NO161914C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazo(1,2-a)(1,2)kondenserte ringsystemer. - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazo(1,2-a)(1,2)kondenserte ringsystemer.

Info

Publication number: NO161914C
Authority: NO; Norway
Prior art keywords: pyridazo; preparation; ring systems; therapeutically active; condensed ring
Prior art date: 1984-08-24

Application number

NO853336A

Other languages

English (en)

Norwegian (no)

Other versions

NO853336L (no

NO161914B (no

Inventor

Cedric Herbert Hassall

Geoffrey Lawton

Sally Redshaw

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-08-24

Filing date

1985-08-23

Publication date

1989-10-11

1984-08-24 Priority claimed from GB848421493A external-priority patent/GB8421493D0/en

1985-08-23 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1986-02-25 Publication of NO853336L publication Critical patent/NO853336L/no

1989-07-03 Publication of NO161914B publication Critical patent/NO161914B/no

1989-10-11 Publication of NO161914C publication Critical patent/NO161914C/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)

NO853336A 1984-08-24 1985-08-23 Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazo(1,2-a)(1,2)kondenserte ringsystemer. NO161914C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB848421493A GB8421493D0 (en)	1984-08-24	1984-08-24	Bicyclic compounds
GB858513541A GB8513541D0 (en)	1984-08-24	1985-05-29	Bicyclic compounds

Publications (3)

Publication Number	Publication Date
NO853336L NO853336L (no)	1986-02-25
NO161914B NO161914B (no)	1989-07-03
NO161914C true NO161914C (no)	1989-10-11

Family

ID=26288155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO853336A NO161914C (no)	1984-08-24	1985-08-23	Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazo(1,2-a)(1,2)kondenserte ringsystemer.

Country Status (14)

Country	Link
US (4)	US4692438A (cs)
EP (1)	EP0172552A3 (cs)
AU (1)	AU583843B2 (cs)
CS (1)	CS255893B2 (cs)
DK (1)	DK384385A (cs)
ES (3)	ES8700258A1 (cs)
FI (1)	FI853174L (cs)
HU (1)	HU193446B (cs)
IL (1)	IL76133A (cs)
MC (1)	MC1694A1 (cs)
NO (1)	NO161914C (cs)
NZ (1)	NZ213130A (cs)
PH (1)	PH21749A (cs)
PT (1)	PT81015B (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4692438A (en) *	1984-08-24	1987-09-08	Hoffmann-La Roche Inc.	Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
ZW11586A1 (en) *	1985-07-01	1987-12-30	Hoffmann La Roche	Bicyclic compounds
GB8629875D0 (en) *	1986-12-15	1987-01-28	Hoffmann La Roche	Pyridazodiazepine derivatives
US5430145A (en) *	1990-10-18	1995-07-04	Merrell Dow Pharmaceuticals Inc.	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) *	1990-12-21	1994-05-03	Merrell Dow Pharmaceuticals Inc.	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
EP0534363B1 (en) *	1991-09-27	1997-07-09	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DE69317764T2 (de) *	1992-02-14	1998-07-30	Merrell Pharmaceuticals Inc., Cincinnati, Ohio	Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
WO1993023403A1 (en) *	1992-05-15	1993-11-25	Merrell Dow Pharmaceuticals Inc.	NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
US5420271A (en) *	1992-08-24	1995-05-30	Merrell Dow Pharmaceuticals, Inc.	2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
AU673857B2 (en) *	1992-10-30	1996-11-28	Aventisub Ii Inc.	Mercaptoacetylamide bicyclic lactam derivatives
WO1994022440A1 (en) *	1993-03-29	1994-10-13	Smithkline Beecham Corporation	Bicyclic compounds which inhibit platelet aggregation
CA2183320C (en) *	1994-02-14	1999-10-26	Gary A. Flynn	Novel mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
EP0746566A1 (en) *	1994-02-14	1996-12-11	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
JPH09508906A (ja) *	1994-02-14	1997-09-09	メレルファーマスーティカルズインコーポレーテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類
HUT74584A (en) *	1994-02-14	1997-01-28	Merrell Pharma Inc	Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
WO1995025532A1 (en) *	1994-03-24	1995-09-28	Merrell Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
AU688012B2 (en) *	1994-03-24	1998-03-05	Merrell Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
US6559304B1 (en)	1998-08-19	2003-05-06	Vertex Pharmaceuticals Incorporated	Method for synthesizing caspase inhibitors
US6177565B1 (en) *	1998-08-19	2001-01-23	Vertex Pharmaceuticals Inc.	Process for synthesizing piperazic acid
US6703500B2 (en)	1998-08-19	2004-03-09	Vertex Pharmaceuticals, Incorporated	Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
AU2001257253B2 (en) *	2000-05-04	2006-03-02	Vertex Pharmaceuticals Incorporated	Asymmetric synthesis of piperazic acid and derivatives thereof
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use
AP2011005597A0 (en) *	2008-07-25	2011-02-28	Chuluun Enkhbold	A method of solid fuel beneficiation and transportation to thermoelectric power stations.
EP2513116B1 (en)	2009-12-16	2015-08-19	Hetero Research Foundation	Polymorphs of darunavir
US8853430B2 (en)	2010-05-20	2014-10-07	Hetero Research Foundation	Crystalline hydrochloride salt of darunavir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4308094A (en) *	1977-02-02	1981-12-29	Sanyo Electric Co., Ltd.	Diaphragm for speaker and method of producing same
IL60617A0 (en) *	1979-07-23	1980-09-16	Sparamedica Ag	Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
EP0025941B1 (de) *	1979-09-19	1983-05-04	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Pyridazopyridazinderivate, Verfahren zu deren Herstellung und Arzneimittel enthaltend solche Pyridazopyridazinderivate
EP0042100A1 (de) *	1980-06-13	1981-12-23	F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft	Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
GB2128984B (en) *	1982-05-12	1985-05-22	Hoffmann La Roche	Diaza-bicyclic compounds
US4692438A (en) *	1984-08-24	1987-09-08	Hoffmann-La Roche Inc.	Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity

1985
- 1985-08-12 US US06/764,372 patent/US4692438A/en not_active Expired - Fee Related
- 1985-08-15 CS CS855928A patent/CS255893B2/cs unknown
- 1985-08-16 NZ NZ213130A patent/NZ213130A/en unknown
- 1985-08-19 FI FI853174A patent/FI853174L/fi not_active Application Discontinuation
- 1985-08-19 AU AU46415/85A patent/AU583843B2/en not_active Ceased
- 1985-08-19 IL IL76133A patent/IL76133A/xx unknown
- 1985-08-19 EP EP85110370A patent/EP0172552A3/de not_active Withdrawn
- 1985-08-21 MC MC851791A patent/MC1694A1/fr unknown
- 1985-08-21 HU HU853187A patent/HU193446B/hu not_active IP Right Cessation
- 1985-08-21 PH PH32671A patent/PH21749A/en unknown
- 1985-08-23 NO NO853336A patent/NO161914C/no unknown
- 1985-08-23 PT PT81015A patent/PT81015B/pt unknown
- 1985-08-23 DK DK384385A patent/DK384385A/da not_active Application Discontinuation
- 1985-08-23 ES ES546360A patent/ES8700258A1/es not_active Expired
1986
- 1986-02-17 ES ES552397A patent/ES8705443A1/es not_active Expired
- 1986-02-17 ES ES552398A patent/ES8705444A1/es not_active Expired
1987
- 1987-05-11 US US07/048,172 patent/US4785093A/en not_active Expired - Fee Related
- 1987-06-15 US US07/062,033 patent/US4762924A/en not_active Expired - Fee Related
1988
- 1988-07-12 US US07/217,805 patent/US4826980A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES8700258A1 (es)	1986-10-01
NO853336L (no)	1986-02-25
FI853174A7 (fi)	1986-02-25
AU583843B2 (en)	1989-05-11
EP0172552A3 (de)	1989-01-11
IL76133A (en)	1989-12-15
ES8705444A1 (es)	1987-05-01
FI853174L (fi)	1986-02-25
PH21749A (en)	1988-02-18
NO161914B (no)	1989-07-03
US4785093A (en)	1988-11-15
CS592885A2 (en)	1987-07-16
US4762924A (en)	1988-08-09
FI853174A0 (fi)	1985-08-19
DK384385A (da)	1986-02-25
PT81015A (en)	1985-09-01
EP0172552A2 (de)	1986-02-26
US4692438A (en)	1987-09-08
HU193446B (en)	1987-10-28
CS255893B2 (en)	1988-03-15
ES552397A0 (es)	1987-05-01
HUT38644A (en)	1986-06-30
US4826980A (en)	1989-05-02
MC1694A1 (fr)	1986-07-18
ES546360A0 (es)	1986-10-01
DK384385D0 (da)	1985-08-23
PT81015B (en)	1987-08-24
IL76133A0 (en)	1985-12-31
ES8705443A1 (es)	1987-05-01
NZ213130A (en)	1988-05-30
AU4641585A (en)	1986-02-27
ES552398A0 (es)	1987-05-01

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