IL76133A - Mercaptomethyl-octahydro-oxo-pyridazino(1,2-a)(1,2)diazepine-,diazocine-and(1,2,5)triazepinecarboxylic acid derivatives,their preparation and pharmaceutical compositions containing them and certain intermediates therefor - Google Patents

Mercaptomethyl-octahydro-oxo-pyridazino(1,2-a)(1,2)diazepine-,diazocine-and(1,2,5)triazepinecarboxylic acid derivatives,their preparation and pharmaceutical compositions containing them and certain intermediates therefor

Info

Publication number
IL76133A
IL76133A IL76133A IL7613385A IL76133A IL 76133 A IL76133 A IL 76133A IL 76133 A IL76133 A IL 76133A IL 7613385 A IL7613385 A IL 7613385A IL 76133 A IL76133 A IL 76133A
Authority
IL
Israel
Prior art keywords
triazepinecarboxylic
diazocine
pyridazino
mercaptomethyl
diazepine
Prior art date
Application number
IL76133A
Other languages
English (en)
Other versions
IL76133A0 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848421493A external-priority patent/GB8421493D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IL76133A0 publication Critical patent/IL76133A0/xx
Publication of IL76133A publication Critical patent/IL76133A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
IL76133A 1984-08-24 1985-08-19 Mercaptomethyl-octahydro-oxo-pyridazino(1,2-a)(1,2)diazepine-,diazocine-and(1,2,5)triazepinecarboxylic acid derivatives,their preparation and pharmaceutical compositions containing them and certain intermediates therefor IL76133A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848421493A GB8421493D0 (en) 1984-08-24 1984-08-24 Bicyclic compounds
GB858513541A GB8513541D0 (en) 1984-08-24 1985-05-29 Bicyclic compounds

Publications (2)

Publication Number Publication Date
IL76133A0 IL76133A0 (en) 1985-12-31
IL76133A true IL76133A (en) 1989-12-15

Family

ID=26288155

Family Applications (1)

Application Number Title Priority Date Filing Date
IL76133A IL76133A (en) 1984-08-24 1985-08-19 Mercaptomethyl-octahydro-oxo-pyridazino(1,2-a)(1,2)diazepine-,diazocine-and(1,2,5)triazepinecarboxylic acid derivatives,their preparation and pharmaceutical compositions containing them and certain intermediates therefor

Country Status (14)

Country Link
US (4) US4692438A (cs)
EP (1) EP0172552A3 (cs)
AU (1) AU583843B2 (cs)
CS (1) CS255893B2 (cs)
DK (1) DK384385A (cs)
ES (3) ES8700258A1 (cs)
FI (1) FI853174A7 (cs)
HU (1) HU193446B (cs)
IL (1) IL76133A (cs)
MC (1) MC1694A1 (cs)
NO (1) NO161914C (cs)
NZ (1) NZ213130A (cs)
PH (1) PH21749A (cs)
PT (1) PT81015B (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
ATE155143T1 (de) * 1991-09-27 1997-07-15 Merrell Pharma Inc 2-substituierte indan-2-mercaptoacetylamid- verbindungen mit enkephalinase und ace- hemmwirkung
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
ATE182892T1 (de) * 1992-05-15 1999-08-15 Merrell Pharma Inc Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
PT669936E (pt) * 1992-10-30 2001-04-30 Merrell Pharma Inc Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace
WO1994022440A1 (en) * 1993-03-29 1994-10-13 Smithkline Beecham Corporation Bicyclic compounds which inhibit platelet aggregation
CA2183313C (en) * 1994-02-14 2001-01-02 Gary A. Flynn Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
PT750631E (pt) * 1994-02-14 2000-07-31 Merrell Pharma Inc Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
JP3561753B2 (ja) * 1994-02-14 2004-09-02 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規な２−置換インダン−２−メルカプトアセチルアミドジスルフィド誘導体類
JP3596778B2 (ja) * 1994-02-14 2004-12-02 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規なメルカプトアセチルアミドジスルフィド誘導体類
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
PT751783E (pt) * 1994-03-24 2000-05-31 Merrell Pharma Inc Derivados aminoacetilmercapto hipocolesterolemicos antiateroscleroticos e hipotrigliceridemicos
ATE246927T1 (de) * 1994-03-24 2003-08-15 Merrell Pharma Inc Cholesterin senkende mercaptoacetylamiddisulfidderivate
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
US6559304B1 (en) 1998-08-19 2003-05-06 Vertex Pharmaceuticals Incorporated Method for synthesizing caspase inhibitors
US6703500B2 (en) 1998-08-19 2004-03-09 Vertex Pharmaceuticals, Incorporated Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
RU2002135314A (ru) 2000-05-04 2004-05-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Асимметричный синтез пиперазиновой кислоты и ее производных
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
WO2010010427A1 (en) * 2008-07-25 2010-01-28 Chuluun Enkhbold A method of solid fuel beneficiation and transportation to thermoelectric power stations
ES2546866T3 (es) 2009-12-16 2015-09-29 Hetero Research Foundation Polimorfos de darunavir
EP2571355B1 (en) 2010-05-20 2016-09-07 Hetero Research Foundation Crystalline hydrochloride salt of darunavir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308094A (en) * 1977-02-02 1981-12-29 Sanyo Electric Co., Ltd. Diaphragm for speaker and method of producing same
IL60617A0 (en) * 1979-07-23 1980-09-16 Sparamedica Ag Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
EP0025941B1 (de) * 1979-09-19 1983-05-04 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyridazopyridazinderivate, Verfahren zu deren Herstellung und Arzneimittel enthaltend solche Pyridazopyridazinderivate
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity

Also Published As

Publication number Publication date
ES8705444A1 (es) 1987-05-01
NZ213130A (en) 1988-05-30
US4826980A (en) 1989-05-02
IL76133A0 (en) 1985-12-31
US4692438A (en) 1987-09-08
ES8700258A1 (es) 1986-10-01
MC1694A1 (fr) 1986-07-18
NO853336L (no) 1986-02-25
AU583843B2 (en) 1989-05-11
FI853174L (fi) 1986-02-25
HUT38644A (en) 1986-06-30
FI853174A7 (fi) 1986-02-25
PH21749A (en) 1988-02-18
EP0172552A3 (de) 1989-01-11
PT81015B (en) 1987-08-24
PT81015A (en) 1985-09-01
US4785093A (en) 1988-11-15
NO161914B (no) 1989-07-03
HU193446B (en) 1987-10-28
ES552397A0 (es) 1987-05-01
DK384385A (da) 1986-02-25
FI853174A0 (fi) 1985-08-19
CS255893B2 (en) 1988-03-15
ES552398A0 (es) 1987-05-01
DK384385D0 (da) 1985-08-23
AU4641585A (en) 1986-02-27
US4762924A (en) 1988-08-09
EP0172552A2 (de) 1986-02-26
ES8705443A1 (es) 1987-05-01
ES546360A0 (es) 1986-10-01
CS592885A2 (en) 1987-07-16
NO161914C (no) 1989-10-11

Similar Documents

Publication Publication Date Title
IL76453A0 (en) Isoxazolecarboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
IL74882A0 (en) Naphthyridine-,quinoline-and benzoxazine-carboxylic acids and derivatives thereof,their manufacture and pharmaceutical compositions containing them
IL76020A0 (en) 3-acylaminomethylimidazo(1,2-a)pyridine derivatives,their preparation and pharmaceutical compositions containing them
IL76405A0 (en) 1,3-diacyl-2-oxyindole derivatives,their preparation and pharmaceutical compositions containing them
IL78942A0 (en) Thiazolidinecarboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
ZA862141B (en) Substituted 1,8-naphthyridinones,processes for their preparation and pharmaceutical compositions containing them
IL77849A0 (en) Aryldihydropyridinedicarboxylic acid ester derivatives,their preparation and pharmaceutical compositions containing them
IL83049A (en) 4-quinolinone-3-carboxylic acid derivatives,their manufacture and pharmaceutical compositions containing them
IL80658A0 (en) 6,7,8,9-tetrahydro-10-methyl-pyrido(1,2-a)indol-9-amines and derivatives thereof,their preparation and pharmaceutical compositions containing them
IL84808A (en) Furanuronic acid derivatives,their preparation and pharmaceutical compositions containing them
EP0159652A3 (en) 4-phenylphthalazine derivatives, their preparation and pharmaceutical compositions containing them
IL75603A0 (en) 1,3-dioxanylheptenoic acid derivatives,their preparation and pharmaceutical compositions containing them
IL76312A (en) Xenocoumacins and derivatives thereof,their preparation and pharmaceutical compositions containing them
IL75913A (en) Phenyl-nonatetraenoic acid derivatives,their preparation and pharmaceutical compositions containing them
IL76019A0 (en) Imidazo(1,2-a)quinoline derivatives,their preparation and pharmaceutical compositions containing them
EP0191735A3 (en) Novel oxaluric acid derivatives and pharmaceutical compositions containing them
ZA864504B (en) Derivatives of 2-fluoroalkylbenzimidazole,process for their preparation and pharmaceutical compositions containing them
IL75775A0 (en) Aminoeburnanecarboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
IL76282A0 (en) Amino acid derivatives,their preparation and pharmaceutical compositions containing them
IL77799A0 (en) Dihydropyridinedicarboxylic acid ester derivatives,their preparation and pharmaceutical compositions containing them
IL75776A (en) Nitroapovincaminic acid derivatives,their preparation and pharmaceutical compositions containing them
IL78186A (en) Pharmaceutical compositions containing 3-alkyl-5,6-dihydroimidazo-isoquinoline and imidazothienopyridine-carboxylic acid derivatives,some such new compounds and their preparation
DE3570667D1 (en) 3-aminopropyloxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
IL77800A0 (en) Dihydropyridinedicarboxylic acid ester derivatives,their preparation and pharmaceutical compositions containing them
IL74776A (en) 14-hydroxyimino eburnane derivatives,their preparation and pharmaceutical compositions containing them