IL78831A - 6-(thiazolidin-2,4-dion-5-ylmethyl)chromans and structurally related compounds as hypoglycemic agents - Google Patents

6-(thiazolidin-2,4-dion-5-ylmethyl)chromans and structurally related compounds as hypoglycemic agents

Info

Publication number
IL78831A
IL78831A IL78831A IL7883186A IL78831A IL 78831 A IL78831 A IL 78831A IL 78831 A IL78831 A IL 78831A IL 7883186 A IL7883186 A IL 7883186A IL 78831 A IL78831 A IL 78831A
Authority
IL
Israel
Prior art keywords
chromans
dion
thiazolidin
ylmethyl
related compounds
Prior art date
Application number
IL78831A
Other languages
English (en)
Other versions
IL78831A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL78831A0 publication Critical patent/IL78831A0/xx
Priority to IL83214A priority Critical patent/IL83214A/xx
Publication of IL78831A publication Critical patent/IL78831A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Pyrane Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Soil Working Implements (AREA)
  • Saccharide Compounds (AREA)
  • Detergent Compositions (AREA)
IL78831A 1985-05-21 1986-05-19 6-(thiazolidin-2,4-dion-5-ylmethyl)chromans and structurally related compounds as hypoglycemic agents IL78831A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL83214A IL83214A (en) 1986-05-19 1987-07-16 5-substituted thiazolidine-2,4-diones as hyperglycemic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1985/000962 WO1986007056A1 (fr) 1985-05-21 1985-05-21 Diones de thiazolidine hypoglycemique

Publications (2)

Publication Number Publication Date
IL78831A0 IL78831A0 (en) 1986-09-30
IL78831A true IL78831A (en) 1990-11-29

Family

ID=22188690

Family Applications (1)

Application Number Title Priority Date Filing Date
IL78831A IL78831A (en) 1985-05-21 1986-05-19 6-(thiazolidin-2,4-dion-5-ylmethyl)chromans and structurally related compounds as hypoglycemic agents

Country Status (26)

Country Link
US (1) US4703052A (fr)
EP (1) EP0207605B1 (fr)
JP (1) JPS61271287A (fr)
KR (1) KR870000903B1 (fr)
CN (1) CN1007248B (fr)
AT (1) ATE50256T1 (fr)
AU (2) AU560179B2 (fr)
CA (1) CA1279320C (fr)
DD (1) DD261154A5 (fr)
DE (1) DE3668892D1 (fr)
DK (1) DK233586A (fr)
EG (1) EG18043A (fr)
ES (1) ES8707210A1 (fr)
FI (1) FI89268C (fr)
GR (1) GR861297B (fr)
HU (1) HU210339B (fr)
IE (1) IE58674B1 (fr)
IL (1) IL78831A (fr)
MY (1) MY108496A (fr)
NO (1) NO166448C (fr)
PH (2) PH22313A (fr)
PL (1) PL147479B1 (fr)
PT (1) PT82610B (fr)
WO (1) WO1986007056A1 (fr)
YU (1) YU44573B (fr)
ZA (1) ZA863762B (fr)

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FI91869C (fi) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
JPS63230689A (ja) * 1987-03-18 1988-09-27 Tanabe Seiyaku Co Ltd ベンゾオキサジン誘導体
GB8713861D0 (en) * 1987-06-13 1987-07-15 Beecham Group Plc Compounds
US4897406A (en) * 1987-11-13 1990-01-30 Nisshin Flour Milling Co., Ltd. Rhodanine derivatives and pharmaceutical compositions
US4791125A (en) * 1987-12-02 1988-12-13 Pfizer Inc. Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents
US4798835A (en) * 1987-12-02 1989-01-17 Pfizer Inc. dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]thiazolidine-2,4-dione as an anti-atherosclerosis agent
WO1989008650A1 (fr) * 1988-03-08 1989-09-21 Pfizer Inc. Agents hypoglycemiques de thiazolidinedione
WO1989008652A1 (fr) * 1988-03-08 1989-09-21 Pfizer Inc. Derives de thiazolidinedione comme agents hypoglycemiques
US5120754A (en) * 1988-03-08 1992-06-09 Pfizer Inc. Thiazolidinedione hypoglycemic agents
US5330998A (en) * 1988-03-08 1994-07-19 Pfizer Inc. Thiazolidinedione derivatives as hypoglycemic agents
US5130379A (en) * 1988-03-08 1992-07-14 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US5223522A (en) * 1988-03-08 1993-06-29 Pfizer Inc. Thiazolidinedione hypoglycemic agents
MX15171A (es) * 1988-03-08 1993-05-01 Pfizer Derivados de tiazolidinodiona hipoglicemicos
US5053420A (en) * 1989-10-13 1991-10-01 Pershadsingh Harrihar A Thiazolidine derivatives for the treatment of hypertension
WO1991007107A1 (fr) * 1989-11-13 1991-05-30 Pfizer Inc. Agents d'oxazolidinedione hypoglycemiques
US5036079A (en) * 1989-12-07 1991-07-30 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US5089637A (en) * 1990-03-21 1992-02-18 Pfizer Inc. Process and intermediates for 2r-benzyl-chroman-6-carbaldehyde
ATE205206T1 (de) * 1990-04-27 2001-09-15 Sankyo Co Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren
US5037842A (en) * 1990-06-05 1991-08-06 Pfizer Inc. Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
WO1992003425A1 (fr) * 1990-08-23 1992-03-05 Pfizer Inc. Derives d'hydroxy-uree hypoglycemique
US5158966A (en) * 1991-02-22 1992-10-27 The University Of Colorado Foundation, Inc. Method of treating type i diabetes
TW222626B (fr) 1991-07-22 1994-04-21 Pfizer
FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DE4142190A1 (de) * 1991-12-20 1993-06-24 Bayer Ag Verfahren zur herstellung von optisch aktiven (alpha)-hydroxycarbonsaeuren
FR2688220A1 (fr) * 1992-03-06 1993-09-10 Adir Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5498621A (en) * 1992-05-01 1996-03-12 Pfizer Inc. Oxazolidinedione hypoglycemic agents
NZ248573A (en) * 1992-09-10 1996-02-27 Lilly Co Eli 5-arylmethyl (and methylidene) thiazolidin-4-one derivatives; their preparation and pharmaceutical compositions
US5594016A (en) * 1992-12-28 1997-01-14 Mitsubishi Chemical Corporation Naphthalene derivatives
JP2845743B2 (ja) * 1992-12-28 1999-01-13 三菱化学株式会社 新規なナフタレン誘導体
JP3195455B2 (ja) * 1993-01-06 2001-08-06 ウェルファイド株式会社 キノリン−３−酢酸誘導体、その製造法と用途
DE4317320A1 (de) * 1993-05-25 1994-12-01 Boehringer Mannheim Gmbh Neue Thiazolidindione und diese enthaltende Arzneimittel
US6046222A (en) * 1993-09-15 2000-04-04 Warner-Lambert Company Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus
US5478852C1 (en) * 1993-09-15 2001-03-13 Sankyo Co Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus
US5401761A (en) * 1993-12-09 1995-03-28 Pfizer, Inc. Thiazolidinedione hypoglycemic agents
GB9326192D0 (en) * 1993-12-22 1994-02-23 Glaxo Group Ltd Chemical compounds
US6251928B1 (en) * 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
US5594015A (en) * 1994-06-22 1997-01-14 Regents Of The University Of California Thiazolidine derivatives for the treatment of psoriasis
US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
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IL118778A (en) * 1995-07-03 1999-07-14 Sankyo Co Pharmaceutical compositions for the treatment of arteriosclerosis and xanthoma containing an hmg-coa reductase inhibitor
GB9604340D0 (en) * 1996-02-29 1996-05-01 Unilever Plc Antiperspirant aerosol composition and method of making same
IL120443A (en) * 1996-03-18 2000-07-16 Sankyo Co Use of an insulin sensitizer for the manufacture of a medicament for the treatment or prophylaxis of pancreatitis
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CA2257284C (fr) * 1996-05-31 2005-10-04 Sankyo Company Limited Remede pour maladies auto-immunes
DE69731840T2 (de) * 1996-07-15 2005-08-04 Sankyo Co., Ltd. Pharmazeutische Zusammensetzungen enthaltend CS-866 und Insulinresistenz verbessernde Mittel und deren Verwendung zur Behandlung von Arteriosklerose und Xanthom
EP1006794B1 (fr) * 1997-03-12 2007-11-28 Robert W. Esmond Procede de traitement ou de prevention de la maladie d'alzheimer
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WO1999018066A1 (fr) 1997-10-02 1999-04-15 Sankyo Company, Limited Derives d'acide amidocarboxylique
HUP9902721A2 (hu) * 1997-11-25 1999-12-28 The Procter & Gamble Co. Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület
WO1999030739A1 (fr) * 1997-12-16 1999-06-24 Sankyo Company, Limited Remede contre la leucemie
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
WO2000030628A2 (fr) * 1998-11-20 2000-06-02 Genentech, Inc. Methode d'inhibition de l'angiogenese
US6191154B1 (en) 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
US5968960A (en) * 1999-01-14 1999-10-19 The Regents Of The University Of California Use of thiazolidinediones to ameliorate the adverse consequences of myocardial ischemia on myocardial function and metabolism
JP2001072592A (ja) 1999-07-01 2001-03-21 Kyowa Hakko Kogyo Co Ltd テロメラーゼ阻害剤
WO2001007031A1 (fr) * 1999-07-26 2001-02-01 Shionogi & Co., Ltd. Derives de benzene, compositions immunostimulantes ou agents de retablissement de la pharmacosensibilite les contenant
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US6559188B1 (en) 1999-09-17 2003-05-06 Novartis Ag Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
US6878749B2 (en) 1999-09-17 2005-04-12 Novartis Ag Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes
EP1743655B1 (fr) 2000-01-21 2014-06-25 Novartis AG Combinaisons à base d'inhibiteurs de DPP-IV et d'antidiabetiques
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WO2004110458A1 (fr) * 2003-05-16 2004-12-23 Board Of Regents, The University Of Texas System Enantiomeres de phenothiazine utiles comme agents de prevention de la perte osseuse
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CN116535379B (zh) * 2023-06-29 2023-09-19 希格生科（深圳）有限公司 化合物及其医药用途

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JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS5697277A (en) * 1980-01-07 1981-08-05 Takeda Chem Ind Ltd Thiazolidine derivative
US4342771A (en) 1981-01-02 1982-08-03 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
JPS58118577A (ja) * 1982-01-07 1983-07-14 Takeda Chem Ind Ltd チアゾリジン誘導体
EP0117035B1 (fr) 1983-01-17 1989-08-16 Pfizer Inc. 5-(2-Alcoxyphényl)thiazolidinediones comme inhibiteurs d'aldose-réductase
JPS6051189A (ja) * 1983-08-30 1985-03-22 Sankyo Co Ltd チアゾリジン誘導体およびその製造法
FI91869C (fi) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi

Also Published As

Publication number Publication date
NO166448C (no) 1991-07-24
KR860009010A (ko) 1986-12-19
ZA863762B (en) 1988-05-25
HU210339B (en) 1995-03-28
JPH0586953B2 (fr) 1993-12-14
EP0207605A1 (fr) 1987-01-07
JPS61271287A (ja) 1986-12-01
NO870241D0 (no) 1987-01-20
NO166448B (no) 1991-04-15
DK233586D0 (da) 1986-05-20
CN86104075A (zh) 1987-03-11
FI870219L (fi) 1987-01-20
MY108496A (en) 1996-10-31
IE58674B1 (en) 1993-11-03
NO870241L (no) 1987-03-20
KR870000903B1 (ko) 1987-05-04
ATE50256T1 (de) 1990-02-15
WO1986007056A1 (fr) 1986-12-04
PH25226A (en) 1991-03-27
PT82610B (pt) 1988-11-30
EP0207605B1 (fr) 1990-02-07
GR861297B (en) 1986-09-16
CA1279320C (fr) 1991-01-22
DD261154A5 (de) 1988-10-19
EG18043A (en) 1992-11-30
FI89268C (fi) 1993-09-10
IL78831A0 (en) 1986-09-30
AU5758086A (en) 1987-01-08
DE3668892D1 (en) 1990-03-15
YU83786A (en) 1987-12-31
AU7507487A (en) 1987-10-15
ES555147A0 (es) 1987-07-16
HUT45247A (en) 1988-06-28
IE861336L (en) 1986-11-21
US4703052A (en) 1987-10-27
FI89268B (fi) 1993-05-31
PT82610A (en) 1986-06-01
PL147479B1 (en) 1989-06-30
AU560179B2 (en) 1987-04-02
DK233586A (da) 1986-11-22
CN1007248B (zh) 1990-03-21
PH22313A (en) 1988-07-29
AU583991B2 (en) 1989-05-11
ES8707210A1 (es) 1987-07-16
FI870219A0 (fi) 1987-01-20
YU44573B (en) 1990-10-31

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