MC1694A1 - Composes bicycliques - Google Patents

Composes bicycliques

Info

Publication number
MC1694A1
MC1694A1 MC851791A MC1791A MC1694A1 MC 1694 A1 MC1694 A1 MC 1694A1 MC 851791 A MC851791 A MC 851791A MC 1791 A MC1791 A MC 1791A MC 1694 A1 MC1694 A1 MC 1694A1
Authority
MC
Monaco
Prior art keywords
group
compound
formula
hydrogen
aroyl
Prior art date
Application number
MC851791A
Other languages
English (en)
French (fr)
Inventor
Cedric Hassall
Geoffrey Lawton
Sally Redshaw
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848421493A external-priority patent/GB8421493D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC1694A1 publication Critical patent/MC1694A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
MC851791A 1984-08-24 1985-08-21 Composes bicycliques MC1694A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848421493A GB8421493D0 (en) 1984-08-24 1984-08-24 Bicyclic compounds
GB858513541A GB8513541D0 (en) 1984-08-24 1985-05-29 Bicyclic compounds

Publications (1)

Publication Number Publication Date
MC1694A1 true MC1694A1 (fr) 1986-07-18

Family

ID=26288155

Family Applications (1)

Application Number Title Priority Date Filing Date
MC851791A MC1694A1 (fr) 1984-08-24 1985-08-21 Composes bicycliques

Country Status (14)

Country Link
US (4) US4692438A (cs)
EP (1) EP0172552A3 (cs)
AU (1) AU583843B2 (cs)
CS (1) CS255893B2 (cs)
DK (1) DK384385A (cs)
ES (3) ES8700258A1 (cs)
FI (1) FI853174L (cs)
HU (1) HU193446B (cs)
IL (1) IL76133A (cs)
MC (1) MC1694A1 (cs)
NO (1) NO161914C (cs)
NZ (1) NZ213130A (cs)
PH (1) PH21749A (cs)
PT (1) PT81015B (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
ZW11586A1 (en) * 1985-07-01 1987-12-30 Hoffmann La Roche Bicyclic compounds
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
DE69220744T2 (de) * 1991-09-27 1997-11-13 Merrell Pharma Inc 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
AU668707B2 (en) * 1992-02-14 1996-05-16 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
DK0640086T3 (da) * 1992-05-15 1999-12-06 Merrell Pharma Inc Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
DE69329701T2 (de) * 1992-10-30 2001-05-10 Merrell Pharmaceuticals Inc., Cincinnati Mercaptoacetylamid substituiertes bizyclisches laktam zur verwendung als enkephalinase und ace-hemmer
WO1994022440A1 (en) * 1993-03-29 1994-10-13 Smithkline Beecham Corporation Bicyclic compounds which inhibit platelet aggregation
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
CN1142831A (zh) * 1994-02-14 1997-02-12 默里尔药物公司 用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物
ATE177098T1 (de) * 1994-02-14 1999-03-15 Merrell Pharma Inc Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
DE69516128T2 (de) * 1994-02-14 2000-12-21 Merrell Pharmaceuticals Inc., Cincinnati Mercaptoacetylamid-1,3,4,5-tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
FI963784A0 (fi) * 1994-03-24 1996-09-23 Merrell Pharma Inc Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä merkaptoasetyyliamididisulfidijohdannaisia
ATE189392T1 (de) * 1994-03-24 2000-02-15 Merrell Pharma Inc Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
US6703500B2 (en) 1998-08-19 2004-03-09 Vertex Pharmaceuticals, Incorporated Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors
US6559304B1 (en) 1998-08-19 2003-05-06 Vertex Pharmaceuticals Incorporated Method for synthesizing caspase inhibitors
US6177565B1 (en) * 1998-08-19 2001-01-23 Vertex Pharmaceuticals Inc. Process for synthesizing piperazic acid
AU5725301A (en) * 2000-05-04 2001-11-12 Vertex Pharma Asymmetric synthesis of piperazic acid and derivatives thereof
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
WO2010010427A1 (en) * 2008-07-25 2010-01-28 Chuluun Enkhbold A method of solid fuel beneficiation and transportation to thermoelectric power stations
CN102686594A (zh) * 2009-12-16 2012-09-19 熙德隆研究基金会 地瑞那韦的多晶型物
WO2011145099A1 (en) 2010-05-20 2011-11-24 Hetero Research Foundation Crystalline hydrochloride salt of darunavir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4308094A (en) * 1977-02-02 1981-12-29 Sanyo Electric Co., Ltd. Diaphragm for speaker and method of producing same
IL60617A0 (en) * 1979-07-23 1980-09-16 Sparamedica Ag Triazolopyridazine derivative,their preparation and pharmaceutical compositions containing them
DE3062972D1 (en) * 1979-09-19 1983-06-09 Hoffmann La Roche Pyridazopyridazine derivatives, processes for their preparation and pharmaceutical compositions containing these pyridazopyridazine derivatives
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity

Also Published As

Publication number Publication date
AU583843B2 (en) 1989-05-11
US4785093A (en) 1988-11-15
DK384385A (da) 1986-02-25
ES552398A0 (es) 1987-05-01
PH21749A (en) 1988-02-18
NO161914C (no) 1989-10-11
PT81015B (en) 1987-08-24
CS592885A2 (en) 1987-07-16
ES546360A0 (es) 1986-10-01
ES8700258A1 (es) 1986-10-01
DK384385D0 (da) 1985-08-23
HU193446B (en) 1987-10-28
AU4641585A (en) 1986-02-27
CS255893B2 (en) 1988-03-15
HUT38644A (en) 1986-06-30
FI853174A0 (fi) 1985-08-19
ES8705443A1 (es) 1987-05-01
FI853174A7 (fi) 1986-02-25
PT81015A (en) 1985-09-01
NZ213130A (en) 1988-05-30
IL76133A (en) 1989-12-15
US4826980A (en) 1989-05-02
ES552397A0 (es) 1987-05-01
NO161914B (no) 1989-07-03
EP0172552A3 (de) 1989-01-11
NO853336L (no) 1986-02-25
EP0172552A2 (de) 1986-02-26
ES8705444A1 (es) 1987-05-01
FI853174L (fi) 1986-02-25
US4762924A (en) 1988-08-09
IL76133A0 (en) 1985-12-31
US4692438A (en) 1987-09-08

Similar Documents

Publication Publication Date Title
MC1694A1 (fr) Composes bicycliques
EP0635003B1 (fr) Derives de perhydroisoindole comme antagonistes de la substance p
MC1515A1 (fr) Composes bicycliques
EP0565396B1 (fr) Dérivés de 1-[2-(arylsulfonylamino)-1-oxoéthyl]pipéridine, leur préparation et leur application en thérapeutique
FR2678938A1 (fr) Derives de pyrrolidine, leur preparation et les medicaments les contenant.
FR2676442A1 (fr) Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
MC1390A1 (fr) Derives de pyrazolopyridazine,procede pour leur preparation et compositions pharmaceutiques les contenant
EP0248734A1 (fr) Dérivés de benzo[b]thiophène et benzo[b]furannecarboxamides, leurs procédés de préparation et les médicaments les contenant
EP0252823B1 (fr) Nouveaux dérivés du 1H, 3H-pyrrolo [1,2-c] thiazole, leur préparation et les compositions pharmaceutiques qui les contiennent
EP0253711B1 (fr) Nouveaux dérivés du 1H,3H-Pyrrolo [1,2-c] thiazole, leur préparation et les Compositions pharmaceutiques qui les contiennent
MC1334A1 (fr) Derives de triazolopyridazine
EP0533827B1 (fr) Nouveaux derives de l'oxazole, leur preparation et les compositions pharmaceutiques qui les contiennent
EP0004494A1 (fr) Nouveaux dérivés de 1,3-dihydro 3-(1-(2-(2,3-dihydro 1,4-benzo-dioxin-2-yl)2-hydroxy éthyl)pipéridin-4-yl)2H-indol 2-one, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant
EP0635002B1 (fr) Nouveaux derives de perhydroisoindole, et leur preparation
FR2611718A1 (fr) Analogues d'amino prostaglandines 7-oxabicycloheptane substitues, a action therapeutique
CH624934A5 (cs)
EP0861247A1 (fr) Nouveaux derives d'imidazole n-benzyldioxol, leur procede de preparation, intermediaires obtenus, compositions pharmaceutiques et leur utilisation comme antagonistes d'endotheline
MC1347A1 (fr) Derives de pyridazopyridazine
EP0119896B1 (fr) Nouveaux dérivés de l'amino-5 dithiole-1,2 one-3, leur préparation et les compositions médicinales qui les contiennent
EP0658557A1 (fr) Nouveaux analogues de l'éburnane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP0234971B1 (fr) Nouveaux amides substitues, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2548184A1 (cs)
EP0271404B1 (fr) Nouveaux dérivés du pyrrole, leur préparation et les compositions pharmaceutiques qui les contiennent
MC1755A1 (fr) Composes bicycliques
EP0659175B1 (fr) Derives d'(amino-3 phenyl)-1 ethanesulfonate d'alkylammonium optiquement actifs, leur preparation et leur utilisation

Legal Events

Date Code Title Description
YP Annual fee paid