abstract 1
239000005017 polysaccharide Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Dental Preparations (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

IL73334A 1983-10-28 1984-10-26 Blood substitutes,their preparation and pharmaceutical compositions containing them IL73334A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB838328917A GB8328917D0 (en)	1983-10-28	1983-10-28	Blood substitute

Publications (2)

Publication Number	Publication Date
IL73334A0 IL73334A0 (en)	1985-01-31
IL73334A true IL73334A (en)	1989-03-31

Family

ID=10550912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL73334A IL73334A (en)	1983-10-28	1984-10-26	Blood substitutes,their preparation and pharmaceutical compositions containing them

Country Status (12)

Country	Link
US (2)	US4650786A (de)
EP (1)	EP0140640B1 (de)
JP (2)	JPH0643444B2 (de)
AT (1)	ATE51629T1 (de)
AU (1)	AU567593B2 (de)
CA (1)	CA1236014A (de)
DE (1)	DE3481844D1 (de)
DK (1)	DK162395C (de)
FI (1)	FI74979C (de)
GB (1)	GB8328917D0 (de)
IL (1)	IL73334A (de)
NO (1)	NO165709C (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4831012A (en) *	1984-03-23	1989-05-16	Baxter International Inc.	Purified hemoglobin solutions and method for making same
US5464814A (en) *	1986-06-20	1995-11-07	Northfield Laboratories, Inc.	Acellular red blood cell substitute
FR2600894B1 (fr) *	1986-07-02	1989-01-13	Centre Nat Rech Scient	Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
DE3636590A1 (de) *	1986-10-28	1988-05-26	Braun Melsungen Ag	Blutersatzmittel
US5449759A (en) *	1987-05-16	1995-09-12	Somatogen, Inc.	Hemoglobins with intersubunit desulfide bonds
GB8712240D0 (en) *	1987-05-23	1987-07-01	Fisons Plc	Pharmaceutical formulation
DK110188D0 (da) *	1988-03-02	1988-03-02	Claus Selch Larsen	High molecular weight prodrug derivatives of antiinflammatory drugs
FR2630329B1 (fr) *	1988-04-20	1991-07-05	Merieux Inst	Conjugues macromoleculaires d'hemoglobine, leur procede de preparation et leurs applications
US4900780A (en) *	1988-05-25	1990-02-13	Masonic Medical Research Laboratory	Acellular resuscitative fluid
EP0519953B1 (de) *	1990-03-14	1996-02-07	The University Of Toronto Innovations Foundation	Acylphosphatester und modifikation von proteinen damit
US6172039B1 (en)	1990-04-16	2001-01-09	Apex Bioscience, Inc.	Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5334705A (en) *	1991-08-15	1994-08-02	Duke University	Benzenetricarboxylate derivative-crosslinked low oxygen affinity hemoglobin
US5679777A (en) *	1991-11-08	1997-10-21	Somatogen, Inc.	Hemoglobins as drug delivery agents
US5334706A (en) *	1992-01-30	1994-08-02	Baxter International	Administration of low dose hemoglobin to increase perfusion
US5900477A (en) *	1992-01-30	1999-05-04	Baxter International, Inc.	Use of hemoglobin in the treatment of hemorrhagic shock
US5612310A (en) *	1993-05-24	1997-03-18	Duke University	Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5554638A (en) *	1993-05-24	1996-09-10	Duke University	Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5578564A (en) *	1993-07-23	1996-11-26	Somatogen, Inc.	Nickel-free hemoglobin and methods for producing such hemoglobin
US5840851A (en) *	1993-07-23	1998-11-24	Plomer; J. Jeffrey	Purification of hemoglobin
US6242417B1 (en)	1994-03-08	2001-06-05	Somatogen, Inc.	Stabilized compositions containing hemoglobin
US5631219A (en) *	1994-03-08	1997-05-20	Somatogen, Inc.	Method of stimulating hematopoiesis with hemoglobin
US6458762B1 (en)	1994-03-28	2002-10-01	Baxter International, Inc.	Therapeutic use of hemoglobin for preserving tissue viability and reducing restenosis
WO1996032130A1 (en) *	1995-04-10	1996-10-17	Baxter International Inc.	The use of cross-linked hemoglobin in treating subarachnoid hemorrhage
US5733869A (en) *	1995-10-06	1998-03-31	Baxter International, Inc.	Therapeutic administration of hemoglobin in cardiac arrest
WO1998017289A1 (en) *	1996-10-21	1998-04-30	Baxter International Inc.	Therapeutic use of hemoglobin to treat head injury
US6054427A (en) *	1997-02-28	2000-04-25	The Regents Of The University Of California	Methods and compositions for optimization of oxygen transport by cell-free systems
US5814601A (en) *	1997-02-28	1998-09-29	The Regents Of The University Of California	Methods and compositions for optimization of oxygen transport by cell-free systems
US6894150B1 (en)	1999-10-01	2005-05-17	Ross Walden Tye	Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
CA2319966A1 (en) *	2000-09-19	2002-03-19	Dextro-Sang Corporation	Improved dextran-hemoglobin conjugate as potential blood substitute
FR2828206B1 (fr) *	2001-08-03	2004-09-24	Centre Nat Rech Scient	Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire
US20050164915A1 (en) *	2002-04-01	2005-07-28	Sangart, Inc.	Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20030153491A1 (en) *	2002-01-11	2003-08-14	Winslow Robert M.	Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
WO2003092700A1 (en) *	2002-04-29	2003-11-13	Gmp Oxycell, Inc.	Inositol pyrophosphates, and methods of use thereof
JP3912206B2 (ja) *	2002-07-05	2007-05-09	株式会社日立製作所	筒内直接燃料噴射装置用燃料ポンプ
WO2004066953A2 (en) *	2003-01-29	2004-08-12	Northfield Laboratories, Inc.	Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing
US20070135389A1 (en) *	2004-07-06	2007-06-14	Claude Nicolau	Tumor eradication by inositol-tripyrophosphate
US20060106000A1 (en) *	2004-07-06	2006-05-18	Claude Nicolau	Use of inositol-tripyrophosphate in treating tumors and diseases
US7745423B2 (en) *	2004-07-06	2010-06-29	NormOxys, Inc	Calcium/sodium salt of inositol tripyrophosphate as an allosteric effector of hemoglobin
US20060258626A1 (en) *	2004-07-06	2006-11-16	Claude Nicolau	Use of inositol-tripyrophosphate in treating tumors and diseases
EP1978802A2 (de) *	2006-01-24	2008-10-15	Northfield Laboratories, Inc.	Polymerisiertes hämoglobinmedium und verwendung davon bei der isolierung und transplantation von inselzellen
US20090004159A1 (en) *	2006-01-24	2009-01-01	The Board Of Trustees Of The University Of Illinoi	Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US7494974B2 (en) *	2006-10-24	2009-02-24	Ikor, Inc.	Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) *	2006-10-23	2009-03-17	Ikor, Inc.	Nitric oxide-blocked cross-linked tetrameric hemoglobin
CA2688233A1 (en) *	2007-05-01	2008-11-06	Normoxys, Inc.	Erythropoietin complementation or replacement
WO2014124278A1 (en) *	2013-02-07	2014-08-14	OPK Biotech, LLC	Perfusion of prospective donor hearts with polymerized hemoglobin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2449885C3 (de) *	1974-10-21	1980-04-30	Biotest-Serum-Institut Gmbh, 6000 Frankfurt	Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat
US4053590A (en) *	1975-02-27	1977-10-11	Alza Corporation	Compositions of matter comprising macromolecular hemoglobin
CA1055932A (en) *	1975-10-22	1979-06-05	Hematech Inc.	Blood substitute based on hemoglobin
DE2616086C2 (de) *	1976-04-13	1986-04-03	Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg	Substanz zur Verwendung in einem kolloidalen Blutvolumenersatzmittel aus Hydroxyethylstärke und Hämoglobin
US4136093A (en) *	1976-04-23	1979-01-23	Biotest-Serum-Institut Gmbh	Hemoglobin preparation with increased oxygen release
DE2740053A1 (de) *	1977-09-06	1979-05-03	Klaus Prof Dr Med Gersonde	Verwendung von allosterischen effektoren mit hilfe von lipidvesikeln ueber eine irreversible inkorporierung zwecks verbesserter o tief 2 -entladung des haemoglobins in erythrozyten
JPS5716815A (en) *	1980-07-02	1982-01-28	Ajinomoto Co Inc	Oxygen transporting agent for artificial blood
US4343715A (en) *	1980-10-10	1982-08-10	Duke University	Immobilized hemoglobin, and processes for extracting oxygen from fluids using the same
US4401652A (en) *	1980-12-31	1983-08-30	Allied Corporation	Process for the preparation of stroma-free hemoglobin solutions
JPS57206622A (en) *	1981-06-10	1982-12-18	Ajinomoto Co Inc	Blood substitute
IN158551B (de) *	1981-08-12	1986-12-06	Gen Electric Co Plc
US4473496A (en) *	1981-09-14	1984-09-25	The United States Of America As Represented By The Secretary Of The Army	Intramolecularly crosslinked hemoglobin
DE3144705C2 (de) *	1981-11-11	1983-12-08	Biotest-Serum-Institut Gmbh, 6000 Frankfurt	Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4529719A (en) *	1983-05-04	1985-07-16	Tye Ross W	Modified crosslinked stroma-free tetrameric hemoglobin
FR2551660B1 (fr) *	1983-09-13	1986-11-14	Centre Nat Rech Scient	Hemoglobine modifiee chimiquement, sa preparation, solutions aqueuses en contenant et leur utilisation
US4600531A (en) *	1984-06-27	1986-07-15	University Of Iowa Research Foundation	Production of alpha-alpha cross-linked hemoglobins in high yield

1983
- 1983-10-28 GB GB838328917A patent/GB8328917D0/en active Pending
1984
- 1984-10-16 DE DE8484307070T patent/DE3481844D1/de not_active Expired - Fee Related
- 1984-10-16 EP EP84307070A patent/EP0140640B1/de not_active Expired - Lifetime
- 1984-10-16 AT AT84307070T patent/ATE51629T1/de not_active IP Right Cessation
- 1984-10-19 US US06/662,588 patent/US4650786A/en not_active Expired - Lifetime
- 1984-10-25 DK DK509884A patent/DK162395C/da not_active IP Right Cessation
- 1984-10-26 JP JP59224269A patent/JPH0643444B2/ja not_active Expired - Lifetime
- 1984-10-26 CA CA000466410A patent/CA1236014A/en not_active Expired
- 1984-10-26 FI FI844204A patent/FI74979C/fi not_active IP Right Cessation
- 1984-10-26 NO NO844282A patent/NO165709C/no not_active IP Right Cessation
- 1984-10-26 AU AU34753/84A patent/AU567593B2/en not_active Ceased
- 1984-10-26 IL IL73334A patent/IL73334A/xx not_active IP Right Cessation
1986
- 1986-09-12 US US06/906,371 patent/US4710488A/en not_active Expired - Lifetime
1993
- 1993-10-13 JP JP5254619A patent/JPH0714961B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0140640A2 (de)	1985-05-08
IL73334A0 (en)	1985-01-31
JPH06298802A (ja)	1994-10-25
FI844204A0 (fi)	1984-10-26
AU567593B2 (en)	1987-11-26
DK162395C (da)	1992-03-09
AU3475384A (en)	1985-05-09
JPH0643444B2 (ja)	1994-06-08
DK509884D0 (da)	1984-10-25
FI844204L (fi)	1985-04-29
EP0140640B1 (de)	1990-04-04
GB8328917D0 (en)	1983-11-30
NO165709B (no)	1990-12-17
FI74979B (fi)	1987-12-31
JPH0714961B2 (ja)	1995-02-22
US4710488A (en)	1987-12-01
CA1236014A (en)	1988-05-03
US4650786A (en)	1987-03-17
NO165709C (no)	1991-04-03
DE3481844D1 (de)	1990-05-10
DK162395B (da)	1991-10-21
EP0140640A3 (en)	1986-05-28
JPS60123503A (ja)	1985-07-02
DK509884A (da)	1985-04-29
FI74979C (fi)	1988-04-11
ATE51629T1 (de)	1990-04-15
NO844282L (no)	1985-04-29

Legal Events

Date	Code	Title
1999-04-11	KB	Patent renewed
2003-01-12	KB	Patent renewed
2005-07-25	EXP	Patent expired

Publication	Publication Date	Title
AU567593B2 (en)	1987-11-26	Polysaccharide - haemoglobin compound
IL77396A (en)	1990-02-09	Pharmaceutical compositions containing bicyclic heteroarylpiperazine derivatives,certain such novel compounds and their preparation
ES8307806A1 (es)	1983-08-01	"procedimiento para la preparacion de 1,2-a piridinas y pirazinas".
EP0310321A3 (de)	1991-02-06	Azaspirane mit immunmodulierender Wirkung
EP0339237A3 (de)	1991-01-09	Phenol-substituierte Gem-Diphosphonat-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
IL66271A (en)	1987-02-27	Substituted imidazole derivatives and their preparation and pharmaceutical compositions containing them
AU584603B2 (en)	1989-06-01	Peritoneal dialysis and compositions for use therein
HU9503273D0 (en)	1996-01-29	Water-soluble camptothecin derivatives, process for their preparation and their use as antitumor agents
WO1979000853A1 (fr)	1979-11-01	Produit medicinal pour organe circulatoire
AU8452991A (en)	1992-03-26	1-aryl-3-pyridinyl-2-propene-1-ones
GEP19971265B (en)	1997-12-01	Substituted sulphonamides,, the substituted cyclic amines in the form of intermediate compounds for reception of the substituted sulphonamides and the pharmaceutical composition on the basis of the substituted sulphonamides displaying activity towards thromboxane receptors
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EP0173664A3 (de)	1986-04-16	Biologisch aktive Benzimidazolderivate und Verfahren zu ihrer Herstellung
IE42840L (en)	1976-12-10	Flameproofing composition
DE3466991D1 (en)	1987-12-03	Penems, pharmaceutical compositions containing them, and process for their preparation
HU913011D0 (en)	1992-01-28	Method for producing inhibitors of calcium ingestion
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ES2000614A6 (es)	1988-03-01	Procedimiento de obtencion de nuevos complejos de platino (ii) derivados del 2,3-dimercapto-2-butene-dinitrilato (2-)-s,s'"
ATE34740T1 (de)	1988-06-15	(bis(hydroxymethyl)methyl)-isochinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
DE3275465D1 (en)	1987-04-02	Thiolactime ethers of delta-1-pyrrolidine, and their preparation